Repositório Institucional - Unifesp :: Navegando por Palavras-chave "Immunity"

Navegando por Palavras-chave "Immunity"

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Alterações das células de Langerhans e sua relação com lesão histopatológica do colo uterino por papilomavírus humano em pacientes com captura híbrida positiva
(Universidade Federal de São Paulo (UNIFESP), 2002) Uchimura, Nelson Shozo [UNIFESP]; Ribalta, Julisa Chamorro Lascasas [UNIFESP]; Ribalta, Julisa Chamorro Lascasas [UNIFESP]
OBJETIVOS: A presenca do HPV associada a imunodepressao mediada por celulas pode ser o inicio da oncogenese. As celulas de Langerhans exercem papel fundamental como celulas apresentadoras de antigenos estranhos aos linfocitos T-CD4. Esse estudo objetivou avaliar as modificacoes morfologicas, densidade, localizacao e tipo de celulas de Langerhans, em mulheres com e sem lesao viral histopatologica. METODOLOGIA: Foram estudadas quatorze mulheres com infeccao sub-clinica de HPV e submetidas a exames clinico, colpocitologico, colposcopico e as biopsias pareadas de colo uterino. Para essas amostras de colo uterino foram efetuados exames de histopatologia, Captura Hibrida para HPV e imuno-histoquimica S100. Analisaram-se os grupamentos atraves de teste do sinal de Wilcoxon. RESULTADOS: A localizacao mais frequente das celulas de Langerhans nas amostras de biopsia de colo uterino foi verificada nas camadas intermediaria e basal do epitelio e na camada sub-epitelial do estroma. Ha importantes modificacoes nos tecidos com e sem lesao histopatologica viral, quanto a densidade nos perfis citoplasmaticos e a relacao perfis citoplasmaticos/nucleo no epitelio e estroma. Modificacoes morfologicas significativas ocorrem na presenca do HPV, tornando as celulas de Langerhans com dendritos curtos e menos numerosos, tanto no epitelio quanto no estroma. CONCLUSOES: O presente estudo observou alteracoes citoplasmaticas significantes das celulas de Langerhans no tecido com lesao histopatologica quando comparada ao tecido sem lesao viral sugerindo que a progressao da infeccao viral determina alteracoes citoplasmaticas nessas celulas,' agravando suas, funcoes, imunologicas e somadas a efeitos do DNA viral contribuiriam de forma incisiva na oncogenese da neoplasia do colo uterino
Acesso aberto (Open Access)
Análise integrada de genes e miRNAs diferencialmente expressos em carcinomas de ovário seroso de alto grau de pacientes com distintas respostas à quimioterapia
(Universidade Federal de São Paulo (UNIFESP), 2021) Melo, Natalia Cruz E [UNIFESP]; Rocha, Rafael Malagoli [UNIFESP]; Universidade Federal de São Paulo
OBJECTIVE: This study intended to evaluate the action of acupuncture on myelodepression in women with breast cancer during treatment with anthracyclines and quality of life, before and after chemotherapy. METHODS: The population of this study was composed of women newly diagnosed with breast cancer at the UNIFESP Mastology outpatient clinic and with indication for chemotherapy with anthracyclines. Patients were randomized into two groups: the Acupuncture Group (GA) and the Control Group (CG). All participants, before and at the end of treatment with anthracyclines and at the end of it, answered the quality of life questionnaire (FACT-G) and were monitored for leukocyte and neutrophil levels in peripheral blood as an indicator of the level of spinal depression. The GA underwent intervention with Acupuncture for up to 10 sessions, starting before the first infusion of chemotherapy and continuing throughout the treatment. The points were used: GV14, CV6, ST36, SP6, KI3, GB39. RESULTS: A total of 26 women were randomized into 2 groups: GA (10) and CG (16). Of these, 7 (26.92%) received a dense dose indication (according to the service protocol) and, therefore, received the granulocyte stimulating factor G- CSF from the first cycle. Thus, for the analysis of the protective effect of acupuncture on the myeloprotective medulla, 2 women from GA and 5 from GC were excluded. The Quality of Life (QOL) analysis was performed for the total sample and also in the subgroups that received G-CSF. The need for secondary prophylaxis with G-CSF occurred in 72.7% (08/11) in the control group and in 12% (08/01) in the acupuncture group (p-value = 0.009). Regarding quality of life (QOL), the initial and final FACT-G showed a difference between the groups, where the mean GA at the end rose from 80.68 to 90.12 (p-value = 0.004) and in the CG mean fell from 81.95 to 70.59 (p-value = 0.003) .In the analysis of subgroups that used G-CSF, the QoL of women in GA showed better QoL (p-value = 0.036). CONCLUSION: Based on the results presented, acupuncture showed efficiency in the prophylaxis of myelosuppression induced by chemotherapy with anthracyclines and increased the quality of life of women during treatment, including those who needed G-CSF.
