Navegando por Palavras-chave "Duchenne muscular dystrophy"
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- ItemSomente MetadadadosAchievement of Virtual and Real Objects Using a Short-Term Motor Learning Protocol in People with Duchenne Muscular Dystrophy: A Crossover Randomized Controlled Trial(Mary Ann Liebert, Inc, 2018) Massetti, Thais; Favero, Francis Meire [UNIFESP]; Menezes, Lilian Del Ciello de; Alvarez, Mayra Priscila Boscolo; Crocetta, Tania Brusque; Guarnieri, Regiani; Nunes, Fatima L. S.; Monteiro, Carlos Bandeira de Mello; Silva, Talita Dias daObjective: To evaluate whether people with Duchenne muscular dystrophy (DMD) practicing a task in a virtual environment could improve performance given a similar task in a real environment, as well as distinguishing whether there is transference between performing the practice in virtual environment and then a real environment and vice versa. Methods: Twenty-two people with DMD were evaluated and divided into two groups. The goal was to reach out and touch a red cube. Group A began with the real task and had to touch a real object, and Group B began with the virtual task and had to reach a virtual object using the Kinect system. Results: ANOVA showed that all participants decreased the movement time from the first (M=973 ms) to the last block of acquisition (M=783 ms) in both virtual and real tasks and motor learning could be inferred by the short-term retention and transfer task (with increasing distance of the target). However, the evaluation of task performance demonstrated that the virtual task provided an inferior performance when compared to the real task in all phases of the study, and there was no effect for sequence. Conclusions: Both virtual and real tasks promoted improvement of performance in the acquisition phase, short-term retention, and transfer. However, there was no transference of learning between environments. In conclusion, it is recommended that the use of virtual environments for individuals with DMD needs to be considered carefully.
- ItemSomente MetadadadosBoys With Duchenne Muscular Dystrophy: 1-Year Locomotor Changes in Relation to a Control Group(Sage Publications Inc, 2018) Martini, Joyce; Caromano, Fatima Aparecida; Carvalho, Eduardo Vital; Goya, Priscila Albuquerque; Hayasaka, Rosana Massae [UNIFESP]; Nakazune, Silvia [UNIFESP]; Favero, Francis Meire [UNIFESP]; Voos, Mariana CallilWe compared the timed performance and compensatory movements of 32 boys (mean age = 10.0 years) with Duchenne muscular dystrophy (DMD) and 38 healthy boys (mean age = 9.2 years) on 10-meter walking and four-step stair work (climbing and descending). Dependent measures were digital scores on the Functional Evaluation Scale for DMD obtained by watching the boys on film. Groups were compared initially and after 6 and 12 months, using General Linear Models analysis (for two groups and three assessments). Results showed no significant timed performance differences between groups on 10-m walking at the initial assessment
- ItemAcesso aberto (Open Access)Caracterização da modulação autonômica e do perfil funcional de pessoas com Distrofia Muscular de Duchenne(Universidade Federal de São Paulo (UNIFESP), 2016-10-17) Silva, Talita Dias da [UNIFESP]; Ferreira, Celso [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Among Muscular Dystrophies, Duchenne muscular dystrophy (DMD) is the most common genetic neuromuscular disease. Abnormal autonomic signaling is increasingly recognized as an important symptom in neuromuscular diseases, since the progressive degeneration and atrophy occur in both skeletal muscle and in the myocardium. Given this, it is important to evaluate the heart rate variability (HRV) of patients with DMD, which reflects the Autonomic Nervous System (ANS) activity on the sinus node. Objective: To characterize the autonomic modulation of people with Duchenne muscular dystrophy, compare the results with those of patients with DMD using beta-blockers (BB). We evaluated 90 adolescents, 30 with DMD, all boys, aged 11 and 18. To control group evaluated 30 with DMD using BB and 30 subjects with normal development, all matched for age and sex. For the assessment of functionality we applied Vignos scales, Motor Function Measure Scale (MFM) and Egen Klassifikation (EK). HRV analysis was made with the Polar ProTrainer 800CX with adolescents at rest spontaneously breathing for 25 minutes. The results showed that the autonomic impairment that individuals with DMD exhibit, promote reduction of RR intervals (mean RR), increased sympathetic (0V%) and parasympathetic reduction (% 2LV and 2UV%). It also decreases the complexity (Shannon Entropy) and fractal properties long term (?2). Therapy with beta-blockers act only in heart rate (HR) average, but not on the time elapsed between adjacent RR intervals, though the BB exert effect on the fractal properties in the long term (?2). In conclusion, the subjects with DMD show a reduction of parasympathetic tone and increased sympathetic. Moreover, BB therapy does not seem to influence the autonomic modulation.
