Navegando por Palavras-chave "Herpes Simplex"

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    Incidência de herpes-vírus na saliva e na lágrima de pacientes com paralisia facial periférica
    (Universidade Federal de São Paulo (UNIFESP), 2020-12-04) Madruga, Thais De Carvalho Pontes [UNIFESP]; Testa, Jose Ricardo Gurgel [UNIFESP]; Universidade Federal de São Paulo
    Objective: To detect the incidence of Herpes Simplex Virus type 1 and 2 (HSV 1 and 2), Varicella Zoster virus (VZV) and Human Herpesvirus type 6 (HHV-6) in saliva and tears of patients with Bell’s palsy, Ramsay-Hunt syndrome or Melkerson-Rosenthal syndrome, and to compare them to healthy controls, as well as to check their relation to symptoms and prognosis and to validate this PCR method for searching for these herpesvirus in the referred fluids. Method: Prospective cohort study developed at the outpatient clinic for facial nerve diseases and at the Ophthalmology laboratory. Sample was composed of patients with Bell palsy, Ramsay Hunt syndrome or MelkerssonRosenthal syndrome who were referred from the urgent care and a control group was composed of people with neither facial palsy nor active herpetic infection. Saliva was expelled into a sterile pipe. Tear was collected by using a Schirmer tape. Both are processed for DNA extracting and then qPCR is performed to detect DNA from HSV1, HSV-2, VZV and HHV-6. Patients have a two month follow-up and receive all usual care for facial palsy. Results: There were 130 patients included. Bell’s palsy: 118 patients; ages from 7 to 84 years (38,3±18,6); 55% female; 53% left. Ramsay Hunt syndrome: 7 patients; ages from 39 to 65 years (46,7±9,2); 57% male, 71% right. Melkersson-Rosenthal syndrome: 5 patients; ages from 17 to 56 (30,8±15,5); 60% female, 60% left. Control group: 50 participants, ages from 7 to 69 years (36±16,3); 55% female. Among patients with Bell’s palsy, HSV-1 incidence was 8,5%, VZV was 5,3% and HHV-6 was 54,2%, not differing statistically from the control group (p values of 0,7576, 0,1792 e 0,8896), the incidence of HHV-6 was higher among younger patients (p<0,05) and HSV-1 incidence was associated to greater severity of facial palsy (0,0174) and to tinnitus (0,0293). In Ramsay Hunt syndrome, VZV was detected in 14% and HHV-6 in 71%, a higher incidence than the control’s, but with no statistical significance (p=0,125 and p=0,443), and HHV-6 incidence was related to tinnitus (p=0,0476). In Melkersson-Rosenthal syndrome, HHV-6 was detected in 60%, also not differing from controls (p=0,999). Conclusion: Herpesvirus HSV-1, VZV and HHV-6 were detected in patients with Bell’s palsy; VZV and HHV-6 in Ramsay Hunt syndrome and HHV-6 in Melkersson-Rosenthal syndrome, but their incidence in each of those groups did not statistically differ from healthy controls.
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    Soroprevalência de anticorpos contra vírus herpes simples 1-2 no Brasil
    (Faculdade de Saúde Pública da Universidade de São Paulo, 2010-08-01) Clemens, Sue Ann Costa [UNIFESP]; Farhat, Calil Kairalla [UNIFESP]; Instituto de Pós-Graduação Médica Carlos Chagas Departamento de Metodologia da Pesquisa; Universidade Federal de São Paulo (UNIFESP)
    OBJECTIVE: To estimate the seroprevalence of HSV-1 and HSV-2 antibodies in Brazil and to analyze factors associated. METHODS: Cross-sectional study including subjects aged 1-40 years from the general population in four different geographical areas in Brazil between 1996 and 1997. All subjects were stratified by age and gender and 1,090 of them were included in the final analysis. Blood samples were tested for HSV-1 and HSV-2 antibodies by type-specific (gG1 and gG2) ELISA. Frequencies and proportions were described and compared among groups using two-sided Fisher's exact test. A logistic regression analysis was performed to assess the influence of the variables age, gender, geographical area, socioeconomic condition, past history of STD, seropositivity for anti-HSV-1 or anti-HSV-2 and interactions of any of these factors on the seroprevalence of HSV-1 and/or HSV-2. RESULTS: The age-adjusted seroprevalences of HSV-1 and HSV-2 antibodies were 67.2% and 11.3%, respectively, without sex differences and being higher in the North region. Seroprevalences increased with age and, for HSV-2 infection, the higher increase was observed among adolescents and young adults. Subjects who tested positive for HSV-1 were more likely to also test positive for HSV-2 (15.7%) compared to HSV-1 negative subjects (4.7%). In the multivariate analysis past history of STD significantly (OR=3.2) increased the likelihood of HSV-2 infection whereas socioeconomic condition did not affect the results. CONCLUSIONS: HSV-1 and HSV-2 seroprevalences vary with age and among Brazilian regions. Past history of STD is a major risk factor for HSV-2 infection.