Acesso aberto (Open Access)
Ataxia-telangiectasia no Brasil: quadro clínico e laboratorial em um estudo multicêntrico
(Universidade Federal de São Paulo (UNIFESP), 2019-03-15) Loekmanwidjaja, Jessica [UNIFESP]; Carvalho, Beatriz Tavares Costa [UNIFESP]; http://lattes.cnpq.br/1072990929102111; http://lattes.cnpq.br/4735719519827158; Universidade Federal de São Paulo (UNIFESP)
Objective: evaluate clinical and laboratorial data and treatment in patients with A-T. Methods: cross-sectional and multi-centric study. Questionnaire was filled based in patient’s charges. Were included patients with A-T diagnosis based on ESID criteria that were in current follow-up, who died and those who lost follow-up. Statistical analyses were performed with SPSS 20.0 and STATA 12 software. Results: twentytwo Brazilians centers participated and a total of 123 patients were included. Were female patients 41,5% and 58,5% were male. Consanguinity was reported by 31,1%. All patients had ataxia, being that 80% presented the symptom until the age of 3 years old. Recurrent airway infections were presented in 66,9%. Opportunistic infections and reaction to attenuated virus vaccine was not reported. Proportion of thinness and severe thinness increased with as the patient grow older, as well as liver enzymes (p<0,001). The most prevalent immunodeficiency was IgA partial deficiency (bellow percentile 3 – 56,1%), followed by IgA deficiency (41,4%) and IgG deficiency (26,6%). IgM was elevated in more than half of the patients. CD4+ lymphopenia was observed in 69% of the patients, CD8+ lymphopenia in 51% and 11,5% had B-lymphocytes bellow 2%. The Kaplan-Meier 20-year survival rate was 63,2% and the survival median time was 25 years. Low levels of IgG were marginally significant with decrease in survival probability ((RR = 2,938, IC 95% = 0,963 - 5,971; p = 0,060). Conclusion: this study showed that clinical features in Brazilian A-T patients are similar to the information described worldwide, with little variation. Low levels of IgG can be related to decrease in estimate survival.
Acesso aberto (Open Access)
Avaliação das subpopulações de linfócitos b em pacientes com ataxia-telangiectasia
(Universidade Federal de São Paulo (UNIFESP), 2016) Silva, Danielli Christinni Bichuete [UNIFESP]; Carvalho, Beatriz Tavares Costa [UNIFESP]; http://lattes.cnpq.br/1072990929102111; http://lattes.cnpq.br/4600003535671037; Universidade Federal de São Paulo (UNIFESP)
Intravenous immunoglobulin (IVIG) is increasingly recommended for many diseases apart from primary immunodeficiency diseases (PID). Although effective and safe, adverse reactions may occur. We conducted a 2-year prospective observational study in 117 patients with PID who received regular replacement therapy to examine IVIG’s adverse effects; 1765 infusions were performed (mean = 15/patient) in 75 males and 42 females (aged 3 months to 77 years) in 3 groups: ≤9 years (34.2%), 10–19 years (26.5%), or ≥20 years (39.3%). Fifty patients had common variable immunodeficiency (CVID), 11 had X-linked agammaglobulinaemia (XLA), and 55 had other immune system disorders. The drugs administered were Octagam® (49.1%), Tegeline® (17.3%), Imunoglobulin® (18.6%), Flebogama® (12.9%), Vigam® (1.2%), and Kiovig® (0.4%). Immediate infusion-related adverse reactions occurred in the cases of 38 of 1765 infusions (2.15%, IC95% 1.53%–2.94%), which were classified as mild (81.6%), moderate (10.5%), or severe (7.9%). Time until reaction ranged from 10 to 240 min (mean = 85.7, median = 60). Reaction rates were similar across age groups. The most common reactions were malaise, headache, and abdominal pain. Reported severe events were tightness of the throat and seizure. All symptoms improved with temporary or complete IVIG interruption and symptomatic medications. Sixteen of 38 reactions to infusions occurred in the presence of an acute infection (p = 0.09). Tegeline® represented a greater reaction risk factor than Octagam® (p < 0.001). These results indicate that IVIG infusion can be considered a safe procedure. Low reaction incidence and few severe immediate infusion-related adverse reactions were observed.