- ItemSomente MetadadadosComputer task performance by subjects with Duchenne muscular dystrophy(Dove Medical Press Ltd, 2016) Pinheiro Malheiros, Silvia Regina; da Silva, Talita Dias [UNIFESP]; Favero, Francis Meire [UNIFESP]; de Abreu, Luiz Carlos; Fregni, Felipe; Ribeiro, Denise Cardoso; de Mello Monteiro, Carlos BandeiraAims: Two specific objectives were established to quantify computer task performance among people with Duchenne muscular dystrophy (DMD). First, we compared simple computational task performance between subjects with DMD and age-matched typically developing (TD) subjects. Second, we examined correlations between the ability of subjects with DMD to learn the computational task and their motor functionality, age, and initial task performance. Method: The study included 84 individuals (42 with DMD, mean age of 18 +/- 5.5 years, and 42 age-matched controls). They executed a computer maze task all participants performed the acquisition (20 attempts) and retention (five attempts) phases, repeating the same maze. A different maze was used to verify transfer performance (five attempts). The Motor Function Measure Scale was applied, and the results were compared with maze task performance. Results: In the acquisition phase, a significant decrease was found in movement time (MT) between the first and last acquisition block, but only for the DMD group. For the DMD group, MT during transfer was shorter than during the first acquisition block, indicating improvement from the first acquisition block to transfer. In addition, the TD group showed shorter MT than the DMD group across the study. Conclusion: DMD participants improved their performance after practicing a computational task however, the difference in MT was present in all attempts among DMD and control subjects. Computational task improvement was positively influenced by the initial performance of individuals with DMD. In turn, the initial performance was influenced by their distal functionality but not their age or overall functionality.
- ItemSomente MetadadadosComputer task performance by subjects with Duchenne muscular dystrophy(Dove Medical Press Ltd, 2016) Pinheiro Malheiros, Silvia Regina; da Silva, Talita Dias [UNIFESP]; Favero, Francis Meire [UNIFESP]; de Abreu, Luiz Carlos; Fregni, Felipe; Ribeiro, Denise Cardoso; de Mello Monteiro, Carlos BandeiraAims: Two specific objectives were established to quantify computer task performance among people with Duchenne muscular dystrophy (DMD). First, we compared simple computational task performance between subjects with DMD and age-matched typically developing (TD) subjects. Second, we examined correlations between the ability of subjects with DMD to learn the computational task and their motor functionality, age, and initial task performance. Method: The study included 84 individuals (42 with DMD, mean age of 18 +/- 5.5 years, and 42 age-matched controls). They executed a computer maze task
- ItemSomente MetadadadosCyclooxygenase-2 expression in skeletal muscle of knockout mice suffering Duchenne muscular dystrophy(Springer, 2013-05-01) Flavia, De Oliveira [UNIFESP]; Quintana, Hananiah Tardivo [UNIFESP]; Bortolin, Jeferson Andre [UNIFESP]; Gomes, Odair Alfredo; Liberti, Edson Aparecido; Ribeiro, Daniel Araki [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Univ Ribeirao Preto; Universidade de São Paulo (USP)The purpose of the present study was to investigate the role of cyclooxygenase-2 (COX-2) expression in fibrotic lesion in mdx mice. A total of six male C57BL/10 mice and six C57BL/10-DMD/mdx were distributed into two groups: control and animals with Duchenne muscular dystrophy (DMD). the medial part of gastrocnemius muscle was evaluated being the specimens stained with hematoxylin and eosin (H&E) and Sirius Red under normal and polarized light to differentiate type I (red and yellow) and III (green) collagen. COX-2 expression was assessed by immunohistochemistry. the results revealed histopathological changes in C57BL/10-DMD/mdx as depicted by regenerating fibers. Sirius Red stain showed a substantial increase in the amount of type I collagen of mdx mice. DMD induced a strong COX-2 immunoexpression in intercellular space. Taken together, our results are consistent with the notion that necrotic and fibrotic lesions are able to increase COX-2 expression in DMD.
