Repositório Institucional - Unifesp :: Navegando por Palavras-chave "Bone mineral density"

Navegando por Palavras-chave "Bone mineral density"

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Acesso aberto (Open Access)
Analysis of the diagnostic presentation profile, parathyroidectomy indication and bone mineral density follow-up of Brazilian patients with primary hyperparathyroidism
(Associação Brasileira de Divulgação Científica, 2007-04-01) Oliveira, Ulisses Eliseu Maia de [UNIFESP]; Ohe, Monique Nakayama [UNIFESP]; Santos, Rodrigo Oliveira [UNIFESP]; Cervantes, Onivaldo [UNIFESP]; Abrahão, Márcio [UNIFESP]; Lazaretti-Castro, Marise [UNIFESP]; Vieira, Jose Gilberto Henriques [UNIFESP]; Hauache, Omar Magid [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Instituto Fleury
Primary hyperparathyroidism is an endocrine disorder with variable clinical expression, frequently presenting as asymptomatic hypercalcemia in Western countries but still predominantly as a symptomatic disease in developing countries. The objective of this retrospective study was to describe the diagnostic presentation profile, parathyroidectomy indication and post-surgical bone mineral density follow-up of patients with primary hyperparathyroidism seen at a university hospital. We found 115 patients (92 women, median age 56 years) with primary hyperparathyroidism diagnosed during the last 20 years. We defined symptomatic patients based on the presence of any classical symptom affecting bone, kidney or the neuromuscular system. Surgical criteria followed the guidelines of the National Institutes of Health regarding asymptomatic primary hyperparathyroidism. Symptomatic patients and patients meeting surgical criteria for parathyroidectomy were 66 and 93% of the sample, respectively. Median calcium and parathyroid hormone values were 11.9 mg/dL and 189 pg/mL, respectively. After surgical treatment, 97% of patients were cured, with increases in bone mineral density of 19.4% in the lumbar spine and 15.7% in the femoral neck 3 years after surgery. Greater bone mass increases were detected in pre-menopausal women, men, and in symptomatic and younger patients, both in the lumbar spine and femoral neck. Our results support the previous findings of a predominantly symptomatic disease with a presentation profile that could be mainly related to a delayed diagnosis. Nevertheless, genetic and racial backgrounds, and nutritional factors such as calcium and vitamin D deficiency may play a role in the clinical presentation of primary hyperparathyroidism of Brazilian patients.
Acesso aberto (Open Access)
Associação entre a composição corporal, das variáveis de aptidão física e da capacidade funcional sobre a densidade mineral óssea em mulheres pós-menopausadas praticantes de atividade física
(Universidade Federal de São Paulo (UNIFESP), 2009-06-24) Marin, Rosangela Villa [UNIFESP]; Lazaretti-Castro, Marise [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Introdução: O aumento da expectativa de vida em nossa população traz preocupações relacionadas a morbi-mortalidade decorrente das fraturas osteoporóticas. É consensual que a prática de atividade física orientada traz benefícios, aumentando as chances de um envelhecimento saudável. A cidade de São Caetano do Sul (SCS) possui o primeiro Índice de desenvolvimento humano (IDH) e possui a 2ª maior renda per capta de nosso país. Tivemos a possibilidade de utilizar os dados do Projeto Longitudinal de Envelhecimento e Aptidão Física de SCS, que consiste em avaliar e acompanhar munícipes de São Caetano do Sul com idade acima de 50 anos, quanto as variáveis de aptidão física, capacidade funcional, aspectos sociais, nutricionais e psicológicos, envolvidos estes na prática de atividades físicas, no mesmo local. Objetivos: verificar a associação entre a composição corporal, das variáveis de aptidão física e da capacidade funcional sobre a densidade mineral óssea em mulheres pós-menopausadas praticantes de atividade física. Desenho do Estudo: Corte transversal da coorte do Projeto Longitudinal de Envelhecimento e Aptidão Física de São Caetano do Sul. Local de realização: Centro Social e Recreacional da Terceira Idade “Dr. Moacyr Rodrigues”, localizado no município de São Caetano do Sul, São Paulo - SP, Brasil. Participantes: 117 mulheres com idade acima de 50 anos e média de 67,8 ± 7,0 anos. Participantes de um programa regular de atividades físicas com sessões de duas vezes semanais e duração de 50 minutos, por em média pelo menos 8,0 ± 6,8 anos. Métodos: Todas as mulheres da amostra responderam a uma anamnese em forma de entrevista e passaram por uma avaliação física e por exames clínicos. Avaliamos a composição corporal (a massa corporal, a estatura corporal total, calculamos o IMC, as circunferências corporais de braço contraído, de perna (panturrilha), de cintura e de quadril, calculamos a RCQ, a massa magra, a massa gorda e a densidade mineral óssea em diversos sítios). Verificamos as variáveis de aptidão física (a força de preensão manual, a força de membros superiores e a força de membros inferiores mediante dois diferentes testes) e na capacidade funcional(equilíbrio estático com controle visual), além de submetermos a amostra a testes bioquímicos (creatinina, cálcio total, paratormônio, TSH). Resultados: Encontramos uma prevalência de osteoporose bastante similar a encontrada em populações de outros países semelhantes quanto à etnia. A força de preensão manual foi a variável de melhor associação com a densidade mineral óssea de todos os sítios ósseos analisados. Quando propusemos o modelo de regressão linear múltipla, a massa magra juntamente com a força de preensão manual explicaram em 28% a DMO de colo de fêmur e 24% DMO de corpo total; enquanto que 21% da DMO de coluna lombar foi explicada pela força de preensão manual, a massa corporal e o equilíbrio estático com controle visual, sempre levando em consideração a correção pela idade cronológica e a idade de menopausa. Conclusões: A variável de melhor associação com os sítios da densidade mineral óssea foi a força de preensão manual e nos modelos múltiplos a massa magra e a força de preensão manual apresentaram melhor relação com a DMO de colo de fêmur e corpo total. Na DMO de coluna lombar (L1- L4) obtivemos associação das variáveis de força de preensão manual, a massa corporal e o equilíbrio estático com controle visual. Isto reforça a importância da melhoria e/ou da manutenção da força de muscular e da massa magra ao longo da vida, com o objetivo de contribuir para a autonomia e independência do indivíduo diante do processo de envelhecimento.
