Repositório Institucional - Unifesp :: Navegando por Palavras-chave "Dyslipidemias"

Navegando por Palavras-chave "Dyslipidemias"

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Acesso aberto (Open Access)
Adherence to statin treatment and associated factors in female users from the Unified Health System (SUS)
(Universidade de São Paulo, Escola de Enfermagem, 2014-06-01) Bonfim, Mariana Rotta; Hansen, Arina; Turi, Bruna Camilo; Zanini, Gabriel De Souza; Oliveira, Acary Souza Bulle [UNIFESP]; Amaral, Sandra Lia do; Monteiro, Henrique Luiz; Universidade Estadual Paulista (UNESP); Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP); Universidade Estadual de Campinas (UNICAMP)
Objective: To identify the adherence rate of a statin treatment and possible related factors in female users from the Unified Health System. Method: Seventy-one women were evaluated (64.2 ± 11.0 years) regarding the socio-economic level, comorbidities, current medications, level of physical activity, self-report of muscular pain, adherence to the medical prescription, body composition and biochemical profile. The data were analyzed as frequencies, Chi-Squared test, and Mann Whitney test (p<0.05). Results: 15.5% of women did not adhere to the medical prescription for the statin treatment, whose had less comorbidities (p=0.01), consumed less quantities of medications (p=0.00), and tended to be younger (p=0.06). Those patients also presented higher values of lipid profile (CT: p=0.01; LDL-c: p=0.02). Musculoskeletal complains were not associated to the adherence rate to the medication. Conclusion: The associated factors to adherence of dyslipidemic women to statin medical prescription were age, quantity of comorbidities and quantity of current medication. 
Acesso aberto (Open Access)
Alterações no perfil lipídico durante o primeiro ano após o transplante renal: Fatores de risco e a influência do regime imunossupressor
(Universidade Federal de São Paulo (UNIFESP), 2010-07-28) Spinelli, Glaucio Amaral [UNIFESP]; Pestana, Jose Osmar Medina [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Aim: Dyslipidemia is a recognized risk factor associated with cardiovascular events after kidney transplantation, Cyclosporine (CSA), tacrolimus (TAC), mycophenolate (MMF), sirolimus (SRL), everolimus (EVR) and prednisone have differential effects on the development of dyslipidemia, This study analyzed the incidence, time-course, severity and risk factors associated with dyslipidemia during the first year after kidney transplantation, Methods: In a cohort of 474 kidney transplant recipients [CSA/SRL (n=137), CSA/MMF (n=58), CSA/EVR (n=47), SRL/MMF (n=32), TAC/SRL (n=86), TAC/MMF (n=114)] we evaluated the influence of demographics, clinical ouCOLomes and statin use on lipid profile changes [total cholesterol (TC), triglycerides (TG), HDL-C, LDL-C, non-HDL-C, COL/HDL-C, LDL-C/HDL-C, TG/HDL-C] during the first year after transplantation, Results: Lipid profile was within recommended ranges in 28% of patients pretransplant and in 10% at one year, with 27% of them receiving statins, LDL-C could not be measured due to high TG concentrations in 20% of patients, At one year, LDL-C < 100 mg/dl was observed in 31,8% of patients, Within this group around 35% of patients still showed lipid fractions or ratios outside recommended target concentrations, Age, gender, time on dialysis, new onset diabetes mellitus, use of CSA or SRL/EVR and dose of prednisone were independent risk factors associated with dyslipidemia at one year, Conclusion: One year after transplant dyslipidemia is almost universal, Modifiable risk factors include the type and dose of immunosuppressive drugs, he variable changes in all lipid fractions and ratios may limit proper therapeutic interventions.