- ItemAcesso aberto (Open Access)Duchenne muscular dystrophy: alpha-dystroglycan immunoexpression in skeletal muscle and cognitive performance(Academia Brasileira de Neurologia - ABNEURO, 2005-12-01) Pereira, Conceição Campanario da Silva [UNIFESP]; Kiyomoto, Beatriz Hitomi [UNIFESP]; Cardoso, Ricardo; Oliveira, Acary Souza Bulle [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); CeT Codificação e TabulaçãoThe Duchenne muscular systrophy (DMD) is a muscular dystrophy with cognitive impairment present in 20-30% of the cases. In the present study, in order to study the relationship between the alpha-dystroglycan (alpha-DG) immunostaining in skeletal muscle and cognitive performance in DMD patients, 19 were assessed. Twelve patients performed the intelligence quotient (IQ) below the average. Among the 19 patients, two were assessed by the Stanford-Binet test and 17 by Wechsler Intelligence Scale for Children-III (WISC-III). Nine patients performed a verbal IQ below the average, only three patients performed an average verbal IQ. The muscle biopsies immunostained with antibodies to alpha-DG showed that 17 patients presented a low expression, below 25% of the total fibers. Two patients presented alpha-DG immunostaining above 40% and an IQ within the average. No significant statistical relationship was demonstrated among total IQ, verbal IQ and execution IQ and alpha-DG immunostaining at these patients muscle samples.
- ItemSomente MetadadadosHeart Rate Variability and Cardiopulmonary Dysfunction in Patients with Duchenne Muscular Dystrophy: A Systematic Review(Springer, 2018) Silva, Talita Dias da [UNIFESP]; Massetti, Thais; Crocetta, Tania Brusque; Monteiro, Carlos Bandeira de Mello; Carll, Alex; Vanderlei, Luiz Carlos Marques; Arbaugh, Carlie; Oliveira, Fernando Rocha; Abreu, Luiz Carlos de; Ferreira Filho, Celso [UNIFESP]; Godleski, John; Ferreira, Celso [UNIFESP]Duchenne muscular dystrophy (DMD) is a genetic recessive disorder with progressive muscle weakness. Despite the general muscle wasting, degeneration and necrosis of cardiomyocytes have been the main causes of morbidity and death in individuals with DMD. Cardiac failure is generally preceded by disturbances in heart rate variability (HRV), and non-invasive measurement of the autonomic nervous system has been an important tool to predict adverse cardiovascular events. Hence, the application of HRV to study autonomic modulation in DMD individuals, and the establishment of correlations between HRV and heart/lung diseases, age, and mortality will have the potential to improve quality of life and life expectancy of individuals with DMD. In order to evaluate the state of the art in this field, we conducted a systematic search in Medline/PubMed and BVS (virtual library in health) databases. We selected 8 studies using pre-defined criteria and meta-analysis revealed decreased parasympathetic activity and increased sympathetic predominance in individuals with DMD as major observations. Moreover, there is a strong association between diminished HRV and myocardial fibrosis with DMD. These patterns are evident in patients at early-stage DMD and become more prominent as disease severity and age increase. Thus, data minning clearly indicates that HRV assessment can be used as a predictor for sudden death in individuals with DMD. The use of the HRV, which is inexpensive, ubiquitously available in clinics and hospitals, and a non-invasive analysis tool, can save lives and decrease the morbity in DMD by alerting care givers to consider autonomic nervous system intervention.
- ItemSomente MetadadadosImpact of corticotherapy, nutrition, and sleep disorder on quality of life of patients with Duchenne muscular dystrophy(Elsevier Science Inc, 2016) Jeronimo, Giovanna [UNIFESP]; Nozoe, Karen T. [UNIFESP]; Polesel, Daniel N. [UNIFESP]; Moreira, Gustavo A. [UNIFESP]; Tufik, Sergio [UNIFESP]; Andersen, Monica L. [UNIFESP]Duchenne muscular dystrophy (DMD) is the second most common hereditary genetic disease in humans and has elevated mortality. DMD is an X-linked, life-limiting progressive muscle-wasting disease found predominantly in boys and young men. One of the main treatments for patients with DMD is corticosteroids. However, long-term use may cause major side effects such as obesity, a reduction in vitamin D, and osteoporosis. Sleep-disordered breathing is a common condition among patients with DMD, especially obstructive sleep apnea (OSA). In children, OSA is associated with obesity and a reduction of vitamin D concentration. In this article we aim to explore the interrelationship that exists between corticosteroids, obesity, OSA, and the risk of osteoporosis. Our main hypothesis is that factors such as nutrition and sleep are related to obesity and OSA, respectively. In addition, the chronic use of corticosteroids, obesity, and OSA are factors that can reduce serum levels of vitamin D, triggering osteoporosis. Thus, these factors play a key role in affecting the quality of life for patients with DMD and intervention based on these aspects may improve survival. (C) 2016 Elsevier Inc. All rights reserved.
