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- ItemSomente MetadadadosEfeitos do exercício orientado em ratas submetidas à ligadura da aorta abdominal infra-renal(Universidade Federal de São Paulo (UNIFESP), 1997) Silva Junior, Otacilio Figueiredo da [UNIFESP]; Miranda Junior, Fausto [UNIFESP]
- ItemAcesso aberto (Open Access)Estudo da morfologia renal após a oclusão da aorta abdominal infra-renal em ratos(Colégio Brasileiro de Cirurgiões, 2005-08-01) Feitosa, Eliane Alencar do Nascimento [UNIFESP]; Taha, Murched Omar [UNIFESP]; Fagundes, Djalma José [UNIFESP]; Takiya, Cristina Maeda; Cardoso, Lúcio Ronaldo; Campos, Doris Moura; Universidade Federal de São Paulo (UNIFESP); UFRJ Departamento de Histologia e Embriologia; UFRJ Disciplina de NefrologiaBACKGROUND: The aim of this study was to investigate the influence of infrarenal corss-clamping in the renal tissue. METHODS: Groups of male Wistar rats (N = 60) were subjected or not to infrarenal aortic cross-clamping following or not by reperfusion according to each group: IA (sham-30 min-n = 10); IB (sham-60min-n = 10); IIA (30min of ischaemia-n = 10); IIB (60min of ischaemia-n =10); IIIA (30min of ischaemia + 30min of reperfusion-n = 10); IIIB (60min of ischaemia + 60min of reperfusionn = 10). All animals were submitted to nephrectomy. The histological analyses (descriptive and morphometry) were accomplished through conventional methodology (paraffin embedding and hematoxilylin and eosin staining). Semiquantitative analyses of tubular damage (modified structure) and intersticial edema were carried out according to an index of intensity of injury. Data was validated by applying statistical tests: Mann-Whitney, Kruskal-Wallis, Multiple Comparisons. Significance was accepted at p < 0.001. RESULTS: Occurrence of signicant tubular and intersticial damages in group III was observed. CONCLUSION: Occlusion of the infrarenal aorta in rats can lead to renal morphological effects, especially in reperfusion phase.
- ItemAcesso aberto (Open Access)O importante valor do deslocamento anterior da aorta abdominal por massa, observado em TC ou RM, no diagnóstico de neuroblastoma em crianças com até 7 anos(Universidade Federal de São Paulo (UNIFESP), 2015-03-25) Schiavon, Jose Luiz de Oliveira [UNIFESP]; Lederman, Henrique Manoel [UNIFESP]; http://lattes.cnpq.br/6102707812313296; http://lattes.cnpq.br/2987887118534856; Universidade Federal de São Paulo (UNIFESP)Objective: Evaluate role of the anterior displacement of the abdominal aorta by tumor, anywhere in the abdomen, or at the level of the contralateral adrenal, in axial CT and/or MRI, to diagnose neuroblastoma, compared to the gold standard pathology report. Methods: This is a retrospective study of patients up to 7 years old who had had abdominal tumors observed on CT and/or MRI, and had their pretreatment images stored in the PACS of the Instituto de Oncologia Pediátrica da Universidade Federal de São Paulo / Grupo de Apoio ao Adolescente e Criança com Câncer IOP-UNIFESP/GRAACC until the end of 2013. The patients? images were classified in consensus by two radiologists for the presence or absence of the anterior displacement of the abdominal aorta. The findings were compared with the pathology report findings (gold standard), and then subjected to the statistical analysis. Results: The anterior displacement of the abdominal aorta, at any level of the abdomen, was present in 26 of the 66 patients included in the study, representing 39.39% of the patients studied. Of these 26 patients, 22 (84.62%) had confirmed neuroblastoma. The other 4 (15.38%) accounted for 3 cases of nephroblastomas and 1 Burkitt's lymphoma, determining a positive predictive value of 84.62% and a specificity of 88.24% for the finding, with a moderate agreement with the pathology report. All these findings were statistically significant with p <0.001. Considering only the displacement of the aorta at the level of the contralateral adrenal, all the 14 patients that displaced the aorta were neuroblastomas, and any non-neuroblastoma tumor had displaced the aorta at that level. Conclusions: We conclude that, when the anterior displacement of the abdominal aorta caused by mass was present at the level of the contralateral adrenal mass, it can be stated that the diagnosis is neuroblastoma, while in cases that the displacement occurs in other abdominal levels, its ability to predict the diagnosis of neuroblastoma is about 85%, all the findings had statistical significance and with a moderate agreement with the pathology report. It should be noted that not all neuroblastoma shifts the aorta, and the neuroblastoma, as in its clinical presentations, may present itself in different ways to imaging. There was no significant influence of tumor size or patients? age in neuroblastoma displacement.