Acesso aberto (Open Access)
Avaliação da adequação do perfil lipídico em pacientes hipertensos
(Universidade Federal de São Paulo (UNIFESP), 2011-02-22) Ribeiro, Hércules Ferreira [UNIFESP]; Batista, Marcelo Costa [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
A hipertensão arterial e a dislipidemia são fatores de risco cardiovascular potencialmente modificáveis, cuja presença concomitante aumenta o risco de novos eventos. Foi estudada uma população de portadores de hipertensão arterial sob acompanhamento ambulatorial em relação à adequação do perfil lipídico, de acordo com as recomendações do NCEP-ATP III. Fatores associados à adequação do LDL-C foram determinados, tanto na população total quanto no grupo de diabéticos. Dos 1202 pacientes estudados, os 886 (73,8% sexo feminino, idade 59,9±11,1 anos, 59% brancos) que apresentavam perfil lipídico completo e dados para estratificação de risco cardiovascular foram incluídos na análise. Da população estudada, 544 (61,4%) tinham LDL-C dentro do alvo recomendado, 663 (74,8%) apresentavam diagnóstico de dislipidemia e 285 (32,2%) estavam em uso de hipolipemiantes. Os indivíduos com LDL-C inadequado apresentavam maior idade (61,3±10,3 vs 58,9±11,6 anos; p<0,001), maior pressão arterial (PA) sistólica (140,7±22,0 vs 137,7±21,1 mmHg; p=0,04), maior prevalência de diabetes (56,1% vs 28,7%; p<0,001), bem como de doença cardiovascular (DCV) (27,8% vs 7,7%; p<0,001). Estes pacientes utilizavam mais frequentemente três ou mais antihipertensivos (42,7% vs 32,7%; p=0,003) e menos comumente apresentavam a PA dentro do alvo terapêutico (27,2% vs 35,8%; p=0,007). Observou-se uma associação positiva entre o risco cardiovascular e o percentual de inadequação do LDL-C. Pacientes com LDL-C inadequado apresentavam maior prevalência de síndrome metabólica (54,1% vs 41%; p<0,001) e o aumento do número de componentes da síndrome se associou a um pior controle do LDL-C. Em um modelo de regressão logística binária incluindo a inadequação do LDL-C como variável dependente, a idade, diabetes e doença cardiovascular se associaram de maneira independente com a inadequação do LDL-C. Adicionalmente, mesmo após a correção para variáveis demográficas e clínicas, a inadequação do LDL-C se associou de maneira independente com a doença cardiovascular tanto na população total quanto nos diabéticos. O controle da dislipidemia em hipertensos permanece inadequado, está relacionado ao mau controle da hipertensão e os resultados são ainda mais proeminentes em indivíduos com DCV.
Acesso aberto (Open Access)
Brazilian guidelines on prevention of cardiovascular disease in patients with diabetes: a position statement from the Brazilian Diabetes Society (SBD), the Brazilian Cardiology Society (SBC) and the Brazilian Endocrinology and Metabolism Society (SBEM)
(Biomed Central Ltd, 2017) Bertoluci, Marcello Casaccia; Moreira, Rodrigo Oliveira; Faludi, Andre; Izar, Maria Cristina [UNIFESP]; Schaan, Beatriz D.; Valerio, Cynthia Melissa; Bertolami, Marcelo Chiara; Chacra, Ana Paula; Bolivar Malachias, Marcus Vinicius; Vencio, Sergio; Kerr Saraiva, Jose Francisco; Betti, Roberto; Turatti, Luiz; Helfenstein Fonseca, Francisco Antonio [UNIFESP]; Bianco, Henrique Tria [UNIFESP]; Sulzbach, Marta; Bertolami, Adriana; Nunes Salles, Joao Eduardo; Hohl, Alexandre; Trujilho, Fabio; Lima, Eduardo Gomes; Miname, Marcio Hiroshi; Zanella, Maria Teresa [UNIFESP]; Lamounier, Rodrigo; Sa, Joao Roberto [UNIFESP]; Amodeo, Celso; Pires, Antonio Carlos; Santos, Raul D.
