Repositório Institucional - Unifesp :: Navegando por Palavras-chave "Birth weight"

Navegando por Palavras-chave "Birth weight"

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Abnormalities in Metalloproteinase Pathways and IGF-I Axis: A Link Between Birth Weight, Hypertension, and Vascular Damage in Childhood
(Nature Publishing Group, 2010-01-01) Sesso, Ricardo de Castro Cintra [UNIFESP]; Franco, Maria do Carmo Pinho [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
BACKGROUNDAlthough numerous studies suggest an inverse relationship between birth weight and cardiovascular disease, the mechanistic basis of this phenomenon is not fully understood. Here, we postulate that alterations in plasma concentration of matrix metalloproteinases (MMPs) and growth factors might show different associations between birth weight, blood pressure levels, and vascular function.METHODSConcentrations of MMP-2 and its tissue inhibitor 2 (TIMP-2), MMP-9, and insulin-like growth factor-I (IGF-I) and its binding protein IGFBP-3 were measured in 64 children (34 boys, 30 girls).RESULTSSmall-for-gestational-age children exhibited elevated amounts of MMP-2, MMP-9, MMP-2/TIMP-2 ratio, MMP-9/TIMP-2 ratio, as well as lower concentration of IGF-I (P < 0.01), a known regulator of elastin synthesis. Similar findings were observed after adjustment for current age, gender, and race. the changes in the circulating levels of MMP-2, MMP-9, and IGF-I correlated significantly with birth weight, systolic blood pressure, and vascular function. Stepwise regression analysis demonstrated that MMP-2 was found to be an independent predictor of systolic blood pressure (R(2) = 0.08), whereas MMP-9 and birth weight were independent predictors of vascular dysfunction (R(2) = 0.38).CONCLUSIONSIt is possible that the association of fetal programming with elevated risk for vascular and metabolic disease in later life is, at least in part, mediated by perturbations in the MMP pathways.
Acesso aberto (Open Access)
Aplicação de uma curva de ganho de peso para gestantes
(Faculdade de Saúde Pública da Universidade de São Paulo, 1977-06-01) Siqueira, Arnaldo Augusto Franco de; Ciari Junior, Cyro; Mattos, Iara Lucia Brayner; Buralli, Keiko Ogura; Baptista Filho, Malaquias [UNIFESP]; Schor, Néia; Almeida, Pedro Augusto Marcondes de [UNIFESP]; Tanaka, Ana Cristina D'andretta; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
The authors studied the influence of maternal nutrition on birth weight using anthropometric techniques because these methods are of low cost, and do not need specialized manpower for their application. In the 460 pregnant women attended at a prenatal care service, there was a positive relationship between pre-gestational weight gain during pregnancy, birth weight and gestational age. Babies born from mothers with adequate pre-gestational weight were 296.7 grammes heavier than those of women with insufficient weight. Anthropometric curves for the measurement of maternal weight have been simplified and now this new curve is being tested.
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Association of ACE Gene Insertion/Deletion Polymorphism With Birth Weight, Blood Pressure Levels, and ACE Activity in Healthy Children
(Nature Publishing Group, 2012-07-01) Ajala, Aline Rodrigues [UNIFESP]; Almeida, Sandro Soares [UNIFESP]; Rangel, Marina [UNIFESP]; Palomino, Zaira [UNIFESP]; Strufaldi, Maria Wany Louzada [UNIFESP]; Puccini, Rosana Fiorini [UNIFESP]; Araújo, Ronaldo de Carvalho [UNIFESP]; Casarini, Dulce Elena [UNIFESP]; Franco, Maria do Carmo Pinho [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
BACKGROUNDThe human angiotensin-converting enzyme (ACE) gene contains a polymorphism consisting of either an insertion (I) or a deletion (D) of a 287 bp Alu repetitive sequence in intron 16. the potential role of ACE polymorphism in the risk of developing hypertension or other cardiovascular disorders has not been determined in relation to birth weight (BW).METHODSThe ACE genotype and plasma ACE activity were determined in 167 children. Among these children, 60 were identified with low BW (LBW), and 107 were of normal BW (NBW).RESULTSACE activity levels were significantly elevated in LBW children compared with the NBW group (P < 0.001). There was a significant association of the ACE activity with systolic blood pressure (SBP) levels in our population (P < 0.001). Among the ACE genotypes, no significant differences were found with respect to BW (P = 0.136). However, our results revealed that LBW children had a higher D allele frequency than NBW children (P = 0.036). When analyzed by quartiles of SBP or ACE activity, we found a greater frequency of both the LBW children and those carrying the DD genotype in the highest quartiles of these parameters, whereas the NBW children tended to be in the lowest quartile (P < 0.001). Similar results were observed with the heterozygote ID children after categorization by quartiles of both SBP (P < 0.001) and ACE activity (P = 0.004).CONCLUSIONSThe ACE I/D polymorphism, especially the DD genotype, can be interpreted as a major factor in association between LBW and high BP levels.
