Navegando por Palavras-chave "Case report"

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    Case report of a metachronous multiple tumor: Mantle cell lymphoma in the orbital region associated with epithelial malignancies at other sites
    (Conselho Brasileiro de Oftalmologia, 2014-01-01) Medrado, Juliana de Sá Freire [UNIFESP]; Dittrich, Mirtha Ramírez [UNIFESP]; Sousa, Jacqueline Martins de [UNIFESP]; Teixeira, Luiz F. [UNIFESP]; Manso, Paulo Góis [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Here we report the case of a 73-year-old man who was diagnosed with metachronous, multiple primary tumors with non-Hodgkin B-cell mantle cell lymphoma involving the orbit on the basis of biopsy and immunohistochemistry in 2012. The patient had been diagnosed with non-Hodgkin small cell lymphoma and basal cell skin carcinoma in 2010 and intestinal adenocarcinoma with metastasis to the regional lymph nodes in 2011, thus representing a typical case of metachronous, multiple primary tumors. Mantle cell lymphoma is a rare disease and its prognosis is quite poor, particularly when it is associated with other metachronous malignancies. Therefore, physicians should consider mantle cell lymphoma as a differential diagnosis for neoplasms of the orbit.
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    Clinical treatment of corneal infection due to Fonsecaea pedrosoi: case report
    (Conselho Brasileiro de Oftalmologia, 2005-04-01) Hofling-Lima, Ana Luisa [UNIFESP]; Guarro, Josep; Freitas, Denise de [UNIFESP]; Godoy, Patricio [UNIFESP]; Gené, Josepa [UNIFESP]; Souza, Luciene Barbosa de [UNIFESP]; Zaror, Luis; Romano, Andre C. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universitat Rovira I Virgili Facultat de Medicina I Ciencies de la Salut; University Austral de Chile Microbiology Unitat Clinic
    To report an unusual case of fungus keratitis due to Fonsecaea pedrosoi that developed after corneal trauma. Case report: A 18-year-old male presented with a corneal ulcer in the right eye, 28 days after a trauma with glass fragments. Corneal scrapings were collected for smears and culture. Dematiaceous hyphae were seen on wet mounts of the scrapings and dark pigmented colonies grew repetitively on the culture media; all colonies were identical, and were subsequently identified as Fonsecaea pedrosoi. Treatment was initiated with topical natamycin at one hour intervals, 200 mg oral ketoconazole per day and later changed to a combination of 200 mg ketoconazole and amphotericin B. In humid tropical regions Fonsecaea pedrosoi is one of the primary causes of human chronic cutaneous mycosis, chromoblastomycosis. Combination of systemic and topical antifungal medications may provide the best option for cure in corneal chromoblastomycosis.
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    Complete depigmentation of a small aperture corneal inlay implanted for compensation of presbyopia
    (Consel Brasil Oftalmologia, 2017) Campos, Mauro Silveira de Queiroz [UNIFESP]; Beer, Sandra Maria Canelas [UNIFESP]; Nakano, Eliane Mayumi [UNIFESP]; Muccioli, Cristina [UNIFESP]; Belfort, Rubens Junior [UNIFESP]; Chamon, Wallace [UNIFESP]
    We describe a case of late-onset remarkable depigmentation of a small aperture corneal inlay implanted for presbyopia compensation. The patient was a participant in a clinical trial designed to evaluate the safety and efficacy of the AcuFocus (TM) ACU-10R160, which is a 10 mu m-thick polyimide film tinted with an organic dye. Inlay implantation occurred under mechanical microkeratome Lasik flaps set for a depth of 120 mu m. The patient returned to the clinic 11 years after surgery and reported loss of near-vision acuity. Clinical examination showed the complete absence of pigments in the device and the total loss of the initial effect on near vision, despite normal distance vision. Manifest refraction remained stable during the follow-up period. Scheimpflug images characterized the loss of the small aperture effect on incoming light. Confocal analysis revealed small hyper-reflective round images on the endothelium and no signs of inflammation.