Acesso aberto (Open Access)
Associação entre a perda de peso, a massa óssea, a composição corporal e o consumo alimentar de adolescentes obesos pós-púberes
(Sociedade Brasileira de Endocrinologia e Metabologia, 2008-08-01) Santos, Luana C.; Cintra, Isa de Pádua [UNIFESP]; Fisberg, Mauro [UNIFESP]; Lazaretti-Castro, Marise [UNIFESP]; Martini, Lígia A.; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
OBJECTIVE: To verify the effects of weight loss on bone mass of obese adolescents submitted to a nutritional intervention based on a hypocaloric diet and nutritional advice over a nine-month-period. METHODS: Anthropometry, body composition, BMD and dietary intake were evaluated. RESULTS: Fifty-five adolescents, 78.2% females, within an average age of 16.6 (1.4) years old participated in the study. Sixteen participants who completed the study did not lose weight. The group that adhered to the nutritional intervention had a mean weight loss of 6.2 (4.6)% baseline. There was a significant increase in total BMD and bone mineral content (BMC) in those adolescents who did not lose weight, while increased BMC and bone area were verified in participants who lost weight, mainly when associated with body composition alterations while changing weight. CONCLUSION: The increment in bone mineral density, even throughout weight loss, has showed no negative effect on bone mass and has also emphasized the importance of nutritional improvement in total bone mass during adolescence.
Somente Metadadados
Association Between Lean Mass and Handgrip Strength With Bone Mineral Density in Physically Active Postmenopausal Women
(Elsevier B.V., 2010-01-01) Marin, Rosangela Villa [UNIFESP]; Carneiro Pedrosa, Marcia Alessandra [UNIFESP]; Fernandes Moreira-Pfrimer, Linda Denise [UNIFESP]; Mahecha Matsudo, Sandra Marcela; Lazaretti-Castro, Marise [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Phys Fitness Res Ctr Sao Caetano do Sul CELAFISCS
The present study evaluated 117 physically active postmenopausal women (67.8 +/- 7.0 yr) who performed neuromotor physical tests (strength, balance. and mobility). Body composition (lean mass [g], fat mass [g], and % fat) and bone mineral density (BMD) of lumbar spine (L1-L4), femoral neck, and total body were measured by dual-energy X-ray absorptiometry. Following the World Health Organization criteria. osteoporosis was found in at least 1 analyzed site in 33 Volunteers (28.2%): 30 (25.6%) in lumbar spine and 9 (7.7%) in femoral neck. Body weight was strongly and positively related to BMD in all sites, but the most important component of body composition was lean mass, also significantly related to all BMD sites, whereas fat mass was weakly related to the femoral neck BMD. Percent fat did not correlate with any BMD site. of all the physical tests, the hand-rip strength was most importantly related to lumbar spine, femoral neck. and total body (r = 0.49, p < 0.001, r = 0.56, p < 0.001; and r = 0.52, p < 0.001. respectively). the static body balance presented a weak but significant positive correlation only with lumbar spine. Our results suggest that strategies aiming to improve Muscle strength and lean mass must contribute to the bone health of physically active postmenopausal women.
Acesso aberto (Open Access)
Bone mineral density in juvenile systemic lupus erythematosus
(Associação Brasileira de Divulgação Científica, 2002-10-01) Castro, Tania Caroline Monteiro de [UNIFESP]; Terreri, Maria Teresa Ramos Ascensão [UNIFESP]; Szejnfeld, Vera Lucia [UNIFESP]; Castro, Charlles Heldan de Moura [UNIFESP]; Fisberg, Mauro [UNIFESP]; Gabay, M. [UNIFESP]; Hilário, Maria Odete Esteves [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
We evaluated spine bone mineral density (BMD) in Brazilian children with juvenile systemic lupus erythematosus (JSLE) in order to detect potential predictors of reduction in bone mass. A cross-sectional study of BMD at the lumbar spine level (L2-L4) was conducted on 16 female JSLE patients aged 6-17 years. Thirty-two age-matched healthy girls were used as control. BMD at the lumbar spine was measured by dual-energy X-ray absorptiometry. Weight, height and pubertal Tanner stage were determined in patients and controls. Disease duration, mean daily steroid doses, mean cumulative steroid doses and JSLE activity measured by the systemic lupus erythematosus disease activity index (SLEDAI) were determined for all JSLE patients based on their medical charts. All parameters were used as potential determinant factors for bone loss. Lumbar BMD tended to be lower in the JSLE patients, however, this difference was not statistically significant (P = 0.10). No significant correlation was observed in JSLE girls between BMD and age, height, Tanner stage, disease duration, corticosteroid use or disease activity. We found a weak correlation between BMD and weight (r = 0.672). In the JSLE group we found no significant parameters to correlate with reduced bone mass. Disease activity and mean cumulative steroid doses were not related to BMD values. We did not observe reduced bone mass in female JSLE.
