Navegando por Palavras-chave "Diabetes mellitus, type 2"
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- ItemSomente MetadadadosDesenvolvimento de um método imuno-enzimático para detecção de anticorpos anti-insulina(Universidade Federal de São Paulo (UNIFESP), 1987) Moises, Regina Celia Mello Santiago [UNIFESP]; Russo, Ewaldo Mario Kuhlmann [UNIFESP]
- ItemAcesso aberto (Open Access)Efeito da freqüência do exercício físico no controle glicêmico e composição corporal de diabéticos tipo 2(Sociedade Brasileira de Cardiologia - SBC, 2009-01-01) Vancea, Denise Maria Martins [UNIFESP]; Vancea, José Nelson; Pires, Maria Izabel Fernandes; Reis, Marco Antonio; Moura, Rafael Brandão; Dib, Sergio Atala [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP); Colégio Estadual Salime Mudeh; Colégio Estadual Marechal Carlos Machado BitencourtBACKGROUND: Diabetes and cardiovascular disease have emerged as key threats to human health, and the risk is increased in individuals with visceral obesity. The consensus is that physical exercise should be part of the treatment of diabetes mellitus (DM). OBJECTIVE: To compare the influence of guided and structured physical exercise programs (SPEP), three to five times per week, during a period of 20 weeks, on glycemic control and body composition of type 2 diabetic patients (DM2). METHODS: The research was conducted at the Universidade Federal de São Paulo (UNIFESP) (Federal University School of Medicine in São Paulo). At the clinical visit, patients from the Control Group (CG) n=17, mean age 55.8 years, were encouraged to engage in a physical exercise program. Patients from Group 3x (G3), n=14, mean age 57.4 years, were to engage in 1 hour of physical exercise, 3x/week, and Group 5x (G5), n=9, mean age 58.8 years, followed the same protocol but 5x/week. Mean of 5 years since diagnosis in all groups. Classes consisted of a 5-minute warm-up, 30-minute treadmill walk at 70% of maximum heart rate, and 10-minute relaxation. BMI, abdominal circumference (AC), percentage of body fat (BF), capillary glycemia (CG), fasting glycemia (FG), and glycated hemoglobin (HbA1c) were assessed. RESULTS: A comparison was made between the baseline time point (B) and the 20th week (20th). BMI in G3 (B:29.5±2.9 vs. 20th: 28.3 ± 2.2 Kg/sqm, p=0.005) and G5 (B:29.7±4.4 vs. 20th: 29.1 ± 4.3 Kg/sqm, p=0.025); abdominal circumference in G5 (B:100.5±11.9 vs. 20th: 933 ± 11.7 cm, p=0.001); BF in G3 (B:31±5.1 vs 20th: 26±5%, p=0.001) and G5 (B:32.4 ± 5.4 vs. 20th: 30.3 ± 6.9%, p=0.001); FG, G5 (B:150.8 ± 47.5 vs. 20th: 109.2± 30.5 mg/dL, p=0.034), showed statistically significant differences. CG did not show statistically significant differences for these variables. CG showed a tendency to drop after physical exercise in G5. HbA1c showed no statistically significant differences in the three groups. CONCLUSION: G5 did better than G3 in most parameters assessed. However, results failed to show a decrease of HbA1c in DM2 patients.
- ItemAcesso aberto (Open Access)Importância da resitência insulínica na hepatite C crônica(Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE Colégio Brasileiro de Cirurgia Digestiva - CBCD Sociedade Brasileira de Motilidade Digestiva - SBMD Federação Brasileira de Gastroenterologia - FBGSociedade Brasileira de Hepatologia - SBHSociedade Brasileira de Endoscopia Digestiva - SOBED, 2007-06-01) Parise, Edison Roberto [UNIFESP]; Oliveira, Ana Claudia de [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)OBJECTIVE: To revise the importance of insulin resistance in the development of chronic hepatitis C and its interference in the response to the antiviral treatment of these patients. DATA SOURCE: Bibliographic revision of published papers in the MEDLINE and the authors data. DATA SYNTHESIS: In the last years several published papers have demonstrated an important relationship between insulin resistance and chronic hepatitis C. Increased prevalence of type 2 diabetes mellitus, the development of hepatic steatosis (specially in non-3 genotype), a more rapid progression of hepatic disease and reduction in the sustained virological response to treatment with pegylated interferon plus ribavirin have been associated with insulin resistance in patients infected with HCV. The mechanism implied in the insulin resistance is the enhanced production of tumor necrosis factor by the HCV core. Tumor necrosis factor affects insulin receptor substrate phosphorylation, resulting in decreased glucose uptake and compensatory hyperinsulinemia. Increased liver iron accumulation and modification in the levels of adipocytokinemia can have an additional effect on insulin sensitivity in chronic C hepatitis. CONCLUSIONS: Diagnosing and treating insulin resistance in patients with chronic hepatitis C could not only avoid complications but also prevent disease progression and increased the sustained virological rate to treatment with pegylated interferon plus ribavarin.
