Navegando por Palavras-chave "IONIZING RADIATION"

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    ACUTE EFFECTS ON BONE-MARROW AFTER ASSOCIATION BETWEEN RADIOSENSITIZER AND X-RAYS - NN/N METHOD
    (Interciencia, 1994-03-01) Segreto, Helena Regina Comodo [UNIFESP]; Segreto, Roberto Araujo [UNIFESP]; Thomaz, K.; Silva, MRR; Novo, Neil Ferreira [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    A histopathological and morphometric study was performed in the bone marrow of mice after association of cisdiamminedi-chloroplatinum II (3.0 mg/kg) plus X-rays (103.20 mC/kg - 400R). Estimation of bone marrow effects was assessed by counting the number of non nucleated-erythrocytes (NN) and nucleated (N) cells, and establishing (NN/N) ratio.The morphomeric method used correlates and makes possible quantification of histopathologic changes of bone marrow through relation of vascular stroma and cellular parenchyma. It can be used as a biological dosimetry parameter and to estimate injury and recovery of hematologic evolution of different myelotoxic agents.
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    WR2721 BONE-MARROW RADIOPROTECTION - LIGHT AND ELECTRON-MICROSCOPE STUDY
    (Interciencia, 1995-07-01) Segreto, Helena Regina Comodo [UNIFESP]; Segreto, Roberto Araujo [UNIFESP]; Silva, MRR; Egami, Mizue Imoto [UNIFESP]; Ghiraldini, M.; Novo, Neil Ferreira [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    To assess the radioprotection afforded by the S- 2- (3 aminopropylamino) ethylphosphorotioic acid (WR2721), bone marrow obtained from mouse femora was examined by means of light and electron microscope 1, 3, 6 and 10 days after a single whole body X ray dose of 7 Gy.Comparing the protected to the unprotected bone marrows, the following features were observed in the protected ones: (1) less depletion of parenchyma cells; (2) less vascular dilatation and hyperemia in parenchyma; (3) apparently less apoptotic figures present 1 day after irradiation and (4) the recovery process occurred earlier.Despite the hyperemia in the parenchyma during the injury phase, the continuity of the sinus wall was maintained in the protected and unprotected marrows.The morphometric method used (NN/N ratio) allowed the estimation of the WR2721 bone marrow radioprotection through the relation of vascular stroma and cellular parenchyma.