Background: Since the first position statement on diabetes and cardiovascular prevention published in 2014 by the Brazilian Diabetes Society, the current view on primary and secondary prevention in diabetes has evolved as a result of new approaches on cardiovascular risk stratification, new cholesterol lowering drugs, and new anti-hyperglycemic drugs. Importantly, a pattern of risk heterogeneity has emerged, showing that not all diabetic patients are at high or very high risk. In fact, most younger patients who have no overt cardiovascular risk factors may be more adequately classified as being at intermediate or even low cardiovascular risk. Thus, there is a need for cardiovascular risk stratification in patients with diabetes. The present panel reviews the best current evidence and proposes a practical risk-based approach on treatment for patients with diabetes. Main body: The Brazilian Diabetes Society, the Brazilian Society of Cardiology, and the Brazilian Endocrinology and Metabolism Society gathered to form an expert panel including 28 cardiologists and endocrinologists to review the best available evidence and to draft up-to-date an evidence-based guideline with practical recommendations for risk stratification and prevention of cardiovascular disease in diabetes. The guideline includes 59 recommendations covering: (1) the impact of new anti-hyperglycemic drugs and new lipid lowering drugs on cardiovascular risk
Acesso aberto (Open Access)
Distúrbios no perfil lipídico são altamente prevalentes em população nipo-brasileira
(Sociedade Brasileira de Endocrinologia e Metabologia, 2008-02-01) Siqueira, Antonela F. A. [UNIFESP]; Harima, Helena A. [UNIFESP]; Osiro, Katsumi [UNIFESP]; Hirai, Amélia Toyomi [UNIFESP]; Gimeno, Suely Godoy Agostinho [UNIFESP]; Ferreira, Sandra Roberta Gouvea [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP); Japanese-Brazilian Diabetes Study Group
High prevalence of diabetes has been previously reported in Japanese-Brazilians. In an attempt to better estimate the cardiometabolic risk, this study evaluated lipid disorders in 1,330 Japanese-Brazilians (46% men) aged >30 years. Hypercholesterolemia was defined as serum cholesterol > 240 mg/dL, hypertriglyceridemia as values > 150 mg/dL and low-HDL-C as values <40 mg/dL and <50 mg/dl for men and women respectively. The prevalence of dyslipidemias was compared by the chi-square test between gender and glycemic category. Mean and Standard Deviation of lipids and lipoproteins were compared by the Student t-Test between gender. Hypertriglyceridemia was detected in 66.0% [95% CI: 63.5-68.5] of the population, being more common in men and increasing with deterioration of glucose metabolism. Mean level of triglycerides was 235.7±196.3 mg/dL. The prevalence of hypercholesterolemia was 24.4% [95% CI: 22.1- 26.7]. Low HDL-C was observed in 17.5% [95% CI: 14.5-20.5] of men and 43.0% [95% CI: 39.4- 46.6] of women but total / HDL-cholesterol ratio was lower in women (4.23 ± 0.68 vs. 4.40 ± 0.73, p<0.001). In Japanese-Brazilians, hypertriglyceridemia is the commonest dyslipidemia, in agreement with the high prevalence of diabetes. Men showed a worse lipid profile than women; it was suggested that the Western diet and living habits could be deteriorating their health.
