Repositório Institucional - Unifesp :: Navegando por Palavras-chave "Circadian rhythm"

Navegando por Palavras-chave "Circadian rhythm"

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Somente Metadadados
Adolescents at clinical-high risk for psychosis: Circadian rhythm disturbances predict worsened prognosis at 1-year follow-up
(Elsevier Science Bv, 2017) Lunsford-Avery, Jessica R.; Brandao Goncalves, Bruno da Silva [UNIFESP]; Brietzke, Elisa [UNIFESP]; Bressan, Rodrigo A. [UNIFESP]; Gadelha, Ary [UNIFESP]; Auerbach, Randy P.; Mittal, Vijay A.
Background: Individuals with psychotic disorders experience disruptions to both the sleep and circadian components of the sleep/wake cycle. Recent evidence has supported a role of sleep disturbances in emerging psychosis. However, less is known about how circadian rhythm disruptions may relate to psychosis symptoms and prognosis for adolescents with clinical high-risk (CHR) syndromes. The present study examines circadian rest/activity rhythms in CHR and healthy control (HC) youth to clarify the relationships among circadian rhythm disturbance, psychosis symptoms, psychosocial functioning, and the longitudinal course of illness. Methods: Thirty-four CHR and 32 HC participants were administered a baseline evaluation, which included clinical interviews, 5 days of actigraphy, and a sleep/activity diary. CHR (n = 29) participants were re-administered clinical interviews at a 1-year follow-up assessment. Results: Relative to HC, CHR youth exhibited more fragmented circadian rhythms and later onset of nocturnal rest. Circadian disturbances (fragmented rhythms, low daily activity) were associated with increased psychotic symptom severity among CHR participants at baseline. Circadian disruptions (lower daily activity, rhythms that were more fragmented and/or desynchronized with the light/dark cycle) also predicted severity of psychosis symptoms and psychosocial impairment at 1-year follow-up among CHR youth. Conclusions: Circadian rhythm disturbances may represent a potential vulnerability marker for emergence of psychosis, and thus, rest/activity rhythm stabilization has promise to inform early-identification and prevention/intervention strategies for CHR youth. Future studies with longer study designs are necessary to further examine circadian rhythms in the prodromal period and rates of conversion to psychosis among CHR teens. (C) 2017 Elsevier B.V. All rights reserved.
Acesso aberto (Open Access)
Associação do padrão e ritmo de sono com o desenvolvimento puberal a partir da avaliação clínica e auto-avaliação
(Universidade Federal de São Paulo (UNIFESP), 2020-03-05) Sánchez, Yessica Alejandra Martínez [UNIFESP]; Hipólide, Débora Cristina [UNIFESP]; http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4795688U9; http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K2798762T2; Universidade Federal de São Paulo (UNIFESP)
The adolescent sleep configuration is unique and brings several factors that interfere with its manifestation, such as age and pubertal development. However, the literature does not seem to be clear about the difference between these two elements when pubertal development is assessed by two different measurement scales. For this, a cross-sectional study was conducted with a sample of young people between 9 and 17 years old (n = 120; 53 men and 67 women; mean 13 years and 7 months ± SD 26 months). Results showed that age was positively associated with pubertal development. Age and Tanner pubic hair ratings were not associated with adolescent evening trend, but rather with maturity and genital stages, as well as the pubertal stage assessed by the Puberal Development Scale (PDS). In conclusion, the older participants (age) were the most developed pubertally, presenting evening preferences, going to sleep later on weekdays and weekends. Furthermore, it was found that these changes in circadian preference were better explained by the stages of pubertal development than by chronological age.
Acesso aberto (Open Access)
Avaliação circadiana da fadiga na sequela de poliomielite e síndrome pós-poliomielite
(Universidade Federal de São Paulo (UNIFESP), 2010-08-25) Viana, Celiana Figueiredo [UNIFESP]; Oliveira, Acary Souza Bulle [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Objective: To evaluate the circadian fatigue in sequelae of poliomyelitis (PS) and Post-Polio Syndrome (PPS) and compare them with actigraphy and polysomnography parameters as well as muscular weakness. Method: Thirty-nine (39) underwent evaluation of the pre-sleep questionnaire and polysomnography, thirty-three (33) underwent actigraphy and data from these examinations were correlated with the scales of the Chalder fatigue, answered by thirty-eight (38) patients and Piper, answered by thirty (30) patients in three periods of the day (sent by mail). Results: This study allowed us to identify the quality of sleep is affected in two populations, both PS and PPS, with increased severity of the situation faced by the PPS group. Fatigue in fact is related to the time of the day, appearing in the population of circadian PPS. Conclusion: The circadian fatigue character takes on well-defined population of PPS, according to the assessment of the scale of Piper. The fatigue is correlated with sleep parameters, especially considering the variables of apnea and hypopnea index, movement of legs and sleep architecture. The intensity of fatigue is greater in patients with PPS. The Piper fatigue scale proved to be very sensitive and can measure the circadian fatigue in PPS. The intensity of fatigue is strongly correlated with the degree of muscular weakness.
