Navegando por Palavras-chave "Cognitive dysfunction"

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    Cognitive impairment in Brazilian patients with Behcet's disease occurs independently of neurologic manifestation
    (Elsevier B.V., 2013-04-15) Dutra, Livia Almeida [UNIFESP]; Silva de Souza, Alexandre Wagner [UNIFESP]; Alessi, Helena [UNIFESP]; Sobreira Guedes, Bruno de Vasconcelos; Braga-Neto, Pedro [UNIFESP]; Pedroso, Jose Luiz [UNIFESP]; Goncalves, Celio Roberto; Rocha, Antonio Jose da; Bertolucci, Paulo Henrique Ferreira [UNIFESP]; Barsottini, Orlando Graziani Povoas [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Fac Ciencias Med Santa Casa São Paulo; Universidade de São Paulo (USP)
    Neuro-Behcet's disease (NBD) presents cognitive and behavioral symptoms possibly explained by secondary dysfunction of frontal and temporal cortices due to subcortical damage, as NBD commonly involves the brainstem and basal ganglia. Nonetheless, there are reports of cognitive impairment in patients without neurological manifestations.Objective: To evaluate cognitive function in Behcet's disease (BD) patients with and without neurological manifestations and to analyze clinical variables associated with cognitive deficits.Methods: This is a cross-sectional study that compared healthy controls, BD patients without neurological manifestations and NBD patients. Each group comprised 24 participants. All participants underwent neuropsychological evaluation, Hamilton Anxiety Rating Scale (HAM-A), Beck Depression Inventory (BDI) application and brain MRI. Cumulative prednisone dose, years of education, and presence of white-matter lesions in brain MRI were recorded.Results: 41.6% of BD and 41.6% of NBD patients showed impaired language and executive function, whereas visual memory was impaired only in NBD patients. Multiple logistic regression revealed that anxiety (OR 1.09 95% CI 1.03-1.16, p = 0.003) and lower educational level (OR 0.62 95% CI 0.48-0.80, p<0.0001) were independently associated with cognitive impairment.Conclusion: Cognitive impairment occurs frequently in patients with BD independently of neurological manifestation. Low educational level and anxiety are risk factors for cognitive impairment in BD. (c) 2013 Elsevier B.V. All rights reserved.
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    A interação entre genótipos de apolipoproteína E, sonolência excessiva diurna e funções cognitivas na síndrome da apneia obstrutiva do sono
    (Universidade Federal de São Paulo (UNIFESP), 2018-11-28) Balthazar, Fernanda Maurer [UNIFESP]; Carvalho, Luciane Bizari Coin de [UNIFESP]; Moraes, Walter André dos Santos [UNIFESP]; http://lattes.cnpq.br/7253538129354609; http://lattes.cnpq.br/4508875707983155; http://lattes.cnpq.br/4084344291512584; Universidade Federal de São Paulo (UNIFESP)
    Objective: To determine the neuropsychological features and cognitive function of adults with obstructive sleep apnea syndrome (OSAS) with or without excessive daytime sleepiness (EDS) and with or without apolipoprotein E (ApoE) ε4 allele. Methods: 21 patients, from 33 to 79 yrs, males and females, underwent a clinical interview, ApoE genotyping, neuropsychological evaluation, Epworth sleepiness scale and polysomnography. Results: EDS is associated with lower IQ (total and performance) and lower immediate visual memory independently of ApoE genotype. Patients carrying ApoE ε4 allele presented worse performance in divided attention, constructional praxis, perceptual organization, and cognitive flexibility. Combination of ε4 allele and EDS potentiates the deleterious effect on cognition, except for immediate visual memory. It was also associated to worse cognitive processing speed, selective attention and visuomotor coordination. Conclusion: EDS and ε4 allele are associated to worse cognitive performance in OSA patients. The combination of EDS and ε4 allele possibly potentiates the cognitive impairment.
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    A randomized, double-blind, placebo-controlled, crossover trial evaluating the effect of intranasal insulin on cognition and mood in individuals with treatment-resistant major depressive disorder
    (Elsevier Science Bv, 2017) Cha, Danielle S.; Best, Michael W.; Bowie, Christopher R.; Gallaugher, Laura Ashley; Woldeyohannes, Hanna O.; Soczynska, Joanna K.; Lewis, Gary; MacQueen, Glenda; Sahakian, Barbara J.; Kennedy, Sidney H.; Lui, Jane P.; Mansur, Rodrigo B. [UNIFESP]; McIntyre, Roger S.
    Background: Cognitive dysfunction in major depressive disorder (MDD) is identified as a primary therapeutic target