Navegando por Palavras-chave "Fibrin tissue adhesive"
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- ItemAcesso aberto (Open Access)Adesivo biológico de fibrina na mioescleropexia posterior em coelhos: estudo experimental(Conselho Brasileiro de Oftalmologia, 2004-04-01) Moreira, Ana Tereza Ramos [UNIFESP]; Bottós, Juliana Mantovani; Bottós, Kátia Mantovani; Buquera, Michele; Anjos, Adilson Dos; Universidade Federal de São Paulo (UNIFESP); Universidade Federal do Paraná Departamento de Oftalmologia; Universidade Federal do Paraná; Hospital de Olhos do Paraná; Universidade Federal do Paraná Laboratório de EstatísticaPURPOSES: 1. To evaluate the adhesion capacity of the fibrin biological adhesive in surgery of posterior fixation of the superior rectus muscle, when it is used for the reduction of the arc of contact. 2. To compare the reduction of the superior rectus muscle's action of eyes in which the biological adhesive has been used with those used as a control group. METHODS: The sample consisted of 30 animals, 60 eyes. One of the eyes of each animal was treated with biological adhesive (30 eyes), while the other was used as a control (30 eyes). All animals were sacrificed on the 60th postoperative day. Muscle reduction was analyzed and the sizes of the adherences produced at surgery and after 60 days were measured. RESULTS: The fibrin clot was produced immediately after applying the biological adhesive and at the end of few seconds all muscle fibers were adhered to the sclera. All muscles treated with biological adhesive showed reduction in motor function on the 60th postoperative day when compared with the control group. The sizes of the initially produced adherence compared with those after 60 days was reduced 28.48%. There was an ascending and positive but weak correlation (r=0.367204). There must exist other variables affecting adherence reduction. There was no significant inflammatory reaction or any other complication related to the surgery. CONCLUSIONS: The clinical results of motor function demonstrated that the biological adhesive of fibrin produced muscle-scleral adhesion, reducing the arc of contact of the superior rectus muscle in rabbits.
- ItemSomente MetadadadosEfeito do enxerto autologo de perichondrium costalis com butil-2-cianoacrilato em lesão provocada na cartilago articulares do joelho de coelhos(Universidade Federal de São Paulo (UNIFESP), 1997) Xavier, Mário Sergio Viana [UNIFESP]; Souza, Virgínio Cândido Tosta de [UNIFESP]
- ItemAcesso aberto (Open Access)Estudo do reparo do ferimento de colon com o lado seroso da parede de jejuno, utilizando cianoacrilato e cola de fibrina(Colégio Brasileiro de Cirurgiões, 2006-04-01) Fontes, Carlos Edmundo Rodrigues; Taha, Murched Omar [UNIFESP]; Fagundes, Djalma José [UNIFESP]; Prado Filho, Orlando; Ferreira, Marcos Victor; Mardegan, Marino José; Universidade Estadual de Maringá Clínica Cirúrgica; Universidade Federal de São Paulo (UNIFESP)BACKGROUND: The present experiment aimed to compare the effect of the use of cyanoacrylate and fibrine glue as adesive on repared colon's wounds with the serosal side of jejuno's wall. METHODS: Forty five male, young adult Wister rats, weighting about 260 g , from the University of Maringá were used.After having been deeply anaesthetized (thiopental was used), the animals underwent a surgery, and a pattern 0,5 cm wound was made, 2 cm away from the cecum, in the caudal location. Group one the wound was repaired by using the jejunal serosal wall and suture.On group two the jejunal serosal wall and fibrine glue was used. Finally on group three the repair was made by using the jejunal serosal wall and cyanoacrylate. The animals were submited to roentgenogram with barium enema on the fourth postoperative day to search for stenosis. On the seventh day, after having been anaesthetized, animals were submited to a laparotomy, segments were collected for both macroscopic and microscopic study. RESULTS: Fibrine glue has shown better result on repair, due to the production of collagen fibres. CONCLUSION: The experiment has come to prove that the wound made on rat's colon can be repaired by the jejunal serosal wall joined to the wound either using the fibrine glue or cyanoacrylate.
- ItemAcesso aberto (Open Access)O papel do adesivo de fibrina e da sutura na fixação do transplante de menisco preservado por ultracongelamento em coelhos(Sociedade Brasileira de Ortopedia e Traumatologia, 2009-10-01) Reckers, Leandro José [UNIFESP]; Fagundes, Djalma José [UNIFESP]; Raymundo, José Luiz Pozo; Granata Júnior, Geraldo Sérgio De Mello [UNIFESP]; Moreira, Márcia Bento [UNIFESP]; Paiva, Vanessa Carla [UNIFESP]; Fagundes, Anna Luiza Negrini; Cohen, Moises [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade Federal de Pelotas Departamento de Ortopedia; Universidade de Santo AmaroOBJECTIVE: To evaluate the ability of fibrin adhesive in promoting the meniscus fixation within two, four and eight weeks compared to the conventional soft-tissue suture technique. MATERIALS AND METHODS: 36 right medial menisci of rabbits preserved at negative 73° Celsius for 30 days were transplanted to animals of the same sample and fixed with soft-tissue suture or fibrin glue. After 2, 4 or 8 weeks, the appearance of the menisci and the quality of fixation were macroscopically checked and evaluated by a scoring system. The findings were subjected to the statistical study of variance analysis (p < 0.05%). RESULTS: The deep-frozen meniscus preservation maintained the integrity of the meniscus transplant, and, macroscopically, there was no significant reduction of the length of the meniscus in all post-transplant periods (p = 0.015). The menisci fixed with fibrin showed slight changes in color and surface roughness. There were no signs of rejection or infection in both groups. Suture fixation scoring was superior (p = 0.015) in all periods (80% of total fixation) as compared to the setting promoted by fibrin (20% of total fixation). CONCLUSION: The homologous transplantation of the meniscus of rabbits experienced various degrees of integration to the knee according to the fixation method; the surgical soft tissues suturing technique was shown to be superior in the evaluation of scores compared to the fixation with fibrin adhesive.
- ItemAcesso aberto (Open Access)Plasma rico em plaquetas (PRP) por meio de centrífuga de bancada(Universidade Federal de São Paulo (UNIFESP), 2011-05-25) Calixto, Carlos Alberto [UNIFESP]; Ferreira, Lydia Masako [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)INTRODUÇÃO: O plasma rico em plaquetas (PRP) é a concentração autóloga de plaquetas em pequeno volume de plasma, obtido por centrifugação do sangue total com anticoagulante, sendo considerada importante fonte de fatores de crescimento (FC). A sua utilização enfatiza a regeneração tecidual. OBJETIVO: Obter o plasma rico em plaquetas (PRP) por meio de centrífuga de bancada. MÉTODOS: Foram coletos 40ml de sangue total de oito voluntários, para 72 testes, divididos em três grupos (grupos controle, de uma centrifugação, e de duas centrifugações), com variação da força de centrifugação em 200, 400 e 800g. RESULTADOS: Verificou-se que a concentração, no Grupo Duas Centrifugações, apresentou média inferior ao mensurado no Grupo Controle. O Grupo Uma Centrifugação, com a força centrifuga relativa de 200g, apresentou os maiores valores de contagem (417.750/μl), bem como as maiores concentrações de plaquetas (99,03%), que equivaleu a 1,99 vezes o aumento no número das plaquetas do GCt, enquanto que forças de centrifugação superiores foram insuficientes para o enriquecimento. CONCLUSÃO: Obteve-se o plasma rico em plaquetas (PRP), a partir de centrifuga de bancada, com maior concentração na força de 200g.