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    Conjuntivite granulomatosa atípica causada pela doença da arranhadura do gato: relato de caso
    (Conselho Brasileiro de Oftalmologia, 2004-06-01) Oliveira, Alexandre Hassler Príncipe de [UNIFESP]; Pereira, Carlos Alberto Pires [UNIFESP]; Sousa, Luciene Barbosa de [UNIFESP]; Freitas, Denise de [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    We report a case of a 23-year-old female patient, Brazilian, resident of Germany, who presented with a bilateral chronic granulomatous conjunctivitis, without lymphoadenopathy and irresponsive to topical treatment. Laboratorial work-up confirmed Bartonella henselae as the etiologic agent. The case shows that the absence of lymphoadenopathy does not exclude the diagnosis of cat-scratch disease.
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    Corpo estranho orgânico intra-orbitário: avaliação tomográfica e conduta
    (Conselho Brasileiro de Oftalmologia, 2001-08-01) Casanova, Fábio Henrique Cacho [UNIFESP]; Mello Filho, Paulo Augusto de Arruda [UNIFESP]; Nakanami, Deise Mitsuko [UNIFESP]; Manso, Paulo Gois [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Purpose: The clinical presentation of orbital foreign bodies is variable. The management and prognosis depends on the composition, location and if there is or not secondary infection. Metallic objects and glass are the most frequently encountered and well-tolerated, while organic foreign bodies can elicit an inflammatory reaction and leads to serious complications. It is frequently difficult to identify and localize organic intraorbital foreign bodies, despite modern imaging methods. Methods: Three patients with intraorbital organic foreign body after penetrating injury were evaluated. Results: All patients were submitted to removal of the foreign body presenting an improved clinical course. Computed Tomography (CT) was essential for evaluation, identification and localization of the foreign body. Conclusion: Preoperative identification of the foreign body in the orbit with the use of computed tomography was very helpful for patient management. The removal of the organic foreign body must be performed in order to avoid complications.
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    Correção cirúrgica da esotropia progressiva do alto míope pela técnica de Yamada: relato de dois casos
    (Conselho Brasileiro de Oftalmologia, 2005-08-01) Ejzenbaum, Fábio [UNIFESP]; Goldchmit, Mauro; Souza-dias, Carlos R.; Universidade Federal de São Paulo (UNIFESP); Irmandade da Santa Casa de Misericórdia de São Paulo Faculdade de Ciências Médicas Departamento de Oftalmologia
    Progressive esotropia fixus is a disease present in high myopic patients with a large angle esotropia associated with hypotropia with poor surgical results. This paper has the purpose to describe Yamada's surgical technique (hemitranspositions of the superior rectus and lateral rectus) applied to 2 patients with good surgical results.
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    Deep stromal mycobacterial keratitis: viable bacteria after six months of treatment: case report and literature review
    (Conselho Brasileiro de Oftalmologia, 2005-08-01) Gusmão, Filipe Brandão Accioly de [UNIFESP]; Alvarenga, Lênio [UNIFESP]; Barbosa, Luciene [UNIFESP]; Sampaio, Jorge; Leao, Sylvia Cardoso [UNIFESP]; Hofling-Lima, Ana Luisa [UNIFESP]; Freitas, Denise de [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Laboratório Fleury
    To report the presence of viable mycobacteria in a patient with keratitis treated for 6 months. Species identification was performed using the PRA method (polymerase chain reaction followed by restriction endonuclease analysis). Clonality was evaluated with RAPD (randomly amplified polymorphic DNA) and ERIC-PCR (enterobacterial repetitive intergenic consensus - polymerase chain reaction) methods. The patient reported trauma due to a metallic foreign body 3 weeks prior to presentation. Initial corneal scraping cultures revealed Mycobacterium abscessus. After 6 months of topical and systemic treatment the patient presented with no active inflammation and was considered clinically cured. An optic penetrating keratoplasty was performed. Culture of the excised cornea revealed Mycobacterium abscessus. Both isolates had the same clonal origin. The most interesting finding of this case report was the positive culture of the excised cornea after 6 months of intensive specific topical therapy. To our knowledge, this is the first report in the literature showing this possibility in the treatment of Mycobacterial keratitis. Thus, Mycobacterium abscessus may present viable bacteria after long-term treatment and should be followed carefully for a long period of time after tapering the medication.
