Navegando por Palavras-chave "Bone mass"

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    Adolescentes jogadoras de handebol apresentam conteúdo mineral ósseo superior ao de adolescentes jogadoras de futebol: um estudo transversal
    (Universidade Federal de São Paulo, 2024-01-18) Fagundes, Ulysses [UNIFESP]; Lira, Claudio Andre Barbosa de; Andrade, Marilia dos Santos [UNIFESP]; http://lattes.cnpq.br/8618739762906389; http://lattes.cnpq.br/3289964716112944; http://lattes.cnpq.br/5352738309999132
    Introdução: A adolescência é o período de vida em que se obtém entre 40 e 60% da massa óssea, algo extremamente importante para prevenção de osteoporose na fase adulta. Entre os vários fatores que podem estimular esse ganho de massa óssea está a prática de atividade física. Entretanto, não está claro na literatura que tipo de atividade física é capaz de gerar maiores ganhos. Objetivo: Comparar o conteúdo mineral ósseo (CMO), a densidade mineral óssea (DMO) e a massa magra de adolescentes atletas (jogadoras de futebol e jogadoras de handebol) e um padrão de referência norte-americano com o intuito de verificar o efeito da modalidade esportiva praticada sobre a massa óssea e massa magra. Métodos: Este estudo transversal mediu o CMO, a DMO, a DMO total do corpo menos cabeça (TBLH) e a massa magra usando absorciometria de raios-X de dupla energia (DXA) em 115 jogadoras de handebol (15,5 ± 1,3 anos, 165,2 ± 5,6 cm e 61,9 ± 9,3 kg) e em 142 jogadoras de futebol (15,5 ± 1,5 anos, 163,7 ± 6,6 cm e 56,5 ± 7,7 kg). Além disso, 136 adolescentes mulheres formaram o grupo de valores padrão de referência norte-americano (15,1 ± 1,3 anos, 163,5 ± 5,8 cm e 67,2 ± 19,4 kg), cujos dados referentes à massa óssea foram extraídos do estudo “National Health and Nutrition Survey” (NHANES). Resultados: Observou-se que jogadoras de handebol, quando comparadas às futebolistas, apresentaram valores maiores de CMO em membros superiores (294,8±40,2 g e 270,7±45,7 g, p < 0,001), membros inferiores (1011,6±145,5 g e 967,7±144,3 g, p = 0,035), tronco (911,1±182,5 g e 841,6±163,7 g, p = 0,001), costelas (312,4±69,9 g e 272,9±58,0 g, p < 0,001), vértebras (245,1±46,8 g e 222,0±45,1 g, p < 0,001) e massa óssea total (2708,7±384,1 g e 2534,8±386,0 g, p < 0,001), respectivamente. Os valores do padrão de referência norte-americano para o CMO em membros inferiores (740,6±132,3 g, p < 0,001), tronco (539,7±98,6 g, p < 0,001), costelas (138,2±29,9 g, p < 0,001), pelve (238,9±54,6 g, p < 0,001), vértebras (152,8±26.4 g, p < 0,001) e massa óssea total (1987,5±311.3 g, p < 0,001) foram inferiores quando comparadas às adolescentes das duas modalidades esportivas. As jogadoras de handebol, quando comparadas às futebolistas, também apresentaram valores maiores de DMO em tronco (1,02±0,87 g/cm2 e 0,99±0,83 g/cm2 , p=0,017), costelas (0,77±0,06 g/cm2 e 0,74±0,05 g/cm2 , p<0,001) e vértebras (1,15±0,11 g/cm2 e 1,09±0,12 g/cm2 , p<0,001). As adolescentes atletas apresentaram DMO superior a apresentada pelo padrão de referência norte-americano para todas as medidas realizadas (membros superiores, inferiores, tronco, costelas, pelve, coluna e total) (p<0,005). Com relação à massa magra, não houve diferença entre os 3 grupos com relação à massa magra de membros superiores (p=0,112) e massa magra total (p=0,524). Porém, a massa magra de membros inferiores foi menor no grupo do ix padrão de referência norte-americano do que nos grupos de jogadoras de futebol e handebol (p=0,001). Conclusões: Meninas adolescentes que praticam handebol por pelo menos um ano apresentam CMO superior ao encontrado em adolescente praticantes de futebol. Além disso, as adolescentes atletas das duas modalidades apresentam CMO e DMO superiores ao padrão de referência norte-americano. Esses resultados podem ser usados por médicos, profissionais de saúde e educação física para justificar a escolha de uma modalidade esportiva específica para aumento de CMO e DMO em meninas adolescentes.
