Navegando por Palavras-chave "Mast Cells"

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    Heparina: ontogenia, correlação com mastócitos, propriedades físico-químicas e atividades farmacológicas
    (Universidade Federal de São Paulo (UNIFESP), 1980) Straus, Anita Hilda [UNIFESP]; Nader, Helena Bonciani [UNIFESP]
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    Mast cell concentration and skin wound contraction in rats treated with Brazilian pepper essential oil (Schinus terebinthifolius Raddi)
    (Acta Cirurgica Brasileira, 2015-04-01) Estevão, Ligia Reis Moura; Simões, Ricardo Santos [UNIFESP]; Arantes, Rosa Maria Esteves; Rachid, Milene Alvarenga; Silva, Regildo Marcio Goncalves da; Mendonca, Fabio de Souza; Evencio-Neto, Joaquim; Medeiros, Juliana Pinto de; Univ Fed Rural Pernambuco; Universidade Federal de São Paulo (UNIFESP); Universidade Federal de Minas Gerais (UFMG); UNESP
    PURPOSE: To evaluate wound contraction and the concentration of mast cells in skin wounds treated with 5% BPT essential oil-based ointment in rats.METHODS: Twenty rats, male, of adult age, were submitted to skin surgery on the right (RA) and left antimeres (LA) of the thoracic region. They were divided into two groups: control (RA - wounds receiving daily topical application of vaseline and lanolin) and treated (LA - wounds treated daily with the topical ointment). the skin region with wounds were collected at days 4, 7, 14 and 21 after surgery. Those were fixed in 10% formaldehyde and later processed for paraffin embedding. Sections were obtained and stained by H.E for histopathology analysis. the degree of epithelial contraction was measured and mast cell concentration were also evaluated.RESULTS: the treated group showed higher mast cell concentrations (p<0.05) associated with increased contraction at day 7 and 14 respectively.CONCLUSION: Ointment containing 5% Brazilian pepper tree oil increases mast cell concentration and promotes skin wound contraction in rats.
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    Mast cell concentration and skin wound contraction in rats treated with Ximenia americana L
    (Acta Cirurgica Brasileira, 2017) Souza Neto Junior, Jose de Castro; de Moura Estevao, Ligia Reis; Baratella-Evencio, Liriane; Feitosa Vieira, Marcela Gabriela; Simoes, Ricardo Santos; Florencio-Silva, Rinaldo [UNIFESP]; Evencio-Luz, Luis; Evencio-Neto, Joaquim
    PURPOSE: To evaluate wound contraction and the concentration of mast cells in skin wounds treated with wild plum (Ximenia americana) essential oil-based ointment in rats. METHODS:Sixty rats were submitted to two cutaneous wounds in the thoracic region, on the right and left antimeres. Thereon, they were divided into three groups: GX (wounds treated once a day with hydro alcoholic branch extract of Ximenia americana), GP (wounds that received vehicle), and GC (wounds without product application). Wounds were measured immediately after the injury as well as 4, 7, 14 and 21 days post-topical application of the extract. At these days, five rats from each group were euthanatized. Thereafter, samples were fixed in 10% formaldehyde and processed for paraffin embedding. Sections were stained with H.E, Masson's Trichrome and toluidine blue for morphological, morphometrical and histopathological analysis, under light microscopy. The degree of epithelial contraction was measured and mast cell concentrations were also evaluated with an image analyzer (Image Pro-plus (R) software). RESULTS: The extract treated group showed lower mast cell concentrations in the 4th day of lesion, as compared to GP (GX GP = GC