Navegando por Palavras-chave "Exercise testing"

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    Effects of tiotropium and formoterol on dynamic hyperinflation and exercise endurance in COPD
    (W B Saunders Co Ltd, 2010-09-01) Berton, Danilo Cortozi [UNIFESP]; Reis, Michel Silva [UNIFESP]; Siqueira, Ana Cristina Barroso de [UNIFESP]; Barroco, Adriano Candido [UNIFESP]; Takara, Luciana Shimizu [UNIFESP]; Bravo, Daniela Manzoli [UNIFESP]; Andreoni, Solange [UNIFESP]; Neder, Jose Alberto [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Feevale Univ
    Background: It is currently unclear whether the additive effects of a long-acting beta(2)-agonist (LABA) and the antimuscarinic tiotropium bromide (TIO) on resting lung function are translated into lower operating lung volumes and improved exercise tolerance in patients with chronic obstructive pulmonary disease (COPD).Methods: On a double-blind and cross-over study, 33 patients (FEV(1) = 47.4 +/- 12.9% predicted) were randomly allocated to 2-wk formoterol fumarate 12 mu g twice-daily (FOR) plus TIO 18 mu g once-daily or for plus placebo (PLA). Inspiratory capacity (IC) was obtained on constant-speed treadmill tests to the limit of tolerance (Tlim).Results: FOR-TIO was superior to FOR-PLA in increasing post-treatment FEV(1) and Tlim (1.34 +/- 0.42 L vs. 1.25 +/- 0.39 L and 124 +/- 27% vs. 68 +/- 14%, respectively; p < 0.05). FOR-TIO slowed the rate of decrement in exercise IC compared to FOR-PLA (Delta isotime-rest = -0.27 +/- 0.40 L vs. -0.45 +/- 0.36 L, p < 0.05). in addition, end-expiratory lung volume (% total lung capacity) was further reduced with FOR-TIO (p < 0.05). of note, patients showing greater increases in Tlim with FOR-TIO (16/26, 61.6%) had more severe airways obstruction and lower exercise capacity at baseline. Improvement in Tlim with FOR-TIO was also related to larger increases in FEN(1) (p < 0.05).Conclusions: Compared to for monotherapy, FOR-TIO further improved effort-induced dynamic hyperinflation and exercise endurance in patients with moderate-to-severe COPD. These beneficial consequences were more likely to be found in severely-disabled patients with larger resting functional responses to the combination therapy.Trial registration: Clinicaltrials.gov Identifier: NCT00680056 [ClinicalTrials.gov]. (C) 2010 Elsevier B.V. All rights reserved.
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    The Incremental Shuttle Walk Test in Older Brazilian Adults
    (Karger, 2011-01-01) Jürgensen, Soraia Pilon [UNIFESP]; Antunes, Letícia Cláudia de Oliveira; Tanni, Suzana Erico; Banov, Marcos Carraro; Lucheta, Paulo Adolfo; Bucceroni, Alessandra Freire; Godoy, Irma; Dourado, Victor Zuniga [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)
    Background: Despite widespread use of the incremental shuttle walk distance (ISWD), there are no reference equations for predicting it. Objectives: We aimed to evaluate ISWD in healthy subjects and to establish a reference equation for its prediction. Methods: 131 Brazilian individuals (61 males; 59 +/- 10 years) performed 2 walk tests in a 10-m long corridor. We assessed height, weight, body mass index, forced expiratory volume in 1 s, forced vital capacity and self-reported physical activity. Results: Mean ISWD was greater in males than in females (606 +/- 167 vs. 443 +/- 117 m; p < 0.001). ISWD correlated significantly (p < 0.05) with age (r = -0.51), height (r = 0.54) and weight (r = 0.20). A predictive model including age, height, weight and gender explained 50.3% of the ISWD variance. in an additional group of 20 subjects prospectively studied, the difference between measured and predicted ISWD was not statistically significant (534 +/- 84 vs. 552 +/- 87 m, respectively), representing 97 +/- 12% of the predicted value calculated with our reference equation for ISWD. Conclusions: This reference equation including demographic and anthropomorphic attributes could be useful for interpreting the walking performance of patients with chronic diseases that affect exercise capacity. Copyright (C) 2010 S. Karger AG, Basel
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    Teste de esforço: alterações do segmento ST restritas à fase de recuperação
    (Associação Médica Brasileira, 1999-04-01) Oliveira Filho, Japy Angelini [UNIFESP]; Luna Filho, Bráulio [UNIFESP]; Salles, T. [UNIFESP]; Brito, R. [UNIFESP]; Palma, L. [UNIFESP]; Barbieri, A. [UNIFESP]; Herrmann, J. L. V. [UNIFESP]; Martinez Filho, Eulogio Emílio [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    PURPOSE: To determine the incidence of atherosclerotic coronary artery disease (CAD) and or myocardial ischemia in patients (pt) with abnormal ST segments restrict to recovery phase (RRAST) of exercise testing (ET). MATERIAL AND METHOD: Retrospective study in 19 non consecutive pt with RRAST, related to coronary arteriography or exercise planar scyntillography (18 men, 58 ± 9 years, 18 asymptomatic). RESULTS: RRAST corresponded to ST segment depression from 1 to 4 mm, with T inversion during early recovery (2pt); late (14 pt) or both (4pt). It was documented CAD (14 pt and 9) with artery-by-pass surgery); hypertensive myocardiopathy with normal coronary (3 pt), and mitral prolapse valve (1 pt).In 13 pt with coronary arteriography or exercise scyntillography, within the first 6 months from exercise testing, myocardial ischemia was confirmed in 8 pt in 3 pt, successive exercise testing showed RRAST reproductive in 2 cases. CONCLUSION: The authors report the high incidence of CAD and or transitory hypoperfusion during myocardial scyntillography in symptomatic men with middle age with RRAST during exercise testing.