Acesso aberto (Open Access)
Bone mineral density in young women of the city of São Paulo, Brazil: correlation with both collagen type I alpha 1 gene polymorphism and clinical aspects
(Associação Brasileira de Divulgação Científica, 2002-08-01) Barros, Elizabete Ribeiro [UNIFESP]; Kasamatsu, Teresa Sayoko [UNIFESP]; Ramalho, Ana Claudia Rebouças [UNIFESP]; Hauache, Omar Magid [UNIFESP]; Vieira, Jose Gilberto Henriques [UNIFESP]; Lazaretti-Castro, Marise [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Faculdade Baiana de Medicina e Saúde Pública
Osteoporosis is a multifactorial disease with great impact on morbidity and mortality mainly in postmenopausal women. Although it is recognized that factors related to life-style and habits may influence bone mass formation leading to greater or lower bone mass, more than 85% of the variation in bone mineral density (BMD) is genetically determined. The collagen type I alpha 1 (COLIA1) gene is a possible risk factor for osteoporosis. We studied a population of 220 young women from the city of São Paulo, Brazil, with respect to BMD and its correlation with both COLIA1 genotype and clinical aspects. The distribution of COLIA1 genotype SS, Ss and ss in the population studied was 73.6, 24.1 and 2.3%, respectively. No association between these genotypes and femoral or lumbar spine BMD was detected. There was a positive association between lumbar spine BMD and weight (P<0.0001), height (P<0.0156), and body mass index (BMI) (P<0.0156), and a negative association with age at menarche (P<0.0026). There was also a positive association between femoral BMD and weight (P<0.0001), height (P<0.0001), and BMI (P<0.0001), and a negative correlation with family history for osteoporosis (P<0.041). There was no association between the presence of allele s and reduced BMD. We conclude that a family history of osteoporosis and age at menarche are factors that may influence bone mass in our population.
Acesso aberto (Open Access)
Bone mineral density of Brazilian girls with juvenile dermatomyositis
(Associação Brasileira de Divulgação Científica, 2005-02-01) Castro, Tania Caroline Monteiro de [UNIFESP]; Terreri, Maria Teresa Ramos Ascensão [UNIFESP]; Szejnfeld, Vera Lucia [UNIFESP]; Len, Claudio Arnaldo [UNIFESP]; Fonseca, A.s.m. da; Hilário, Maria Odete Esteves [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade Federal do Rio Grande do Norte Departamento de Pediatria
We measured bone mineral density (BMD) in girls with juvenile dermatomyositis (JDM) considering multiple factors in order to determine if it could be used as a predictor of reduction in bone mass. A cross-sectional study of lumbar spine BMD (L2-L4) was conducted on 10 girls aged 7-16 years with JDM. A group of 20 age-matched healthy girls was used as control. Lumbar spine BMD was measured by dual-energy X-ray absorptiometry. Weight, height and pubertal Tanner stage were determined in all patients and controls. Duration of disease and mean daily and cumulative steroid doses were calculated for all patients on the basis of their medical charts. JDM activity was determined on the basis of the presence of muscle weakness, cutaneous vasculitis and/or elevation of serum concentration of one or more skeletal muscle enzymes. Seven patients demonstrated osteopenia or osteoporosis. Lumbar BMD was significantly lower in the JDM patients than the age-matched healthy control girls (0.712 vs 0.878, respectively; Student t-test, P = 0.041). No significant correlation between BMD and age, height, Tanner stage, disease duration, corticosteroid use, or disease activity was observed in JDM girls, but a correlation was observed between BMD and weight (Pearson's correlation coefficient, r = 0.802). Patients with JDM may be at risk for a significant reduction in BMD that might contribute to further skeletal fragility. Our results suggest that reduced bone mass in JDM may be related to other intrinsic mechanisms in addition to steroid treatment and some aspects of the disease itself may contribute to this condition.
Acesso aberto (Open Access)
Bone mineral density of the lumbar spine of Brazilian children and adolescents aged 6 to 14 years
(Associação Brasileira de Divulgação Científica, 2001-03-01) Fonseca, A.s.m.; Szejnfeld, Vera Lucia [UNIFESP]; Terreri, Maria Teresa Ramos Ascensão [UNIFESP]; Goldenberg, J. [UNIFESP]; Ferraz, Marcos Bosi [UNIFESP]; Hilário, Maria Odete Esteves [UNIFESP]; Universidade Federal do Rio Grande do Norte Departamento de Pediatria; Universidade Federal de São Paulo (UNIFESP)
The authors performed a study of bone mass in eutrophic Brazilian children and adolescents using dual-energy X-ray absorptiometry (DXA) in order to obtain curves for bone mineral content (BMC) and bone mineral density (BMD) by chronological age and correlate these values with weight and height. Healthy Caucasian children and adolescents, 120 boys and 135 girls, 6 to 14 years of age, residents of São Paulo, Brazil, were selected from the Pediatric Department outpatient clinic of Hospital São Paulo (Universidade Federal de São Paulo (UNIFESP)). BMC, BMD and the area of the vertebral body of the L2-L4 segment were obtained by DXA. BMC and BMD for the lumbar spine (L2-L4) presented a progressive increase between 6 and 14 years of age in both sexes, with a distribution that fitted an exponential curve. We identified an increase of mineral content in female patients older than 11 years which was maintained until 13 years of age, when a new decrease in the velocity of bone mineralization occurred. Male patients presented a period of accelerated bone mass gain after 11 years of age that was maintained until 14 years of age. At 14 years of age the mean BMD values for boys and girls were 0.984 and 1.017 g/cm², respectively. A stepwise multiple regression analysis of paired variables showed that the vertebral area-age pair was the most significant in the determination of BMD values and the introduction of a third variable (weight or height) did not significantly increase the correlation coefficient.
