Navegando por Palavras-chave "Bone Density"
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- ItemSomente MetadadadosDensidade óssea e abertura da sutura palatina mediana após expansão rápida da maxila assistida cirurgicamente(Universidade Federal de São Paulo (UNIFESP), 2020-11-10) Lima, Carlos Alysson Aragao [UNIFESP]; Pereira, Max Domingues [UNIFESP]; Universidade Federal de São PauloThe bone density of midpalatal suture in patients undergoing SARPE has not been fully clarified, especially in relation to the amount of neoformed bone density and direction of bone neoformation. Objective: To evaluate bone density of midpalatal suture after SARPE as well as the direction of ossification and opening pattern of median palatal suture after SARPE. Methods: A total of 60 CT of 20 patients submitted to SARPE were analyzed, at the following times: T0: 1 week before the surgical procedure, right after the installation of Hyrax device; T1: Right after the end of Hyrax device; T2: 10 months after the completion of Hyrax device activities. They were measured as bone densities in three patients with CT, using a Hounsfield scale, in axial and coronal sections, in three different regions on the midpalatal suture. A1: anterior region, A2: middle region and A3: posterior region. In addition, the opening of midpalatal suture in these regions was evaluated using T1-weighed tomography in coronal and axial sections. Results: The average values of relative density (T2 / T0) in regions A1, A2 and A3 were 68.4% HU, 38.2% HU and 55.9% HU, respectively, view axial cut and 64.1% HU, 36, 8% HU and 55.5% HU, in the coronal view , with a statistically significant difference, with the anterior region having the major bone density of the middle and posterior regions, and the posterior region having the highest density in the middle region (A1= A3 > A2). There was a statistically significant difference when compared to the measurement of palatal suture opening in the anterior and posterior region (p <0.05), with greater opening in the anterior region. The proportion between the average opening of expander device and tomographic opening media of median palatal suture was 60.9% in the posterior region, 64,5% in the medium region and 65.3% in the anterior region. Conclusion: The bone density in the region of median palatal suture, after 10 months of ERMAC, is lower than pre-expansion density. The direction of ossification after ERMAC follows a centripetal pattern with greater ossification in the extremities than in the center, and the opening of medial palatal suture occurs slightly in a “V” shape, being greater in the anterior region.
- ItemAcesso aberto (Open Access)Efeito da estatina sobre a densidade óssea avaliada pela tomografia computadorizada vertebral em receptores de transplante renal(Universidade Federal de São Paulo (UNIFESP), 2019-08-02) Sa, Cinara Barros De [UNIFESP]; Carvalho, Aluizio Barbosa De [UNIFESP]; Canziani, Maria Eugênia Fernandes [UNIFESP]; http://lattes.cnpq.br/8616590420890318; http://lattes.cnpq.br/7909431111187945; http://lattes.cnpq.br/5353063932221435; Universidade Federal de São Paulo (UNIFESP)Bone disease after successful kidney transplantation is common and represents an association of pre-existing renal osteodystrophy, the reduced renal function after renal transplantation and the consequences of transplantation specific therapies on bone. Statins are widely prescribed drugs for the treatment of dyslipidemia that have a wide range of pleiotropic effects including a possible positive effect on bone metabolism. One hundred and seventeen patients incidents in kidney transplant were randomized to receive statin or not during 12 months. Clinical evaluation, laboratorial analysis and chest-computed tomography were performed within 1 and 2 months after kidney transplantation and with 12-month follow-up. The thoracic vertebra was used to the vertebral bone density measurement. At baseline, statin group had higher BMI, total cholesterol, LDL cholesterol, triglycerides levels and malnutrition frequency than control group. At the end of follow up period, there was no significant difference in the clinical or laboratorial parameters between groups. There was no difference in vertebral bone density comparing statin and control groups neither in univariate or multivariate analysis. The main explanations for our result are the complexity of bone disease in kidney transplant recipients and the way statins were administered, probably inadequate to achieve an effective bone concentration.
- ItemSomente MetadadadosEstudo da relação entre a variação de massa óssea aferida por densitometria óssea e progressão de calcificação vascular em pacientes com doença renal crônica(Universidade Federal de São Paulo (UNIFESP), 2021) Campagnaro, Layon Silveira [UNIFESP]; Canziani, Maria Eugenia Fernandes [UNIFESP]; Universidade Federal de São PauloBackground and objectives: Low bone mass is frequently seen in CKD. KDIGO guidelines suggest the use of dual-energy X-ray absorptiometry (DXA) to assess bone mineral density (BMD) in patients with CKD 3a-5D. Previous studies have demonstrated an association between trabecular bone mass loss evaluated by computed tomography and bone biopsy with coronary artery calcification (CAC) progression. This study aimed to prospectively investigate the relationship between BMD change by DXA and CAC progression. Design, setting, participants, & measurements: In this post hoc study, BMD by DXA was measured at the lumbar spine and total hip at baseline and 12-month. Patients were categorized according to BMD changes into 3 different groups: LOSS, UNCHANGED and GAIN. CAC quantification was obtained by a multislice computed tomography at baseline and 12-month. CAC progression was defined as calcium score changes greater than 0. Results: 87 patients (55.6 ± 10.7 years, 62% males, 30% diabetic, eGFR = 39.2 ± 18.1 mL/min/1.73m2 ) were enrolled. CAC was observed in 41 (47%) of the patients at baseline and CAC progression in 25 (64%) of them. Considering the lumbar spine and total hip BMD changes together, 24%, 48%, and 25% of the patients were in the LOSS, UNCHANGED and GAIN groups, respectively. During the follow-up, patients of the GAIN group had an increase of calcium score compared to those of the UNCHANGED or LOSS groups (p = 0.04). Besides, the prevalence of CAC progression was higher in the GAIN compared to the UNCHANGED or LOSS groups (p = 0.01). In the logistic regression analysis, CAC progression was independently associated with an increase of BMD assessed by DXA. Conclusion: There was a direct relationship between bone mass gain and vascular calcification progression when the bone is analyzed by DXA. The presence of vascular calcification leads to a misinterpretation of DXA results in CKD patients.
