Navegando por Palavras-chave "Chemotaxis"

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    Changes in the pro-inflammatory cytokine production and peritoneal macrophage function in rats with chronic heart failure
    (Elsevier B.V., 2006-06-01) Batista, M. L.; Santos, Ronaldo Vagner Thomatieli dos [UNIFESP]; Cunha, L. M.; Mattos, K.; Oliveira, E. M.; Seelaender, M. C. L.; Rosa, L. F. B. P. Costa; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
    Chronic heart failure (CHF) is a state of immune activation, and pro-inflammatory cytokines play an important role in its development and progression. Macrophages (M phi s), when activated, are the main source of pro-inflammatory cytokines. We measured interjeukin-6 (IL-6), interleukin (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) production after lipopolysaccharide (LPS)-stimulation, as well as peritoneal M phi s migration, phagocytic capacity, chemotaxis index, and hydrogen peroxide production, in an attempt to clarify the role of this cell in an animal model of CHF. Ligature of the left coronary artery or sham operation was performed in adult Wistar rats. After 12 weeks, resident and total cell number, phagocytic capacity, chemotaxis index, and hydrogen peroxide production in M phi s were significantly higher in CHF than in control rats. the production of IL-6 and TNF-alpha was similarly significantly enhanced in CHF as compared with controls. M phi s obtained from CHF rats were more responsive to LPS, suggesting the existence, in vivo, of possible factor(s) modulating the production of pro-inflammatory cytokines. the results demonstrated that there is modification of peritoneal M phi s function along CHF development, possibly contributing to the pathophysiological process in the establishment of CHF. (c) 2006 Elsevier B.V. All rights reserved.
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    Chemotaxis of leukocytes from peripheral-blood of patients with juvenile rheumatoid-arthritis (JRA)
    (Editorial Garsi, 1990-09-01) Hilário, Maria Odete Esteves [UNIFESP]; Goldenberg, José [UNIFESP]; Atra, Edgard [UNIFESP]; Naspitz, Charles Kirov [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Spontaneous and stimulated migration of leukocytes from peripheral blood was studied in 15 patients with JRA and 15 controls.Cells from both groups showed equal migratory ability. However, in the presence of the activated serum of the JRA patients, there was a significant decrease in migration of leukocytes from JRA patients and from controls, suggesting the existence of a serum factor responsible for this chemotatic impairment.The effect of washing on the migration of these cells was also studied. A significant decrease could be observed in the spontaneous and stimulated migration of washed cells from both JRA patients and controls.