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Consensus Paper: Radiological Biomarkers of Cerebellar Diseases
(Springer, 2015-04-01) Baldarcara, Leonardo [UNIFESP]; Currie, Stuart; Hadjivassiliou, M.; Hoggard, Nigel; Jack, Allison; Jackowski, Andrea P. [UNIFESP]; Mascalchi, Mario; Parazzini, Cecilia; Reetz, Kathrin; Righini, Andrea; Schulz, Joerg B.; Vella, Alessandra; Webb, Sara Jane; Habas, Christophe; Fed Univ Tocantins; Universidade Federal de São Paulo (UNIFESP); Univ Sheffield; Royal Hallamshire Hosp; Yale Univ; Univ Florence; Meyer Children & Careggi Hosp Florence; Childrens Hosp Buzzi; RWTH Aachen Univ Hosp; Forschungszentrum Julich; Julich Aachen Res Alliance JARA; Univ Hosp Siena; Univ Washington; CHNO Quinze Vingts
Hereditary and sporadic cerebellar ataxias represent a vast and still growing group of diseases whose diagnosis and differentiation cannot only rely on clinical evaluation. Brain imaging including magnetic resonance (MR) and nuclear medicine techniques allows for characterization of structural and functional abnormalities underlying symptomatic ataxias. These methods thus constitute a potential source of radiological biomarkers, which could be used to identify these diseases and differentiate subgroups of them, and to assess their severity and their evolution. Such biomarkers mainly comprise qualitative and quantitative data obtained from MR including proton spectroscopy, diffusion imaging, tractography, voxel-based morphometry, functional imaging during task execution or in a resting state, and from SPETC and PET with several radiotracers. in the current article, we aim to illustrate briefly some applications of these neuroimaging tools to evaluation of cerebellar disorders such as inherited cerebellar ataxia, fetal developmental malformations, and immune-mediated cerebellar diseases and of neurodegenerative or early-developing diseases, such as dementia and autism in which cerebellar involvement is an emerging feature. Although these radiological biomarkers appear promising and helpful to better understand ataxia-related anatomical and physiological impairments, to date, very few of them have turned out to be specific for a given ataxia with atrophy of the cerebellar system being the main and the most usual alteration being observed. Consequently, much remains to be done to establish sensitivity, specificity, and reproducibility of available MR and nuclear medicine features as diagnostic, progression and surrogate biomarkers in clinical routine.
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Could adult female acne be associated with modern life?
(Springer, 2014-10-01) Albuquerque, R. G. R. [UNIFESP]; Rocha, M. A. D. [UNIFESP]; Bagatin, Edileia [UNIFESP]; Tufik, S. [UNIFESP]; Andersen, M. L. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
In recent years, the prevalence of adult female acne has increased, but the reason for this increase remains unclear. Acne is one of the most common skin disorders. It can be triggered or worsened by endogenous and exogenous factors, including genetic predisposition, hormone concentrations, diet, smoke and stress; although the interaction with this last factor is not well understood. Modern life presents many stresses including urban noises, socioeconomic pressures and light stimuli. Women are especially affected by stress during daily routine. the recent insertion in the labor market is added to the duties of the mother and wife. Women also have a higher risk of developing psychiatric disorders such as depression and anxiety. Sleep restriction is added to these factors, with several negative consequences on health, including on hormonal secretion and the immune system. This is further complicated by the natural variation in sleep architecture across the menstrual cycle. Recent studies have brought new data about the mechanisms and possible factors involved. This review aims to establish a connection between stress, sleep deprivation and adult female acne.
