Navegando por Palavras-chave "Hodgkin disease"

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    Aspectos da imunidade celular em moléstia de Hodgkin
    (Universidade Federal de São Paulo (UNIFESP), 1981) Yamamoto, Mihoko [UNIFESP]
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    Dermatomiosite juvenil e linfoma de Hodgkin: uma rara associação
    (Sociedade Brasileira de Reumatologia, 2007-12-01) Cavalcanti, André [UNIFESP]; Terreri, Maria Teresa Ramos Ascensão [UNIFESP]; Sallum, Adriana Maluf Elias; Marie, Suely Kazue Nagahashi; Luisi, Flávio [UNIFESP]; Hilário, Maria Odete Esteves [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)
    Dermatomyositis (DM) in adults is frequently associated with cancer. In contrast, during childhood juvenile dermatomyositis (JDM) is predominantly idiopathic and its association with neoplasia is rare and based only in case reports. Although rare, the presence of neoplasia in JDM patients must always be suspected in face of atypical clinical manifestations and uncommon laboratorial findings. We describe and discuss a case of JDM and Hodgkin disease in an adolescent.
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    Estudo do mielograma na moléstia de hodgkin: comparação entre material de biópsia, imprinte e aspirado
    (Universidade Federal de São Paulo (UNIFESP), 1985) Oliveira, José Salvador Rodrigues de [UNIFESP]; Kerbauy, José [UNIFESP]
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    Proliferating cell nuclear antigen (PCNA), p53 and MDM2 expression in Hodgkin's disease
    (Associacao Paulista Medicina, 2007-03-01) Pinheiro, Gevina Silva [UNIFESP]; Silva, Maria Regina Regis [UNIFESP]; Rodrigues, Celso Arrais [UNIFESP]; Kerbauy, Jose [UNIFESP]; Oliveira, José Salvador Rodrigues de [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    CONTEXT and OBJECTIVE: Tumor cells in Hodgkin's disease (HD) express cell proliferation markers that are evaluated according to the oncogenes involved or the expression of their proteins. Correlations between the protein expression grade and clinical data are now important for disease prognosis.DESIGN and SETTING: This was a retrospective analysis on proliferating cell nuclear antigen (PCNA), p53 and MDM2 (murine double minute-2) expression using immunohistochemistry, on formalin-fixed, paraffin-embedded tissues from diagnostic biopsies on 51 patients with HID. the study was conducted at the Division of Hematology and Transfusion Medicine, Hospital São Paulo, Universidade Federal de São Paulo.METHODS: Antigen expression was evaluated as the proportions of positive Hodgkin and Reed-Sternberg (HRS) cells and reactive lymphocytes (L), which were compared using Spearman correlation coefficients. the Friedman test was used for comparisons between the markers. the Pearson test was used to investigate associations between marker expression and clinical and laboratory parameters, marrow involvement, complete remission (CR) and overall survival (OS) rates.RESULTS: There was overexpression of antigen proteins in HRS, in relation to L (p < 0.001). in HRS, MDM2 was higher than p53 and PCNA (p < 0.003), while the latter two were equivalent. in L, p53 was lower than MDM2 and PCNA (p < 0.001), while the latter two were equivalent. There was no relationship between protein expression and clinical and laboratory variables or outcome.CONCLUSIONS: PCNA, p53 and MDM2 are tumor markers for HID, but showed no clinical or prognostic significance in our analysis.