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    Aerobic Plus Resistance Training Improves Bone Metabolism and Inflammation in Adolescents who Are Obese
    (Lippincott Williams & Wilkins, 2014-03-01) Campos, Raquel Munhoz da Silveira [UNIFESP]; Mello, Marco Tulio de [UNIFESP]; Tock, Lian [UNIFESP]; Silva, Patricia Leao da [UNIFESP]; Masquio, Deborah Cristina Landi [UNIFESP]; Piano, Aline de [UNIFESP]; Sanches, Priscila de Lima [UNIFESP]; Carnier, June [UNIFESP]; Corgosinho, Flavia Campos [UNIFESP]; Foschini, Denis [UNIFESP]; Tufik, Sergio [UNIFESP]; Dâmaso, Ana Raimunda [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Campos, RMS, de Mello, MT, Tock, L, Silva, PL, Masquio, DCL, de Piano, A, Sanches, PL, Carnier, J, Corgosinho, FC, Foschini, D, Tufik, S, and Damaso, AR. Aerobic plus resistance training improves bone metabolism and inflammation in adolescents who are obese. J Strength Cond Res 28(3): 758-766, 2014-Obesity is a worldwide epidemic with a high prevalence of comorbidities, including alterations in bone mineral metabolism. the purpose of this yearlong study was to evaluate the role of 2 types of exercise training (aerobic and aerobic plus resistance exercise) on adipokines parameters and bone metabolism in adolescents who are obese. This was a clinical trial study with interdisciplinary weight loss therapy. Forty-two postpubertal adolescents who are obese were subjected to interdisciplinary weight loss therapy with physical exercise, medical monitoring, nutritional intervention, and psychological intervention. Data were collected from serum analyses of leptin, ghrelin, adiponectin, glucose, and insulin. Anthropometric measurements of body composition, bone mineral density, visceral, and subcutaneous fat were also performed. Statistical tests were applied using repeated-measures analysis of variance. Correlations were established using the Pearson test, and dependencies of variables were established using simple linear regression test. Both training types promoted reductions in body mass index, total central, visceral and subcutaneous fat, insulin concentration, and homeostasis model assessment insulin resistance (HOMA-IR) index, but only aerobic plus resistance training showed statistical improvements in the bone mineral content, adiponectin concentration, and lean tissue. Effective reduction in the visceral/subcutaneous ratio, central/peripheral ratio, and leptin concentration was observed. Insulin and the HOMA-IR index were negative predictors of bone mineral content in the combined training group. Moreover, fat distribution was a negative predictor for bone mineral density in both groups. Aerobic plus resistance training promotes a protective role in bone mineral content associated with an improvement in adiponectin and leptin concentrations, favoring the control of the inflammatory state related to obesity in adolescents. Aerobic plus resistance training combined with interdisciplinary interventions provides important strategies to approach obesity, and these strategies may contribute to clinical practice.