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Association of adipokines with cardiovascular risk factors in low birth weight children: a case-control study
(Springer, 2013-01-01) Strufaldi, Maria Wany Louzada [UNIFESP]; Puccini, Rosana Fiorini [UNIFESP]; Silverio, Olga Maria Amancio [UNIFESP]; Franco, Maria Carmo do Pinho [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Our aim was to investigate plasma levels of adiponectin, monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in low birth weight (LBW) children and to determine correlations among these adipokines and birth weight and cardiovascular disease risk factors. in a case-control study, the concentrations of adiponectin, MCP-1 and PAI-1 were measured in 180 schoolchildren (ages 6-11 years). MCP-1 and PAI-1 levels were significantly elevated in LBW children. Conversely, adiponectin concentration was significantly reduced in these children. Similar findings were observed after adjustment for current age, gender and abdominal circumference. Because the children with LBW had altered adipokine levels, as well as higher abdominal circumference, HOMA-IR and systolic blood pressure (SBP), we evaluated the correlation among these variables. These analyses showed that adiponectin levels were inversely correlated with systolic blood pressure (SBP) (r = -0.501; P < 0.001), HOMA-IR (r = -0.293; P = 0.023) and waist circumference (r = -0.317; P = 0.014). the proinflammatory markers were positively correlated with HOMA-IR (PAI-1: r = 0.358; P = 0.005) and waist circumference (PAI-1: r = 0.571; P < 0.001 and MCP-1: r = 0.267; P = 0.039). Conclusion: Adipokines levels were correlated with cardiovascular risk factors in LBW children, and these compounds could be involved in the mechanism that links birth weight to the development of cardiovascular diseases in adulthood.
Acesso aberto (Open Access)
Avaliação da condição nutricional, níveis pressóricos e perfil metabólico em crianças com elevado peso ao nascer
(Universidade Federal de São Paulo (UNIFESP), 2016-11-24) Ledo, Daniel Lopez [UNIFESP]; Strufaldi, Maria Wany Louzada [UNIFESP]; http://lattes.cnpq.br/1532899000031715; http://lattes.cnpq.br/2805727742334941; Universidade Federal de São Paulo (UNIFESP)
Objective: To identify a possible association between high birth weight (HBW) and overweight / obesity, increased blood pressure levels, altered lipid profile and altered glucose metabolism in children and adolescents between 6 and 12 years of age. Methods: A cross-sectional study with students, enrolled in a public school in the metropolitan region of Sao Paulo. Anthropometric data, family history and blood pressure levels were obtained from 719 children and 518 collected laboratory tests. 25 Risk variables for CVD were waist circumference, blood pressure (SBP/DBP), body mass index (BMI), lipid profile, blood glucose, insulin and insulin resistance (HOMA). The birth weight was classified into 3 groups: low birth weight (LBW < 2,500g), appropriate weight (AW: 2,500g ? BW < 4000g) and high birth weight (HBW ? 4000g). Results: In 719 children evaluated, the average age was 9.5 ± 2.0 years old and 371 (51.6%) were male. There was no statistically significant difference in relation to the classification of nutritional status and birth weight. The average values of Z BMI, waist/height and Z high/age were higher in schoolchildren with HBW, however, without statistically significant difference in relation to the other groups. Children/adolescents with HBW didn?t have a worse lipid or glucose profile and insulin resistance. The group with low birth weight showed the highest percentage of unsuitability for SBP, DBP and triglycerides compared to groups with AW and HBW, even after adjustment for sex. Conclusion: No associations were found between being born with high weight and obesity, blood pressure levels, changes in lipid profile and insulin resistance in children and adolescents.