Somente Metadadados
Circadian preference in bipolar disorder
(Springer, 2010-06-01) Falsin Giglio, Larriany Maria; Magalhaes, Pedro V. S.; Andersen, Monica Levy [UNIFESP]; Walz, Julio Cesar; Jakobson, Lourenco; Kapczinski, Flavio; Univ Fed Rio Grande do Sul; Universidade Federal de São Paulo (UNIFESP); Univ Fed Rio Grande do Norte; Hosp Clin Porto Alegre
A role for circadian rhythm abnormalities in the pathogenesis of bipolar disorder (BD) has been suggested. the present study assessed circadian preference, a subjective preference for activities in the morning or evening related to chronotype.The sample was comprised of 81 outpatients with BD in remission and 79 control subjects. Circadian preference was derived from an interview evaluating biological rhythms and sleep pattern from the Pittsburgh Sleep Quality Index.Patients were significantly more likely to have an evening preference than control subjects. Circadian preference was also associated with sleep latency.The association of evening preference and longer sleep latency may be related to the frequent clinical observation of a sleep/wake cycle reversal in bipolar disorder.
Acesso aberto (Open Access)
Correlation between diurnal variation of intraocular pressure, ocular pulse amplitude and corneal structural properties
(Conselho Brasileiro de Oftalmologia, 2009-06-01) Villas-bôas, Flávia Silva; Doi, Larissa Morimoto [UNIFESP]; Sousa, Aline Katia Siqueira [UNIFESP]; Melo Jr., Luiz Alberto S. [UNIFESP]; Instituto Brasileiro de Oftalmologia e Prevenção à Cegueira; Universidade Federal de São Paulo (UNIFESP)
PURPOSE: The purpose of this study was to evaluate the fluctuation of intraocular pressure measurements obtained by Goldmann applanation tonometry, dynamic contour tonometry, and corneal compensated non-contact tonometry during office hours in glaucoma and healthy participants. This study also aims at correlating the intraocular pressure fluctuations with fluctuations of corneal hysteresis, central corneal thickness, mean central corneal curvature and ocular pulse amplitude. METHODS: A total of 12 controls (24 eyes) and 21 patients (38 eyes) with open-angle glaucoma were recruited. Intraocular pressure measured by Goldmann applanation tonometry, dynamic contour tonometry and corneal compensated non-contact tonometry, ocular pulse amplitude, central corneal curvature and thickness, corneal hysteresis, and resistance factor were obtained at intervals of 2 hours, between 9 AM and 5 PM. RESULTS: Intraocular pressure fluctuated significantly throughout the day in controls and glaucoma individuals with all tonometers (P<0.001). There was no statistically significant variation in mean corneal curvature (P=0.048 in controls; P=0.04 in glaucomatous) or hysteresis over time (P=0.12 in controls; P=0.36 in glaucomatous). The ocular pulse amplitude showed a significant diurnal fluctuation in both groups (P<0.001). There was a significant correlation between the intraocular pressure measured by dynamic contour tonometry and ocular pulse amplitude (P<0.001). CONCLUSION: There was significant intraocular pressure fluctuation over office hours on measurements performed by Goldmann applanation tonometry, dynamic contour tonometry, and corneal compensated non-contact tonometry in normal and glaucoma individuals. Intraocular pressure varied independently of corneal hysteresis, central corneal thickness, and central curvature variation. However, there was significant correlation between ocular pulse amplitude and intraocular pressure measurements performed by dynamic contour tonometry.