Acesso aberto (Open Access)
Efeito da acupuntura na mielossupressão e qualidade de vida em mulheres com câncer de mama durante a quimioterapia: estudo clínico randomizado
(Universidade Federal de São Paulo, 2021-04-29) Alliz, Carmen Sylvia Varella [UNIFESP]; Elias, Simone [UNIFESP]; Rizzi, Samantha Karlla de Almeida [UNIFESP]; http://lattes.cnpq.br/5651190805842271; http://lattes.cnpq.br/7745925386381770; http://lattes.cnpq.br/3632079140447413
OBJETIVO: Esse estudo propôs-se a avaliar a ação da acupuntura na mielodepressão em mulheres com câncer de mama durante o tratamento com antracíclicos e a qualidade de vida, antes e depois da quimioterapia. MÉTODOS: A população deste estudo foi composta por mulheres recém diagnosticadas de câncer de mama do ambulatório de Mastologia da UNIFESP e com indicação de quimioterapia com antracíclicos. As pacientes foram aleatorizadas em dois grupos: o Grupo Acupuntura (GA) e Grupo Controle (GC). Todas as participantes, antes e ao final do tratamento com antracíclicos, responderam ao questionário de qualidade de vida (FACT-G) e tiveram acompanhamento dos níveis de leucócitos e neutrófilos no sangue periférico como indicador do nível de depressão medular. O GA sofreu intervenção com Acupuntura por até 10 sessões, iniciando antes da primeira infusão de quimioterápicos e prosseguindo ao longo do tratamento. Foram usados os pontos: GV14, CV6, ST36, SP6, KI3, GB39. RESULTADOS: O total de 26 mulheres foram aleatorizadas em 2 grupos: GA (10) e GC (16). Destas, 7 (26,9%) receberam indicação de dose densa de acordo com o protocolo do serviço e, portanto, receberam o fator estimulante de granulócitos (G-CSF) desde o primeiro ciclo. Assim para análise do efeito protetivo da acupuntura sobre a medula, foram excluídas 2 mulheres do GA e 5 do GC. A análise da Qualidade de Vida (QV) foi realizada para a amostra total e também nos subgrupos que receberam G-CSF. A necessidade de profilaxia secundária com G-CSF ocorreu em 72,7% (08/11) no grupo controle e em 12% (01/08) no grupo acupuntura (p-valor=0,009). Em relação à qualidade de vida (QV), o FACT-G inicial e final mostrou diferença entre os grupos, onde a média do GA ao final subiu de 80,68 para 90,12 (p-valor = 0,004) e no GC a média caiu de 81,95 para 70,59 (p-valor=0,003). Na análise de subgrupos que utilizaram G-CSF, a QV das mulheres do GA apresentaram melhor QV (p-valor=0,036). CONCLUSÃO: Com base nos resultados apresentados a acupuntura mostrou eficiência na profilaxia da mielossupressão induzida pela quimioterapia com antracíclicos e aumentou a qualidade de vida das mulheres durante o tratamento, inclusive das que necessitaram de G-CSF.
