Navegando por Palavras-chave "Hypnotics and sedatives"

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    Avaliação de um modelo de anestesia local (com sedação) para vitrectomias via pars plana
    (Universidade Federal de São Paulo (UNIFESP), 1994) Goncalves, Joao Carlos de Miranda [UNIFESP]; Farah, Michel Eid [UNIFESP]
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    Hipnoindutores e insônia
    (Associação Brasileira de Psiquiatria - ABP, 2005-05-01) Poyares, Dalva [UNIFESP]; Pinto Jr, Luciano Ribeiro [UNIFESP]; Tavares, Stella; Barros-vieira, Sergio; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP); Hospital Saint Antoine
    The purpose of this updating manuscript is to briefly describe the profile, clinical use and indication of some of the most used sedative and hypnotic compounds. About 2/3 of all hypnotic prescriptions go to chronic use. Benzodiazepines are among the most prescribed drugs worldwide. Women, elderly, psychiatric and medical disease patients are among chronic users of hypnotics. Zolpidem is now the most prescribed hypnotic in most countries. It appears to be safer, compared to benzodazepines, and might be an option for long-term and controlled use (as needed). Sedative antidepressants are also among the most prescribed drug for sedation in insomnia patients in USA and UK. Sedative effect and use of trazodone, mirtazapine, doxepine, amitryptilin are described. The authors also discuss the use of melatonin and its sleep properties, and the rational use of sedative antipsychotics for chronic insomnia, particularly in psychiatric patients. Finally, some phytotherapeutic compounds are mentioned.
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    Interação da ação analgésica da bupremorfina com a ação hipnótica do tiopental sódico, administrados por via intra-peritoneal: estudo experimental em ratos
    (Universidade Federal de São Paulo (UNIFESP), 1994) Vieira, Antonio Mauro [UNIFESP]; Fagundes, Djalma José [UNIFESP]
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    Novos sedativos hipnóticos
    (Associação Brasileira de Psiquiatria - ABP, 2010-09-01) Sukys-Claudino, Lucia [UNIFESP]; Moraes, Walter André dos Santos [UNIFESP]; Tufik, Sergio [UNIFESP]; Poyares, Dalva [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    There has been a search for more effective and safe hypnotic drugs in the last decades. Zolpidem, zaleplon, zopiclone, eszopiclone (the z-drugs) and indiplon are GABA-A modulators which bind selectively α1 subunits, thus, exhibiting similar mechanisms of action, although recent evidence suggests that eszopiclone is not as selective for α1 subunit as zolpidem is. Ramelteon and tasimelteon are new chrono-hypnotic agents, selective for melatonin MT1 and MT2 receptors. On the other hand, the consumption of sedative antidepressant drugs is significantly increasing for the treatment of insomnia, in the last years. As an experimental drug, eplivanserin is being tested as a potent antagonist of serotonin 2-A receptors (ASTAR) with a potential use in sleep maintenance difficulty. Another recent pharmacological agent for insomnia is almorexant, which new mechanism of action involves antagonism of hypocretinergic system, thus inducing sleep. Finally we also discuss the potential role of other gabaergic drugs for insomnia.