Acesso aberto (Open Access)
Cortisol salivar em indivíduos saudáves
(Universidade Federal de São Paulo, 2024-04-19) Lemos, Fabíola Tavares [UNIFESP]; Spadari, Regina Celia [UNIFESP]; Garcia, Marcia Carvalho [UNIFESP]; http://lattes.cnpq.br/5830789869797235; http://lattes.cnpq.br/0172317187841453; http://lattes.cnpq.br/7395566089052711; Universidade Federal de São Paulo (UNIFESP)
Objetivo: organizar um banco de dados do Laboratório de Biologia do Estresse (BEST) para determinar: padrões basais da concentração salivar de cortisol; o ritmo circadiano do cortisol e a resposta do cortisol ao acordar; além de identificar fatores preditores do comportamento da curva de cortisol para aplicabilidade clínica. Métodos: As concentrações salivares de cortisol foram determinadas em situação basal (sem estresse) em sujeitos sedentários e atletas. Os grupos foram definidos por faixa etária: até 21 anos - jovens; de 22 a 54 anos - adultos; maiores de 55 anos - idosos; e por sexo: feminino e masculino. As coletas foram feitas: ao acordar, 30 minutos após acordar, antes do almoço, antes do jantar e antes de dormir. Resultados: A faixa etária tem forte efeito preditivo na concentração salivar de cortisol em homens e em mulheres, mas, de maneiras diferentes. Em homens jovens e idosos e em mulheres adultas e idosas não houve diferença, mas a concentração de cortisol na saliva foi maior em homens adultos e em mulheres jovens em relação aos outros grupos etários de mesmo sexo. Existe diferença entre os sexos feminino e masculino, a prática de exercício físico influencia a concentração salivar de cortisol de diferentes maneiras, sendo maior em homens. Nos idosos, a curva diurna de cortisol se mostrou achatada enquanto nas demais faixas etárias o ritmo circadiano foi bem marcado. Foram padronizados modelos de regrssao linear com vários preditores. Conclusões: O trabalho expôs as diferenças na concentração salivar de cortisol em diferentes horários do dia. Além disso, padronizou modelos de regressão linear com preditores como: faixa etária, sexo e exercício físico.
Acesso aberto (Open Access)
Cronotipo e danos relacionados ao trabalho em trabalhadores de enfermagem
(Universidade Federal de São Paulo (UNIFESP), 2014-05-30) Silva, Rosangela Marion da [UNIFESP]; Zeitoune, Regina Celia Gollner [UNIFESP]; Beck, Carmem Lúcia Colomé; http://lattes.cnpq.br/2883979357361814; http://lattes.cnpq.br/2267710105940770; http://lattes.cnpq.br/9967441352483506; http://lattes.cnpq.br/2110092444567232; Universidade Federal de São Paulo (UNIFESP)
Analisar a associação entre cronotipo, turno de trabalho e os Danos Físicos, Sociais e Psicológicos relacionados ao trabalho em trabalhadores de enfermagem de Clínica Cirúrgica dos Hospitais Universitários do Rio Grande do Sul. Material e Métodos: Estudo com delineamento transversal e abordagem quantitativa realizado em quatro hospitais universitários localizados na Região Sul do Brasil. A coleta de dados ocorreu nos anos de 2012 e 2013, sendo a seleção da amostra aleatória, por categoria profissional. Participaram 270 trabalhadores de enfermagem. Como instrumentos de coleta de dados foram utilizados um questionário para caracterização sociodemográfica e laboral; a versão brasileira do Questionário de Matutinidade/Vespertinidade de Horne, Östberg; e a Escala de Avaliação dos Danos Relacionados ao Trabalho. Os dados foram analisados com auxílio do software Predictive Analytics Software versão 15.0 for Windows. Resultados: Com relação ao cronotipo, identificou-se 45,2% do tipo indiferente entre as categorias profissionais. Foi identificada associação entre cronotipo e as variáveis filho(s) (p=0,025), uso de medicação (p=0,018), turno de trabalho (p=0,001) e afastado do trabalho por motivo de doença (p=0,021). Sobre a avaliação dos danos relacionados ao trabalho, constatou-se que, ao categorizar os fatores Danos Físicos, Sociais e Psicológicos em adoecimento e não adoecimento, não foi observada associação entre as categorias profissionais (p>0,05). Ao associar o cronotipo ao adoecimento e não adoecimento para Danos Físicos, Sociais e Psicológicos, não foi encontrada associação significativa (p>0,05). Ao associar adoecimento e não adoecimento por tipo de dano, categoria profissional e a concordância e discordância entre turno de trabalho e cronotipo, não foi encontrada associação significativa (p>0,05). Conclusões: A hipótese testada para este estudo não foi confirmada, uma vez que não houve diferença estatística entre a discordância do turno de trabalho e cronotipo. Na organização dos serviços da saúde, em especial na enfermagem, há necessidade de considerar os aspectos próprios do processo de trabalho e pessoais do trabalhador que possam influenciar na saúde dessas pessoas que atuam em turnos, com vistas a promover a qualidade de vida e a saúde do trabalhador, os quais podem se refletir na assistência em saúde.
Acesso aberto (Open Access)
Do Circadian Preferences Influence the Sleep Patterns of Night Shift Drivers?