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Effect of transgastric peritoneal access on peritoneal innate cellular immunity: experimental study in swine
(Springer, 2013-03-01) Rodrigues, Rodrigo [UNIFESP]; Rezende, Marcelo [UNIFESP]; Gomes, Gustavo [UNIFESP]; Souza, Fernando; Blagitz, Maiara; Della Libera, Alice; Taha, Murched [UNIFESP]; Ferrari, Angelo Paulo [UNIFESP]; Della Libera, Ermelindo [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Fleury Med & Saude; Hosp Israelita Albert Einstein
One of the main concerns of natural orifice surgery is the local and systemic impact on physiology. Few studies have compared natural orifice transluminal endoscopic surgery (NOTES) with other surgical modalities. Most studies are based on systemic variables such as postoperative serum cytokines, with conflicting results. Surgical trauma induces an early inflammatory response, release of cytokines, and local leukocyte activation and oxidative burst. Major surgical trauma is related to impairment of phagocytic function and an increase in production of active oxygen species by phagocytes. the aim of this study was to evaluate the impact of transgastric peritoneoscopy on peritoneal innate immune response compared with laparoscopy and laparotomy in swine.Thirty-four male Sus scrofa domesticus swine were assigned to four groups: transgastric peritoneoscopy (13), laparoscopy (7), laparotomy (7), and sham procedure (7). Twenty-four hours after the procedure, peritoneal fluid cells were harvested by peritoneal washing after necropsy. Flow cytometry analysis of labeled S. aureus and E. coli phagocytosis by peritoneal neutrophils and macrophages was blindly performed. Oxidative burst activity measured by H2O2 production under different challenges was also evaluated.Total operative time varied between all groups. the transgastric, laparoscopy, and laparotomy groups required 56, 17.2, and 40.3 min of mean operative time, respectively (p < 0.05). Even though the mean percentage and intensity of phagocytosis by peritoneal phagocytes were higher in the sham, transgastric, and laparoscopy groups, there was no significant difference between these groups and laparotomy. Macrophage production of H2O2 has been shown to be similar among the transgastric, laparoscopy, and sham groups, and smaller than that in laparotomy (p < 0.05), either under basal conditions, while performing E. coli phagocytosis, or challenged by the presence of E. coli membrane lipopolysaccharide.Under the conditions of this study, transgastric peritoneoscopy has been shown to have minimal impact on peritoneal innate immune response.
Acesso aberto (Open Access)
Estudo da imunogenicidade e segurança da vacina tríplice bacteriana acelular do adulto (dTpa) em crianças e adolescentes com artrite idiopática juvenil (AIJ)
(Universidade Federal de São Paulo (UNIFESP), 2017-05-25) Nicacio, Aline Alencar Martins Fernandes [UNIFESP]; Terreri, Maria Teresa de Sande e Lemos Ramos Ascensão [UNIFESP]; Pinto, Maria Isabel de Moraes [UNIFESP]; http://lattes.cnpq.br/0967318191677557; http://lattes.cnpq.br/2661280959330284; http://lattes.cnpq.br/1618399462513631; Universidade Federal de São Paulo (UNIFESP)
Introduction: Juvenile Idiopathic Arthritis (JIA) is the most common chronic rheumatic disease in childhood, accounting for varying degrees of physical disability. Protection of infections through active immunization is essential in patients with JIA using immunosuppressive drugs. However, there are still doubts about indication, safety and efficacy, as well as reactivation of the disease in this group of patients when using these vaccines. Objectives: The aim of this study was to evaluate the immunogenicity and safety of adult acellular bacterial triple vaccine (dTpa) in patients with JIA with or without use of anti-TNF agents. Methods: This is a prospective longitudinal experimental study in which three groups of individuals were assessed: one with patients with JIA according to ILAR criteria using anti-TNF agent (n=19), another with JIA patients without use of anti-TNF agent (n=19) and another from healthy individuals (Control, n=27), paired with case groups by age and gender. A 0.5 ml dose of the diphtheria, tetanus, acellular pertussis (dTpa) adsorbed vaccine (ADACEL® Sanofi Pasteur, Toronto, Canada) was administered intramuscularly in the non-dominant arm of the selected subjects. Samples of 10 mL of peripheral blood were collected on the day of vaccination (D0), after 14 days (D14) and 28 days after vaccination (D28). Serology for tetanus, diphtheria and pertussis and immunophenotyping of lymphocytes in peripheral blood were performed. Results: Patients with and without anti-TNF agents did not present significant differences in the frequency of ANA (anti-nuclear antibody), RF (rheumatoid factor) and presence of uveitis. There was only association between use of anti-TNF and course subtype (p = 0.009). Thus, it was observed that patients without anti-TNF had a higher percentage of persistent oligo (36.8% vs 0%) and lower ERA frequency (0.0% vs 21.1%) compared to the group onf anti-TNF. In the group on anti-TNF agent, about half were on fusion protein (etanercept), while the other half were on monoclonal antibody (adalimumab or infliximab). We did not observe reactivation of the disease after vaccination. We observed presence of adverse events in about one third of the individuals, being pain at the site of the vaccine the most prevalent. Differences in the immunophenotypic profile were observed, but without repercussion in the humoral immune response to the three antigens evaluated. Conclusion: The subjects with JIA with or without use of anti-TNF agents showed a good response to a booster dose for the three antigens studied in the absence of major adverse events and without reactivation of the disease.