- ItemAcesso aberto (Open Access)Patients with Duchenne and Becker muscular dystrophies are not more asymmetrical than healthy controls on timed performance of upper limb tasks(Assoc Bras Divulg Cientifica, 2017) Artilheiro, Mariana Cunha; Sá, Cristina dos Santos Cardoso de [UNIFESP]; Favero, Francis Meire [UNIFESP]; Caromano, Fatima Aparecida; Voos, Mariana CallilThis study aimed to investigate possible asymmetries and relationships between performance of dominant and non-dominant upper limbs (UL) in patients with Duchenne and Becker muscular dystrophies (DMD/BMD), to compare UL performance of patients and healthy subjects and to investigate the relationship between timed performance of UL and age, motor function and muscle strength in DMD/BMD patients. Sixteen patients with DMD and 3 with BMD were evaluated with Jebsen-Taylor Test (timed performance), Vignos scale and Dimension 3 of Motor Function Measure (motor function), and Medical Research Council scale (muscle strength) on a single session. ANOVA showed no asymmetry between dominant and non-dominant UL, except in the writing subtest, in patients and in healthy controls. There were relationships between dominant and non-dominant UL performances. Correlations between timed performance, motor function and muscle strength were found, but age was not correlated with these variables. These findings may reduce the assessment time, prevent fatigue and provide more accurate clinical reasoning involving UL in DMD/BMD treatment.
- ItemAcesso aberto (Open Access)Percurso Escolar de Pessoas com Distrofia Muscular de Duchenne: Contingências Sociais e Constituição dos Sujeitos(Universidade Federal de São Paulo (UNIFESP), 2016-09-20) Rozante, Gessica Torres [UNIFESP]; Carvalho, Maria de Fatima [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)This research is inserted in the field of studies about inclusion of people with disabilities in the scholar education. Its objective is to comprehend the schooling path of people with Duchenne Muscular Dystrophy (DMD) through the investigation of the roles of the subjective, historic, social and educational-political aspects, as well as those related to their organic conditions, which are contingencies in such paths. This research evinces in the diversity that can feature those paths, how it is the intertwining of social and personal histories of the subjects in their relation with the school. It has as theoretical-methodological framework the cultural-historical psychology, highlighting the contributions of Vygotsky and the studies about language in a dialogic and enunciative perspective, based on studies of the Bakhtin Circle (BAKHTIN/VOLOCHINOV), in a way that the look is directed to the social constitution of the educational paths and subjects. It has as references other theorists as Ecléa Bosi, in order to expand the discussion about the social constitution of the memory; Norberto Bobbio, in order to enable the reflection on the relation between the rights and their practical realization; Erwing Goffman from the sociology field, whose work allows to base arguments about the stigmatization process. The empiric work consists on the bibliographic review about the topic, in particular the Neuropsychology researches about intellectual disability and DMD; on the contextualization of the Inclusive Education policies; finally, on the realization of open interviews with people with DMD and their relatives. The analysis has two areas of thought: conditions of possibilities for access and staying in the school, and the constitution of the subjects in relation with the school, from which we increase the discussion about the impacts of the meaning of the diagnosis by the mothers, as well as the conditions of volitional possibilities of learning and confrontation of stigma. The investigation undertaken points the difficulties of access and staying faced by the subjects with DMD in their paths, despite the political-pedagogical context of School Inclusion. It highlights the role of the mothers efforts on seeking guarantees of conditions of educational possibilities for their children and, in conclusion, it clarifies how these schooling paths are constitutives of the subjectives of the research