Somente Metadadados
Classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency: a cross-sectional study of factors involved in bone mineral density
(Springer, 2003-01-01) Freire, Patricia Oliveira de Almeida; Lemos-Marini, Sofia Helena Valente de; Maciel-Guerra, Andrea Trevas; Morcillo, André Moreno; Baptista, Maria Teresa Matias; Mello, Maricilda Palandi de; Guerra Junior, Gil; Universidade Federal de São Paulo (UNIFESP); Universidade Estadual de Campinas (UNICAMP)
Glucocorticoids are essential in the treatment of patients with congenital adrenal hyperplasia (CAH). the opposite actions of glucocorticoids and androgens in bone mass achievement justify a study of bone mineral density (BMD) in these patients. We evaluated BMD in patients with CAH due to classic 21-hydroxylase (CYP21A2) deficiency and investigated the involvement of clinical and laboratory factors in the BMD. This study assessed the clinical and laboratory factors involved in BMD of 45 patients at the Pediatric Unit of Endocrinology, UNICAMP, who had been diagnosed as having classical CAH due to CYP21A2 deficiency including molecular characterization. the sample consisted of 28 females and 17 males; 23 salt-wasting (SW) and 22 simple virilizing (SV) cases, with average of 9.9 years (ranges, 5.1-16.3 years) when bone densitometry was performed. the DEXA method was used for calculating the areal BMD Z score in L2-L4. the variables were analyzed with reference to the BMD for chronological age (BMD/CA), height age (BMD/HA), and bone age (BMD/BA). the mean Z score for BMD/CA was 0.08 +/- 1.21 (-2.55 to 2.64); it was 0.29 +/- 1.33 (-2.01 to 4.00) for BMD/HA, and -0.90 +/- 1.24 (-3.41 to 1.92) for BMD/BA. the BMD/CA was significantly lower in females and in patients on treatment for a long period and of more advanced chronological age. Weight and body mass index (BMI) Z scores showed a positive correlation with advanced BA, the higher the weight and BMI Z scores, the higher the BMD/HA. the BMD/BA values were significantly higher in the group in which BA was closer to CA. the BMD/BA value was significantly lower when compared to the value obtained with height and chronological ages. Sex, duration of treatment, weight, BMI, and bone age have an effect on areal BMD in patients with CAH due to CYP21A2 deficiency, which may be underestimated when evaluated in relation to CA and HA.
Somente Metadadados
Comparison of thoracic kyphosis degree, trunk muscle strength and joint position sense among healthy and osteoporotic elderly women: A cross-sectional preliminary study
(Elsevier B.V., 2012-03-01) Granito, Renata Neves; Aveiro, Mariana Chaves [UNIFESP]; Renno, Ana Claudia Muniz [UNIFESP]; Oishi, Jorge; Driusso, Patricia; Universidade Federal de São Carlos (UFSCar); Universidade Federal de São Paulo (UNIFESP)
Increased thoracic kyphosis is one of the most disfiguring consequences of osteoporotic spine fractures in the elderly. However, mechanisms involved in the increasing of the kyphosis degree among osteoporotic women are not completely understood. Then, the aims of this cross-sectional preliminary study were comparing thoracic kyphosis degree, trunk muscle peak torque and joint position sense among healthy and osteoporotic elderly women and investigating possible factors affecting the kyphosis degree. Twenty women were selected for 2 groups: healthy (n = 10) and osteoporotic (n = 10) elderly women. Bone mineral density (BMD), thoracic kyphosis degree, trunk muscles peak torque and joint position sense were measured. Differences among groups were analyzed by Student's Test T for unpaired data. Correlations between variables were performed by Pearson's coefficient correlation. the level of significance used for all comparisons was 5% (p <= 0.05). We observed that the osteoporotic women demonstrated a significantly higher degree of kyphosis and lower trunk extensor muscle peak torque. Moreover, it was found that the BMD had a negative correlation with the thoracic kyphosis degree. Kyphosis degree showed a negative correlation between extensor muscle strength and joint position sense index. This study suggests that lower BMD may be associated to higher degree of kyphosis degree, lower trunk extensors muscle strength and an impaired joint position sense. It is also suggested that lower extensor muscle strength may be a factor that contributes to the increasing in kyphosis thoracic degree. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
Acesso aberto (Open Access)
Composição corporal, densidade mineral óssea e gasto energético de bailarinos contemporâneos de uma companhia de dança profissional
(Universidade Federal de São Paulo (UNIFESP), 2017-11-30) Paiva, Catharina Callil Joao [UNIFESP]; Zanella, Maria Teresa [UNIFESP]; Pereira, Andréa [UNIFESP]; http://lattes.cnpq.br/5258074280407484; http://lattes.cnpq.br/0797782255785305; http://lattes.cnpq.br/1370933691728065; Universidade Federal de São Paulo (UNIFESP)