Acesso aberto (Open Access)
Birth weight and its relationship with endothelial function and pattern of endotheliumderived microparticles during childhood: New insight about early vascular damage
(Universidade Federal de São Paulo, 2021) Parizotto, Giovanna Pachele [UNIFESP]; Franco, Maria do Carmo Pinho [UNIFESP]; http://lattes.cnpq.br/0138099513326464
Objectives: To investigate whether a specific endothelium-derived microparticles (EMPs) phenotype could be associated with birth weight and microvascular endothelial function in children. Study design: A total of 95 children, aged 6-14 years, were recruited. Anthropometric measurement, blood pressure, microvascular endothelial function, the biochemical profile was performed. Standardized flow cytometry methods were used to identify and quantify circulating CD144+, CD31+/annexin V+, and CD62E+ EMPs. Results: We found that the circulating number of CD31+/annexin V+ EMPs and CD144+ EMPs EMP levels were correlated with birth weight, systolic blood pressure, microvascular endothelial function, total cholesterol, and LDLc levels. In the multivariable logistic regression models, we identified strong evidence of higher risk of microvascular endothelial dysfunction among children with low birth weight and increased levels of both CD31+/annexin V+ EMPs and LDLc, while low birth weight and elevated LDLc levels have been identified as independent predictors of the high circulating number of both CD31+/annexin V+ and CD144+ > 75th percentile EMPs. Conclusion: our data provide evidence that children who had birth weight at the lowest values showed higher levels of the circulating number of CD31+/annexin V+ and CD144+ EMPs. In addition, the LBW and high levels of both CD31+/annexin V+ and LDLc were significant risk factors for the presence of microvascular endothelial dysfunction.
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Blood pressure levels in childhood: probing the relative importance of birth weight and current size
(Springer, 2009-05-01) Strufaldi, Maria Wany Louzada [UNIFESP]; Silva, Edina Mariko Koga da [UNIFESP]; Franco, Maria do Carmo Pinho [UNIFESP]; Puccini, Rosana Fiorini [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Several studies have reported data supporting the idea that an impaired intrauterine environment that deprives the fetus of optimal nutrient delivery results in the predisposition of the fetus to experience cardiovascular and metabolic dysfunction in later life. However, contradictory data still exist. Our purpose was to investigate the effects of both birth weight and weight gain on the risk for high blood pressure levels in 6- to 10-year-old children. This cross-sectional study included 739 children divided into quartiles of birth weight. the mean values of both systolic and diastolic pressure were significantly different between quartiles of birth weight, with increasing blood pressure values as the birth weight decreased (P < 0.001). Covariance analysis adjusting for gender, prematurity, and body mass index (BMI) showed that both systolic and diastolic pressure remained greater in the lowest than in the highest birth weight quartile. Separating those with low and normal birth weight demonstrated that the risk of childhood hypertension was significantly higher among children with low birth weight and current obesity (odds ratio [OR]: 5.0, confidence interval [CI]: 3.3 to 16.1; P = 0.023). the inverse association between birth weight and blood pressure levels appears to be programmed during fetal life, while weight gain during childhood adds to this risk.
Acesso aberto (Open Access)
Características da sucção não-nutritiva em RN a termo e pré-termo tardio
(Sociedade Brasileira de Fonoaudiologia, 2011-09-01) Kao, Ana Paula D'oliveira Gheti [UNIFESP]; Guedes, Zelita Caldeira Ferreira [UNIFESP]; Dos Santos, Amelia Miyashiro [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
PURPOSE: To compare non-nutritive sucking parameters between late preterm and full-term infants. METHODS: Infants were divided into two groups, full-term and late preterm, and were submitted to non-nutritive sucking assessment using a protocol adapted from the Oral Motor Assessment Scale. Statistical analysis was conducted for comparison between the groups. RESULTS: The seeking and sucking reflexes were less frequent in late preterm than in full-term newborns, as well as palmar grip and hands in the midline. Most late preterm infants presented light sleep or drowsiness before the assessment. Late preterm subjects predominantly presented sporadic sucking or blocks of sucking with long pauses and mandibular locking and/or tremors. Tongue retraction and protrusion were mostly present in late preterm infants, and tongue central groove formation, in full-term infants. CONCLUSION: Readiness for feeding, behavioral state, axial tonus, sucking pattern and strength, and tongue movements were the less frequent parameters in late preterm infants, in comparison to full-term infants.