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    The benefits of a high-intensity aquatic exercise program (HydrOS) for bone metabolism and bone mass of postmenopausal women
    (Springer, 2014-07-01) Moreira, Linda Denise Fernandes [UNIFESP]; Fronza, Fernanda Cerveira Abuana Osorio; Santos, Rodrigo Nolasco dos [UNIFESP]; Zach, Patricia Lins [UNIFESP]; Kunii, Ilda Sizue [UNIFESP]; Hayashi, Lilian Fukusima [UNIFESP]; Teixeira, Luzimar Raimundo; Martins Kruel, Luis Fernando; Lazaretti-Castro, Marise [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP); Univ Fed Rio Grande do Sul
    This study aimed to evaluate the 24-week effects of a high-intensity aquatic exercise program on bone remodeling markers and bone mass of postmenopausal women. in this randomized, controlled trial we studied 108 women (58.8 +/- A 6.4 years), randomized into Aquatic Exercise Group (AEG), n = 64, performing 24 weeks of aquatic exercises, and Control Group (CG), n = 44, sedentary. They had their fasting morning blood sample collected for the measures of intact parathyroid hormone (iPTH), procollagen type 1 amino-terminal propeptide (P1NP) and carboxy-terminal cross-linking telopeptide of type I collagen (CTx). Bone mass was measured by dual-energy X-ray absorptiometry before and after the intervention. Participants of both groups received a daily supplementation of 500 mg of elementary calcium and 1,000 IU of vitamin D (cholecalciferol). Results showed an augment in bone formation marker (P1NP) only in the AEG (15.8 %; p = 0.001), and although both groups experienced significant enhancements in bone resorption marker (CTx), this increase was less considerable in the AEG (15 % in the AEG and 29 % in the CG). IPTH was increased by 19 % in the CG (p = 0.003) at the end. the femoral trochanter BMD presented a 1.2 % reduction in the CG (p = 0.009), whereas in the AEG no change was observed (p = 0.069). the proposed aquatic exercise program was efficient in attenuating bone resorption raise and enhancing bone formation, which prevented the participants in the AEG from reducing the femoral trochanter BMD, as happened in the CG.
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    Bone quantity and quality in Brazilian female schoolchildren and adolescents
    (Springer, 2009-07-01) Santos, Keila Donassolo; Petroski, Edio Luiz; Ribeiro, Roberto Regis; Guerra-Junior, Gil; Universidade Federal de São Paulo (UNIFESP); Universidade Federal de Santa Catarina (UFSC)
    The aim of the present study was to evaluate quantitative ultrasound parameters of the finger phalanges bones (AD-SoS, amplitude-dependent speed of sound, and BTT, bone transmission time) of schoolchildren, using a DBM Sonic device (IGEA, Carpi, Italy), to obtain normative values for the Brazilian population. the sample consisted of 1,775 healthy schoolchildren, all females, aged 8-17 years. We observed a progressive increase for the variables of weight, height, body mass index (BMI), AD-SoS, and BTT with advancing age. Results for AD-SoS showed increasing and significant variation from 8 to 17 years old (1,938-2,103 m/s, an increase of 8.52%, P < 0.0001), and also for BTT (0.84-1.45 mu s, an increase of 72.6%, P < 0.0001). A gradual increase in the values of AD-SoS and BTT was observed with advances in pubertal stages. There was an interaction between the variables of age, height, and pubertal stages, predicting AD-SoS (R (2) = 0.49) and BTT (R (2) = 0.53). the study showed that AD-SoS and BTT, evaluated by means of bone ultrasonometry of the phalanges in females, increase gradually with age, being more evident during puberty, probably as a reflex of the structural organization of bone growth and development, or changes in the content of the bone tissue.
