Navegando por Palavras-chave "Diaphragm"
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- ItemSomente MetadadadosContribution Towards the Anatomy of the Esophageal Hiatus and its Relationship with the Presence of Bundles of Collagen Fibers in its Margins(Soc Chilena Anatomia, 2012-01-01) Oliveira Filho, Jose Jeova de [UNIFESP]; Herani Filho, Benedito [UNIFESP]; Reis, Francisco Prado [UNIFESP]; Correa Feitosa, Vera Lucia; Aragão, José Aderval [UNIFESP]; Tiradentes Univ UNIT; Universidade Federal de São Paulo (UNIFESP); Univ Fed Sergipe; Universidade Federal de Sergipe (UFS)The aim was to detect the presence of bundles of collagen fibers in the margins of the esophageal hiatus and establish if there is any relationship of these bundles with the anatomy of the hiatus. Ten adult male cadavers, with no gross anatomical alteration caused by trauma, surgery or disease, upon the esophageal hiatus were used in the study. A piece of anatomical structure comprising the diaphragm with the esophageal hiatus and adjacent tissues was removed, dissected and 10% formol embedding. With the aid of a digital caliper, measurements of the perimeter of the esophageal hiatus were done both in the abdominal and thoracic sides. For the structural study each margin was divided in six sections. Staining techniques of Masson and Picrosirius-hematoxilin were used. Collagen fibers bundles had been found in 8/10 studied cadavers, distributed in 13 margins of the hiatus, of which 7 to left and 6 to the right. The muscle fibers originating from the right pillar had participated in forming both margins of the esophageal hiatus in 60% of cadavers, while in 40%, the fibers of the left pillar had formed the medial side of the right margin. The right margin was statistically thicker than the left. It did not have a correlation between the measures of the vertices of the angles superior/inferior and the transversal measure of the esophageal hiatus. The measures between the vertices of the angles superior/inferior, respectively, with the central tendon and median arcuate ligament, had presented thoracic values that tended to the double, in relation to the abdominal ones, and had been statistically significant. These distances were smaller in cadavers who possessed bundles of collagen fibers in the margins of the esophageal hiatus. Bundles of collagen fibers bundles were found in 65% of the 20 margins of the esophageal hiatus. The margins of the esophageal hiatus were predominantly formed by muscles fibers originated of the right pillar of the muscle diaphragm. The anatomical and morphometric data presented statistically significant values regarding: thickness of the right arm in relation to the left; distance between the vertex of the superior angle and the central tendon; and distance between the vertex of the inferior angle and the median arcuate ligament.
- ItemAcesso aberto (Open Access)O diafragma como método contraceptivo: a experiência de usuárias de serviços públicos de saúde(Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz, 1997-10-01) Kalckmann, Suzana; Lago, Tania Giacomo do; Barbosa, Regina Maria; Villela, Wilza Vieira [UNIFESP]; Goihman, Samuel [UNIFESP]; Secretaria de Estado da Saúde de São Paulo; Universidade Federal de São Paulo (UNIFESP)This study, started in August 1989, describes the acceptability of diaphragms as part of the daily routine of 194 women enrolled at five public health care centers in Osasco, (Greater São Paulo). Follow-up of the cohort was performed by semestral home interviews until August 1991. Our data indicate that the diaphragm can be a viable alternative within the public health care setting. Women, including those from low-income groups, are interested in new alternatives to currently available contraceptive practices. Nevertheless, the cumulative rate of continuity for use of the method was only 25.7% (39 women) after a period of 12 months. Only 37.1% of women opting for the diaphragm confirm its use during every act of sexual intercourse. Most of the women (72.7%) only learned about diaphragms during the process of choosing a contraceptive method. The main reasons for discontinued use were partners' complaints, discomfort, and difficulty in handling. The findings point to the need for reformulating family planning activities to provide greater support for women, introduce initiatives to enhance male participation, and promote on-going training of health professionals with regard to the management of the method and support for its users.