As condições físicas impostas aos dançarinos como tempo de treino, coreografia e desempenho são comparáveis a atletas de alto rendimento. Nem sempre o gasto energético dos ensaios é provido de forma adequada, ou por falta de orientação nutricional ou pela exigência de físicos magros com baixo percentual de gordura. Esse desequilíbrio nutricional aumenta o risco para fraturas ósseas e/ou lesões musculares graves e para o desenvolvimento de distúrbios orgânicos, tais como amenorreia, anemia, osteoporose, baixo peso, alteração da função reprodutiva e aumento do catabolismo do tecido muscular. Esses distúrbios já foram muito descritos nos bailarinos clássicos, porém há uma escassez de trabalhos com bailarinos contemporâneos. O objetivo deste trabalho foi avaliar a adequação da composição corporal e da massa óssea de um grupo de homens e mulheres, bailarinos profissionais da dança contemporânea. Secundariamente, objetivamos avaliar a adequação do consumo alimentar em termos calóricos e de macronutrientes. A amostra foi composta por 65% de mulheres e 35% de homens; a média de idade dos homens foi de 32 anos e das mulheres foi de 34 anos; a média de anos de formação das bailarinas foi de 24 anos e dos bailarinos foi de 14 anos. Os homens apresentaram maior quantidade de massa magra. Embora a quantidade de gordura corporal tenha sido semelhante nos dois grupos, em termos porcentuais, as mulheres apresentaram quantidades maiores deste indicador. Os resultados obtidos na densitometria óssea também estão dentro da faixa de normalidade e não houve diferença significativa entre mulheres e homens. Não houve diferença significativa no GER entre homens e mulheres e os resultados encontrados no cálculo do registro alimentar de 72 horas mostram que todos os bailarinos têm consumo (em %) adequado de macronutrientes, como proteína e lipídeos, e abaixo do recomendado em carboidratos, segundo a American College of Sports Medicine. Todos os bailarinos foram eutróficos quanto aos dados antropométricos, de bioimpedância e de densitometria óssea. O consumo alimentar supriu o gasto energético de repouso, mas sugere ser insuficiente para o gasto com a atividade praticada.
Acesso aberto (Open Access)
O efeito do treinamento de kendo sobre a densidade mineral óssea em mulheres pós-menopausa: estudo piloto
(Universidade Federal de São Paulo (UNIFESP), 2011-12-05) Ito, Grace Kaori [UNIFESP]; Colantonio, Emilson [UNIFESP]; http://lattes.cnpq.br/9840076091240222; http://lattes.cnpq.br/9840076091240222; Universidade Federal de São Paulo (UNIFESP)
Introdução: Sabe-se dos benefícios da prática de exercícios físicos para a saúde e, em especial, para a saúde da massa óssea devido ao efeito do estresse mecânico oferecido pelos movimentos no próprio tecido ósseo. Entretanto, a literatura carece de estudos que utilizaram a arte marcial Kendo como um veículo não medicamentoso promotor de saúde, sobretudo no tocante aos níveis de densidade mineral óssea (DMO) em mulheres idosas. Objetivo: O presente trabalho teve objetivo analisar os benefícios da prática do Kendo sobre as patologias ligadas à DMO, em pessoas do sexo feminino com descendência asiática, com idade acima de 50 anos, pós-menopausa. Metodologia: Dessa forma, as voluntárias foram divididas em um grupo controle formado por mulheres sedentárias e um grupo experimental formado por mulheres praticantes de Kendo. Todas as voluntárias foram submetidas a algumas avaliações primárias (anamnese, questionários e antropometria) e o exame de densitometria óssea (DEXA). Análise estatística: análise descritiva e inferencial através do test t de Student. Resultados: Praticantes de Kendo: idade (58,40 ± 8,17 anos), massa corporal (57,20 ± 3,70 kg), estatura (1,55 ± 0,04 m), índice de massa corporal (23,84 ± 2,15 kg/m2); DEXA: coluna lombar (1,05 ± 0,18 g/cm2), t-score(CL) -1,08, colo do fêmur (0,92 ± 0,17 g/cm2), t-score(CF) -0,84. Sedentárias: idade (58,29 ± 5,68 anos), massa corporal (62,10 ± 8,22 kg), estatura (1,54 ± 0,06 m), índice de massa corporal (26,60 ± 4,92 kg/m2); DEXA: coluna lombar (1,04 ± 0,12 g/cm2), t-score(CL) -1,19, colo do fêmur (0,85 ± 0,20 g/cm2), t-score(CF) -1,19. Considerações finais: Os resultados obtidos não permitem afirmar que houve diferenças entre os grupos. No entanto, por tratar-se de um estudo-piloto, é importante ressaltar que o tamanho da amostra não permite que se tirem conclusões sobre o comportamento das variáveis. Apesar do conhecido impacto oferecido pela prática do Kendo, outros trabalhos futuros com um controle mais aprimorado de outras variáveis devem ser conduzidos
Acesso aberto (Open Access)
Efeitos do treinamento físico sobre a densidade mineral óssea regional e total em crianças, jovens e adultos
(Universidade Federal de São Paulo (UNIFESP), 2011-12-05) Gradwool, Kelly Cristina Rocha [UNIFESP]; Colantonio, Emilson [UNIFESP]; http://lattes.cnpq.br/9840076091240222; http://lattes.cnpq.br/9564750965720708; Universidade Federal de São Paulo (UNIFESP)