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Experiências de um centro de referência em Erros Inatos da Imunidade (EII) no interior de São Paulo
(Universidade Federal de São Paulo (UNIFESP), 2021) Ain, Ana Carolina Da Matta [UNIFESP]; Condino Neto, Antonio [UNIFESP]; Universidade Federal de São Paulo
Introduction: The Inborn Errors of Immunity (IEI) are a group of congenital, genetic and hereditary diseases that cause immunological alterations with an increase in infections, autoimmunity, autoinflammatory diseases, atopy or malignancy. Objective: To describe the clinical profile of patients in the Pediatric Immunology Service linked to the Municipal University Hospital of Taubaté (HMUT) and of patients who had an extended neonatal screening test altered for inborn errors of immunity (NSTIEII) performed at the HMUT. Methods: This was a retrospective cross-sectional study, carried out by collecting data from the medical records of patients with IEI followed up in the service between 2014 and 2020, analyzing the profile of these patients and those who presented changes in NSTIEII between 2016 and 2020. Results: Assessed - 112 patients with a diagnosis of EII attended at the service (study 1), divided into predominant antibody deficiencies (41.1%), combined immunodeficiency with associated or syndromic characteristics (10.7%), congenital phagocyte defects (3.6%), immunodeficiency affecting cellular and humoral immunity (1.8%), immune dysregulation diseases (0.9%), probable diagnosis of IEI (42.0%). Between 2016 and 2020, 2679 NSTIEII were performed and 33 altered results were found (study 2), with cases of severe combined immunodeficiency (SCID), agammaglobulinemia, actinopathy, trisomy 21 and hypogammaglobulinemia. Twelve patients are still under investigation and 9 with IIE later discarded. When describing the patients in study 1 and study 2, we could observe male prevalence, presence of allergies, hospitalization (79.5% x 75.8%), admission to the NICU (40.2% x 45.5%) and 22.3% in pediatric ICU (with p<0.001) x 30.3%. The use of intravenous immunoglobulin was 49.1% x 39.4% respectively. Mortality was 6.3% (study 1) x 18.2% (study 2). There was greater administration of immunoglobulin and mortality among patients who underwent postnatal TREC and KREC collection. Conclusion: The clinical profile of patients with IEI from the Pediatric Immunology Service linked to the HMUT was described,demonstrating that there was a great delay in diagnosis. The most frequent class of IEI was the predominant antibody deficiency and the presence of hospitalization, especially in the pediatric ICU, proved to be important among these patients. The performance of TNEII is feasible and can be used. It should be considered that it is possible to make the diagnosis and the appropriate treatment, in addition to setting up a reference center for IEI in the interior of the country.