- ItemAcesso aberto (Open Access)Efeitos da aplicação da Kinesio Taping nos músculos respiratórios: revisão integrativa(Universidade Federal de São Paulo, 2023-01-06) Schiavoni, Larissa Cristina [UNIFESP]; Yamauchi, Liria Yuri [UNIFESP]; Oliveira, Daianny Seoni de [UNIFESP]; http://lattes.cnpq.br/4811679938448350; http://lattes.cnpq.br/3898949209852523; http://lattes.cnpq.br/8129243788327888; Universidade Federal de São Paulo (UNIFESP)Introdução. O diafragma é o principal músculo respiratório e doenças que interferem em sua inervação, propriedade contrátil ou em seu acoplamento mecânico à caixa torácica podem ocasionar a disfunção diafragmática. Vários mecanismos fisiopatológicos da DPOC assim como tempo prolongado de ventilação mecânica se envolvem neste processo de comprometimento da função diafragmática. A técnica de Kinesio tape (KT) , desenvolvida pelo quiropraxista japonês Kenzo Kase, quando colocada sobre a pele fornece sustentação às articulações e aos músculos. Estudos acerca dos efeitos da Kinesio, em condições variadas, tem mostrado resultados benéficos de sua aplicação na musculatura respiratória. Objetivo. Realizar uma revisão integrativa de projetos experimentais e não experimentais para a compreensão completa dos efeitos da aplicação técnica de Kinesio taping nos músculos respiratórios. Método. Foi realizada uma busca nas bases de dados: LILACS, BVS, PubMed, Web of Science e PEDro. Foram utilizados, para busca dos artigos, os seguintes descritores e suas combinações nas línguas portuguesa e inglesa: “função respiratória”, “disfunção respiratória”, “insuficiência respiratória” e “kinesio tape”. Os critérios de inclusão definidos para a seleção dos artigos foram: artigos publicados em português, inglês e espanhol; artigos na íntegra que retratassem a temática referente a revisão integrativa e artigos publicados e indexados nos referidos bancos de dados nos últimos 30 anos. Resultados. Foram incluídos 6 artigos, dos quais 3 estudaram a população com DPOC, 2 estudaram pacientes oncológicos e 1 estudou com pacientes saudáveis. Os artigos mostram influência da KT nos valores de VEF1 e pico de fluxo expirarório, dispneia e dor , mas não em força muscular respiratória, saturação de oxigênio, e capacidade inspiratória. Conclusão. Essa revisão conclui que a KT parece melhorar valores de pico de fluxo, assim como os de VEF1. Não foram encontradas evidências de efeitos acerca da força muscular respiratória ou na capacidade inspiratória. Os efeitos placebos da intervenção também necessitam de mais investigações.
- ItemSomente MetadadadosFunctional characterization of heterotrimeric G-proteins in rat diaphragm muscle(Elsevier B.V., 2011-02-15) Andrade-Lopes, Ana Luiza [UNIFESP]; Pires-Oliveira, Marcelo [UNIFESP]; Sandro Menezes-Rodrigues, Francisco [UNIFESP]; Godinho, Rosely Oliveira [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Seven-transmembrane receptors mediate diverse skeletal muscle responses for a wide variety of stimuli, via activation of heterotrimeric G-proteins. Herein we evaluate the expression and activation of rat diaphragm or cultured skeletal muscle G-proteins using [(35)S]GTP gamma S. Total membrane G alpha subunit content was 4-7 times higher in rat primary cultured myotubes and L6 cell line than in diaphragm (32.6 +/- 1.2 fmol/mg protein) and 7-27% of them were in the active conformational state. Immunoprecipitation assay showed equal expression of diaphragm G alpha s, G alpha q and G alpha i/o. Addition of GDP allowed the measurement of G-protein activation by different GPCR, including adrenoceptor, adenosine, melatonin and muscarinic receptors. Diaphragm denervation resulted in a marked increase in both total and active state G-protein levels. Together, the results show that [(35)S]GTP gamma S binding assay is a sensitive and valuable method to evaluate GPCR activity in skeletal muscle cells, which is of particular interest for pharmacological analysis of drugs with potential use in the management of respiratory muscle failure. (C) 2010 Elsevier B.V. All rights reserved.