- ItemSomente MetadadadosPhotobiomodulation therapy protects skeletal muscle and improves muscular function of mdx mice in a dose-dependent manner through modulation of dystrophin(Springer London Ltd, 2018) Albuquerque-Pontes, Gianna Moes; Casalechi, Heliodora Leao; Tomazoni, Shaiane Silva; Serra, Andrey Jorge; Ferreira, Cheila de Sousa Bacelar; Brito, Rodrigo Barbosa de Oliveira; Melo, Brunno Lemes de [UNIFESP]; Vanin, Adriane Aver; Monteiro, Kadma Karenina Damasceno Soares; Delle, Humberto; Frigo, Lucio; Marcos, Rodrigo Labat; Carvalho, Paulo de Tarso Camillo de; Leal-Junior, Ernesto Cesar PintoThis study aimed to analyze the protective effects of photobiomodulation therapy (PBMT) with combination of low-level laser therapy (LLLT) and light emitting diode therapy (LEDT) on skeletal muscle tissue to delay dystrophy progression in mdx mice (DMD (mdx) ). To this aim, mice were randomly divided into five different experimental groups: wild type (WT), placebo-control (DMD (mdx) ), PBMT with doses of 1 J (DMD (mdx) ), 3 J (DMD (mdx) ), and 10 J (DMD (mdx) ). PBMT was performed employing a cluster probe with 9 diodes (1 x 905nm super-pulsed laser diode
- ItemEmbargoResposta de diferentes músculos de um modelo experimental para distrofia muscular de Duchenne após exacerbação da doença pelo exercício físico(Universidade Federal de São Paulo, 2024-11-18) Costa, Pietra Mascarenhas Souza [UNIFESP]; De Oliveira, Flavia [UNIFESP]; http://lattes.cnpq.br/3387760393535776; http://lattes.cnpq.br/4352024478331464; Universidade Federal de São Paulo (UNIFESP)Introdução: A distrofia muscular de Duchenne (DMD) é uma doença ainda sem cura, caracterizada por necrose muscular progressiva. Sabe-se que no músculo distrófico, as fibras musculares do tipo I (de contração lenta) são mais resistentes à necrose e, em contraponto, as fibras tipo II (de contração rápida) são mais vulneráveis ao dano muscular induzido pelo exercício. O m. tibial anterior possui predominantemente fibras do tipo rápidas, enquanto o m. sóleo possui predominância de fibras do tipo lentas. Objetivo: Investigar os achados morfométricos e histopatológicos de músculos com diferentes composições de predominância de tipos de fibras musculares (tibial anterior e sóleo) em camundongos mdx submetidos à exacerbação da doença por protocolo de exercício físico em esteira. Material e métodos: Camundongos C57BL10-DMD/mdx com 8 meses de vida foram distribuídos em dois grupos: Mdx sedentário (Mdx-S) e Mdx+exercício (Mdx-T), sendo que para o m. tibial anterior, acrescentou-se TA à sigla (Mdx-S-TA e Mdx-T-TA) e, para o sóleo, acrescentou-se S a sigla (Mdx-S-S e Mdx-T-S). Somente o grupo Mdx-T foi submetido ao protocolo de exercício por 8 semanas. Os mm. tibial anterior e sóleo foram avaliados quanto à análise morfométrica (densidade e área das fibras musculares) e histopatológica qualitativa e semiquantitativa (área de degeneração-inflamação, regeneração e infiltrado inflamatório). Os dados foram comparados por meio do teste t de Student para análise da variável exercício em cada músculo, e foi adotado para ambos os músculos (em mdx-T e Mdx-S) n=8 na análise morfométrica e n=6 na análise histopatológica. Resultados: A análise morfométrica da média da densidade celular do m. tibial anterior entre grupo Mdx-S-TA e Mdx-T-TA, assim como do m. sóleo entre Mdx-S-S e Mdx-T-S, não apresentou diferença na comparação. A análise morfométrica da área das fibras do m. tibial anterior mostrou que entre grupo Mdx-S-TA e Mdx-T-TA, assim como a análise da área das fibras do m. sóleo entre Mdx-S-S e Mdx-T-S, não houve diferença na área das fibras entre os grupos. Na frequência de distribuição das diferentes áreas encontradas e na análise histopatológica qualitativa, observou-se que há heterogeneidade na área das fibras de ambos os músculos, e maior heterogeneidade em TA (em Mdx-S e Mdx-T). Com relação a análise histopatológica semiquantitativa (em %), não houve diferença na comparação da média da área de degeneração no m. tibial anterior e m. sóleo entre grupo Mdx-S e Mdx-T. Na comparação das médias da área de inflamação no m. tibial anterior entre grupo Mdx-S-TA e Mdx-T-TA não houve diferença entre os grupos comparados. Já no m.sóleo, Mdx-T-S apresentou menor porcentagem de inflamação que o grupo Mdx-S-S. Na comparação da média da área de regeneração, Mdx-T-TA apresentou maior regeneração que o grupo Mdx-S-TA. No m. sóleo, entre grupo Mdx-S-S e Mdx-T-S, não houve diferença entre os grupos comparados para área de regeneração. Conclusão: Os músculos investigados não apresentaram alterações morfométricas quando submetidos ao exercício, a fim de exacerbar a doença. O m. tibial anterior apresenta maior acometimento na resposta de cada músculo ao exercício. Ademais, o exercício intenso diminuiu a inflamação, causando efeito positivo no m.sóleo. Assim, esse estudo traz informações relevantes sobre as interferências das diferentes predominâncias de fibras (tipo I e II) em estágios avançados da doença e que podem ser utilizadas para tratamentos futuros.