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    Correlação entre ultrassonometria quantitativa de calcâneo e densitometria óssea duo-energética de coluna e fêmur na avaliação óssea
    (Sociedade Brasileira de Endocrinologia e Metabologia, 1999-06-01) Lazaretti-Castro, Marise [UNIFESP]; Brandão, Cynthia [UNIFESP]; Yassuda, Mirna Yae [UNIFESP]; Martin, Luciana N.c. [UNIFESP]; Vieira, José Gilberto H. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    The dual-energy X-ray absorptiometry (DEXA) is the most commonly used technique for bone mass density (DMO), although the quantitative calcaneus bone ultrasonometry (USQ) shows good results as a predictor for fracture risk. We compared the results obtained by these two methods in patients referred to the Endocrine Division at the Universidade Federal de São Paulo (UNIFESP) for DEXA evaluation. A total of 189 patients were studied, 165 women / 24 men, with ages from 20 to 84 years (Mi: 51 and 53, respectively for women and men) with distinct diagnosis. All were submitted on the same day to DEXA (Lunar,DPX-L) for lumbar spine (LOMB), neck (COLO) and major throcanter (TROC) and to USQ of calcaneus (Lunar, Aquilles), measuring speed of sound (SOS) and broadband ultrasound attenuation (BUA). A significant positive correlation was found between DEXA values in all sites and USQ. The best correlation was seen in men, between TROC and SOS (r=0.82). When only individuals 50 years or older (n=102) were evaluated, the coefficient of correlation was lower than in the younger than 50, but still significant. In evaluating the utility of USQ as a screening for DEXA measurement, we found that 21.4% of patients with normal values for T score on USQ were osteopenic or osteporotic on TROC. This discrepancy was even more evident on LOMB, where 29.9% of the patients with normal DMO presented T<-1 on USQ, and 35.8% of the patients with normal USQ had T<-1 on DMO of the same region. The coefficient of variation of USQ obtained after 9 measurements in the same person on different days was 0.66% for SOS and 2.75% for BUA. In conclusion, the USQ is only moderately related to DMO and has little utility as a screening for DEXA examination. Its value to determine fracture risk is already established, however prospective studies are necessary to evaluate its usefulness in the diagnosis and follow-up of osteoporosis.
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    Performance of phalangeal quantitative ultrasound parameters in the evaluation of reduced bone mineral density assessed by DX in patients with 21 hydroxylase deficiency
    (Elsevier B.V., 2014-07-01) Goncalves, Ezequiel Moreira; Sewaybricker, Leticia Esposito; Baptista, Fatima; Silva, Analiza Mónica; Carvalho, Wellington Roberto Gomes; Santos, Allan de Oliveira; Mello, Maricilda Palandi de [UNIFESP]; Lemos-Marini, Sofia Helena Valente de; Guerra-Junior, Gil; Universidade Estadual de Campinas (UNICAMP); Universidade Federal de São Paulo (UNIFESP); Univ Lisbon; Univ Fed Maranhao; PhD Student Program Child & Adolescent Hlth
    The purpose of this study was to verify the performance of quantitative ultrasound (QUS) parameters of proximal phalanges in the evaluation of reduced bone mineral density (BMD) in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency (21 OHD). Seventy patients with 21 OHD (41 females and 29 males), aged between 6-27 y were assessed. the QUS measurements, amplitude-dependent speed of sound (AD-SoS), bone transmission time (BTT), and ultrasound bone profile index (UBPI) were obtained using the BMD Sonic device (IGEA, Carpi, Italy) on the last four proximal phalanges in the non-dominant hand. BMD was determined by dual energy X-ray (DXA) across the total body and lumbar spine (LS). Total body and LS BMD were positively correlated to UBPI, BTT and AD-SoS (correlation coefficients ranged from 0.59-0.72, p < 0.001). in contrast, when comparing patients with normal and low (Z-score < -2) BMD, no differences were found in the QUS parameters. Furthermore, UBPI, BTT and AD-SoS measurements were not effective for diagnosing patients with reduced BMD by receiver operator characteristic curve parameters. Although the AD-SoS, BTT and UBPI showed significant correlations with the data obtained by DXA, they were not effective for diagnosing reduced bone mass in patients with 21 OHD. (E-mail: ezequiel@fcm.unicamp.br) (c) 2014 World Federation for Ultrasound in Medicine & Biology.