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Expressão de genes da imunidade em queloide de lóbulo de orelha
(Universidade Federal de São Paulo (UNIFESP), 2020-03-31) Conceicao, Danielle Tafner [UNIFESP]; Gragnani Filho, Alfredo [UNIFESP]; Universidade Federal de São Paulo
Introduction: Keloid is a cutaneous lesion characterized by the growth of dense fibrous tissue that extends beyond the limits of the original site and is considered a benign tumor restricted to humans and its etiopathogenesis has not been clarified due to the multifactorial influence and lack of experimental animal model. This altered wound healing is associated with various immunity factors such as cytokines, growth factors, and immune system cells. Objective: To evaluate the gene expression of immunity in earlobe keloid. Methods: Twelve (12) earlobe keloid samples and twelve (12) skin samples from mammoplasty were collected for the control group.Total RNA was purified with Qiagen RNeasy Minikit™ DNAse and the amount and quality of extracted RNA were evaluated by spectrophotometry (Nanovue™). Patients' mRNA from each group was pooled for cDNA synthesis. Reverse transcription reactions were performed in triplicate using the RT2 First Strand Kit™ Superarray Bioscience according to the manufacturer's protocol and RT-qPCR was performed using the RT2 Profiler™ PCR array from Superarray Bioscience. 84 genes relevant to the human immunity response were analyzed - Human Innate & Adaptive Immune Responses (PAHS - 052ZC). Results: Of the 84 immunity genes,20 (20/84 = 24%) were differentially expressed. Of the 20 differentially expressed genes, 100% were hypoexpressed. Through the analysis of canonical pathways by Metacore™, we obtained 6 networks between differentially expressed genes. Conclusion: The expression of the earlobe keloid immunity genes resulted in 20 differentially expressed genes, all hypoexpressed, the genes of interest being for earlobe keloid CXCR3, MX1, FOXP3, SLC11A1, TICAM1, TLR6, ITGAM, IL-8, IL -13, CD40LG, CD8A, IL1A, ICAM1, TLR4, IL-18, HLA-A, FASLG, NFKBIA, MPO and TLR7.
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Imunidade contra formas metacíclicas do Trypanosoma cruzi: identificação de antígenos de superfície e resistência à infecção aguda
(Universidade Federal de São Paulo (UNIFESP), 1988) Yoshida, Nobuko [UNIFESP]; Universidade Federal de São Paulo [UNIFESP]
Acesso aberto (Open Access)
Peripheral chemokine levels in women with recurrent major depression with suicidal ideation
(Associação Brasileira de Psiquiatria - ABP, 2012-03-01) Grassi-Oliveira, Rodrigo; Brietzke, Elisa [UNIFESP]; Teixeira, Antonio Lúcio [UNIFESP]; Pezzi, Júlio Carlos; Zanini, Márcio [UNIFESP]; Lopes, Rodrigo Pestana; Bauer, Moisés Evandro; Pontifícia Universidade Católica Post-Graduate Program in Psychology Developmental Cognitive Neuroscience Research Group; Universidade Federal de São Paulo (UNIFESP); Universidade Federal Minas Gerais School of Medicine Department of Internal Medicine; Universidade Federal de Ciências da Saúde de Porto Alegre Post-Graduate Program in Health Sciences; Pontifícia Universidade Católica Institute of Biomedical Research and Faculty of Biosciences
OBJECTIVE: To compare serum levels of MCP-1/CCL2, RANTES/CCL5, and Eotaxin/CCL11 between female patients with recurrent major depressive disorder (MDD) and healthy controls, verifying if there is a difference in the levels of these mediators between those with or without current suicidal ideation. METHODS: Thirty female outpatients with recurrent MDD were divided in two groups accordingly the presence or absence of suicidal ideation. These groups were compared with 16 healthy controls. Serum levels of MCP-1/CCL2, RANTES/CCL5, and Eotaxin/CCL11 were determined. Depression severity was evaluated by Beck Depression Inventory (BDI). Suicidal ideation was assessed by SCID-I and BDI. RESULTS: Patients with recurrent MDD and healthy controls did not differ in age, socioeconomic status, and education. All patients reported high scores of BDI (mean, SD, n; 29.75, 10.55, 28). Multivariable analysis of covariance adjusted for age and BMI showed that MDD patients with suicidal ideation presented lower levels of MCP-1/ CCL2 and RANTES/CCL5 (p < 0.001) and higher levels of Eotaxin/CCL11 (p = 0.04) compared to healthy controls. These differences remained significant after adjusting for depression severity. CONCLUSION: The findings of this study indicated that the presence of recurrent MDD with suicidal ideation is associated with differences in inflammatory chemokines when compared to those without suicidal ideation.
