Navegando por Palavras-chave "Experimental diabetes"

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    B-1 cells produce insulin and abrogate experimental streptozotocin-induced diabetes
    (Wiley-Blackwell, 2015-05-01) Alvares-Saraiva, Anuska M. [UNIFESP]; Novo, Marilia C. T. [UNIFESP]; Oliveira, Vivian Cristina de [UNIFESP]; Maricato, Juliana Terzi [UNIFESP]; Lopes, Jose Daniel [UNIFESP]; Popi, Ana Flavia [UNIFESP]; Mariano, Mario [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Univ Paulista UNIP
    The participation of B-1 cells in a murine model of spontaneous diabetes has been recently reported. Here, we describe the role of B-1 cells in streptozotocin (STZ) induced diabetes in mice. We demonstrated that XID (B-1 cell-deficient) mice are more susceptible to STZ treatment than WT mice, as evidenced by their higher blood glucose level in response to STZ. Unexpectedly, the XID mice that were i.p. transferred with purified B-1 cells, either before or after the STZ treatment, did not develop diabetes. These cell transfers provided long-lasting protection for the XID mice against STZ-induced diabetes, suggesting that B-1 cells play an important role in the experimental diabetes pathobiology. We also showed that B-1 cell culture supernatants were able to regulate the blood glucose level of the diabetic XID mice, and we identified insulin-producing cells when B-1 cells were differentiated in B-1 cell-derived phagocyte in vitro. These findings provide a novel role for B-1 cells in metabolic processes, presenting a new mechanism to explain the pathogenesis of diabetes and a possible therapeutical target.
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    Cardiovascular control in experimental diabetes
    (Associação Brasileira de Divulgação Científica, 2002-09-01) De Angelis, Katia; Schaan, Beatriz D'Agord; Maeda, C.y.; Dal Lago, Pedro; Wichi, Rogerio Brandao [UNIFESP]; Irigoyen, Maria Claudia [UNIFESP]; Universidade de Santo Amaro UNIPESQ Laboratório de Cardiovascular; Universidade Federal do Rio Grande do Sul Instituto de Ciências Básicas da Saúde Departamento de Fisiologia; Instituto de Cardiologia do Rio Grande do Sul Fundação Universitária de Cardiologia; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP); Pontifícia Universidade Católica do Rio Grande do Sul FAENFI Curso de Fisioterapia
    Several studies have reported impairment in cardiovascular function and control in diabetes. The studies cited in this review were carried out from a few days up to 3 months after streptozotocin administration and were concerned with the control of the circulation. We observed that early changes (5 days) in blood pressure control by different peripheral receptors were maintained for several months. Moreover, the impairment of reflex responses observed after baroreceptor and chemoreceptor stimulation was probably related to changes in the efferent limb of the reflex arc (sympathetic and parasympathetic), but changes also in the central nervous system could not be excluded. Changes in renal sympathetic nerve activity during volume expansion were blunted in streptozotocin-treated rats, indicating an adaptive natriuretic and diuretic response in the diabetic state. The improvement of diabetic cardiovascular dysfunction induced by exercise training seems to be related to changes in the autonomic nervous system. Complementary studies about the complex interaction between circulation control systems are clearly needed to adequately address the management of pathophysiological changes associated with diabetes.
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    Response of the lung after pneumonectomy in alloxan diabetic rats
    (Instituto de Tecnologia do Paraná - Tecpar, 2003-03-01) Seidel, Amélia Cristina [UNIFESP]; Fagundes, Djalma José [UNIFESP]; Novo, Neil Ferreira [UNIFESP]; Juliano, Yara [UNIFESP]; Meister, Hugo; Bazotte, Roberto Barbosa; Universidade Estadual de Maringá Departamento de Medicina; Universidade Federal de São Paulo (UNIFESP); Universidade Estadual de Maringá Departamento de Farmácia e Farmacologia
    In order to determine the response of remaining lung after pneumonectomy during diabetes, female Wistar rats that received an intraperitoneal injection of alloxan (D Group) or saline (C Group) were submitted to lung resection. Six days after alloxan injection (45 mg/kg), diabetes was confirmed. The rats were randomized divided in 3 subgroups: non-operated (NO), sham operation (SO) and left pneumonectomy (PE). Thirty days after the surgery all rats were killed and the weight and volume of the lungs were measured. PE-diabetic rats showed smaller lung weight and volume than PE-non-diabetic animals. The results demonstrated that the compensatory lung growth postpneumonectomy were not observed in diabetic rats.