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    O diagnóstico do carcinoma metastático de coróide pela biópsia aspirativa com agulha fina (BAAF): relato de caso
    (Conselho Brasileiro de Oftalmologia, 2003-01-01) Corrêa, Zélia Maria da Silva [UNIFESP]; Irion, Luciane Cristina Dreher; Marcon, Ítalo Mundialino; Goldhardt, Raquel; Travi, Giovanni Marcos; Universidade Federal de São Paulo (UNIFESP); Fundação Faculdade Federal de Ciências Médicas de Porto Alegre; Serviço de Oftalmologia da Santa Casa de Porto Alegre; Santa Casa de Porto Alegre
    PURPOSE: To report a case of a patient with lung carcinoma in which the first detected metastasis was to the choroid, how it was diagnosed and confirmed. METHODS: A 35 year-old white male, while being treated for a solitary pulmonary condensation, reported sudden loss of vision, pain, discharge and red eye (right eye) for 10 days. During the ophthalmic examination a nonregmatogenous retinal detachment as well as multiple choroidal tumors were confirmed by diagnostic ocular ultrasound. Fine-needle aspiration biopsy (FNAB) was suggested to diagnose a possible metastatic disease. Fine-needle aspiration biopsy was performed under peribulbar anesthesia with sedation. A transvitreous route was chosen through a sclerotomy 4 mm from the limbus. The procedure was monitored via binocular indirect ophthalmoscopy. Two sample aspirates were obtained from different tumour foci. After fine-needle aspiration biopsy, the aspirates were sent for processing, fixation and stained with Papanicolaou and HE. RESULTS: Cytology confirmed the diagnosis of multiple metastatic tumors. Immunocytochemistry of ocular and lung aspirates revealed a common cell origin by a pankeratin (AE1/AE3) positive test. Regardless of systemic treatment with chemotherapy and improvement of the ocular status, the patient died 4 months after cytological diagnosis of metastatic carcinoma of the choroid. CONCLUSIONS: Fine-needle aspiration biopsy was efficient to diagnose and correlate ocular cytology with the primary tumor by imunohistochemical methods in this case. Fine-needle aspiration biopsy should still be used only in selected cases and further research will be necessary for it to become a standard diagnostic procedure in ophthalmology.
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    Efeitos de um protocolo de exercício aeróbico associado a fotobiomodulação sistêmica (ILIB transcutânea) no condicionamento cardiorrespiratório em uma mulher com fibromialgia: estudo de caso
    (Universidade Federal de São Paulo, 2024-11-27) Sena, Bruna Genari [UNIFESP]; Carvalho, Cristiano [UNIFESP]; Santos, Thatiane Izabele Ribeiro [UNIFESP]; http://lattes.cnpq.br/1725465289809307; http://lattes.cnpq.br/4296634454655924; http://lattes.cnpq.br/2102205370437321; Universidade Federal de São Paulo (UNIFESP)
    Introdução: A fibromialgia (FM) é uma condição crônica que afeta aproximadamente 7% da população global, sendo mais prevalente em mulheres. Caracteriza-se por dor musculoesquelética generalizada, fadiga e disfunções cognitivas, que comprometem a qualidade de vida e reduzem a capacidade física dos pacientes, gerando um ciclo de descondicionamento cardiorrespiratório, no qual a inatividade e a dor levam à diminuição progressiva do condicionamento físico. Nesse contexto, o exercício aeróbico tem se mostrado eficaz na interrupção desse ciclo, melhorando o condicionamento cardiorrespiratório, o VO2 máximo e o limiar anaeróbico. Além disso, a fotobiomodulação (FBM) tem sido explorada como uma terapia complementar com efeitos analgésicos e anti-inflamatórios. Um dos métodos é a irradiação intravascular do sangue com laser de baixa intensidade (ILIB do inglês intravascular laser irradiation of blood) de forma transcutânea, que modula a inflamação e alivia a dor de forma sistêmica. No entanto, faltam estudos que investiguem especificamente os efeitos da FBM sistêmica (ILIB transcutânea) no condicionamento cardiorrespiratório de pacientes com FM. Objetivo: Avaliar os efeitos da combinação de exercício aeróbico com FBM sistêmica (ILIB transcutânea) no condicionamento cardiorrespiratório de uma mulher com FM. Metodologia: Relato de caso aprovado pelo Comitê de Ética em Pesquisa em Seres Humanos da UNIFESP (CAAE 79737724.3.0000.5505). O estudo incluiu uma paciente com FM diagnosticada segundo os critérios do Colégio Americano de Reumatologia. A intervenção consistiu em 12 semanas de exercício aeróbico supervisionado, duas vezes por semana, associada à aplicação de FBM sistêmica (ILIB