Acesso aberto (Open Access)
Efeito do exercício de força sobre a adiposidade periférica e visceral, perfil lipídico, glicídico e hormonal em adolescentes obesos
(Universidade Federal de São Paulo (UNIFESP), 2006-12-31) Stella, Sérgio Garcia [UNIFESP]; Mello, Marco Tulio de [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Objective: Verify the possible changes promote by strength exercise to visceral and periferic adipose tissue, lipidic profile, glucose and hormonal aswers, after twelvy weeks of intervention, in obese adolescents Methods: was select 126 adolescents, both genders, aged between 14and 19 years, and body mass index (BMI) 95 th, distributed in four groups: control (no exercise), leasure activity, aerobic exercise and strength exercise. They performed physical exercise for 12 weeks, 3 sessions each week, with 1hour of duration. Training intensity was not controlled in the leasure activity group, aerobic group training was at intensity corresponding to ventilatory threeshold – I, strength exercise was performed at 70% of 1 Maximun Repetition. Total body fat, subcutaneous fat and lean body mass was assessed by whole-body dual-energy X-ray absormetry scan (DEXA), visceral adipose tissue assessed by ultrassonography. Lipidic profile was measured by calorimetry and hormonals assays by radioimmunoassay. Results: Relation to body composition, after treatment, strength training promoted significant decreased in the BMI, body mass, visceral and subcutaneous fat in boys. Aerobic training promoted same changes in boys and girls. There was lean body mass preservation in both genders in all groups. Aerobic training decreased total cholesterol and LDL – c in both genders. The leasure physical activity reduced the blood levels of glucose and insulin, ass well in HOMA, only in girls. Conclusions: Strength training was the more effective to promote changes in body composition in boys. However to total cholesterol and LDL – c aerobic training is better in both genders.
Acesso aberto (Open Access)
Efeitos de dois tipos de treinamento de natação sobre a adiposidade e o perfil lipídico de ratos obesos exógenos
(Pontificia Universidade Catolica Campinas, 2009-09-01) Zambon, Lucimara; Duarte, Fernanda Oliveira; Freitas, Laura Franco de; Scarmagnani, Flavia Regina Rodrigues [UNIFESP]; Dâmaso, Ana Raimunda [UNIFESP]; Duarte, Ana Claudia Garcia de Oliveira; Sene-Fiorese, Marcela; Universidade Federal de São Carlos (UFSCar); Universidade Federal de São Paulo (UNIFESP); Univ Camilo Castelo Branco
ObjectiveThe objective was to look into the effects of intermittent swimming against continuous exercise and inactivity in Wistar rats after they developed exogenous obesity though the consumption of a palatable fat-rich diet. The following was investigated: evolution of body weight, food intake, adiposity, fat percentage in tissues and lipid profile.MethodsAdult rats were kept in individual cages with free access to food and water. The experimental protocol included: 1) development of exogenous obesity (3 weeks). The animals were divided into S - inactive animals fed the standard Primor(R) diet (n=8) and HF - inactive animals fed a high-fat diet (n=32); 2) Treatment (the 8 following weeks) - the animals (n=24) were given the standard diet and divided into an inactive group, a continuous training group and an intermittent training group. Training occurred 5 times per week and was either continuous (90 minutes per day) or intermittent (3 times 30 minutes per day). The animals were killed at 3 and 8 weeks and the fat tissues, the liver and the blood were collected. Adiposity, fat percentage of the fat tissues and liver, gain of body weight, food consumption and lipid profile were determined.ResultsThe high-fat diet increased adiposity, percentage of fat in the liver, and induced dyslipidemias. Diet change and the two types of training were capable of reducing exogenous obesity. However, intermittent exercise was more efficient in reducing adiposity and preventing weight gain.ConclusionWhen associated with a balanced diet, the trainings used in this study can be used as a strategy to control weight and dyslipidemias, both in experimental models and in human beings.