(Karger, 2013-01-01) Narciso, Fernanda Veruska [UNIFESP]; Esteves, Andrea Maculano; Oliveira e Silva, Luciana; Bittencourt, Lia Rita Azeredo [UNIFESP]; Santos-Silva, Rogerio [UNIFESP]; Pires, Maria Laura Nogueira; Tufik, Sergio [UNIFESP]; Mello, Marco Tulio de [UNIFESP]; Associação Fundo de Incentivo à Pesquisa; Universidade Federal de São Paulo (UNIFESP); UNESP; Universidade Estadual de Campinas (UNICAMP)
Objective: the objective of this study was to analyze the effect of individual circadian preferences of drivers with fixed night work schedules on sleep patterns. Subjects and Methods: A total of 123 professional drivers, 32 indifferent preference drivers and 91 morning preference drivers of an intermunicipality and interstate bus transportation company were evaluated. All drivers underwent polysomnographic recordings after their shifts. Furthermore, they filled out a questionnaire that contained sociodemographic and health questions. the Home and Ostberg questionnaire was used to assess the subjects' morningness-eveningness preference. Results: the mean age was 42.54 +/- 6.98 years and 82 (66.66%) of the drivers had worked for = 15 years. A significant effect on rapid eye movement (REM) was observed in the morning preference drivers. They showed an increased sleep latency and an REM sleep percentage of 5% of the total REM time. This reveals a significant effect on sleep architecture associated with work time. Conclusion: the drivers reported that morning preference had a significant effect on their sleep pattern indicating less REM sleep and longer REM sleep latency in the morning preference group. Thus, it is important to evaluate interactions between individual aspects of health and other parameters, such as sleep quality and work organizational factors, to promote night shift workers' health and well-being. (C) 2013 S. Karger AG, Basel
Somente Metadadados
Do sleep abnormalities and misaligned sleep/circadian rhythm patterns represent early clinical characteristics for developing psychosis in high risk populations?
(Elsevier B.V., 2013-12-01) Zanini, Marcio [UNIFESP]; Castro, Juliana [UNIFESP]; Coelho, Fernando Morgadinho [UNIFESP]; Bittencourt, Lia [UNIFESP]; Bressan, Rodrigo A. [UNIFESP]; Tufik, Sergio [UNIFESP]; Brietzke, Elisa [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Sleep architecture changes, such as slow-wave sleep (SWS) percentage variations and reductions in latency and density of rapid eye movement (REM), are found in most patients with schizophrenia and are considered to be an important part of the pathophysiology of the disorder. in addition to these sleep parameters changes, disruptions in sleep homeostasis and the sleep/circadian rhythm also occur in these patients. Sleep/circadian rhythm abnormalities negatively affect neocortical plasticity and cognition and often precede the diagnosis of the illness. Thus, it has been suggested that the sleep/circadian rhythm might be involved in the pathophysiology of psychosis.Recent advances in the identification of individuals at a high risk for developing schizophrenia allow us to investigate several neurobiological processes involved in the development of psychosis. in this article, we review the current evidence of the effects of sleep parameter abnormalities, disruptions in sleep homeostasis and misalignments of sleep circadian rhythm on the early stages of schizophrenia. in addition, we discuss the preliminary evidence of sleep and circadian rhythm abnormalities during the prodromal stages of psychosis and propose that these abnormalities can be explored as potential predictors, as an adjunct to clinical diagnosis, of developing a psychotic disorder in at risk populations. (C) 2013 Elsevier B.V. All rights reserved.
Acesso aberto (Open Access)
Efeito da variação diurna na resposta da cinética do VO2 de ciclistas treinados
(Universidade Federal de São Paulo (UNIFESP), 2006-02-22) Santana, Marcos Gonçalves de [UNIFESP]; Mello, Marco Tulio de [UNIFESP]; Denadai, Benedito Sérgio [UNIFESP]; http://lattes.cnpq.br/1907479250833033; http://lattes.cnpq.br/4215971444001756; http://lattes.cnpq.br/3117518320254299; Universidade Federal de São Paulo (UNIFESP)
Objetivo: Avaliar a influência da hora do dia nos parâmetros da cinética do consumo de oxigênio (V02) durante exercício muito intenso. Métodos: Nove ciclistas treinados, do gênero masculino (idade: 25±3.8 anos, massa corporal: 66.8:t 4.6 kg, altura: 174.4±6.7 cm e V02max 63.0±2.73 ml.kg-1.min-1), realizaram em cíclo-ergômetro, um teste incremental (11 :00 h) e repetidas transições de carga constante (08:00, 13:00 e 18:00 h) em dias diferentes. Foram realizadas duas transições de carga constante para cada horário, com um intervalo de 1 h entre as transições. A intensidade da carga utilizada nas transições foi de 75 por cento (75 por cento da diferença entre o V02 no limiar de lactato e o V02max)' Resultados: Os valores da constante de tempo do componente primário (19.3± 2.5 s, 18.4±3.0 s e 19.7±3.9 s) e da amplitude do componente lento (735 :t 81 ml.min-\ 764 :t 99 ml.min-1 e 680 :t 121 ml.min-1) não apresentaram diferenças significativas nos diferentes horários (08:00 , 13:00 e 18:00 h), assim como os demais parâmetros da cinética do V02. Conclusão: Estes resultados sugerem que as respostas da cinética do V02 de ciclistas treinados durante exercício muito intenso (75 por cento∆), não sofrem influência da hora do dia.