- ItemSomente MetadadadosEstudo das propriedades mecânicas da diáfise radial humana sob compressão axial(Universidade Federal de São Paulo (UNIFESP), 1987) Ulson, Heitor José Rizzardo [UNIFESP]; Koberle, Gottfried [UNIFESP]
- ItemAcesso aberto (Open Access)Pamidronate and zoledronate effects in the increment of bone mineral density and histomorphometry in rats(Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2011-04-01) Cruz Júnior, Antônio Fiel; Buchpiguel, Carlos; Guarniero, Roberto; Barbieri, Antonio [UNIFESP]; Faculty of Medicine of Uninga Department of Clinical Medicine; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)PURPOSE: To compare increment of bone mineral density (BMD) with pamidronate, zoledronate and the isolated effect of proteinous diet in undernourished oophorectomized and non-oophorectomized female rats, besides validating BMD's indexes. METHODS: 60 young female Lewis rats were divided into five experimental groups and a control group, oophorectomized and non-oophorectomized. The administration of drugs were submitted to proteinous and aproteinous diets. The variables analyzed were weight, bone densitometry, histomorphometry and biochemical evolution. RESULTS: In weight evaluation, the first interval showed a statistically meaningful increase in oophorectomized sample. In densitometry evaluation, the first interval showed statistically meaningful decrease in four medicated groups and third showed a statistically meaningful increase in 2 non-oophorectomized groups. In laboratory evaluation, there were an increase of total proteins and globulin, decrease of alkaline phosphatase, phosphorus and calcium (except for the oophorectomized) in four medicated groups and increase of phosphorus and calcium in 2 not medicated groups. In histomorphometric evaluation, the oophorectomized groups had smaller increment of BMD. CONCLUSIONS: The pamidronate and zoledronate have shown effectives in the increment of BMD. The proteinous diet itself possesses therapeutic effect in BMD though not significant compared with medicated animals. The results of histomorphometry allow validating BMD's indexes in this experimental model.
- ItemAcesso aberto (Open Access)Risk factors for osteoporotic fractures and low bone density in pre and postmenopausal women(Faculdade de Saúde Pública da Universidade de São Paulo, 2010-06-01) Pinheiro, Marcelo de Medeiros [UNIFESP]; Reis Neto, Edgard Torres dos [UNIFESP]; Machado, Flávia Soares [UNIFESP]; Omura, Felipe [UNIFESP]; Yang, Jeane Jeong Hoon [UNIFESP]; Szejnfeld, Jacob [UNIFESP]; Szejnfeld, Vera Lucia [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)OBJECTIVE: To estimate the prevalence and analyze risk factors associated to osteoporosis and low-trauma fracture in women. METHODS: Cross-sectional study including a total of 4,332 women older than 40 attending primary care services in the Greater São Paulo, Southeastern Brazil, between 2004 and 2007. Anthropometrical and gynecological data and information about lifestyle habits, previous fracture, medical history, food intake and physical activity were obtained through individual quantitative interviews. Low-trauma fracture was defined as that resulting from a fall from standing height or less in individuals 50 years or older. Multiple logistic regression models were designed having osteoporotic fracture and bone mineral density (BMD) as the dependent variables and all other parameters as the independent ones. The significance level was set at p<0.05. RESULTS: The prevalence of osteoporosis and osteoporotic fractures was 33% and 11.5%, respectively. The main risk factors associated with low bone mass were age (OR=1.07; 95% CI: 1.06;1.08), time since menopause (OR=2.16; 95% CI: 1.49;3.14), previous fracture (OR=2.62; 95% CI: 2.08;3.29) and current smoking (OR=1.45; 95% CI: 1.13;1.85). BMI (OR=0.88; 95% CI: 0.86;0.89), regular physical activity (OR=0.78; 95% CI: 0.65;0.94) and hormone replacement therapy (OR=0.43; 95% CI: 0.33;0.56) had a protective effect on bone mass. Risk factors significantly associated with osteoporotic fractures were age (OR=1.05; 95% CI: 1.04;1.06), time since menopause (OR=4.12; 95% CI: 1.79;9.48), familial history of hip fracture (OR=3.59; 95% CI: 2.88;4.47) and low BMD (OR=2.28; 95% CI: 1.85;2.82). CONCLUSIONS: Advanced age, menopause, low-trauma fracture and current smoking are major risk factors associated with low BMD and osteoporotic fracture. The clinical use of these parameters to identify women at higher risk for fractures might be a reasonable strategy to improve the management of osteoporosis.