Acesso aberto (Open Access)
Serum cytokine responses over the entire clinical-immunological spectrum of human leishmania (l.) infantum chagasi infection
(Hindawi ltd, 2016) Ramos, Patricia Karla; Carvalho, Karina Inacio; Rosa, Daniela Santoro [UNIFESP]; Rodrigues, Ana Paula; Lima, Luciana Vieira; Campos, Marliane Batista; Gomes, Claudia Maria C.; Laurenti, Marcia Dalastra; Corbett, Carlos Eduardo; Silveira, Fernando Tobias
The clinical-immunological spectrum of human Leishmania (L.) infantum chagasi infection in Amazonian Brazil was recently reviewed based on clinical, DTH, and IFAT (IgG) evaluations that identified five profiles: three asymptomatic (asymptomatic infection, AI
Acesso aberto (Open Access)
Swimming against the current: genetic vaccination against Trypanosoma cruzi infection in mice
(Fundação Oswaldo Cruz, 2009-07-01) Rodrigues, Mauricio Martins [UNIFESP]; Alencar, Bruna Cunha Gondim de [UNIFESP]; Claser, Carla [UNIFESP]; Tzelepis, Fanny [UNIFESP]; Silveira, Eduardo Lani Volpe da [UNIFESP]; Haolla, Filipe Augusto Bettencourt [UNIFESP]; Dominguez, Mariana Ribeiro [UNIFESP]; Vasconcelos, Jose Ronnie Carvalho de [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)
Vaccines have had an unquestionable impact on public health during the last century. The most likely reason for the success of vaccines is the robust protective properties of specific antibodies. However, antibodies exert a strong selective pressure and many microorganisms, such as the obligatory intracellular parasite Trypanosoma cruzi, have been selected to survive in their presence. Although the host develops a strong immune response to T. cruzi, they do not clear the infection and instead progress to the chronic phase of the disease. Parasite persistence during the chronic phase of infection is now considered the main factor contributing to the chronic symptoms of the disease. Based on this finding, containment of parasite growth and survival may be one method to avoid the immunopathology of the chronic phase. In this context, vaccinologists have looked over the past 20 years for other immune effector mechanisms that could eliminate these antibody-resistant pathogens. We and others have tested the hypothesis that non-antibody-mediated cellular immune responses (CD4(+) Th1 and CD8(+) Tc1 cells) to specific parasite antigens/genes expressed by T. cruzi could indeed be used for the purpose of vaccination. This hypothesis was confirmed in different mouse models, indicating a possible path for vaccine development.
Acesso aberto (Open Access)
Vitamina D e COVID-19: o estado da arte
(Universidade Federal de São Paulo, 2023-01-12) Oliveira, Amanda Bernardo Padovan de [UNIFESP]; Speridião, Patrícia da Graça Leite [UNIFESP]; http://lattes.cnpq.br/7520873457028761; http://lattes.cnpq.br/0388030400004679; Universidade Federal de São Paulo (UNIFESP)
Introdução: recentemente observou-se níveis, significativamente, menores de 25(OH)D em pacientes com PCR positivo para SARS-CoV-2 em comparação com pacientes negativos. Um estudo sobre envelhecimento reiterou que durante a atual pandemia, a suplementação adequada de vitamina D, especialmente, em pessoas mais velhas, pode ser benéfica para populações vulneráveis. Objetivo: apresentar e discutir os aspectos envolvidos na relação entre a vitamina D e a COVID-19. Material e Método: trata-se de um estudo de revisão do estado da arte no qual buscou-se nas bases de dados Medline, Lilacs e Scielo, os estudos sobre a temática a partir de 2019, em língua portuguesa, inglesa e espanhola, utilizando-se os descritores: vitamina D; imunidade; deficiência vitamínica; pandemia. Desenvolvimento: estudos observacionais mostraram uma ligação consistente entre deficiência de vitamina D e suscetibilidade às infecções respiratórias agudas. Em relação ao COVID-19, um dos estudos mostrou que a chance de infecção com o vírus, é três vezes maior para indivíduos com deficiência de vitamina D e a probabilidade de desenvolver quadro grave nesses pacientes, é cerca de cinco vezes maior do que em outros. Considerações finais: No contexto da COVID-19, alguns estudos mostram benefícios em relação a níveis adequados ou suplementação desse hormônio na melhora ou impedimento da gravidade da doença, sendo um tratamento com potencial exitoso no que se refere ao Coronavírus.

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