Navegando por Palavras-chave "Genetic predisposition to disease"

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    Aspectos genéticos do transtorno obsessivo-compulsivo
    (Associação Brasileira de Psiquiatria - ABP, 2001-10-01) Gonzalez, Christina H [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Since the first descriptions of obsessive-compulsive disorder (OCD), genetic factors have been implicated in the etiology of the illness. Twin studies show a high concordance rate for monozygotic twins. Family studies found a higher risk for OCD among relatives of OCD patients. Segregation analysis studies suggest the possible role of a major effect gene in the etiology of OCD. Association studies using molecular techniques have been conducted to try to find a specific gene or polymorphism involved in OCD. This review outlines the evidence gathered to date, including the recent findings in the molecular genetics analysis.
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    Estado nutricional e fatores de risco cardiovascular em crianças e adolescentes filhos ou netos de coronariopatas jovens
    (Universidade Federal de São Paulo (UNIFESP), 2011-05-25) Kovacs, Cristiane [UNIFESP]; Schimith Escrivão, Maria Arlete Meil [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Background: Family history of early cardiovascular disease is a major cardiovascular risk factor in childhood and adolescence. Children and adolescents with positive family history that also often have other cardiovascular risk factors. Objective: To evaluate the nutritional status and its relationship with cardiovascular risk factors in children or young grandchildren of coronary artery disease. Methods: A cross-sectional study with 100 children and adolescents 5-17 years, children or grandchildren of young coronary patients. The variables studied were gender, age, weight, height, body mass index (BMI), waist circumference, nutritional status, blood pressure, metabolic syndrome, dietary habits, physical activity, results of laboratory tests (glucose, total cholesterol and fractions, triglycerides). To examine the associations between the variables we used the Fisher exact test, with significance level of 5%. Results: The nutritional status, it was observed that 60% were normal and 40% were overweight. In the evaluation of laboratory tests, 29% had total cholesterol, LDL increased 8%, 45% low HDL and triglycerides increased 13%. In the group with overweight, the percentages were higher triglyceride levels (p = 0.005) and increased waist circumference (p <0.001), 22.5% had abnormal blood pressure and altered glucose 5%. Physical inactivity was present in 40% and 87% of them had excessive intake of atherogenic fat. Besides a family history of coronary disease, 30% of the population had more than two cardiovascular risk factors and 41% more than three. Conclusion: The association of cardiovascular risk factors among children and adolescents, children or grandchildren of young coronary patients, this study confirms the influence of family history and his contribution to the risk of developing cardiovascular disease.
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    O papel da genética na dependência do álcool
    (Associação Brasileira de Psiquiatria - ABP, 2004-05-01) Messas, Guilherme Peres [UNIFESP]; Vallada Filho, Homero Pinto; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)
    In this article we examined the heritability of alcohol dependence. A review of family, twin and adoption studies, allowed us to support the thesis of an important genetic component in this dependence. The transmission of this heritability occurs through a biological vulnerability associated to environmental factors, in a model called epigenetic. We also discussed the relationship between biological vulnerability and high-risk phenotypes for alcohol dependence. In the end, we briefly comment on the molecular genetic studies associated with this disorder.