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Does low birth weight affect the presence of cardiometabolic risk factors in overweight and obese children?
(Springer, 2013-12-01) Ponzio, Caroline [UNIFESP]; Palomino, Zaira [UNIFESP]; Puccini, Rosana Fiorini [UNIFESP]; Strufaldi, Maria Wany Louzada [UNIFESP]; Franco, Maria do Carmo Pinho [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Recent findings suggest that low-birth-weight children with current obesity are more likely to have higher systolic blood pressure levels and impaired beta-cell function than those who are obese with normal birth weight. It seems possible, however, that concurrent low birth weight with excess weight gain can exacerbate other risk factors for cardiometabolic diseases. the purpose of this study is to investigate the influence of birth weight on the lipid/apolipoprotein profile, visfatin levels, and insulin parameters in overweight/obese children. A cross-sectional study of 68 overweight/obese children was conducted. Among these children, 28 were identified with low birth weight and 40 were of normal birth weight. Blood lipid profile, apolipoproteins, visfatin, glucose, and insulin were measured. Our results show that systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels, triglycerides (TG), very low-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDLc), apolipoprotein B and E, insulin, apolipoprotein B/A(1) ratio, and homeostasis model assessment insulin resistance (HOMA-IR) were significantly elevated in overweight/obese low-birth-weight (LBW) children. There was a significant association of the SBP levels with TG (P = 0.027), LDLc (P = 0.001), HOMA-IR (P < 0.001), apolipoprotein B (P = 0.001), and apolipoprotein E (P = 0.039). Conclusion: Our findings suggest that LBW children with overweight or obesity have an additional risk factor for both atherogenic and insulinogenic profile.
Acesso aberto (Open Access)
Estudo sobre nascidos vivos em maternidades: 1. Peso ao nascer, sexo, tipo de nascimento e filiação previdenciária das mães
(Faculdade de Saúde Pública da Universidade de São Paulo, 1988-12-01) Souza, Maria de Lourdes R. de; Tanaka, Ana Cristina D'Andretta; Siqueira, Arnaldo Augusto Franco de; Santana, Renato Martins [UNIFESP]; Universidade Federal de Santa Catarina Centro de Ciências da Saúde Departamento de Saúde Pública; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
Birthweight is the result of many factors (organic, psychological, social) acting on the genetic potential of the fetus. Consequently, its distribution is different according to the characteristics of the population. In this paper the authors studied the weight at birth of live newborns (from 1978 to 1979) in the two big maternity hospitals, in Florianópolis, responsible for 90% of all births in the area, by sex, litter size and mother's health security. The authors verified that the mean birthweight of the 18,491 live newborns was 3,347.6gr. In that population 5.3% of the newborns were low birthweight infants, and 11.1% weighed 4,000gr or more. Male newborns weighed significantly more than female babies, and the same difference occurred between single and multiple births. The relationship between the newborn's birthweight and the kind of health security the mother had showed that the mothers who didn't pay any kind of health security had babies with lower birthweight than those of the mothers who subscribed to some health security scheme. The data showed that this population has a low incidence of low birthweight babies, with a distribution similar to that observed in developed countries.
