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- ItemSomente MetadadadosAssociações De Micrornas Via Mapas Auto-Organizáveis Binários E Categóricos(Universidade Federal de São Paulo (UNIFESP), 2017-08-21) Santana, Alessandra De Franca [UNIFESP]; Quiles, Marcos Goncalves [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)The small non-coding RNA fragments, known as microRNAs, are part of a complex network of biological interaction, acting as regulators in several processes, from cell differentiation to the development of diseases such as cancer. Understanding the existing relationships between microRNAs and their functions is an important step to reveal their mechanisms of action and thus to develop new therapies for the prevention and treatment of diseases. Machine learning techniques, such as the Self-Organizing Maps, or SOM network, have been widely used in several areas, including Biology, to assist in the manipulation of the generated data and to help in the search for a better understanding of the mechanisms and phenomena of these areas. After a review of existing SOM network variations, it was observed that in their majority there is the use of data encryption mechanisms and/or complex mathematical approaches, sometimes obtaining unsatisfactory clustering performances. So, considering the microRNAs complexity and the nature of their data, it was necessary to develop in this work an alternative computational approach to the SOM network. The proposed new algorithm will manipulate binary and categorical data in a simple and efficient way, addressing the two main processes of network operation: competition and updating. Thus, this work aims to create a new database of microRNAs associations through the application of a new binary and categorical SOM network algorithm. Finally, it is expected to contribute to a better understanding of microRNAs and their mechanisms of functioning through the study of their associations and thus collaborate with the development of the preventive medicine.
- ItemSomente MetadadadosEffects of physiotherapy on hemodynamic variables in newborns with Acute Respiratory Distress Syndrome(Drunpp-sarajevo, 2011-01-01) Abreu, Luiz Carlos de [UNIFESP]; Valenti, Vitor Engrácia [UNIFESP]; Oliveira, Adriana G. de; Leone, Claudio; Siqueira, Arnaldo Augusto Franco de; Gallo, Paulo R.; Fonseca, Fernando Luiz Affonso [UNIFESP]; Simon, Viviane G. N.; Saldiva, Paulo Hilário Nascimento [UNIFESP]; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)Background: Acute respiratory distress syndrome (ARDS) is a frequent respiratory disturbance in preterm newborns. Preceding investigations evaluated chronic physiotherapy effects on newborns with different lung diseases; however, no study analyzed acute physiotherapy treatment on premature newborns with ARDS. In this study we aimed to evaluate the acute effects of chest and motor physiotherapy treatment on hemodynamic variables in preterm newborns with ARDS.Methods: We evaluated heart rate (HR), respiratory rate (RR), systolic (SAP), mean (MAP) and diastolic arterial pressure (DAP), temperature and oxygen saturation (SO(2)%) in 44 newborns with ARDS. We compared all variables between six periods in one day: before first physiotherapy treatment vs. after first physiotherapy treatment vs. before second physiotherapy treatment vs. after second physiotherapy treatment vs. before third physiotherapy treatment vs. after third physiotherapy treatment. Variables were measured 2 minutes before and 5 minutes after each physiotherapy session. We applied Anova one way followed by post hoc Bonferroni test.Results: HR (147.5 +/- 9.5 bpm vs. 137.7 +/- 9.3 bpm; p<0.001), RR (45.5 +/- 8.7cpm vs. 41.5 +/- 6.7 cpm; p=0.001), SAP (70.3 +/- 10.4 mmHg vs. 60.1 +/- 7.1 mmHg; p=0.001) and MAP (55.7 +/- 10 mmHg vs. 46 +/- 6.6 mmHg; p=0.001) were significantly reduced after the third physiotherapy treatment compared to before the first session. There were no significant changes regarding temperature, DAP and SO(2) %.Conclusion: Chest and motor physiotherapy acutely improves HR, RR, SAP, MAP and SO(2) % in newborns with ARDS.