Objetivo: avaliar o efeito do treinamento sobre a DMO de crianças, jovens e adultos praticantes de natação (N) e futebol (F) entre 7 a 30 anos de idade. Material e Métodos: Estudo experimental transversal e quantitativo. Amostra: 54 voluntários, de 7 a 30 anos, masculino, 35 jogadores de futebol e 19 nadadores, subdivididos em pré-púbere, púbere e pós-púbere. Protocolo: avaliações como anamnese, avaliação socioeconômica, nível de atividade física, avaliação maturacional, estatura (E), massa corporal (MC), composição corporal (índice de massa corporal, massa gorda e massa magra) e densitometria mineral óssea (DMO). Análise Estatística: análise descritiva e inferencial, e modelo de análise de variância com dois fatores fixos e o teste exato de Fischer, e o método de comparações múltiplas de Tukey. Resultados: Idade (anos) 13,38 ± 5,35 (F) e 13 ± 3,76 (N), MC (kg) 50,93 ± 20,32 (F) e 52,18 ± 16,24 (N), E (cm) 154,84 ± 21,66 (F) e 159,32 ± 16,51 (N), IMC (kg/m2) 20,34 ± 3,87 (F) e 20,01 ± 2,91 (N), MG (%) 19,08 ± 9,92 (F) e 18,14 ± 6,76 (N), e MM (%) 80,83 ± 9,56 (F) e 81,86 ± 6,76 (N). Quanto aos valores de DMO, não foram encontradas diferenças significantes entre os pré-púberes para todas as avaliações em ambos os grupos. Por outro lado, os púberes e pós-púberes F apresentaram maiores índices do que os N em todas as regiões analisadas na densitometria (Coluna Lombar, Colo Proximal do Fêmur, Triângulo de Ward, Trocânter Maior e Densidade Mineral Óssea Total). Conclusão: Os resultados apontam que a DMO em todos os segmentos foi maior em praticantes de futebol do que de natação, em especial para os púberes e pós-púberes. O mesmo não foi possível de observar naqueles sujeitos de ambos os grupos para os pré-púberes. Parece que essas alterações observadas na DMO nos sujeitos púberes e pós-púberes ocorreram em decorrência do efeito do tipo de treinamento físico realizado.
Acesso aberto (Open Access)
The effects of discontinuing long term alendronate therapy in a clinical practice setting
(Sociedade Brasileira de Endocrinologia e Metabologia, 2011-06-01) Silva, André Gonçalves da [UNIFESP]; Vieira, José Gilberto H. [UNIFESP]; Kunii, Ilda Sizue [UNIFESP]; Lana, Janaína Martins de [UNIFESP]; Lazaretti-Castro, Marise [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Fleury Institute
OBJECTIVE: To assess bone turnover markers (BTM) and bone mineral density (BMD) after discontinuation of alendronate treatment used for five or more years. SUBJECTS AND METHODS: 40 patients (pt) with post-menopausal osteoporosis treated with alendronate (10 mg/d) for at least five years (Group 1, G1) had their medication discontinued. Group 2 (G2): 25 pt treated with alendronate for at least one year. Group 3 (G3): 23 treatment-naïve osteoporotic pt. BMD was evaluated in G1 and G2 at baseline and after 12 months. Collagen type I cross-linked C-telopeptide (CTX) and procollagen type 1 N-terminal propeptide (P1NP) levels were measured in all pt at baseline, and in G1 and G2 every three months for 12 months. Data were analyzed using ANOVA on ranks and Mann-Whitney tests. RESULTS: Mean BMD values in G1 and G2 did not differ during follow-up. However, 16 pt (45.7%) in G1 and one (5.2%) in G2 lost BMD (P < 0.001). BTM at baseline was not different between G1 and G2, and both were lower than G3. A significant increase in BTM levels was detected in G1 pt after three months, but not in G2. CONCLUSION: Observed BMD loss and BTM rise after alendronate withdrawal imply that bone turnover was not over suppressed, and alendronate discontinuation may not be safe.
Acesso aberto (Open Access)
Electrical field stimulation improves bone mineral density in ovariectomized rats
(Associação Brasileira de Divulgação Científica, 2006-11-01) Lirani-Galvão, Ana Paula Rebucci [UNIFESP]; Bergamaschi, Cassia Toledo [UNIFESP]; Silva, Orivaldo Lopes; Lazaretti-Castro, Marise [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)
Osteoporosis and its consequent fractures are a great social and medical problem mainly occurring in post-menopausal women. Effective forms of prevention and treatment of osteoporosis associated with lower costs and the least side effects are needed. Electrical fields are able to stimulate osteogenesis in fractures, but little is known about their action on osteoporotic tissue. The aim of the present study was to determine by bone densitometry the effects of electrical stimulation on ovariectomized female Wistar rats. Thirty rats (220 ± 10 g) were divided into three groups: sham surgery (SHAM), bilateral ovariectomy (OVX) and bilateral ovariectomy + electrical stimulation (OVX + ES). The OVX + ES group was submitted to a 20-min session of a low-intensity pulsed electrical field (1.5 MHz, 30 mW/cm²) starting on the 7th day after surgery, five times a week (total = 55 sessions). Global, spine and limb bone mineral density were measured by dual-energy X-ray absorptiometry (DXA Hologic 4500A) before surgery and at the end of protocol (84 days after surgery). Electrical stimulation improved (P < 0.05) global (0.1522 ± 0.002), spine (0.1502 ± 0.003), and limb (0.1294 ± 0.003 g/cm²) bone mineral density compared to OVX group (0.1447 ± 0.001, 0.1393 ± 0.002, and 0.1212 ± 0.001, respectively). The OVX + ES group also showed significantly higher global bone mineral content (9.547 ± 0.114 g) when compared to both SHAM (8.693 ± 0.165 g) and OVX (8.522 ± 0.207 g) groups (P < 0.05). We have demonstrated that electrical fields stimulate osteogenesis in ovariectomized female rats. Their efficacy in osteoporosis remains to be demonstrated.