- ItemAcesso aberto (Open Access)Undulatory physical resistance training program increases maximal strength in elderly type 2 diabetics(Instituto Israelita de Ensino e Pesquisa Albert Einstein, 2014-12-01) Santos, Gilberto Monteiro dos [UNIFESP]; Montrezol, Fábio Tanil [UNIFESP]; Pauli, Luciana Santos Souza; Sartori-Cintra, Angélica Rossi; Colantonio, Emilson [UNIFESP]; Gomes, Ricardo José [UNIFESP]; Marinho, Rodolfo; Moura, Leandro Pereira de; Pauli, José Rodrigo; Universidade Federal de São Paulo (UNIFESP); Universidade Estadual de Campinas (UNICAMP); Faculdade Anhanguera de Campinas; Universidade Estadual Paulista (UNESP)Objective To investigate the effects of a specific protocol of undulatory physical resistance training on maximal strength gains in elderly type 2 diabetics. Methods The study included 48 subjects, aged between 60 and 85 years, of both genders. They were divided into two groups: Untrained Diabetic Elderly (n=19) with those who were not subjected to physical training and Trained Diabetic Elderly (n=29), with those who were subjected to undulatory physical resistance training. The participants were evaluated with several types of resistance training’s equipment before and after training protocol, by test of one maximal repetition. The subjects were trained on undulatory resistance three times per week for a period of 16 weeks. The overload used in undulatory resistance training was equivalent to 50% of one maximal repetition and 70% of one maximal repetition, alternating weekly. Statistical analysis revealed significant differences (p<0.05) between pre-test and post-test over a period of 16 weeks. Results The average gains in strength were 43.20% (knee extension), 65.00% (knee flexion), 27.80% (supine sitting machine), 31.00% (rowing sitting), 43.90% (biceps pulley), and 21.10% (triceps pulley). Conclusion Undulatory resistance training used with weekly different overloads was effective to provide significant gains in maximum strength in elderly type 2 diabetic individuals.
- ItemAcesso aberto (Open Access)Urinary beta-trace protein gene expression analysis in type 2 diabetes mellitus patients(Inst Israelita Ensino & Pesquisa Albert Einstein, 2017) Bacci, Marcelo Rodrigues; Aguiar Alves, Beatriz da Costa; Cavallari, Marina Romera; Azzalis, Ligia Ajaime [UNIFESP]; de Rozier-Alves, Ross Martin; Perez, Matheus Moreira; Chehter, Ethel Zimberg; Pereira, Edimar Cristiano [UNIFESP]; Affonso Fonseca, Fernando Luiz [UNIFESP]Objective: To evaluate the gene expression of beta-trace protein in urine of diabetic patients, with no reduction in glomerular filtration rate, which was defined as below 60mL/min/1.73m(2). Methods: Type 2 diabetes mellitus patients were recruited, and a group of non-diabetic individuals served as control. Beta-trace protein gene expression was analyzed by quantitative PCR. Blood samples were collected to establish glucose levels and baseline kidney function. Accuracy was analyzed using ROC curves. Results: Ninety type 2 diabetes mellitus patients and 20 non-diabetic individuals were recruited. The area under the curve was 0.601, sensitivity of 20% and specificity of 89.47%. Among diabetic participants, 18% showed an expression above the cutoff point. Conclusion: These results of accuracy of beta-trace protein gene expression in urine of diabetic patients are promising, although they did not achieve a higher area under the curve level.