transcutânea) na mesma frequência. Foram realizadas avaliações pré e pós-intervenção, incluindo teste cardiopulmonar em uma bicicleta estacionária para mensuração de VO2 máximo e limiar anaeróbico. O ILIB de forma transcutânea foi realizado com laser vermelho (660nm), energia de 144 J, emissão em modo contínuo, potência de 80 mW e dose de 286,5 J/cm² durante 30 minutos. Resultados: A.F.R.F., 49 anos, índice de massa corporal: 32,2 kg/m², do lar, diagnosticada com FM. Na avaliação pré-intervenção, a voluntária apresentou um VO2 máximo de 16,6 mL/min/Kg e limiar anaeróbico de 10 mL/min/Kg. Após o protocolo, o VO2 máximo aumentou para 17,8 mL/min/Kg, representando uma melhora de 7,22%. Entretanto, o limiar anaeróbico reduziu para 9,7 mL/min/Kg, correspondendo a uma diminuição de 3%. Conclusão: A associação de exercício aeróbico com FBM sistêmica parece ter um efeito positivo no condicionamento físico de uma paciente com FM. Embora tenha sido observada uma melhora no VO2 máximo, indicando uma melhor capacidade cardiorrespiratória, a diminuição no limiar anaeróbico sugere uma limitação na capacidade do organismo de sustentar esforços intensos por longos períodos sem acumular lactato. Isso pode ser atribuído à complexidade da síndrome, que pode limitar a resposta metabólica ao treinamento. Estudos futuros com uma amostra maior são necessários para validar esses achados.
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    Estenose bilateral de seio venoso transverso associado a papiledema: relato de caso
    (Conselho Brasileiro de Oftalmologia, 2003-06-01) Gouveia, Enéias Bezerra; Lobato, Frederico José Corrêa; Veras, José Filho De Sousa Lobão; Nunes, João Claudio; Muccioli, Cristina [UNIFESP]; Melo Filho, Agenor De; Real e Benemérita Sociedade Portuguesa de Beneficência Hospital São Joaquim Serviço de Oftalmologia; Universidade Federal de São Paulo (UNIFESP)
    The authors report the case of a female patient, 39 years old, presenting bilateral transverse venous sinus stenosis, associated with papilledema, visual acuity deficit and headache. Cerebral angiographic finding of bilateral transverse venous sinus stenosis elucidated the diagnosis. The patient was treated with cerebral angiographic stent implant, with consequent remission of ophthalmologic and neurological clinical findings.
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    Evolução da esclerite nodular com biomicroscopia ultrassônica: relato de caso
    (Conselho Brasileiro de Oftalmologia, 2013-12-01) Martinez, Andrea Alejandra Gonzalez [UNIFESP]; Matos, Kimble Teixeira Fonseca [UNIFESP]; Trevisani, Virgínia Fernandes Moça [UNIFESP]; Hirai, Alcides [UNIFESP]; Allemann, Norma [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de Santo Amaro Departamento de Medicina Urgência e Medicina Baseada em Evidências
    To stablish evolutionary pattern of a case of nodular scleritis with high frequency ultrasound during treatment. Twenty-seven year old female, initial manifestation of intermediate uveitis, bilateral macular edema after clinical treatment with topical and oral steroids. After four months, we observed the formation of a scleral nodule in the right eye when patient underwent high frequency ultrasound (Paradigm, 50 MHz transducer, immersion technique). The lesion in right eye was characterized at high frequency ultrasound as a nodular lesion located at the anterior inferior temporal wall associated with localized reduction of scleral thickness. After intravitreal injection of triamcinolone for treatment of macular edema, clinical regression of the scleral nodule was observed in right eye, maintaining reduced scleral thickness. High frequency ultrasound assisted in the diagnosis of nodular scleritis during the phases of treatment and in the identify its characteristic sequel feature, the scleral thinning.
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    Evolution of optic nerve and retina alterations in a child with indirect traumatic neuropathy as assessed by optical coherence tomography
    (Consel Brasil Oftalmologia, 2017) Rossetto, Julia Dutra [UNIFESP]; Novais, Eduardo [UNIFESP]; Capo, Hilda
    Herein, we describe the case of a 4-year-old child with indirect traumatic optic neuropathy and serial changes of the optic nerve head and retinal nerve fiber layer (RNFL) documented using optical coherence tomography (OCT). Visual acuity improved despite progressive RNFL thinning and optic disc pallor. We concluded that OCT may be useful for monitoring axonal loss but may not predict the final visual outcome.