Acesso aberto (Open Access)
Estimulação tátil-cinestésica: uma integração entre pele e sistema endócrino?
(Instituto de Medicina Integral Prof. Fernando Figueira, 2006-09-01) Fogaça, Monalisa C. [UNIFESP]; Carvalho, Werther Brunow de [UNIFESP]; Verreschi, Ieda Therezinha do Nascimento [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
A literature review on skin neuroendocrine aspects and the consequences of the tactile- kinesthetic stimulation on the adrenal cortex are presented. The articles were identified through MEDLINE and LILACS data bases, using the keywords suprarenal cortex, skin, massage, infants, glucocorticoid and circadian rhythm. Single articles published between 1990 and 2003 were considered, as well as outstanding ones prior to this period. Studies recognize that the hypothalamus, the pituitary and the adrenal gland are dynamic organs during fetal and neonatal development, and that stress responses are active at birth. Most of the studies reviewed, using tactile-kinesthetic stimulation, both in humans and animals, confirm skin's ability to metabolize, coordinate and organize external stimuli, attempting to maintain both external and internal homeostasis, demonstrating an interaction between the neuroendocrine system and tactile stimulation. Tactile-kinesthetic stimulation seems to have an effect on hormonal reactivity, although the issue demands further investigation.
Acesso aberto (Open Access)
Estudo de associações entre o gene PER3 e a sincronização de ritmos circadianos pelo claro/escuro
(Universidade Federal de São Paulo (UNIFESP), 2011-09-28) Pereira, Danyella Silva [UNIFESP]; Pedrazzoli, Mario [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Per3 gene is a component of the circadian molecular mechanism. Its function is not completely understood. One of the hypotheses is that Per3 gene may be involved in light synchronization mechanism. The aim of this project was investigate the association between Per3 gene and circadian rhythmicity dependent of the photophase duration in different light/dark cycle regimens. The experimental protocol was divided in two parts: 1. We investigated the possible mechanisms of association between Per3 gene and adaptation/duration of the photophase in Per3-/- mice by exposing the animals to different light/dark cycles with long or short photophases 2. Based on the results of experiment 1, we developed an experiment in humans in order to investigate if the results in mice were someway applicable to our population. Subjects from two locations with different latitudes were selected (Natal and São Paulo) and the experiment was carried out in two different seasons of the year to mimic photophase variation. The first part of our results suggested that Per3 gene is associated with sensitivity of masking by light. In the second part of the study, we found a phase delay in the circadian parameters analyzed (beginning and end of activity, markers of activity (M10) and temperature (M6)) in the PER35/5 group from Natal on November, when compared to the São Paulo group. Our data in mice point out a new hypothesis related to masking effect that may contribute to the understanding of Per3 gene function in the regulation of circadian rhythms and the human data show that it is possible to associate Per3 gene with the phase adjustments derived from specific characteristics of light/dark cycle in different latitudes.
Acesso aberto (Open Access)
Influence of chronotype and social zeitgebers on sleep/wake patterns
(Associação Brasileira de Divulgação Científica, 2008-10-01) Korczak, A.l.; Martynhak, B.j.; Pedrazzoli, Mario [UNIFESP]; Brito, A.f.; Louzada, F.m.; Universidade Federal do Paraná Departamento de Fisiologia Setor de Ciências Biológicas; Universidade Federal de São Paulo (UNIFESP)
Inter-individual differences in the phase of the endogenous circadian rhythms have been established. Individuals with early circadian phase are called morning types; those with late circadian phase are evening types. The Horne and Östberg Morningness-Eveningness Questionnaire (MEQ) is the most frequently used to assess individual chronotype. The distribution of MEQ scores is likely to be biased by several fact, ors, such as gender, age, genetic background, latitude, and social habits. The objective of the present study was to determine the effect of different social synchronizers on the sleep/wake cycle of persons with different chronotypes. Volunteers were selected from a total of 1232 UFPR undergraduate students who completed the MEQ. Thirty-two subjects completed the study, including 8 morning types, 8 evening types and 16 intermediate types. Sleep schedules were recorded by actigraphy for 1 week on two occasions: during the school term and during vacation. Sleep onset and offset times, sleep duration, and mid-sleep time for each chronotype group were compared by the Mann-Whitney U-test separately for school term and vacation. School term and vacation data were compared by the Wilcoxon matched-pair test. Morning types showed earlier sleep times and longer sleep duration compared with evening types (23:00 ± 44 and 508.9 ± 50.27 vs 01:08 ± 61.95 and 456.44 ± 59.08, for the weekdays during vacation). During vacation, the subjects showed later sleep times, except for the morning types, who did not exhibit differences for sleep onset times. The results support the idea that social schedules have an impact on the expression of circadian rhythmicity but this impact depends on the individual chronotype.