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    Prevalence and risk factors associated with low-impact fractures in men with rheumatoid arthritis
    (Springer, 2014-10-01) Amaral Filho, Jose Carlos; Pinheiro, Marcelo Medeiros [UNIFESP]; Moura Castro, Charlles Heldan de [UNIFESP]; Szejnfeld, Vera Lucia [UNIFESP]; Univ Fed Mato Grosso; Universidade Federal de São Paulo (UNIFESP)
    The aim of this study is to describe the prevalence of fractures in men with rheumatoid arthritis (RA) and identify potential risk factors associated with skeletal fragility. We consecutively studied 50 men with RA. Clinical risk factors were evaluated by clinical questionnaire, functional capacity by M-HAQ1, and disease activity by DAS-28. RA men were compared to 52 healthy controls paired for age and BMI. Bone mineral density (BMD) and quantitative ultrasound (QUS) at the heel were performed in all participants. Morphometric vertebral fractures (VF) were classified by a semiquantitative method. Men with RA were 51.7 years old on average and had mean disease duration of 115 months. Fragility fractures were found in 40 % of individuals, of which 36 % were VF, significantly higher than in healthy controls (p < 0.01). Age, anthropometric data, and lifestyle were similar between RA men with and without fractures. About 94 % of the men with RA were on long-term glucocorticoid (GC) use. Patients with fractures were more frequently positive for rheumatoid factor (RF), had longer morning stiffness, and higher DAS-28 when compared to patients without fractures (p a parts per thousand currency signaEuro parts per thousand 0.05). in addition, they had significantly lower spine and hip BMD as well as a lower stiffness index (p a parts per thousand currency signaEuro parts per thousand 0.05). There was no statistically significant correlation between fracture and cumulative GC use. the final model of logistic regression showed a significant association and interaction between lower weight and physical activity in men with RA and fragility fractures. RA in men as well as in women is a risk factor for fragility fractures. the risk of fractures is higher in patients with positive RF, prolonged morning stiffness, higher scores of disease activity, and lower values of BMD and QUS.
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    Relationship between bone mineral density, leptin and insulin concentration in Brazilian obese adolescents
    (Springer, 2009-09-01) Prado, Wagner Luiz do; Piano, Aline de [UNIFESP]; Lazaretti-Castro, Marise [UNIFESP]; Mello, Marco Tulio de [UNIFESP]; Stella, Sérgio Garcia; Tufik, Sergio [UNIFESP]; Nascimento, Claudia Maria da Penha Oller do [UNIFESP]; Oyama, Lila Missae [UNIFESP]; Lofrano-Prado, Mara Cristina [UNIFESP]; Tock, Lian [UNIFESP]; Caranti, Danielle Arisa [UNIFESP]; Dâmaso, Ana Raimunda [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Univ Pernambuco; Univ Ribeirao Preto UNAERP
    Despite the epidemic of adolescent obesity, the effect of obesity and hormones on bone mineral accrual during growth is poorly understood. Studies using dual-energy X-ray to examine the effect of obesity on bone mass in children and adolescents have yielded conflicting results. the aim of this study was to explore the combined and independent contributions of body mass index, body composition, leptin, insulin, glucose levels and Homeostasis Model Assessment Insulin Resistance (HOMA-IR) to bone mineral density (BMD) and bone mineral content in a group of Brazilian obese adolescents. This study included 109 post-pubescent obese adolescents. A whole-body dual-energy X-ray absorptiometry scan was performed,using a HOLOGIC QDR4200, to determine whole-body BMD and body composition. Blood samples were collected in the outpatient clinic after an overnight fast, and evaluated for fasting blood glucose and immunoreactive insulin. Leptin levels were assessed with a radioimmunoassay kit. Insulin resistance was assessed by HOMA-IR and the quantitative insulin sensitivity check index. Our results showed that insulin levels and HOMA-IR correlated negatively with BMD and a linear regression analysis showed that serum leptin is inversely associated to BMD adjusted for body mass. in conclusion, our data support the hypothesis that leptin, insulin and HOMA-IR are inversely associated with BMD and play a significant direct role in bone metabolism.