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GFR estimated from cystatin C versus creatinine in children born small for gestational age
(Elsevier B.V., 2008-06-01) Franco, Maria do Carmo Pinho [UNIFESP]; Nishida, Sonia Kiyomi [UNIFESP]; Sesso, Ricardo de Castro Cintra [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Background: Low birth weight caused by intrauterine growth restriction may be a risk factor for renal impairment in the adult life.Study Design: A cross-sectional study.Setting & Participants: 71 children aged 8 to 13 years living in the community of São Paulo, Brazil, were included in the study. Gestational age was within the normal range.Predictors: Birth weight (range, 2,052 to 3,560 g) divided into quartiles: 2,500 g or less; 2,501 to 2,740 g; 2,741 to 3,000 g; and greater than 3,000 g. Birth weight ascertained by birth records in 43 and by recall in 28 participants.Outcomes & Measurements: Cystatin C, creatinine, and glomerular filtration rate (GFR) estimated by equations using cystatin C (eGFR(cys)) or creatinine (eGFR(cr)).Results: Overall, mean serum creatinine level was 0.8 +/- 0.01 (SE) mg/dL (range, 0.7 to 1.1 mg/dL); mean plasma cystatin C level was 0.9 +/- 0.02 mg/L (range, 0.5 to 1.6 mg/L), and eGFR(cr) and eGFR(cys) were 102.4 +/- 2.16 (range, 66 to 140) and 91.8 +/- 2.46 mL/min/1.73 m(2) (range, 49 to 139 mL/min/1.73 m(2)), respectively. No differences were found for serum creatinine or eGFR(cr) values among the birth-weight quartiles. There was a significant linear trend of increasing cystatin C levels (decreasing eGFR(cys) in the lower birth-weight quartile groups (P = 0.002 and P = 0.02, respectively). Systolic blood pressure correlated with plasma cystatin C level (r = 0.31; P = 0.008) and eGFR(cys) (r = -0.26; P = 0.028). Covariance analysis adjusting for age, sex, body mass index for age compared with standards of the National Center for Health Statistics and expressed as a z score, and systolic blood pressure showed that cystatin C values remained greater in the lowest than highest birth-weight quartile (1.01 +/- 0.05 versus 0.83 +/- 0.05 mg/L; P = 0.02).Limitations: Ascertainment of birth weight by recall in some participants. Lack of measurement of microalbuminuria, absence of direct GFR measurement, and small sample size.Conclusions: Lower birth weight is associated with higher levels of cystatin C but not creatinine in 8-13 yr. old children born full-term.
Acesso aberto (Open Access)
A influência do peso ao nascer e do aleitamento materno exclusivo sobre a composição corporal, síndrome metabólica, perfil metabólico e inflamatório em adolescentes obesos
(Universidade Federal de São Paulo, 2012-03-15) Masquio, Deborah Cristina Landi [UNIFESP]; Dâmaso, Ana Raimunda [UNIFESP]; Piano, Aline de; Mello, Marco Tulio de [UNIFESP]; http://lattes.cnpq.br/2228187432443594; http://lattes.cnpq.br/4215971444001756; http://lattes.cnpq.br/8198400959291700; http://lattes.cnpq.br/1472275486966625; Universidade Federal de São Paulo (UNIFESP)
Programação metabólica é definida como um fenômeno biológico no qual experiências nutricionais e intra-uterinas podem influenciar o metabolismo e o desenvolvimento humano, predispondo à doenças. O objetivo deste estudo foi verificar a influência do peso ao nascer e do aleitamento materno exclusivo sobre a composição corporal, síndrome metabólica, perfil metabólico e inflamatório em adolescentes obesos. Realizou-se um estudo transversal com 118 adolescentes obesos entre 14 e 19 anos. Mensurou-se a massa corporal, estatura, índice de massa corporal (IMC), circunferência da cintura, composição corporal, adiposidade visceral e subcutânea, perfil bioquímico, parâmetros preditores da síndrome metabólica, concentrações séricas de adiponectina, leptina e resistina e espessura da íntima média da artéria carótida (IMTc). A resistência insulínica foi verificada pelo Homeostasis Model Assesment Insulin Resistance (HOMA-IR) e a sensibilidade insulínica pelo Quantitative Insulin Sensitivity Check Index (QUICKI). Informações sobre o tempo de aleitamento materno exclusivo (AME) e peso ao nascer foram coletadas por meio de entrevista com os pais dos adolescentes. A análise estatística foi realizada por meio do software STATISTICA considerando-se o nível de significância de p<0,05. Adolescentes nascidos com peso adequado apresentaram concentrações superiores de adiponectina e inferiores da IMTc quando comparados aqueles que nasceram com peso insuficiente. Adolescentes que receberam AME por 6 meses quando comparados aos que nunca receberam AME apresentaram valores inferiores de massa corporal, IMC e circunferência da cintura. O grupo que recebeu AME entre 1 e 5 meses apresentou concentrações séricas de adiponectina superiores ao grupo que nunca recebeu AME. Observou-se também que aqueles que receberam AME entre 1 e 5 meses apresentaram valores inferiores de pressão arterial sistólica (PAS) ao serem comparados com os que não receberam AME. Além disso, verificou-se associação significativa entre AME e PAS. A massa corporal, IMC e circunferência da cintura correlacionaram-se positivamente com a gordura corporal (% e kg), massa magra (kg), gordura visceral, gordura subcutânea, insulina, HOMA-IR, pressão arterial sistólica (PAS) e diastólica (PAD), e negativamente com a massa magra (%) e QUICKI. A adiponectina correlacionou-se negativamente com a gordura subcutânea, resistina e leptina. Já a resistina apresentou-se correlacionada positivamente com a massa corporal, gordura corporal (% e kg), leptina e IMTc, e negativamente com a massa magra(%). Por sua vez, a leptina se correlacionou positivamente com a massa corporal, IMC, gordura corporal e subcutânea. A PAS correlacionou-se positivamente com a gordura corporal, e a PAD correlacionou-se positivamente com a gordura visceral, insulina HOMA-IR e negativamente com o QUICKI. Os resultados deste estudo indicam que adolescentes obesos que receberam AME por 6 meses apresentam um perfil antropométrico e inflamatório menos alterado, bem como aqueles que nasceram com peso adequado.