Acesso aberto (Open Access)
Family history of cardiovascular disease and non-HDL cholesterol in prepubescent non-obese children
(Assoc Medica Brasileira, 2016) Strufaldi, Maria Wany Louzada [UNIFESP]; Souza, Fabíola Isabel Suano de [UNIFESP]; Puccini, Rosana Fiorini [UNIFESP]; Franco, Maria do Carmo Pinho [UNIFESP]
Objective: To describe the values of non-HDL cholesterol (NHDL-c) and the frequency of a family history of early cardiovascular disease (family HCVD) in healthy prepubescent children. Analyze the association between NHDL-c and family HCVD, and possible associations with other risk factors for cardiovascular disease (CVD). METHOD: Cross-sectional study including 269 prepubescent (aged 6-10 years) schoolchildren with a normal body mass index (+1SD-2SD). Data collected: Family HCVD; weight and height, waist circumference and systemic blood pressure; lipid profile (total cholesterol TC, HDL-c, triglycerides and LDL-c), NHDL-c calculation (CT-HDL-c, cut-off = 145 mg/dL) and insulin resistance (HOMA-IR). RESULTS: High levels were found for NHDL-c in 10 (3.7%) of these schoolchildren, and family early HCVD was found in 46 (17.1%) of them. There was a weak association between family HCVD and NHDL-c (Cramer’s-V-test = 0.120; p=0.050). Among the children with NHDL-c≥145 mg/dL, 4 (40%) have family HCVD. The presence of family HCVD was not associated with the variables being studied. The variables independently associated with NHDL-c ≥ 145 mg/dL were: HOMA-IR (OR=1.7; 95CI 1.1-2.6) and diastolic blood pressure (OR=1.1; 95CI 1.02-1.2). CONCLUSION: NHDL-c values were associated with blood pressure and insulin resistance. Family HCVD was not associated with other classic risk factors for CVD, even though the frequency found was five times higher than that of high NHDL-c.
Embargo
A ingestão de ácidos graxos trans, durante a gestação e lactação, modifica os mecanismos intracelulares envolvidos com a resposta inflamatória, na prole com 21 dias de vida
(Universidade Federal de São Paulo (UNIFESP), 2010-11-24) Oliveira, Juliana Lopez de [UNIFESP]; Nascimento, Claudia Maria da Penha Oller do [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Although lipids transfer through placenta is very limited, modification in dietary fatty acids can lead to implications in fetal and postnatal development. Trans fatty acid intake during gestation and lactation have been reported to promote dyslipidemia and increase in pro- inflammatory adipokines in offspring. The aim of this study was to evaluate whether the alterations on proinflammatory cytokines and dyslipidemia observed previously in 21-d-old offspring of rats fed a diet containing hydrogenated vegetable fat during gestation and lactation were related to alterations in TLR-4, TRAF-6 and adipo- R1 receptor in white adipose tissue and muscle. On the first day of gestation, rats were randomly divided into two groups: (C) received a control diet, and (TFA) received a diet enriched with hydrogenated vegetable fat, rich in trans fatty acids. The diets were maintained throughout gestation and lactation. Each mother was given eight male pups. On the 21st day of life the offspring were killed. Blood, soleus and extensor digital longus (EDL) muscles, and retroperitoneal (RET) white adipose tissue were collected. 21-d-old of TFA rats had higher serum triacylglycerols, cholesterol, and insulin. The Adipo R1 protein expression was lower in RET and higher in EDL of TFA group than C. TLR-4 protein content in all studied tissues were similar between groups, the same was verified in TRAF-6 protein expression in soleus and EDL. However, TRAF- 6 protein expression in RET was higher in TFA than C. These results demonstrated that maternal ingestion of hydrogenated vegetable fat rich in TFAs during gestation and lactation decrease in Adipo R1 protein expression and increase in TRAF-6 protein expression in retroperitoneal adipose tissue, but not in skeletal muscle, which could contributed for hyperinsulinemia and dyslipidemia observed in their 21-d-old offspring.
