Navegando por Palavras-chave "Iodine"

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    Application of computed tomography images in the evaluation of magnetic nanoparticles biodistribution
    (Elsevier B.V., 2010-08-01) Dias, Argleydson Leao; Kunzel, Roseli; Levenhagen, Ronaldo Savarino [UNIFESP]; Okuno, Emico; Universidade de São Paulo (USP); Ctr Univ Franciscano; Universidade Federal de São Paulo (UNIFESP)
    In this work we evaluate the effectiveness of computed tomography images as a tool to determine magnetic nanoparticle biodistribution over biological tissues. for this purpose, tomography images for magnetic nanoparticles, composed of Fe(3)O(4), coated with 2,3-dimercaptosuccinic acid (DMSA), were generated at several material concentrations. the comparison of CT numbers, calculated from these images generated at clinical conditions, with typical CT numbers for biological tissues, shows that the detection of nanoparticle in most tissues is only possible for high material concentrations. (C) 2010 Elsevier B.V. All rights reserved.
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    Fluorescence analysis of iodinated acetophenone derivatives
    (Elsevier B.V., 2015-03-15) Crivelaro, F.; Oliveira, M. R. S.; Lima, S. M.; Andrade, L. H. C.; Casagrande, G. A.; Raminelli, C. [UNIFESP]; Caires, A. R. L.; Fundacao Univ Fed Grande Dourados; Universidade Estadual de Mato Grosso do Sul (UEMS); Universidade Federal de Mato Grosso do Sul (UFMS); Universidade Federal de São Paulo (UNIFESP)
    In the present paper the synthesis and optical characterization of iodinated acetophenone, 4-hydroxy-3-iodoacetophenone and 4-hydroxy-3,5-diiodoacetophenone obtained from 4-hydroxyacetophenone, were carried out. the optical features of iodinated molecules were determined by performing the UV-Vis absorption, fluorescence and thermal lens spectroscopies. the results showed that the optical properties of the 4-hydroxyacetophenone is altered when the iodine atom is inserted, as substituent, in the aromatic ring. Although it was determined that the optical feature was changed when one iodine atom was inserted in the aromatic ring (4-hydroxy-3-iodoacetophenone), the results revealed that emission behavior was strongly altered when two iodine atoms (4-hydroxy-3,5-diiodoacetophenone) were acting as substituents: the fluorescence quantum efficiency increases approximately 60%. (C) 2014 Elsevier B.V. All rights reserved.
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    Methylation levels of sodium-iodide symporter (NIS) promoter in benign and malignant thyroid tumors with reduced NIS expression
    (Humana Press Inc, 2013-02-01) Galrao, Ana Luiza Resende; Sodre, Ana Karina de Melo Bezerra; Camargo, Rosalinda Yossie Asato de; Friguglietti, Celso Ubirajara; Kulcsar, Marco Aurelio Vamondes; Lima, Erika Urbano de; Medeiros-Neto, Geraldo; Rubio, Ileana Gabriela Sanchez de [UNIFESP]; Universidade de São Paulo (USP); Santa Catarina Hosp; ICESP; Universidade Federal de São Paulo (UNIFESP)
    DNA methylation regulates gene expression. Aberrant methylation plays an important role in human tumorigenesis. We have previously detected reduced NIS mRNA expression in thyroid tumors as compared to non-tumor tissues. Thus, in this study we investigated whether the methylation of the CpG-island located in the NIS gene promoter was associated with reduced mRNA expression in thyroid tumors. Methylation levels of 30 pairs of samples from 10 benign and 20 malignant thyroid tumors (T) along with matched non-tumor (NT) areas were determined by semiquantitative methylation specific-PCR. NIS methylation was detected in all samples. Methylation levels and frequencies did not differ between the groups and were not associated with BRAF mutational status. Highest methylation levels and frequencies were detected in the 5' region of the CpG-island decreasing toward the 3' end. Intraindividual analysis (T versus NT) showed high tumor methylation levels in 40 % of the samples in the benign group and 30 % in the malignant group, associated with low NIS mRNA expression. No quantitative correlation was detected between methylation levels and mRNA expression in any the groups. the results of this study showed that methylation of NIS promoter is a very frequent event in both benign and malignant tumors as well as in their surrounding tissues, and characterized a non-homogeneous methylation pattern along the CpG island. Therefore, further investigations involving other sites that may be implicated in methylation regulation of NIS expression are warranted.