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Leukemia, non-Hodgkin's lymphoma, and Wilms tumor in childhood: the role of birth weight
(Springer, 2010-07-01) Rangel, Marina [UNIFESP]; Cypriano, Monica [UNIFESP]; Martino Lee, Maria Lucia de [UNIFESP]; Vercillo Luisi, Flavio Augusto [UNIFESP]; Petrilli, Antonio Sergio [UNIFESP]; Strufaldi, Maria Wany Louzada [UNIFESP]; Franco, Maria do Carmo Pinho [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)
There is emerging evidence that higher birth weight is associated with increased risk of cancer, in particular childhood leukemia. the purpose of this paper is to study whether this correlation is also significant with other childhood cancer. for this, we conducted a case-control study including 410 childhood cancer patients and 1,575 matched controls to investigate birth weight as a risk factor for leukemia, Wilms tumor, and non-Hodgkin's lymphoma. the estimated risk for all cancers has been found to be statistically and significantly higher in birth weight of more than 4,000 g (odds ratio, 2.50 and 95% confidence intervals (CI), 1.72-3.63). for leukemia, the estimated risk was 1.86 (95% CI, 1.04-3.30), for non-Hodgkin lymphoma, 1.99 (95% CI, 1.08-3.69), and being more remarkable for Wilms tumor, 4.76 (95% CI, 2.73-8.28). Moreover, moderate increased risk of both leukemia and non-Hodgkin lymphoma was also associated with birth weight between 3,000 and 3,999 g. High birth weight was associated with all cancers also when adjusted by gestational age, length at birth, and gender (odds ratio, 6.10 and 95% CI, 1.15-32.57). No associations were found for maternal alcohol consumption during pregnancy, maternal smoking, or smoking by other people at home or presence of obstetric variables (e.g., gestational diabetes, preeclampsia, and abruptio placentae). the present study supports the hypothesis that high birth weight is an independent risk factor for childhood Wilms tumor, leukemia, and non-Hodgkin lymphoma. Further studies should explore biological reasons to explain this relationship and, ultimately, to expand our knowledge about prenatal influences on the occurrence of this disease.
Acesso aberto (Open Access)
Predição de peso ao nascimento pela ultra-sonografia tridimensional usando o volume do braço fetal: resultados preliminares
(Federação Brasileira das Sociedades de Ginecologia e Obstetrícia, 2008-04-01) Vieira, Márcio Fragoso [UNIFESP]; Nardozza, Luciano Marcondes Machado [UNIFESP]; Araujo Júnior, Edward [UNIFESP]; Guimarães Filho, Hélio Antonio [UNIFESP]; Moron, Antonio Fernandes [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
PURPOSE: to evaluate the accuracy of fetal upper arm volume, using three-dimensional ultrasound (3DUS), in the prediction of birth weight. METHODS: this prospective cross-sectional study involved 25 pregnancies without structural or chromosomal anomalies. Bidimensional parameters (biparietal diameter, abdominal circumference and femur length) and the 3DUS fetal upper arm volume were obtained in the last 48 hours before delivery. The multiplanar method, using multiple sequential planes with 5.0-mm intervals, was used to calculate fetal upper arm volume. Polynomial regressions were used to determine the best equation in the prediction of fetal weight. The accuracy of this new formula was compared with Shepard's and Hadlock's formulas. RESULTS: fetal upper arm volume was strongly correlated to birth weight (r=0.83; p<0.005). Linear regression was the best equation [birth weight=681.59 + 43.23 x fetal upper arm volume]. The fetal upper arm volume mean error (0 g), mean absolute error (196.6 g) and mean percent absolute error (6.5%) were lower than using Shepard's formula; however, the difference did not reach significance (p>0.05). Birth weight predicted by fetal upper arm volume had a mean error lower than Hadlock's formula, but this difference was not statistically significant (p>0.05). CONCLUSIONS: the accuracy of fetal upper arm volume obtained through 3DUS is similar to the accuracy of bidimensional ultrasound in the prediction of birth weight. These findings need to be confirmed by larger studies.