- ItemAcesso aberto (Open Access)Variantes no gene da adiponectina (AdipoQ): relações com adiponectina e Diabetes Mellitus tipo 2 em nipo-brasileiros(Universidade Federal de São Paulo (UNIFESP), 2007) Vendramini, Marcio Faleiros [UNIFESP]; Moises, Regina Celia Mello Santiago [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Artigo 1: Plasma adiponectin levels and incident glucose intolerance in Japanese–Brazilians: A seven-year follow-up study (The objective of this study was to investigate whether decreased baseline adiponectin levels are an independent risk factor for development of glucose intolerance in a population-based study of Japanese–Brazilians, a group with one of the highest prevalence rates of diabetes worldwide. We examined 210 Japanese–Brazilians (97 male and 113 female, aged 56.7 ± 10.1 years) with normal glucose tolerance (NGT). Plasma adiponectin, insulin, fasting and 2-h plasma glucose and lipid profile were evaluated at baseline and also at 7-year follow-up. Plasma adiponectin levels were significantly lower in glucose intolerance progressors compared with subjects who remained NGT. By increasing tertiles of adiponectin, the frequencies of subjects who progressed to glucose intolerance were 40%, 33% and 27% and the frequencies of subjects who remained NGT were 13%, 35% and 52% (÷2 = 15.8, p = 0.001). Logistic regression analyses showed that adiponectin levels (OR for the highest versus lowest tertile: 0.31; 95% CI: 0.12–0.84, p = 0.021), male sex (OR: 2.61, 95% CI: 1.21–5.65, p = 0.015), fasting plasma glucose (OR: 3.05, 95% CI: 1.35–6.91, p = 0.008) and waist circumference (OR: 1.04, 95% CI: 1.00–1.08, p = 0.046) were independent risk factors for the progression to glucose intolerance. In conclusion, low plasma levels of adiponectin is one of several independent predictors of glucose intolerance in a Japanese–Brazilian population).Artigo 2: Association of genetic variants in the adiponectin encoding gene (ADIPOQ) with type 2 diabetes in Japanese-Brazilians (Aim: To assess the contribution of ADIPOQ variants to type 2 diabetes in Japanese-Brazilians. Methods: we genotyped 200 patients with diabetes mellitus (100 male and 100 female, aged 55.5 ± 10.8 years) and 200 control subjects with NGT (72 male and 128 female, aged 54.0 ± 13.4 years). Results: whereas each polymorphism studied (T45G, G276T and A349G) was not significantly associated with type 2 diabetes mellitus, the haplotype GGA was over-represented in our diabetic population (9.3% against 3.1% in NGT individuals, p = 0.0003). Also, this haplotype was associated with decreased levels of adiponectin. We also identified three mutations in exon 3: I164T, R221S and H241P but, owing the low frequencies of them, associations with type 2 diabetes could not be evaluated. The subjects carrying the R221S mutation had plasma adiponectin levels lower than those without the mutation (1.97 ± 0.80 ìg/ml vs 8.08 ± 6.27 ìg/ml, p= 0.015). Similarly, the I164T mutation carriers had mean plasma adiponectin levels lower than those non-carriers (3.73 ± 0.88 ìg/ml vs 8.08 ± 6.27 ìg/ml) but this difference was not significant (p= 0.23). Conclusions: we identified in the ADIPOQ gene a risk haplotype for type 2 diabetes that affects plasma adiponectin levels in the Japanese-Brazilian population).Artigo 3: A Novel Mutation in the Adiponectin (ADIPOQ) Gene is Associated with Hypoadiponectinemia in Japanese-Brazilians (Objective: Adiponectin, an important mediator of insulin sensitivity, is encoded by the ADIPOQ gene. Here we describe two Japanese-Brazilian families with hypoadiponectinemia due to a novel mutation on ADIPOQ gene. Design and Patients: In this study, we examined the entire translated regions of adiponectin in Japanese-Brazilians, a population with one of the highest prevalence rates of diabetes worldwide. We screened 200 patients with type 2 diabetes and 240 age-matched subjects with normal glucose tolerance. Results: A novel heterozygous T deletion at position 186 in exon 2 of the ADIPOQ gene, causing a frameshift at codon 62 leading to a premature termination at codon 168 (p.Gly63ValfsX106) was found in two individuals with diabetes. This mutation was not found in 240 nondiabetic control subjects. In addition, we screened the mutation in an expanded set of 100 nondiabetic subjects from general Brazilian population, but we found no mutation. Six additional mutation carriers family members of probands were identified. Mutation-carrier individuals had markedly low plasma adiponectin concentrations compared with those without the mutation (DM: 1.01 ± 0.69 ìg/ml vs 6.49 ± 5.04 ìg/ml, p< 0.001; NGT: 1.10 ± 0.49 ìg/ml vs 10.36 ± 6.63 ìg/ml, p= 0.003). All individuals carrying the p.Gly63ValfsX106 mutation and older than 30 years were found to be diabetic. Conclusions: We describe for the first time a frameshift mutation in exon 2 of the ADIPOQ gene, which modulates adiponectin levels and may contribute to the genetic risk of late-onset diabetes in Japanese-Brazilians)..