Navegando por Palavras-chave "Extended cycle"

Agora exibindo 1 - 2 de 2
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Effects of extended regimens of the contraceptive vaginal ring on carbohydrate metabolism
    (Elsevier B.V., 2012-03-01) Guazzelli, Cristina A. F. [UNIFESP]; Barreiros, Fernando A. [UNIFESP]; Torloni, Maria R. [UNIFESP]; Barbieri, Marcia [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Background: There are few publications on the metabolic effects of extended regimens of the contraceptive vaginal ring. the aim of this study was to assess changes in fasting plasma glucose levels and insulin concentration of women using the contraceptive vaginal ring continuously over a 1-year period.Study Design: This prospective cohort enrolled 75 women (ages 18-37 years) who used a contraceptive vaginal ring releasing 120 mcg of etonogestrel and 15 mcg of ethinyl estradiol daily continuously for 84 days, followed by a 7-day ring-free interval, during I year. Fasting glucose and insulin levels were measured, and homeostatic model assessment was calculated at baseline and every 3 months during the 1-year study period. the repeated-measures analysis of variance test was used to analyze differences in the results of these exams over time.Results: None of the 75 participants had results outside the normal range in any of the assessments. There were no pregnancies during the 1-year period, and a total of 62 participants completed the study. There were no significant changes in mean fasting glucose levels (79.3 and 78.9 mg/dL at baseline and after 12 months, respectively), mean fasting insulin concentration (9.6 and 10.1 mu U/mL) or mean homeostatic model assessment results (1.88% and 1.97%).Conclusion: Fasting plasma glucose concentration, insulin levels and homeostatic model assessment values of women using the vaginal ring on an extended regimen did not change significantly over a 1-year period. (c) 2012 Elsevier Inc. All rights reserved.
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Extended regimens of the contraceptive vaginal ring versus hormonal oral contraceptives: effects on lipid metabolism
    (Elsevier B.V., 2012-04-01) Falbo Guazzelli, Cristina Aparecida [UNIFESP]; Barreiros, Fernando Augusto [UNIFESP]; Barbosa, Ricardo; Torloni, Maria Regina [UNIFESP]; Barbieri, Marcia [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)
    Background: Combined oral contraceptives used in an extended regimen have been studied because of their potential benefits; however, there have been few publications on extended regimens of contraceptive vaginal rings. the aim of this study was to assess the effects of these two extended regimens on the lipid metabolism of women using these contraceptive methods during 1 year.Study Design: This prospective study enrolled 150 women: 75 used a vaginal contraceptive ring (11.7 mg etonogestrel and 2.7 mg ethinyl estradiol), and 75 used oral contraceptives (30 mcg ethinyl estradiol and 150 mg desogestrel). Both groups used their respective method for 84 days followed by a 7-day pause during I year. At baseline and every 3 months during the study period, blood was collected to assess total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides and apolipoprotein (apo) A-I and B. the analysis of variance test was used to analyze differences in the results of these exams over time.Results: A total of 62 vaginal ring and 61 oral contraceptive users completed the study. There were no significant differences in the discontinuation rate, mean total cholesterol and fraction levels, apo B concentration or apo A-I/apo B ratio. Vaginal ring users had significantly higher apo A-I levels than oral contraceptive users.Conclusion: Despite the vaginal route of administration, the steroids released by the ring had the same effects on the lipid metabolism and lipoprotein levels typically seen with ethinyl estradiol given either by oral or parenteral routes. (C) 2012 Elsevier Inc. All rights reserved.