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Prediction of birth weight using fetal thigh and upper-arm volumes by three-dimensional ultrasonography in a Brazilian population
(Informa Healthcare, 2010-05-01) Machado Nardozza, Luciano Marcondes [UNIFESP]; Vieira, Márcio Fragoso [UNIFESP]; Araujo Junior, Edward [UNIFESP]; Rolo, Liliam Cristine [UNIFESP]; Moron, Antonio Fernandes [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
Methods. A cross-sectional study involving 81 live singletons was performed. VolArm and VolTh were obtained using 3DUS multiplanar mode with 5 mm slices. Linear and polynomial regressions were calculated to determine the best formula to predict BW using VolArm and VolTh. Analysis of variance was used to compare errors in BW using these formulae and using Shepard's and Hadlock's formulae. the interclass correlation coefficient (ICC) was used to assess intra and interobserver variability of measurements.Results. the best formula to predict BW based on VolArm was a simple linear equation (BW = 803.91 + 39.89VolArm), and for VolTh it was a second degree polynomial equation (BW = 32.37VolTh - 0.06VolTh
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Predictors of Higher Blood Pressure in a Clinical Setting in Normotensive Children: A Prospective Study
(Karger, 2009-01-01) Bohlke, Maristela [UNIFESP]; Dullius, Fernanda; Menezes, Juliana; Cunha, Tiago; Boemer, Hayslan; Menezes, Adriana; Caruso, Paulo; Univ Catolica Pelotas; Universidade Federal de São Paulo (UNIFESP)
This study was designed to assess the predictors of a higher blood pressure (BP) in a clinical setting in a prospective cohort of normotensive children recruited in an outpatient pediatric clinical setting in Southern Brazil. the study evaluated 443 children 3-12 years of age. If the mean value of BP was greater than the 95th percentile for age, sex and height in the medical setting, children were scheduled to other two evaluations at home. the systolic BP percentile in the clinical consultation was associated with BMI and birth weight. the diastolic BP in the clinical consultation was associated with birth weight, age, and BMI. Weight excess, low birth weight and younger age were associated with a higher BP in normotensive children seen in a clinical setting. To our knowledge, this is the first study to describe the association between lower birth weight and a greater BP response to medical consultation. Our finding suggests that the tendency to higher white-coat effect is determined, at least to some extent, in intrauterine life. Copyright (C) 2009 S. Karger AG, Basel
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Recém-nascido de mãe adolescente de baixo nível socioeconômico (antropometria e outras variáveis)
(Universidade Federal de São Paulo (UNIFESP), 1994) Vitalle, Maria Sylvia de Souza [UNIFESP]; Nóbrega, Fernando José de [UNIFESP]
Acesso aberto (Open Access)
Transtornos mentais durante a gravidez e condições do recém-nascido: estudo longitudinal com gestantes assistidas na atenção básica no município de Embu das Artes
(Universidade Federal de São Paulo (UNIFESP), 2015-09-24) Costa, Daisy Oliveira [UNIFESP]; Strufaldi, Maria Wany Louzada [UNIFESP]; Pedroso, Glaura César [UNIFESP]; http://lattes.cnpq.br/4659715388917533; http://lattes.cnpq.br/1532899000031715; http://lattes.cnpq.br/3452456321980703; Universidade Federal de São Paulo (UNIFESP)
Os transtornos mentais (TM) constituem um problema de saúde pública e a gestação pode desencadear ou exacerbar transtornos psiquiátricos, com consequente comprometimento da saúde da criança. A investigação de TM na Atenção Básica (AB) ainda é um desafio para os profissionais de saúde, com dificuldades na elaboração do diagnóstico Objetivo: Verificar a presença e possível associação entre diagnósticos prováveis de TM em gestantes usuárias da AB e condições dos recém-nascidos (RN). Métodos: Estudo longitudinal com gestantes (18 a 39 anos), durante o segundo e terceiro trimestres da gravidez, assistidas na AB da região Metropolitana de São Paulo, de