Navegando por Palavras-chave "HOMA"

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    Diabetes mellitus tipo 2: fatores preditivos na população nipo-brasileira
    (Sociedade Brasileira de Endocrinologia e Metabologia, 2003-10-01) Nascimento, Rogéria do [UNIFESP]; Franco, Laercio Joel [UNIFESP]; Gimeno, Suely Godoy Agostinho [UNIFESP]; Hirai, Amélia Toyomi [UNIFESP]; Ferreira, Sandra Roberta Gouvea [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    In order to identify the main predictors for the development of type 2 diabetes mellitus (DM2) in a population with high prevalence of DM - the Japanese-Brazilians -, we evaluated 314 individuals with Japanese ancestry from Bauru, SP, aged 40 years or more, without miscegenation, in 1993 and 2000. The parameters evaluated, obtained in 1993, were sex, age, body mass index (BMI), waist and hip circumferences, fasting and 2h after 75g of glucose load glycemia, insulinemia and proinsulinemia, HOMA (function of the b cell and insulin resistance), lipid profile and blood pressure. The glycemic homeostasis evaluated in 2000 showed that individuals with impaired fasting glycemia or impaired glucose tolerance presented a higher risk for the progression to DM2 (60 and 70%, respectively) than normals (19%). The main variables involved in the progression to DM were BMI, waist circumference (only women), systolic blood pressure, fasting and 2h glycemia, and VLDL-cholesterol. These results showed the existing potential for the reduction in the incidence of DM2 in this population, because the main risk factors can be modified by interventions in lifestyle.
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    Evidence for impaired insulin production and higher sensitivity in stunted children living in slums
    (Cambridge Univ Press, 2006-05-01) Martins, Paula Andrea [UNIFESP]; Sawaya, Ana Lydia [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    The objective of the present study was to investigate the changes in glucose and insulin metabolism in nutritionally stunted children that can be involved in the appearance of chronic diseases in adulthood. for this purpose, sixty-one children were selected, thirty-five boys and twenty-six girls, residents of slums in São Paulo, Brazil. the children were classified according to the height-for-age as stunted (l-1.5 Z-score; n 21) or non-stunted (>-1.5 Z-score; n 40). the glucose and insulin plasma levels were determined and, from these values, the indexes that evaluate the pancreatic beta-cell function (homeostasis model assessment (HOMA-B)) and insulin sensitivity (HOMA-S) were assessed. Stunted children showed lower values of fasting insulin than those of the non-stunted group (boys: 29.7 (sd 14.9) v. 50.4 (sd 29.2) pmol/l, P=0.019; girls: 34.4 (sd 12.6) v. 62.3 (sd 28.7) pmol/l, P=0.016) but the glucose levels were similar (boys: 4.6 (sd 0.3) v. 4.5 (sd 0.3) mmol/l; girls: 4.2 (sd 0.3) v. 4.4 (sd 0.3) mmol/l). Stunted children showed lower HOMA-B values (boys: 83 (sd 22) % v. 115 (sd 36) %, P=0.011; girls: 107 (sd 23) % v. 144 (sd 46) %, P=0.045) and higher HOMA-S values (boys: 196 (sd 92) % v. 120 (sd 62) %, P=0.014; girls: 159 (sd 67) % v. 98 (sd 57) %, P=0.016). the results show a decreased activity of beta-cell function and increased insulin sensitivity in stunted children. the decreased beta-cell function of this group may strongly predict type 2 diabetes.
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    Family History of Diabetes as a New Determinant of Insulin Sensitivity and Secretion in Patients Who Have Undergone a Simultaneous Pancreas-Kidney Transplant
    (Baskent Univ, 2010-03-01) Rangel, Erika Bevilaqua [UNIFESP]; Melaragno, Cláudio Santiago [UNIFESP]; Neves, Maria Deolinda F. [UNIFESP]; Dib, Sergio Atala [UNIFESP]; Gonzalez, Adriano Miziara [UNIFESP]; Linhares, Marcelo Moura [UNIFESP]; Pacheco-Silva, Alvaro [UNIFESP]; Sá, João Roberto de [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Objectives: We used homeostasis model assessment to investigate insulin sensitivity and secretion after a simultaneous pancreas-kidney transplant or kidney transplant alone. In that model, fasting plasma glucose and C-peptide levels are used to evaluate insulin sensitivity and beta-cell function.Materials and Methods: Factors (eg, age, sex, race, delayed kidney allograft function) were correlated with homeostasis model assessment of beta-cell function and homeostasis model assessment of insulin sensitivity values after simultaneous pancreas-kidney transplant (n=89) or kidney transplant alone (n=68), and the results were compared with those in healthy subjects (n=49).Results: Homeostasis model assessment of beta-cell function values were similar in patients who underwent kidney transplant alone or a simultaneous pancreas-kidney transplant, and were higher than homeostasis model assessment of beta-cell function values in healthy subjects. The homeostasis model assessment of insulin sensitivity showed intermediate values for patients who underwent a simultaneous pancreas-kidney transplant and correlated with prednisone dosages (in those who underwent kidney transplant alone) and tacrolimus levels (in patients who underwent a simultaneous pancreas-kidney transplant). Homeostasis model assessment of beta-cell function values correlated with prednisone dosages in both groups and with tacrolimus levels in only those who underwent a simultaneous pancreas-kidney transplant. The body mass index of subjects who underwent kidney transplant alone correlated with both homeostasis model assessment of beta-cell function results and homeostasis model assessment of insulin sensitivity results. A family history of diabetes in subjects who underwent a simultaneous pancreas-kidney transplant correlated with homeostasis model assessment of beta-cell function results and homeostasis model assessment of insulin sensitivity results.Conclusions: Immunosuppressive regimen and body mass index were linked with reduced insulin sensitivity after kidney transplant. A family history of diabetes was linked with higher values of insulin secretion and lower insulin sensitivity in patients who underwent a simultaneous pancreas-kidney transplant.