- ItemSomente MetadadadosHeart failure with preserved ejection fraction induces molecular, mitochondrial, histological, and functional alterations in rat respiratory and limb skeletal muscle(Wiley-Blackwell, 2015-03-01) Bowen, T. Scott; Rolim, Natale P. L.; Fischer, Tina; Baekkerud, Fredrik H.; Medeiros, Alessandra [UNIFESP]; Werner, Sarah; Bronstad, Eivind; Rognmo, Oivind; Mangner, Norman; Linke, Axel; Schuler, Gerhard; Silva, Gustavo J. J.; Wisloff, Ulrik; Adams, Volker; Optimex Study Grp; Univ Leipzig; Norwegian Univ Sci & Technol; Universidade Federal de São Paulo (UNIFESP)AimsPeripheral muscle dysfunction is a key mechanism contributing to exercise intolerance (i.e. breathlessness and fatigue) in heart failure patients with preserved ejection fraction (HFpEF); however, the underlying molecular and cellular mechanisms remain unknown. We therefore used an animal model to elucidate potential molecular, mitochondrial, histological, and functional alterations induced by HFpEF in the diaphragm and soleus, while also determining the possible benefits associated with exercise training.Methods and resultsFemale Dahl salt-sensitive rats were fed a low (CON; n = 10) or high salt (HFpEF; n = 11) diet of 0.3% or 8% NaCl, respectively, or a high salt diet in combination with treadmill exercise training (n = 11). Compared with low-salt rats, high-salt rats developed (P < 0.05) HFpEF. Compared with CON, the diaphragm of HFpEF rats demonstrated (P < 0.05): a fibre type shift from fast-to-slow twitch; fibre atrophy; a decreased pro-oxidative but increased anti-oxidant capacity; reduced proteasome activation; impaired in situ mitochondrial respiration; and in vitro muscle weakness and increased fatigability. the soleus also demonstrated numerous alterations (P < 0.05), including fibre atrophy, decreased anti-oxidant capacity, reduced mitochondrial density, and increased fatigability. Exercise training, however, prevented mitochondrial and functional impairments in both the diaphragm and soleus (P < 0.05).ConclusionOur findings are the first to demonstrate that HFpEF induces significant molecular, mitochondrial, histological, and functional alterations in the diaphragm and soleus, which were attenuated by exercise training. These data therefore reveal novel mechanisms and potential therapeutic treatments of exercise intolerance in HFpEF.
- ItemAcesso aberto (Open Access)Hérnia de bochdalek em adulto(Colégio Brasileiro de Cirurgiões, 2008-02-01) Oliveira, Daniel Riccioppo C.f. De [UNIFESP]; Rodrigues Jr., Aldo Junqueira; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)Bochdalek´s hernia is a congenital malformation of the posterolateral diaphragm region. It is more common on the left and more frequently seen in newborns and rare in adults, with over a few 100 reported cases. We present a case of Bochdalek´s hernia in a 49-year-old patient with long term dyspeptic symptoms. The upper endoscopy showed a gastric fundus herniation sliding into the chest through the diaphragmatic defect. The patient also presented with a rare pulmonary malformation diagnosed during surgery. It was corrected through thoracic approach with no other complications.
- ItemSomente MetadadadosReliability of an Analysis Method for Measuring Diaphragm Excursion by Means of Direct Visualization with Videofluoroscopy(Ediciones Doyma S A, 2011-06-01) Yi, Liu Chiao [UNIFESP]; Nascimento, Oliver Augusto [UNIFESP]; Jardim, José Roberto [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Objective: the purpose of this study was to verify the reproducibility between two different observers of an analysis method for diaphragmatic displacement measurements using direct visualization with videofluoroscopy.Patients and methods: 29 mouth breathing children aged 5 to 12 years from both genders were analyzed. the diaphragmatic displacement evaluation was divided in three parts: videofluoroscopy with VHS recording in standing, sitting, and dorsal positions; digitalization of the images; and measurement of the distance between diaphragmatic domes during a breathing cycle using Adobe Photoshop 5.5 and Adobe Premiere PRO 6.5 software.Results: the intraclass correlation coefficients presented excellent reproducibility in all positions, with coefficients always above 0.94. Mean of the measurements of the diaphagramatic domes displacement done by the two observers were similar (P<.05), with the exception of right diaphragmatic displacement in the seated position and left diaphragmatic displacement in the standing position (P<.05).Conclusion: This study demonstrated that the evaluation of diaphragmatic displacement via videofluoroscopy is a reproducible measurement when two trained investigators are compared. This fact indicates that the present technique can be disseminated and performed by other healthcare professionals
- ItemSomente MetadadadosA Review on the Celiac Trunk Compression Syndrome: Some Anatomic Clinical-Surgical Aspects(Soc Chilena Anatomia, 2008-06-01) Petrella, Selma; Prates, José Carlos [UNIFESP]; Adolfo Lutz Inst; Universidade Federal de São Paulo (UNIFESP)The objective of this study was to review some celiac trunk compression syndrome aspects such as: symptom-posture relationship; absence of symptoms; syndrome-age relationship; angiographic study on anatomy of the celiac trunk stenosis; congenital or acquired origin; invasive diagnostic tests; surgical and postoperative results.