fevereiro a agosto de 2014. Foram aplicados: questionário sociodemográfico, instrumento para Avaliação de TM para Atenção Primária (PRIME-MD) e entrevista sobre informações e percepção sobre o comportamento (choro, cólica, sono, alimentação) do RN. Resultados: Das 300 gestantes entrevistadas, 76 (26,6%) apresentaram diagnóstico provável de TM. Entre os transtornos, 46 (16,2%) gestantes apresentavam sintomas de depressão/distimia e 58 (20,4%) ansiedade/pânico. Observou-se baixo peso ao nascer (BPN) e prematuridade em 14 (4,9%) e 19 (6,7%) dos RN, respectivamente. Não foi verificada associação entre os diagnósticos prováveis de TM e BPN ou prematuridade; a presença de possíveis TM associou-se com a percepção materna de alterações no comportamento do RN (p = 0,001). Conclusão: Observou-se que gestantes em acompanhamento de pré-natal de baixo risco apresentam frequência relevante de TM com associação à percepção materna de alterações no comportamento do RN. A identificação de possíveis TM na gestação pode também colaborar para uma melhor compreensão da dinâmica do binômio mãe-filho e contribuir com a qualidade na assistência à família.
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Transtornos mentais na gravidez e condições do recém-nascido: estudo longitudinal com gestantes assistidas na atenção básica
(Abrasco, 2018) Costa, Daisy Oliveira [UNIFESP]; Souza, Fabiola Isabel Suano de [UNIFESP]; Pedroso, Glaura Cesar [UNIFESP]; Strufaldi, Maria Wany Louzada [UNIFESP]
This study aimed to determine the presence and association of possible mental disorders diagnoses in primary care pregnant women and newborns' conditions. This is a longitudinal study with pregnant women (18-39 years), in the second and third trimesters of pregnancy, attended at primary care facilities in the metropolitan region of Sao Paulo (February to August/2014). The following tools were used: sociodemographic questionnaire
Somente Metadadados
Turner syndrome and metabolic derangements: Another example of fetal programming
(Elsevier B.V., 2012-02-01) Baldin, Alexandre Duarte; Siviero-Miachon, Adriana Aparecida [UNIFESP]; Fabbri, Tatiana [UNIFESP]; Valente de Lemos-Marini, Sofia Helena; Spinola-Castro, Angela Maria [UNIFESP]; Matias Baptista, Maria Tereza; Rodrigues D'Souza-Li, Lilia Freire; Morcillo, Andre Moreno; Maciel-Guerra, Andrea Trevas; Guerra-Junior, Gil; Universidade Estadual de Campinas (UNICAMP); Universidade Federal de São Paulo (UNIFESP)
Background and aim: Turner syndrome (TS) patients have an increased risk of weight gain and metabolic syndrome. To date, it is unknown what factors are involved in this metabolic process, even though it is recognized that TS patients are frequently born small-for-gestational age. the aim of this study was to evaluate the correlation between lipid and glucose profiles with being overweight and birth weight and length in TS patients.Study design: This was a cross-sectional study.Subjects and outcome measures: Serum glucose, insulin (HOMA-IR), total cholesterol, and triglycerides were measured in 64 patients with TS. Data regarding birth weight and length and current body mass index (BMI) were also evaluated.Results: Total cholesterol showed a significant negative correlation with birth weight and a positive correlation with BMI; triglycerides showed significant negative correlation with birth weight and length and a positive correlation with BMI; and HOMA-IR showed a significant negative correlation with birth weight and length. Low birth weight and a high BMI were predictive for 28% of total cholesterol and triglycerides; and low birth weight for 22% of HOMA-IR.Conclusions: Lipid profile was correlated with a high current BMI and low birth weight and length in TS patients and glucose profile only with low birth weight. Thus far, growth retardation may play a role in metabolic derangements in this group of patients, being considered another example of fetal programming. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

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