Acesso aberto (Open Access)
Intraocular pressure fluctuation in healthy and glaucomatous eyes: a comparative analysis between diurnal curves in supine and sitting positions and the water drinking test
(Conselho Brasileiro de Oftalmologia, 2014-10-01) Caiado, Rafael Ramos [UNIFESP]; Badaró, Emmerson [UNIFESP]; Kasahara, Niro; Universidade Federal de São Paulo (UNIFESP); Santa Casa de Misericórdia de São Paulo Department of Ophthalmology Glaucoma Sector
Purpose: To compare intraocular pressure (IOP) using the simplified daily tensional curve (SDTC) between supine and sitting positions in terms of peak levels and amount of fluctuation in both, glaucomatous and healthy subjects. The secondary endpoint was the comparison of these measures with those derived from the water drinking test (WDT). Methods: Thirty patients with primary open-angle glaucoma (POAG) that were undergoing medical therapy and 30 healthy subjects were enrolled in this study. Each patient underwent a diurnal curve between 8 am and 4 pm. After lying down for 5 minutes, the IOP was measured with the Perkins tonometer. Patients were instructed to sit in the upright position for 5 minutes and the tonometry was repeated. At 4:15 pm, the WDT test was performed. Fluctuation was defined as the difference between the highest and the lowest IOP readings (range). The Student's t test was used to assess differences and a P value <0.05 was considered to be statistically significant. Results: The diurnal curve in the supine position demonstrated higher IOP average values (on average 3-4 mmHg higher) compared to the sitting position (p<0.0001) for both groups. IOP peaks were higher in the supine position; however, the IOP range was essentially the same between the three methods. Treated glaucomatous patients had higher IOP levels in all measurements, but the fluctuation for all tests performed appeared to be similar to that of healthy patients. Conclusion: The data suggested that WDT can be used to estimate the diurnal IOP peak and fluctuation observed in the SDTC of the supine position for treated glaucomatous patients. Further studies can compare the possible correlation between the WDT results and those obtained from nocturnal supine measurements.
Acesso aberto (Open Access)
Lack of circadian change of concentration of C-type natriuretic peptide in rabbit aqueous humor
(Conselho Brasileiro de Oftalmologia, 2006-10-01) Paranhos Junior, Augusto [UNIFESP]; Okada, Koji; Mello, Paulo Augusto de Arruda [UNIFESP]; Prata Junior, João Antonio [UNIFESP]; Gregory, Douglas; Universidade Federal de São Paulo (UNIFESP); Universidade de YALE
PURPOSE: To determine whether there is a circadian change of the concentration of C-type natriuretic peptide (CNP) in rabbit aqueous humor. METHODS: Forty-one male white New Zealand rabbits were submitted to a 12 h light and 12 dark lighting schedule; lights on was at 0 h, lights off at 12 h. C-type natriuretic peptide was assayed at 3 light (2 h, 6 h and 10 h) and 3 dark (14,18 and 22 h) times. All groups consisted of four animals but two had more animals to increase the power of tests (6 h, n=12; 22 h, n=13). Dependence between the two eyes was tested by Pearson's correlation. The mean of two eyes was considered for analysis. Differences in concentration in pg/200 ml were evaluated by one-way ANOVA, t test and COSINOR analysis. RESULTS: There were no significant differences between the 6 analyzed groups (one-way ANOVA p=0.157). Pooled into two groups (light and dark), the C-type natriuretic peptide concentration of the light group was lower, 2.626±0.92 pg/200 ml compared with the dark group 3.02±1.16 pg/200 ml but did not reach a significant difference (t test; p=0.23). COSINOR analysis was not statistically significant (R%=7.72 p=0.209). CONCLUSION: These data demonstrate that the concentration of CNP in aqueous humor did not show a statistically significant circadian change in rabbits entrained to a 12 h light: 12 h dark lighting schedule.