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    Fabry disease - importance of screening in cornea verticillata: case report
    (Conselho Brasileiro de Oftalmologia, 2011-12-01) Yonamine, Fabio Yamasato [UNIFESP]; Arantes, Tiago Eugênio Faria e [UNIFESP]; Muccioli, Cristina [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Fabry disease is an X-linked disease of glycosphingolipid (GL) metabolism. The accumulation of GL in tissues can affect multiple organ systems. Initial symptoms includes episodes of severe pain in the extremities, cornea verticillata and skin lesions. In late stages, kidney, heart and brain can be involved. This report attempts for importance of cornea verticillata in the diagnosis of Fabry disease in a young patient with pain in the lower limb extremities.
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    Glaucoma persistente secundário à injeção subtenoniana posterior de acetato de triancinolona (Kenalog®): relato de casos
    (Conselho Brasileiro de Oftalmologia, 2003-01-01) Finamor, Luciana Peixoto; Dimantas, Maria Angélica P.; Campos, Vânia Ewert De; Muccioli, Cristina [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    PURPOSE: To describe 3 cases of children submitted to posterior subtenon steroid injection (PSSI) of triamcinolone acetonide (Kenalog® 40mg) for the treatment of intermediate uveitis, with development of refractory glaucoma. METHODS: Case report. RESULTS: Three children with the diagnosis of intermediate uveitis were treated with PSSI of triamcinolone for the control of a chronic vitreous inflammation and/or cystoid macular edema. After treatment they developed refractory glaucoma and were submitted to surgery, for removal of the steroid deposit and/or filtering surgery to control the intraocular pressure (IOP). CONCLUSION: The use of PSSI can represent a high risk for development of secondary glaucoma, with difficult control in children. Surgery to remove the remaining steroid may control IOP, but in some cases filtering surgery may be necessary.
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    In vivo ultrathin Descemet stripping automated endothelial keratoplasty with a low-energy and high-frequency femtosecond laser
    (Conselho Brasileiro de Oftalmologia, 2014-04-01) Victor, Gustavo; Nosé, Walton [UNIFESP]; Sousa, Sidney Júlio de Faria e; Forseto, Adriana dos Santos [UNIFESP]; Alves, Milton Ruiz; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
    This case report describes the production of an ultrathin endothelial donor corneal lamella using a femtosecond laser with low energy and a high frequency. In addition, we report its use in vivo in an eye with pseudophakic bullous keratopathy. The outcomes were observed 3 months after surgery in terms of the change in endothelial donor lamella and full cornea thickness (including pachymetric mapping), visual acuity, and endothelial cell count.
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    Intravitreal Angiostrongylus cantonensis: first case report in South America
    (Consel Brasil Oftalmologia, 2018) de Andrade, Gabriel Costa [UNIFESP]; de Oliveira Dias, Joao Rafael [UNIFESP]; Maia, Andre [UNIFESP]; Kanecadan, Liliane de Almeida [UNIFESP]; Bueno Moraes, Nilva Simeren [UNIFESP]; Belfort Junior, Rubens [UNIFESP]; Lasiste, Jade Marie Edenvirg; Burnier, Miguel N.
    This study reports the first case of intravitreal angiostrongyliasis in South America treated with posterior worm removal via pars plana vitrectomy. This was a retrospective, observational case study. Data from medical charts, wide-field digital imaging, ocular ultrasound, and visual evoked potential studies were reviewed. A 20-month-old boy presented with eosinophilic meningitis and right eye exotropia. Polymerase chain reaction analysis of the cerebrospinal fluid showed a positive result for Angiostrongylus cantonensis. Fundus examination revealed a pale optic disc, subretinal tracks, vitreous opacities, peripheral tractional retinal detachment, and a dead worm in the vitreous cavity. The patient underwent pars plana vitrectomy with worm removal. This case report illustrates the first case of intravitreal angiostrongyliasis in South America, possibly related to the uncontrolled spread of an exotic invasive species of snail.