Acesso aberto (Open Access)
Estudo da densidade óssea na esclerodermia sistêmica
(Associação Médica Brasileira, 1997-03-01) Da Silva, H.c. [UNIFESP]; Szejnfeld, Vera Lucia [UNIFESP]; Assis, L.s.s. [UNIFESP]; Sato, Emilia Inoue [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
BACKGROUND - Osteopenia in systemic sclerosis (scleroderma) patients was reported in X-ray studies of hands and by proximal and distal forearm bone mass measurement. It has been suggested that bone loss in these patients might be due to chronic ischemia, immobilization and early menopause. Nevertheless it is not established if these patients present generalized osteopenia. To shed light into this point we studied bone mineral density in the spine, proximal femur and total body in patients with systemic sclerosis. PATIENTS AND METHOD - Twenty-five Caucasian women were evaluated. Mean age of patients was 48 ± 12 years and mean time of disease was 7 ± 7 years; 13 were postmenopausal (8 ± 8 years). Bone mass was measured in the spine, proximal femur and total body by using a dual-photon absorptiometry with X rays source (Lunar - Model DPX). RESULTS - Bone mass in different sites was not statistically different from the age-matched control healthy women. Mean bone mass of patients with limited form was not different from patients with diffuse form of systemic sclerosis. Patients with calcinosis had lower bone mass at proximal femur than those without this alteration. CONCLUSIONS - Patients with systemic sclerosis do not present bone loss and this disease is not a risk factor for generalized osteoporosis.
Acesso aberto (Open Access)
Evolução da aptidão física e capacidade funcional de mulheres ativas acima de 50 anos de idade de acordo com a idade cronológica, na cidade de Santos
(ABRASCO - Associação Brasileira de Saúde Coletiva, 2012-01-01) Penha, José Carlos Lopes; Piçarro, Ivan da Cruz [UNIFESP]; Barros Neto, Turibio Leite de [UNIFESP]; Universidade Paulista; Universidade Federal de São Paulo (UNIFESP)
The scope of this study was to compare the evolution of physical fitness, functional capacity and bone mineral density in active elderly women over a one-year period. The sample consisted of 78 women from 50 to 79 years of age (c:62.4 ± 7.1) participating in an aerobic program, twice a week, 50 minutes per session during 3.4 years and divided into three age groups: A: 50-59 (n:38); B: 60-69 (n:28); C: 70-79 (n:12). Results were compared using Two Way ANOVA, post-hoc Bonferroni and delta (D%) variations (*p<.o1). The velocity of rising from a chair and gait speed revealed a significant difference in the three groups ranging from -14.3% to -45.5%; there was a significant improvement in A and B groups in walking speed (-12.1% to -13.9%), and also in maximum gait speed (-15.4% to -18.5%), elbow flexion in all the groups (18.9% to 24.1%), vertical jump (22.5% to 43.9%) in groups B and C, and rising from a chair in 30 seconds (25.2% to 30.8%) in groups A and B, the flexibility test showed an increase in group A (16.2% to 33.3%) and stationary walking in the three groups of (16,4% 30.0%) and bone mineral density (BMD) presented a significant increase (3.1% to 10.2%). The results indicate the salutary effect of regular physical activity.