Acesso aberto (Open Access)
Metabolismo lipídico em pacientes com artrite idiopática juvenil dos subtipos poliarticular e sistêmico
(Universidade Federal de São Paulo (UNIFESP), 2018-03-01) Rodrigues, Wellington Douglas Rocha [UNIFESP]; Terreri, Maria Teresa De Sande E Lemos Ramos Ascensao [UNIFESP]; http://lattes.cnpq.br/2661280959330284; Universidade Federal de São Paulo (UNIFESP)
Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in the pediatric population. Mortality due to disease activity and secondary infectious complications has decreased, however, this group of patients coexists chronically with the disease and presents, to a greater extent, early negative outcomes such as osteoporosis and late as cardiovascular diseases. Objective: To describe the biomarkers of lipid metabolism related to the cardiovascular risk of children and adolescents with JIA and to relate them to variables of the disease, lipid and glucose profile, nutritional status and food consumption. Methods: Cross-sectional study with 62 patients with JIA. The following were evaluated: disease activity and medications used, body mass index, height for age (z score), skin folds (bicipital, tricipital, subscapular and suprailiac), food consumption (24 hour recall), lipid profile (Total Cholesterol, low density lipoprotein - LDL, high density lipoprotein - HDL and triglycerides - TG and non-HDL), C-reactive protein, erythrocyte sedimentation rate (ESR), apolipoproteins AI and B Paraoxonase (PON). Statistical analysis: Exact Fischer, Chi-square, Mann-Whitney and Spearman correlation tests, p <0.05. Results: The mean duration of the disease was 5 years (± 3.4) and the active disease was observed in 33.9% of the patients. The prevalence of dyslipidemia in general was 62.9% when the lipid profile (CT, LDL-c, HDL-c, non-HDL-c and TG) and 82.3% were evaluated, including apolipoproteins (Apo AI and Apo B) altered. HDL-c and Apo A-I were the most frequent lipid profile changes. The low concentrations of Apo A-I were statistically more frequent in systemic JIA compared to polyarticular. Patients using biological agents showed better adequacy of Apo A-I concentrations. There was no significant correlation between us-CRP and variables related to lipid metabolism. However, HSV showed a negative correlation with Apo A-I levels (r = -0.25, p = 0.047). Conclusion: We conclude that dyslipidemia and alteration of lipid biomarkers are common in patients with JIA. The systemic form and the elevated HSV were associated with lower concentrations of Apo A-I suggesting the participation of the inflammatory process. In addition, the use of biological agents may be a protective factor for dyslipidemia.
Acesso aberto (Open Access)
PCSK9 and its clinical importance with the new therapeutic targets against dyslipidemia
(Instituto Israelita de Ensino e Pesquisa Albert Einstein, 2012-12-01) Ferreira, Carlos Eduardo dos Santos [UNIFESP]; Fonseca, Francisco Antonio Helfenstein [UNIFESP]; Mangueira, Cristóvão Luis Pitangueiras; Hospital Israelita Albert Einstein; Universidade Federal de São Paulo (UNIFESP)
This is a remarkable progress; since the finding of statins, there was no new way of reducing, significantly, cholesterol and LDL fraction. It is also clear that this decrease, by statins, is related to future cardiovascular lesions, being useful in its primary and secondary prophylaxis. The authors presented studies on research to promote the falling of blood cholesterol by means of antibodies, which inhibit the pro-protein PCSK9, as well as agents that act performing the RNA interference. We had two advantages immediately: for patients with myopathy associated with statins, and the fact of being injected every 15 days, that may contribute to better treatment adherence.
Acesso aberto (Open Access)
Prevalência e características associadas à síndrome metabólica em nipo-brasileiros com e sem doença periodontal
(Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz, 2007-03-01) Borges, Pollyanna Kassia de Oliveira [UNIFESP]; Gimeno, Suely Godoy Agostinho [UNIFESP]; Tomita, Nilce Emy; Ferreira, Sandra Roberta Gouvea [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)
This cross-sectional study focused on the relationship between periodontal disease and metabolic syndrome. Data were analyzed from 1,315 Japanese-Brazilians ranging from 30 to 92 years of age, submitted to physical, laboratory, and dental exams. Means and percentages were used in the data description and logistic regression pattern in the analysis of associations among variables. 484 (36.8%) of the 1,315 were edentulous, 215 (16.4%) enjoyed periodontal health, 513 (39%) had gingivitis, 85 (6.5%), showed initial or moderate periodontitis, and 18 (1.4%) suffered from chronic periodontits. Prevalence of metabolic syndrome was 54.3%, higher among individuals with periodontitis than in the healthy (51.5% vs. 48.8%), but this association was not statistically significant. Individuals with metabolic syndrome showed a worse metabolic and anthropometric profile.