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    The relationship between lean mass, muscle strength and physical ability in independent healthy elderly women from the community
    (Springer, 2014-05-01) Pisciottano, M. V. C. [UNIFESP]; Pinto, S. S.; Szejnfeld, V. L. [UNIFESP]; Castro, C. H. M. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Univ Cidade São Paulo
    The association between muscle mass, strength and physical performance has been established in the elderly with co-morbidities. in this study, lean and fat mass, bone mineral density, knee extension and flexion strength and physical ability tests in healthy independent elderly women were investigated. Main determinants of lean mass, strength and physical ability were determined searching for predictors of healthy aging.A total of 100 healthy women aged a parts per thousand yen 65 years considered independent and active were invited. Bone mass and body composition were assessed by DXA. the strength of the lower limb was assessed by isokinetic dynamometry, and physical ability was measured by: Timed Up and Go (TUG), Berg Balance Test (BBT) and Dynamic Gait Index (DGI).Women were on average 70.8 +/- 4.92 years old, had BMI of 27.38 +/- 5.11 kg/m2 and fat mass of 26.96 +/- 9.62 kg or 40.65 +/- 8.06%. Total lean mass and appendicular lean mass (ALM) were 35.38 +/- 4.83 kg and 15.32 +/- 2.26 kg, respectively, while relative skeletal mass index (RSMI) was 6.51 +/- 0.77 kg/m2. Age did not correlate significantly with ALM. Age and ALM were the main determinants of the strength of the lower limb (p < 0.001) while age and strength of the lower limb were significantly associated with the performance on the physical tests (p < 0.001).Age has a negative impact on the strength and the physical performance in independent healthy women without co-morbidities. Physical ability tests are positively influenced by the strength of the lower limb. These relationships suggest that muscle strength should be the parameter to be prioritized when preparing for healthy aging.
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    The role of pro/anti-inflammatory adipokines on bone metabolism in NAFLD obese adolescents: effects of long-term interdisciplinary therapy
    (Humana Press Inc, 2012-08-01) Campos, Raquel Munhoz da Silveira [UNIFESP]; Piano, Aline de [UNIFESP]; Silva, Patricia Leao da [UNIFESP]; Carnier, June [UNIFESP]; Sanches, Priscila de Lima [UNIFESP]; Corgosinho, Flavia Campos. [UNIFESP]; Masquio, Deborah Cristina Landi [UNIFESP]; Lazaretti-Castro, Marise [UNIFESP]; Oyama, Lila Missae [UNIFESP]; Nascimento, Claudia Maria da Penha Oller do [UNIFESP]; Tock, Lian [UNIFESP]; Mello, Marco Tulio de [UNIFESP]; Tufik, Sergio [UNIFESP]; Dâmaso, Ana Raimunda [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    To investigate the role of pro-and anti-inflammatory adipokines in the bone metabolism of nonalcoholic fatty liver disease (NAFLD) obese adolescents as well as the effects of long-term interdisciplinary therapy on metabolic-related risk factors. Forty post-puberty obese adolescents were randomly assigned into two groups: (1) NAFLD group and (2) non-NAFLD group (diagnosis by ultrasonography) and submitted to a weight loss therapy. Body composition was analyzed by air displacement plethysmography, bone mineral density (BMD) and content by dual-energy X-ray absorptiometry, blood samples were collected to measure lipid profile, hepatic enzymes, and adipokines. Leptin and adiponectin concentrations were measured by ELISA. A decrease in total body mass, BMI, body fat, visceral and subcutaneous fat, insulin concentration, HOMA-IR, total cholesterol and an increase in lean body mass were observed in both groups after therapy. It was found positive correlation between the Delta BMD and the Delta fat mass (%) (r = 0.31, P = 0.01) and negative correlations between Delta BMC with Delta HOMA-IR (r = -0.34, P = 0.02) and Delta HOMA-IR with Delta leptin (r = -0.34, P = 0.02). in addition, increased levels of adiponectin and reduction in leptin concentrations were observed in NAFLD group. in the simple regression analysis, the HOMA-IR was an independent predictor changes in BMC in total obese adolescents and in the non-NAFLD group. One year of interdisciplinary weight loss therapy for obese adolescents with or without NAFLD, could regulate bone mineral metabolism as result of an increased BMC and improved inflammatory state.