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    Invasão do nervo óptico por melanoma peripapilar: relato de caso
    (Conselho Brasileiro de Oftalmologia, 2003-06-01) Marback, Eduardo Ferrari [UNIFESP]; Arias, Victor Eduardo Aruá; Gonzaga, Renato Luiz [UNIFESP]; Pinto, Clóvis Antônio; Erwenne, Clélia Maria [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Fundação Antônio Prudente Hospital do Câncer Departamento de Anatomia Patológica; Universidade de São Paulo (USP)
    Small-pigmented lesions over the optic disc are very rare and may represent a diagnostic challenge. To report a case of a small malignant choroidal melanoma invading the optic nerve. A 60-year-old male presents with low vision in the left eye due to a small, pigmented lesion over the optic disc. At first the patient refused enucleation. One month later, after further drop in visual acuity, the patient was seen at another service, diagnosed as having a retinal detachment, and pars plana vitrectomy was proposed but also refused by the patient. Returning to our service, the eye was enucleated and a final diagnosis of choroidal melanoma with post-laminar optic nerve invasion was made. Although rare, pigmented lesions over the optic disc may represent a malignant melanoma. The prognostic significance of optic nerve invasion by choroidal melanoma is not clear yet. The differential diagnosis in these cases is usually difficult but a solid lesion is clear at ultrasonography and serous retinal detachment may predict a active tumor lesion. The management of these cases needs accuracy to avoid the unpleasant consequences of dissemination.
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    Keratoconus and corneal stability after radial keratectomy in the fellow eye: case report
    (Conselho Brasileiro de Oftalmologia, 2013-06-01) Sousa, Jacqueline Martins de [UNIFESP]; Hirai, Flávio Eduardo [UNIFESP]; Sato, Elcio Hideo [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Keratoconus has usually been described as bilateral but asymmetric disease. Corneal ectasia is one of the long-term complications of modern refractive surgery, especially those submitted to laser in situ keratomileusis (LASIK). We describe a patient with keratoconus in the right eye that was submitted to radial keratectomy (RK) in the left eye 19 years ago with no progression of the ectatic cornea and no complications related to the refractive surgery. Because unilateral keratoconus is rare, we believe that RK was performed on an already ectatic cornea (not clinically detected) or with fruste keratoconus. However, neither corneal ectasia progressed, nor ectasia was induced by RK in the fellow eye.
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    Late recurrent iris synechia following laser goniopuncture for deep sclerectomy enhancement: case report
    (Conselho Brasileiro de Oftalmologia, 2012-12-01) Hilgert, Christiana Rebello; Hilgert, Guilherme Luz; Hardoim, Vinicius Andrighetto; Omi, Carlos Akira [UNIFESP]; Instituto da Visão de Mato Grosso do Sul Departamento de Glaucoma; UNIFENAS; Pontificia Universidade Católica de Sorocaba; Universidade Federal de São Paulo (UNIFESP)
    We report a case of recurrent iris synechiae one year after Nd:YAG laser goniopuncture for deep sclerectomy enhancement in the only functional eye of a patient with end-stage glaucoma. The possible pathophysiology of this uncommon complication and laser treatment aspects are discussed.
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    Late-onset persistent retinal microvascular changes after bone marrow transplantation: 3-year follow-up
    (Conselho Brasileiro de Oftalmologia, 2002-06-01) Muccioli, Cristina [UNIFESP]; Belfort, Rubens Junior [UNIFESP]; Jorge, Rodrigo; Farah, Michel Eid [UNIFESP]; Pereira, Mauricio B.; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP); Universidade Federal do Rio de Janeiro Faculdade de Medicina Setor de Retina
    Purpose: To describe a case of persistent retinopathy after bone marrow transplantation in the absence of radiation therapy. Methods: Case Report. Results: A 42 year-old man developed bilateral visual loss 15 months after receiving a bone marrow transplant for acute leukemia. The patient was treated with a high dose of cyclosporin A and oral corticosteroids. No radiation therapy was given. Late-onset, multiple, bilateral cotton-wool spots developed 15 months after the bone marrow transplantation and still persist. After three years other cotton-wool spots arose in the absence of any immunosuppressive therapy. Conclusions: Bone marrow transplantation microvasculopathy of the retina may be related to certain combinations of chemotherapy drugs or immunosuppression itself and may persist in the absence of these immunosuppressive drugs.