Acesso aberto (Open Access)
Reverse Cholesterol Transport: Molecular Mechanisms and the Non-medical Approach to Enhance HDL Cholesterol
(Frontiers Media Sa, 2018) Marques, Leandro Ribeiro; Diniz, Tiego Aparecido; Antunes, Barbara Moura; Rossi, Fabricio Eduardo; Caperuto, Erico Chagas; Lira, Fabio Santos de [UNIFESP]; Gonçalves, Daniela Caetano [UNIFESP]
Dyslipidemia (high concentrations of LDL-c and low concentrations of HDL-c) is a major cause of cardiovascular events, which are the leading cause of death in the world. On the other hand, nutrition and regular exercise can be an interesting strategy to modulate lipid profile, acting as prevention or treatment, inhibiting the risk of diseases due to its anti-inflammatory and anti-atherogenic characteristics. Additionally, the possibility of controlling different training variables, such as type, intensity and recovery interval, can be used to maximize the benefits of exercise in promoting cardiovascular health. However, the mechanisms by which exercise and nutrients act in the regulation of cholesterol and its fractions, such as reverse cholesterol transport, receptors and transcription factors involved, such as PPARs and their role related to exercise, deserve further discussion. Therefore, the objective of this review is to debate about non-medical approaches to increase HDL-c, such as nutritional and training strategies, and to discuss the central mechanisms involved in the modulation of lipid profile during exercise, as well as that can be controlled by physical trainers or sports specialists in attempt to maximize the benefits promoted by exercise. The search for papers was performed in the databases: Medline (Pubmed), Science Direct, Scopus, Sport Discus, Web of Science, Scielo and Lilacs until February 2016.
Acesso aberto (Open Access)
Self-Reported High-Cholesterol Prevalence in the Brazilian Population: Analysis of the 2013 National Health Survey
(Arquivos Brasileiros Cardiologia, 2017) Lotufo, Paulo A.; Santos, Raul D.; Sposito, Andrei C.; Bertolami, Marcelo; Neto, Jose Rocha-Faria; Cristina Izar, M. [UNIFESP]; Szwarcwald, Celia; Prado, Rogerio R.; Stoppa, Sheila R.; Malta, Deborah C.; Bensenor, Isabela M.
Background: Data on the prevalence of dyslipidemia in Brazil are scarce, with surveys available only for some towns. Objective: To evaluate the prevalence of the self-reported medical diagnosis of high cholesterol in the Brazilian adult population by use of the 2013 National Health Survey data. Methods: Descriptive study assessing the 2013 National Health Survey data, a household-based epidemiological survey with a nationally representative sample and self-reported information. The sample consisted of 60,202 individuals who reported a medical diagnosis of dyslipidemia. The point prevalence and 95% confidence interval (95% CI) for the medical diagnosis of high cholesterol/triglyceride by gender, age, race/ethnicity, geographic region and educational level were calculated. Adjusted odds ratio was calculated. Results: Of the 60,202 participants, 14.3% (95% CI=13.7-14.8) never had their cholesterol or triglyceride levels tested, but a higher frequency of women, white individuals, elderly and those with higher educational level had their cholesterol levels tested within the last year. The prevalence of the medical diagnosis of high cholesterol was 12.5% (9.7% in men and 15.1% in women), and women had 60% higher probability of a diagnosis of high cholesterol than men. The frequency of the medical diagnosis of high cholesterol increased up to the age of 59 years, being higher in white individuals or those of Asian heritage, in those with higher educational level and in residents of the Southern and Southeastern regions. Conclusion: The importance of dyslipidemia awareness in the present Brazilian epidemiological context must be emphasized to guide actions to control and prevent coronary heart disease, the leading cause of death in Brazil and worldwide.

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