- ItemAcesso aberto (Open Access)Polifarmácia em idosos e a associação com doenças crônicas e perdas funcionais(Universidade Federal de São Paulo (UNIFESP), 2017-02-22) Mercadante, Ana Claudia Costa [UNIFESP]; Ramos, Luiz Roberto [UNIFESP]; Andreoni, Solange [UNIFESP]; http://lattes.cnpq.br/7300291437204130; http://lattes.cnpq.br/3798829566782422; http://lattes.cnpq.br/8850552075327252; Universidade Federal de São Paulo (UNIFESP)Objective: to characterize the use of drugs of cronic use in population composed of elderly people ages 60 years or more in association with chronical diseases and functional losses. Methodology: this is a cross sectional observational study, grounded on surveyed information by the EPIDOSO Project (phase 2), based on surveys established in the CEE (Centro de Estudos do Envelhecimento), which belongs to the discipline of Clinical Preventive Medicine (UNIFESP). It´s about a middle class population, with individuals in both genders residents in Vila Clementino. The Great Geriatric Evaluation has been use for the data collection and with this instrument, 1002 elderly were interview. The data were transferred to an electronic spreadsheet (Excel®2003) and the statistical evaluations were arranged using the SPSS software 20,0 version. The dependent variable is the polypharmacy (use of 5 or more medicines) and logistic regression models were devise in order to evaluate the association between the use of polypharmacy and the independent variables. Results: the average age was 73 years old, being 67.2% females, with predominance of coupled (52.4%), with 8 years or more of study (66.1%). The prevalence of the medicine use was 92.7%. The average rates were use of medicine = 4.8, number of diagnosis = 8.7 and compromised activities of daily living (ADL) = 3.0. The polypharmacy was verified in 50.0% of the elderly and, among women, 53.8% has this habit. Within the interviewees, the most prevalence disease was the Arterial Hypertension (71.9%) and the medications operating in the cardiovascular system were the most used (34.6%). The risk factors to polypharmacy were: females (OR 1.42; CI 95% 1.06-1.91); not engaged in remunerated activities (OR 2.06; CI 95% 1.47-2.89); have 4 to 7 diseases (OR 3.57; CI 95% 1.74-7.32), have 7 or more compromised ADL (OR 1.82; CI 95% 1.23-2.69). The variables with more correlation with the use of five or more medicines are: females, bigger amount of health problems, not gainfully employed, have a bigger number of compromised activities of daily living and have being hospitalized. CONCLUSION: the findings of this study show a high ratio of the use of medicines among the elderly people, since the grievances in health make them need the pharmacotherapy and the concept preached by the society that the way to obtain health is to consume health. The risk factors associated to polypharmacy may be useful to warn the healthcare professionals about the importance to identify and to monitor groups of elderly people more vulnerable to this habit.
- ItemAcesso aberto (Open Access)A system biology approach based on metabolic biomarkers and protein–protein interactions for identifying pathways underlying schizophrenia and bipolar disorder(Nature Research, 2021-07-14) Altaf-Ul-Amin, Md; Hirose, Kazuhisa; Nani, João Victor [UNIFESP]; Porta, Lucas C [UNIFESP]; Tasic, Ljubica; Hossain, Shaikh Farhad; Huang, Ming; Ono, Naoaki; Hayashi, Mirian [UNIFESP]; Kanaya, Shigehiko; http://lattes.cnpq.br/5559309395232147Mental disorders (MDs), including schizophrenia (SCZ) and bipolar disorder (BD), have attracted special attention from scientists due to their high prevalence and significantly debilitating clinical features. The diagnosis of MDs is still essentially based on clinical interviews, and intensive efforts to introduce biochemical based diagnostic methods have faced several difficulties for implementation in clinics, due to the complexity and still limited knowledge in MDs. In this context, aiming for improving the knowledge in etiology and pathophysiology, many authors have reported several alterations in metabolites in MDs and other brain diseases. After potentially fishing all metabolite biomarkers reported up to now for SCZ and BD, we investigated here the proteins related to these metabolites in order to construct a protein–protein interaction (PPI) network associated with these diseases. We determined the statistically significant clusters in this PPI network and, based on these clusters, we identified 28 significant pathways for SCZ and BDs that essentially compose three groups representing three major systems, namely stress response, energy and neuron systems. By characterizing new pathways with potential to innovate the diagnosis and treatment of psychiatric diseases, the present data may also contribute to the proposal of new intervention for the treatment of still unmet aspects in MDs.