- ItemAcesso aberto (Open Access)Reação histopatológica da parede da aorta abdominal ao stent não recoberto(Sociedade Brasileira de Cirurgia Cardiovascular, 2006-06-01) Bombonato, Rubio [UNIFESP]; Fonseca, José Honório de Almeida Palma da [UNIFESP]; Marcondes, José Augusto [UNIFESP]; Moraes, Aury Nunes de; Rocha, João Luiz da; Martins, Márcio Rodrigo; Tchaick, Rodrigo Mezzalira; Domingos, Júlio; Buffolo, Enio [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade do Estado de Santa Catarina CAV/UDESC Hospital Veterinário; Laboratório Rocha de Criciúma; Universidade do Sul Catarinense UNESCOBJECTIVE: To evaluate the histopathological reaction of the abdominal aorta wall in pigs' renal arteries to the presence of non-covered stainless steel stents. METHODS: The abdominal aorta of ten pigs (6 months old and weighing 86.6 kg on average) was histopathologically studied 100 days after the implant to a stainless steel stents in the abdominal aorta, with one segment of the stent inplanted in the renal artery. Self-expanding non-covered stents were released by laparotomy. The histological slices were made at the transition from the normal aorta and the aorta containing the stent; the aorta portion containing the stent; the portion with the ostia of renal arteries; periaortic lymph nodes and renal parenchyma. The samples were stained by hematoxylin and eosin technique. RESULTS: Macroscopic findings showed periaortic lymphadenopathy, thickened aortic wall, patency of lumbar and renal arteries and normal renal anatomical structure. Microscopic analyses near the stents revealed thickening of vessel wall, secondary to the intima fibrosis, and media layer affected by interstitial fibrosis. Micrometric measurements of aorta wall with the stent, compared to the aortic portion without it, presented a 75.90% increasein the total thickness of the wall by thickening of the intima layer secondary to fibroblast proliferation, collagen deposits with lymphocitary inflammatory infiltrate and foreign body-type granulomas. CONCLUSION: The non-covered stainless steel stent in pigs' aortas produced a significant inflammatory reaction with fibrosis in the media and intima layers evidenced by histopathological analyses; their presence did not interfere in the patency of the abdominal aorta or the renal and lumbar arteries.
- ItemAcesso aberto (Open Access)O stent descoberto não promove reações em artérias renais e parênquima renal em suínos(Sociedade Brasileira de Cirurgia Cardiovascular, 2009-06-01) Bombonato, Rubio [UNIFESP]; Fonseca, José Honório de Almeida Palma da [UNIFESP]; Marcondes, José Augusto [UNIFESP]; Moraes, Aury Nunes de; Rocha, João Luiz da; Martins, Marcio Rodrigo; Tchaick, Rodrigo Mezzalira; Buffolo, Enio [UNIFESP]; INCOR Hospital Maternidade Marieta Konder Bonhausem; Universidade Federal de São Paulo (UNIFESP); Universidade do Estado de Santa Catarina Hospital Veterinário; Laboratório Rocha; Hospital São José; Santa CasaOBJECTIVE: To assess the histological changes of the aorta, the renal arteries and the renal parenchyma in swine, induced by a metalic uncovered stent implanted in transrenal position in the abdominal aorta. METHODS: Ten pigs with a mean weight of 86.6 kg and mean age of 6 months underwent implantation of metal stent graft placed in the aorta at the level of the renal arteries after 100 days of implantation. The self-expanding stents were released by laparotomy. Anatomic and histological analyses of the abdominal aorta, the renal arteries and the renal parenchyma were performed. Histological slices were performed in the following sites: 1) transitional zone between the aorta with and without stent graft; 2) portion of the renal arteries ostia; 3) renal parenchyma. The slices were stained through the hematoxylin and eosin stain technique and analyzed according the protocol of histological analyses applied in the clinical practice of pathology labs. RESULTS: The macroscopic findings showed thickening of the aortic wall; patent renal arteries; and normal anatomic renal structures. Microscopic analyses, close to the stents, showed thickening of the vascular wall, renal arteries without changes, and preserved renal parenchyma. CONCLUSION: The uncovered stainless steel stent caused a significant inflammatory reaction with thickening of the aortic wall. However, the renal arteries remained patent and the renal parenchyma did not present embolic or ischemic changes.