Navegando por Palavras-chave "Carrier"

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    Nanopartícula pH responsiva para administração oral de antiparasitários no tratamento de peixes ornamentais
    (Universidade Federal de São Paulo (UNIFESP), 2020-01-30) Patta, Ana Carolina Monge Fernandes [UNIFESP]; Mertins, Omar [UNIFESP]; Delgado, Patrick Mathews [UNIFESP]; http://lattes.cnpq.br/1954400993734545; http://lattes.cnpq.br/8704899939986920; http://lattes.cnpq.br/4702078949333472; Universidade Federal de São Paulo
    Studies show that the global trade in ornamental fish has a high economic impact, as it involves buying and selling millions of specimens a year, generating thousands of jobs and revenues. Meanwhile, it increases the risk of cross-border spread of infectious diseases through the spread of live animals, with devastating consequences. The present study aimed to develop a strategy of innovative aspects in the treatment of endoparasites in ornamental fish, through the production, characterization and application of nanoparticles with specific molecular characteristics of biological interaction. These chitosan-N-arginine and alginate composite nanoparticles were developed as a carrier system for anthelmintic ivermectin and praziquantel drugs and with muco-adhesive and pH responsive characteristics as a function of the application medium. For the development and study, physicochemical techniques of characterization were applied and application studies of the composites containing drugs were performed by oral administration in adult ornamental fish Corydoras schwartzi, parasitized with nematodes and digenetic trematodes, for evaluation of endoparasitic treatment. Studies have shown that the particles have pH-dependent surface charge and colloidal structure characteristics. With in vivo experiments it was observed that the particles remained in the fish's gastrointestinal system for periods longer than eight hours after administration, favoring the attenuated release of the drugs and the efficacy of the treatments, which achieved a reduction of up to 95% of the fish intestinal parasites. Thus, it was evidenced that the particles were effective in transporting and releasing drugs to the target region, enabling an innovative and effective treatment. The studies also open perspectives for the use of fish as an in vivo biological model to evaluate the applicability of bioactive carrier systems.
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    Sleep pattern and spectral analysis of caregiver-mothers of sons with Duchenne muscular dystrophy, and an examination of differences between carriers and non-carriers
    (Elsevier Science Bv, 2017) Nozoe, Karen Tieme [UNIFESP]; Kim, Lenise Jihe [UNIFESP]; Polesel, Daniel Ninello [UNIFESP]; Hirotsu, Camila [UNIFESP]; de Souza, Altay Lino [UNIFESP]; Hachul, Helena [UNIFESP]; Tufik, Sergio Brasil [UNIFESP]; Tufik, Sergio [UNIFESP]; Andersen, Monica Levy [UNIFESP]; Moreira, Gustavo Antonio [UNIFESP]
    Objectives: Sleep is essential for physical and mental well-being. However, poor sleep is a common complaint among caregivers. The aim of the present study was to determine sleep patterns of caregiver-mothers (CM group) of sons with Duchenne muscular dystrophy (DMD) and also to examine the differences between non-carriers and carriers of the gene related to DMD within the CM group. Methods: Observational case-control study. Participants: The CM and control (CTRL) groups were matched for age, body mass index and social class. Polysomnography was conducted in a sleep laboratory for one night. The discrete fast Fourier transformation method was used to calculate the electroencephalogram (EEG) power spectrum for the entire night and sleep stages. Results: The CM group presented higher sleep latency and N3 sleep stage compared with the CTRL. When carrier and non-carrier CM subgroups were analyzed, increased sleep latency and time awake, as well as reduced sleep efficiency and N2, were observed in the carrier group. Regarding respiratory parameters, carriers demonstrated higher hypopnea index values compared with non-carriers. Spectral analysis showed that carriers compared with non-carrier DMD caregiver-mothers presented lower spectral power in fast waves, mainly beta, during REM sleep in some EEG derivations. Conclusions: There was an impairment of sleep pattern in the CM group compared with CTRL mothers