Navegando por Palavras-chave "Brain tumor"
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- ItemSomente MetadadadosAre patients with encephalocraniocutaneous lipomatosis at increased risk of developing low-grade gliomas?(Springer, 2012-01-01) Valera, Elvis Terci; Brassesco, Maria Sol; Scrideli, Carlos Alberto; Castro Barros, Marcus Vinicius de; Santos, Antonio Carlos; Oliveira, Ricardo Santos; Machado, Helio Rubens; Tone, Luiz Gonzaga; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)Cancer-prone genetic disorders are responsible for brain tumors in a considerable proportion of children. Additionally, rare genetic syndromes associated to cancer development may potentially disclose genetic mechanisms related to oncogenesis.We describe two pediatric patients with encephalocraniocutaneous lipomatosis (ECCL), a very rare genetic syndrome with around 60 reported cases, which developed low-grade astrocytoma at 3 and 12 years of age.Patients with ECCL seem to be at risk of benign forms of osseous tumors such as ossifying fibromas, odontomas, and osteomas.The association between brain tumor and ECCL was previously reported only once, in a pediatric case of a mixed neuronal-glial histology. Whether ECCL may be a genetic condition of predisposing brain tumor in children strongly needs to be addressed.
- ItemSomente MetadadadosAssessment of irradiated brain metastases using dynamic contrast-enhanced magnetic resonance imaging(Springer, 2014-06-01) Almeida-Freitas, Daniela B.; Pinho, Marco C.; Otaduy, Maria C. G.; Braga, Henrique F.; Meira-Freitas, Daniel [UNIFESP]; Leite, Claudia da Costa; Universidade de São Paulo (USP); Univ Calif San Diego; Univ Texas SW Med Ctr Dallas; Universidade Federal de São Paulo (UNIFESP)The purpose of this study was to evaluate the effect of stereotactic radiosurgery (SRS) on cerebral metastases using the transfer constant (K (trans)) assessed by dynamic contrast-enhanced (DCE) MRI. Furthermore, we aimed to evaluate the ability of K (trans) measurements to predict midterm tumor outcomes after SRS.The study received institutional review board approval, and informed consent was obtained from all subjects. Twenty-six adult patients with a total of 34 cerebral metastases underwent T1-weighted DCE MRI in a 1.5-T magnet at baseline (prior to SRS) and 4-8 weeks after treatment. Quantitative analysis of DCE MRI was performed by generating K (trans) parametric maps, and region-of-interest-based measurements were acquired for each metastasis. Conventional MRI was performed at least 16 weeks after SRS to assess midterm tumor outcome using volume variation.The mean (+/- SD) K (trans) value was 0.13 +/- 0.11 min(-1) at baseline and 0.08 +/- 0.07 min(-1) after 4-8 weeks post-treatment (p < 0.001). the mean (+/- SD) total follow-up time was 7.9 +/- 4.7 months. Seventeen patients (22 lesions) underwent midterm MRI. of those, nine (41 %) lesions had progressed at the midterm follow-up. An increase in K (trans) after SRS was predictive of tumor progression (hazard ratio = 1.50; 95 % CI = 1.16-1.70, p < 0.001). An increase of 15 % in K (trans) showed a sensitivity of 78 % and a specificity of 85 % for the prediction of progression at midterm follow-up.SRS was associated with a reduction of K (trans) values of the cerebral metastases in the early post-treatment period. Furthermore, K (trans) variation as assessed using DCE MRI may be helpful to predict midterm outcomes after SRS.
- ItemSomente MetadadadosPediatric glioblastoma cell line shows different patterns of expression of transmembrane ABC transporters after in vitro exposure to vinblastine(Springer, 2009-01-01) Valera, Elvis Terci; Cortez, Maria Angelica; Paula Queiroz, Rosane Gomes de; Oliveira, Fabio Morato de; Brassesco, Maria Sol; Jabado, Nada; Faury, Damien; Bobola, Michael S.; Machado, Helio Rubens; Scrideli, Carlos Alberto; Tone, Luiz Gonzaga; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP); McGill Univ; Childrens Hosp; Reg Med CtrResistance to drug is a major cause of treatment failure in pediatric brain cancer. the multidrug resistance (MDR) phenotype can be mediated by the superfamily of adenosine triphosphate-binding cassette (ABC) transporters. the dynamics of expression of the MDR genes after exposure to chemotherapy, especially the comparison between pediatric brain tumors of different histology, is poorly described.To compare the expression profiles of the multidrug resistance genes ABCB1, ABCC1, and ABCG2 in different neuroepithelial pediatric brain tumor cell lines prior and following short-term culture with vinblastine.Immortalized lineages from pilocytic astrocytoma (R286), anaplasic astrocytoma (UW467), glioblastoma (SF188), and medulloblastoma (UW3) were exposed to vinblastine sulphate at different schedules (10 and 60 nM for 24 and 72 h). Relative amounts of mRNA expression were analyzed by real-time quantitative polymerase chain reaction. Protein expression was assessed by immunohistochemistry for ABCB1, ABCC1, and ABCG2.mRNA expression of ABCB1 increased together with augmenting concentration and time of exposure to vinblastine for R286, UW467, and UW3 cell lines. Interestingly, ABCB1 levels of expression diminished in SF188. Following chemotherapy, mRNA expression of ABCC1 decreased in all cell lines other than glioblastoma. ABCG2 expression was influenced by vinblastine only for UW3. the mRNA levels showed consistent association to protein expression in the selected sets of cell lines analyzed.The pediatric glioblastoma cell line SF188 shows different pattern of expression of multidrug resistance genes when exposed to vinblastine. These preliminary findings may be useful in determining novel strategies of treatment for neuroepithelial pediatric brain tumors.
- ItemSomente MetadadadosQuality of life and physical limitations in primary brain tumor patients(Springer, 2011-12-01) Gazzotti, Mariana Rodrigues [UNIFESP]; Malheiros, Suzana Maria Fleury [UNIFESP]; Alith, Marcela Batan [UNIFESP]; Nascimento, Oliver [UNIFESP]; Santoro, Ilka Lopes [UNIFESP]; Jardim, José Roberto [UNIFESP]; Vidotto, Milena Carlos [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)To correlate quality of life (QoL) and physical limitations in histological proven primary brain tumor patients using a battery of generic, disease-specific and symptom questionnaires.Thirty patients with primary brain tumors were selected from a neuro-oncology outpatient clinic. the FACT-Br Functional Assessment of Cancer Therapy-Brain (specific quality of life questionnaire for patients with brain tumors), SF-36 (generic quality of life questionnaire), HADS (anxiety and depression), and Barthel Index (functionality scale) were answered by the patients at the same interview.The Barthel index did not demonstrate correlation with any subscale of the FACT-Br questionnaire. the HADS had a negative correlation with all FACT-Br subscales and its total score. the SF-36 had a significant weak to moderate correlation with the FACT-Br questionnaire.Considering that the FACT-Br is a quick specific questionnaire, it can be a valuable and simple option in evaluating QoL in brain tumor patients with good functional capacity.