- ItemSomente MetadadadosSleep pattern and spectral analysis of caregiver-mothers of sons with Duchenne muscular dystrophy, and an examination of differences between carriers and non-carriers(Elsevier Science Bv, 2017) Nozoe, Karen Tieme [UNIFESP]; Kim, Lenise Jihe [UNIFESP]; Polesel, Daniel Ninello [UNIFESP]; Hirotsu, Camila [UNIFESP]; de Souza, Altay Lino [UNIFESP]; Hachul, Helena [UNIFESP]; Tufik, Sergio Brasil [UNIFESP]; Tufik, Sergio [UNIFESP]; Andersen, Monica Levy [UNIFESP]; Moreira, Gustavo Antonio [UNIFESP]Objectives: Sleep is essential for physical and mental well-being. However, poor sleep is a common complaint among caregivers. The aim of the present study was to determine sleep patterns of caregiver-mothers (CM group) of sons with Duchenne muscular dystrophy (DMD) and also to examine the differences between non-carriers and carriers of the gene related to DMD within the CM group. Methods: Observational case-control study. Participants: The CM and control (CTRL) groups were matched for age, body mass index and social class. Polysomnography was conducted in a sleep laboratory for one night. The discrete fast Fourier transformation method was used to calculate the electroencephalogram (EEG) power spectrum for the entire night and sleep stages. Results: The CM group presented higher sleep latency and N3 sleep stage compared with the CTRL. When carrier and non-carrier CM subgroups were analyzed, increased sleep latency and time awake, as well as reduced sleep efficiency and N2, were observed in the carrier group. Regarding respiratory parameters, carriers demonstrated higher hypopnea index values compared with non-carriers. Spectral analysis showed that carriers compared with non-carrier DMD caregiver-mothers presented lower spectral power in fast waves, mainly beta, during REM sleep in some EEG derivations. Conclusions: There was an impairment of sleep pattern in the CM group compared with CTRL mothers
- ItemAcesso aberto (Open Access)Sleep quality of mother-caregivers of Duchenne muscular dystrophy patients(Springer Heidelberg, 2016) Nozoe, Karen T. [UNIFESP]; Polesel, Daniel N. [UNIFESP]; Moreira, Gustavo A. [UNIFESP]; Pires, Gabriel N. [UNIFESP]; Akamine, Ricardo T. [UNIFESP]; Tufik, Sergio [UNIFESP]; Andersen, Monica L. [UNIFESP]Background Sleep disturbance is a common problem for caregivers. In general, patients with Duchenne muscular dystrophy (DMD) use noninvasive ventilation to maintain quality of life and improve survival. Objective The aim of this study was to evaluate the sleep quality of caregiver-mothers of sons with DMD and factors that are associated with their sleep quality. Methods We evaluated 32 caregiver-mothers of sons with DMD and 32 mothers of sons without any neuromuscular or chronic disease (control-CTRL group). The evaluation of quality of sleep was made using the Pittsburgh Sleep Quality Index (PSQI). Results Caregiver-mothers had poor sleep quality, specifically longer sleep latency and reduced sleep efficiency. The impaired sleep quality of the caregiver-mothers was associated with the length of time of noninvasive ventilation used by their sons. Conclusions Our results suggest that caregiver-mothers of sons with DMD have poor quality of sleep, and the length of use of noninvasive ventilation of their sons is associated with better sleep of caregiver-mothers.