Acesso aberto (Open Access)
Low urinary 6-sulphatoxymelatonin concentrations in acute migraine
(Springer, 2008-08-01) Masruha, Marcelo Rodrigues [UNIFESP]; Vieira, Domingos Sávio de Souza [UNIFESP]; Minett, Thaís Soares Cianciarullo [UNIFESP]; Cipolla-Neto, Jose; Zukerman, Eliova [UNIFESP]; Vilanova, Luiz Celso Pereira [UNIFESP]; Peres, Mario Fernando Prieto [UNIFESP]; Hosp Israelita Albert Einstein; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)
Substantial evidence points to melatonin as playing a role in the regulation of circadian rhythms, sleep, and headache disorders. the objective of the study was to assess 6-sulphatoxymelatonin (aMT6s) levels in a large consecutive series of patients with migraine, comparing with controls. A total of 220 subjects were evaluated-146 had migraine and 74 were control subjects. Urinary samples were collected into the same plastic container since 8:00 p.m. to 8:00 a.m. of the next day (12-h period) and aMT6s was measured with quantitative ELISA technique. Among patients with migraine, 53% presented pain on the day of the urine samples collection. Their urinary aMT6s concentration was significantly lower than in the urine of patients without pain [14.0 +/- 7.3 vs. 49.4 +/- 19.0; t(143) = -15.1; 95% CI = -40.0 to -30.8; P<0.001]. There was no significant difference in the aMT6s concentration of patients with migraine without pain on the day of their urine samples collection and controls [49.4 +/- 19.0 vs. 42.5 +/- 27.9; t(140) = 1.7; 95% CI = -1.2 to 14.8; P = 0.094]. To our knowledge, this is the first study to demonstrate reduction in melatonin levels during attacks in episodic and chronic migraine.
Acesso aberto (Open Access)
Moléculas que marcam o tempo: implicações para os fenótipos circadianos
(Associação Brasileira de Psiquiatria - ABP, 2009-03-01) Pereira, Danyella Silva [UNIFESP]; Tufik, Sergio [UNIFESP]; Pedrazzoli, Mario [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
OBJECTIVE: The aim of this study was to review the molecular chronobiology studies in the last 36 years in order Eto point out the advances in this area to health professionals. METHOD: We searched in the PubMed and Scopus data banks for articles related with human molecular chronobiology. The keywords used were clock genes, circadian rhythms, diurnal preference, delayed sleep phase syndrome, advanced sleep phase syndrome, photoperiod and mood disorder. DISCUSSION: The knowledge about molecular mechanism of circadian rhythms increased a lot in the last years and now we are able to better understand the details of molecular processes involved in circadian and sleep regulation. Studies show that polymorphisms in clock genes are associated with sleep and mood disorders. These studies will be helpful to further elucidate the regulation of molecular mechanisms of circadian rhythms. CONCLUSIONS: The development of these studies in molecular chronobiology can be helpful to treat circadian and mood disorders and to prevent health risks caused by intercontinental flights (Jet Lag), nocturnal or shift work schedule.
Restrito
Morningness-Eveningness Questionnaire (MEQ): tradução, adaptação cultural e validação
(Universidade Federal de São Paulo, 2024-01-18) Abe, Paulo Toshio [UNIFESP]; Carvalho, Luciane Bizari Coin de [UNIFESP]; Prado, Gilmar Fernades do [UNIFESP]; http://lattes.cnpq.br/2617510083171521; http://lattes.cnpq.br/4508875707983155; http://lattes.cnpq.br/3092592429603747
Objetivo: Tradução, adaptação cultural e validação do Questionário Morningness-Eveningness (MEQ). Método: A versão do MEQ para o Português do Brasil obedeceu às etapas de tradução, retrotradução (backtranslation), avaliação da equivalência semântica da tradução e retrotradução por especialistas e prova técnica. O MEQ (BR) foi posteriormente aplicado a 97 voluntários, de ambos os sexos, com idade entre 19 e 83 anos, do ambulatório da Neuro Sono, da disciplina de Neurologia do Hospital São Paulo. A partir dos dados coletados foram realizados testes estatísticos que possibilitaram avaliar as propriedades psicométricas das escalas através da análise da confiabilidade e validade de critério. Resultados: 97 participantes responderam ao questionário sendo 56 (57,7%) pessoas do sexo feminino. A média de idades dos participantes foi de 49,0±17,9 anos. Considerando os cronotipo dos participantes, 12 (12,4%) foram classificados como tipo Matutino, 32 (33,0%) como tipo Moderadamente Matutino, 11 (11,3%) como tipo Moderadamente Vespertino e 42 (43,3%) como nenhum tipo. A consistência interna representada pelo coeficiente Alfa de Cronbach e pelo Ômega de McDonald apontam para uma confiabilidade adequada para o instrumento. O coeficiente kappa demonstrou uma concordância moderada (k=0,48). Conclusão: O instrumento Morningness-Eveningness Questionnaire - MEQ (BR) traduzido para o português do Brasil, apresentou boas propriedade psicométricas confirmadas por um nível adequado da confiabilidade e da validade de critério. As equivalências semântica, cultural, conceitual e idiomática foram realizadas de foram satisfatória e tiveram boa compreensão das pessoas avaliadas. Não houve necessidade de mudança na comunicação visual do questionário.