Acesso aberto (Open Access)
Evolução da osteoporose no paciente com doença pulmonar obstrutiva crônica (DPOC) no intervalo de um ano
(Universidade Federal de São Paulo (UNIFESP), 2016-08-31) Moussalem, Gleice Castrillon de Souza [UNIFESP]; Gazzotti, Mariana Rodrigues [UNIFESP]; http://lattes.cnpq.br/5901080332011696; http://lattes.cnpq.br/8786701247524258; Universidade Federal de São Paulo (UNIFESP)
Introduction: chronic obstructive pulmonary disease (COPD) is characterized by reduced airflow, that can be progressive and chronic inflammation of the lungs. COPD is often associated with comorbidities that contribute to disease severity. Among those comorbidities, is osteoporosis, which is characterized by decreased bone mass accompanied by deterioration of their microstructure, leading to decreased resistance and thus an increased risk of fractures. Early recognition of reduced bone mass in this population of patients is important for the nstitution of measures to minimize the likelihood of falls and fractures. Objective: Evaluate the evolution of bone mineral density in patients with COPD in the one year period and compared with a control group. Materials and Methods: This was a prospective cohort study that evaluated 155 individuals twice with an interval of a year, divided in COPD group and control group. Subjects were assessed with questionnaires, spirometry and bone densitometry. Bone densitometry were acquired femoral neck images, proximal femur and lumbar spine. The diagnosis of osteoporosis was based on T-score values. It was considered as BMD loss when individuals had ariation between follow-up and initial assessment of 0.04 g / cm2 in proximal femur and 0.02 g / cm2 in lumbar spine. Results: There were initially 97 patients with COPD and 85 controls, and after one year were re-evaluated 86 patients with COPD and 69 controls. The COPD group had higher prevalence of osteoporosis (31%) than the control group (18%). In both evaluations the COPD group had lower BMD values when compared to the control group in the three areas assessed, with statistical difference (p <0.05). There was no statistical difference between the groups when evaluating the difference in BMD at the femoral neck and proximal femur in one year, the COPD group had a median of 0.003 g/cm2 (- 0.02 to 0.03) in the lumbar spine and -0.006 g/cm2 (-0.02 to 0.009) in the proximal femur, CG, respectively 0.011 g/cm2 (-0.01 to 0.04) and -0.006 g/cm2 (-0.02 to -0.007). As for bone loss at one year follow-up, there was no statistical difference between the groups, 16% in the COPD group and 20% in the control group, with p = 0.70. We also found no association between bone loss and factors associated with osteoporosis. Conclusion: Although patients with COPD have higher prevalence of osteoporosis than control subjects, and lower BMD values in all areas assessed, COPD and factors associated with the disease, they do not appear to influence the evolution of bone loss in one year.
Somente Metadadados
Higher prevalence of morphometric vertebral fractures in patients with recent coronary events independently of BMD measurements
(Elsevier B.V., 2013-02-01) Silva, Henrique Carriço da [UNIFESP]; Pinheiro, Marcelo M.; Genaro, Patricia S.; Castro, Charlles H. M. [UNIFESP]; Monteiro, Carlos M. C. [UNIFESP]; Fonseca, Francisco A. H. [UNIFESP]; Szejnfeld, Vera Lúcia [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Cardiovascular disease and osteoporosis are important causes of morbi-mortality in the elderly and may be mutually related. Low bone mineral density (BMD) may be associated with increased risk of cardiovascular events. We investigated the prevalence of low bone mass and fractures in metabolic syndrome patients with acute coronary events. A case-control study was conducted with 150 individuals (30-80 years-old) with metabolic syndrome. Seventy-one patients had had an acute coronary syndrome episode in the last 6 months (cases) and the remaining 79 had no coronary event (controls). Cases and controls were matched for gender, BMI and age. DXA measurements and body composition were performed while spine radiographs surveyed for vertebral fractures and vascular calcification. Biochemical bone and metabolic parameters were measured in all patients. No statistically significant difference in BMD and the prevalence of osteopenia, osteoporosis and non-vertebral fractures was observed between cases and controls. the prevalence of vertebral fractures and all fractures was higher in the cases (14.1 versus 1.3%, p = 0.003 and 22.5versus7.6%, p = 0.010, respectively). Male gender (OR = 0.22 95% CI 0.58 to 0.83, p = 0.026) and daily intake of more than 3 portions of dairy products (OR = 0.19 95% CI 0.49 to 0.75, p = 0.017) were associated with lower prevalence of fractures. Cases had higher risk for fractures (OR = 4.97, 95% CI 1.17 to 30.30, p = 0.031). Bone mass and body composition parameters were not associated with cardiovascular risk factors or bone mineral metabolism. Patients with fragility fractures had higher OPG serum levels than those without fractures (p<0.001). Our findings demonstrated that patients with recent coronary events have a higher prevalence of vertebral fractures independently of BMD. (C) 2012 Elsevier Inc. All rights reserved.
Somente Metadadados
Influence of body composition on bone mass in postmenopausal osteoporotic women
(Elsevier B.V., 2010-11-01) Genaro, Patricia S.; Pereira, Giselle A. P.; Pinheiro, Marcelo M. [UNIFESP]; Szejnfeld, Vera L. [UNIFESP]; Martini, Ligia A.; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
We aimed at evaluating the relationship of lean and fat mass to bone mass in osteoporotic postmenopausal women. We invited 65 women who were being treated at the São Paulo Hospital osteoporosis outpatients' clinic to participate. Body composition and bone mineral density (BMD) measurements were performed using Dual-energy X-ray absorptiometry methodology (DXA). the mean age and weight were 69.7 +/- 6.4 years and 56.3 +/- 7.6 kg, respectively. Accordingly to the body mass index (BMI), 52.8% were of normal weight and 47.1% of the patients were overweight. Overweight women had significantly higher bone mass. Similarly, skeletal muscle index (SMI) showed a positive effect on BMD measurements and women with sarcopenia had significantly lower BMD measurements in total femur and femoral neck. in multiple regression analysis only lean mass and age, after adjustments to fat mass and BMI, were able to predict total body bone mineral content (BMC) (R(2) = 28%). Also lean mass adjusted to age and BMI were able to predict femoral neck BMD (R(2) = 14%). On the other hand, none of the components of the body composition (lean mass or fat mass) contributed significantly to explaining total femur BMD and neither body composition measurements were associated with spine BMD. These findings suggest that lean mass has a relevant role in BMC and BMD measurements. in addition, lower BMI and lean mass loss (sarcopenia) is associated to lower BMC and BMD of femoral neck and total femur and possible higher risk of osteoporotic fracture. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

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