Navegando por Palavras-chave "HTLV-I"

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    Genetic mutation and early onset of T-cell leukemia in pediatric patients infected at birth with HTLV-I
    (Elsevier B.V., 2002-02-01) Pombo-de-Oliveira, M. S.; Dobbin, J. A.; Loureiro, P.; Borducchi, D.; Maia, R. C.; Fernandes, M. A.; Cavalcanti, G. B.; Takemoto, S.; Franchini, G.; Inst Nacl Canc; HEMOPE; Universidade Federal de São Paulo (UNIFESP); NCI
    T-cell leukemia/lymphoma (T-c LL) associated with prior infection with HTLV-I is rarely described in children. We present herein, the clinical, morphological, and virologic features of T-c LL, which occurred in eight pediatric cases with similar features of ATLL described in adults. There were three girls and five boys with age ranging from 2 to 18 years. Lymphoadenopathy, hepatosplenomegaly and marked skin lesions were presented in all cases. Five patients had hypercalcemia. the diagnostic criteria of T-c LL were based on both morphological and immunophenotypical analyses characterized by T-cell markers positively. Seven cases were cCD3 +, CD4/CD25 +, whereas CD1a and TdT were negative in all cases tested. HTLV-I antibodies were detected in all cases. HTLV-I provirus integration of at least one provirus was seen in all cases tested by molecular analysis. Mother-to-child transmission of HTLV-I was demonstrated in six cases. Interestingly, a homozygous deletion in p16 gene locus was observed in all four cases studied, while exons 7 and 8 of p53 were deleted in one child. the deletion of the p16(INK4A)/p14(ARF) or mutation of p53, key regulatory protein of cell cycle checkpoint in G1/S progression, found in five of the eight pediatric patients suggests that in these cases genetic lesions associated with HTLV-I infection may predispose for an early onset of leukemia. (C) 2002 Elsevier B.V. All rights reserved.
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    Impact of HTLV-I in quality of life and urogynecologic parameters of women with urinary incontinence
    (Elsevier B.V., 2009-12-01) Costa Diniz, Monica Suzana [UNIFESP]; Feldner, Paulo Cezar [UNIFESP]; Castro, Rodrigo Aquino [UNIFESP]; Ferreira Sartori, Marair Gracio [UNIFESP]; Batista Castello Girao, Manoel Joao [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade Federal de Pernambuco (UFPE)
    Objective: To assess the impact of urinary incontinence in quality of life, epidemiological data, symptoms, findings of gynecological/neurological examination and urodynamic of HTLV-I seropositive women compared with HTLV-I negative women.Study design: 43 incontinent women were divided in two groups: 24 serropositives and 19 seronegatives for HTLV-I. We used King's Health Questionnaire (KHQ), standardized recorded data and urodynamics. Data were compared using Mann-Whitney test or Chi-squared test.Results: Quality of life was significantly worse in seropositive incontinent women in the following parameters: general perception of health, impact of incontinence, limitation of daily life activities, social relations, sleep and disposition. Also, the following gynecological/neurological symptoms were more prevalent in seropositives: pain on vesical filling, dyspareunia, parestesis in inferior members, increased perineal sensitivity, pain in vaginal palpation, increased vaginal tonus, gait alteration, increased patellar reflex, Babinski reflex positive and increased tonus in inferior members.Conclusion: Poor quality of life and physical abnormalities were identified in incontinent HTLV-I seropositive women when compared with incontinent HTLV-I seronegative women. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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    Linfoma/Leucemia de células T do adulto
    (Associação Médica Brasileira, 1999-03-01) Borducchi, Davimar Miranda Maciel [UNIFESP]; Kerbauy, José [UNIFESP]; Oliveira, José Salvador Rodrigues de [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
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    Ressonância magnética na mielopatia associada ao HTLV-I: Leucoencefalopatia e atrofia medular
    (Academia Brasileira de Neurologia - ABNEURO, 1997-01-01) Ferraz, Ana Claudia; Gabbai, Alberto Alain [UNIFESP]; Abdala, Nitamar [UNIFESP]; Nogueira, Roberto Gomes [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Cerebral white matter lesions and spinal cord atrophy have been frequently reported in patients with HTLV-I associated myelopathy (HAM). The exact frequency and the clinical relevance of these findings still remain to be elucidated. Twenty-nine patients with HAM were studied by magnetic resonance imaging of the brain and spine. Cerebral white matter lesions equal or over 3 mm in diameter were considered abnormal. The spinal cord size was evaluated using an index we have called spinal cord index. The radiological findings were correlated to the clinical features of the myelopathy. Cerebral white matter lesions occurred in 52% of the patients, and spinal cord atrophy in 74%. There was no significant correlation between these abnormalities and the clinical features studied. These findings suggest that the resonance imaging is a useful method for detection of cerebral and spinal cord abnormalities in HAM patients. The absence of correlation between cerebral white matter lesions and either patient age or risk factors for cardiovascular disease suggests a possible association between the leukoencephalopathy and the infection.