Acesso aberto (Open Access)
Psychometric properties of commonly used morningness-eveningness questionnaires in adults and adolescents by applying structural equation modeling
(Universidade Federal de São Paulo, 2023-03-27) Panjeh, Sareh [UNIFESP]; Cogo-Moreira, Hugo [UNIFESP]; http://lattes.cnpq.br/3049836001727444; http://lattes.cnpq.br/0189885104001032
Introduction:morningness-eveningness refers to individual differences in sleep-wake patterns, preferred time for activities and levels of alertness in the morning and evening. It is believed to be a unidimensional construct but this has not been properly tested via robust structural equation modeling techniques. Objective: to investigate the underlying factor structure of two morningness-eveningness questionnaires that are frequently used in the international literature in adults (the MorningnessEveningness Questionnaire: MEQ) and in children and adolescents (the MorningnessEveningness Scale for Children: MESC). Methods: the MEQ’s internal consistency was investigated by conducting exploratory factor analysis in four different adult samples, two each from Brazil and the United Kingdom (total N = 3,457). Confirmatory factor analysis was applied to the MESC based on a sample of Brazilian adolescents (N=394) to investigate if the factor solution found in the MEQ could also be used to structure the confirmatory model. Results: we found a three-correlated factor solution with acceptable model fit indexes across all four studied adult populations who answered the MEQ. The domains/factors were formed by(1) questionnaire items related to how people feel in the morning (interpreted as the efficiency of dissipation of sleep pressure or a recovery process); (2) items related to how people feel before sleep (interpreted as the sensitivity to buildup of sleep pressure); and (3) peak time of cognitive arousal. In the following study, these three underlying constructs were confirmed with answers in the MESC using the sample of adolescent. We also tested a bifactor model-S-1 model in the data from the adolescents considering above mentioned factor two as the general factor because sensitivity to the buildup of sleep pressure/phase delay has been proposed tobe themost deterministic aspectsofsleep that drive latter sleep patterns in adolescence. Conclusion: the morningnesseveningness construct found in both scales and ages was found to be multidimensional. By analyzing factors that affect each factor in coming studies it may be possible both to identify people at a higher risk of sleep-related problems and to design factor-specific interventions.
Acesso aberto (Open Access)
Relationship between Brazilian airline pilot errors and time of day
(Associação Brasileira de Divulgação Científica, 2008-12-01) Mello, Marco Tulio de [UNIFESP]; Esteves, Andrea Maculano [UNIFESP]; Pires, Maria Laura Nogueira [UNIFESP]; Santos, Deborah Cristina dos [UNIFESP]; Bittencourt, Lia Rita Azeredo [UNIFESP]; Santos-Silva, Rogerio [UNIFESP]; Tufik, Sergio [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Flight safety is one of the most important and frequently discussed issues in aviation. Recent accident inquiries have raised questions as to how the work of flight crews is organized and the extent to which these conditions may have been contributing factors to accidents. Fatigue is based on physiologic limitations, which are reflected in performance deficits. The purpose of the present study was to provide an analysis of the periods of the day in which pilots working for a commercial airline presented major errors. Errors made by 515 captains and 472 copilots were analyzed using data from flight operation quality assurance systems. To analyze the times of day (shifts) during which incidents occurred, we divided the light-dark cycle (24:00) in four periods: morning, afternoon, night, and early morning. The differences of risk during the day were reported as the ratio of morning to afternoon, morning to night and morning to early morning error rates. For the purposes of this research, level 3 events alone were taken into account, since these were the most serious in which company operational limits were exceeded or when established procedures were not followed. According to airline flight schedules, 35% of flights take place in the morning period, 32% in the afternoon, 26% at night, and 7% in the early morning. Data showed that the risk of errors increased by almost 50% in the early morning relative to the morning period (ratio of 1:1.46). For the period of the afternoon, the ratio was 1:1.04 and for the night a ratio of 1:1.05 was found. These results showed that the period of the early morning represented a greater risk of attention problems and fatigue.

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