Navegando por Palavras-chave "Aerobic exercise"

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    The action of pre-exercise low-level laser therapy (LLLT) on the expression of IL-6 and TNF-alpha proteins and on the functional fitness of elderly rats subjected to aerobic training
    (Springer, 2015-04-01) Amadio, Eliane Martins; Serra, Andrey Jorge; Guaraldo, Simone A.; Silva Junior, Jose Antonio; Antonio, Ednei Luiz [UNIFESP]; Silva, Flavio [UNIFESP]; Portes, Leslie Andrews [UNIFESP]; Tucci, Paulo José Ferreira [UNIFESP]; Pinto Leal-Junior, Ernesto Cesar; Carvalho, Paulo de Tarso Camillo de; Univ Nove Julho UNINOVE; Universidade Federal de São Paulo (UNIFESP)
    The aim of the present study was to determine whether low-level laser therapy (LLLT), when used in conjunction with aerobic training, interferes with the expression of inflammatory markers IL-6 and TNF-alpha, thereby influencing the performance of old rats participating in swimming. A total of 30 Wistar rats (Rattus norvegicus albinus) were used for this study: 24 aged rats, and 6 young rats. the older animals were randomly divided into four groups designated as follows: aged-control, aged-exercise, aged-LLLT, aged-LLLT/exercise group, and young-control animals. Aerobic capacity (VO(2)max) was analyzed before and after training period. the aged-exercise and aged-LLLT/exercise groups were trained for 6 weeks. LLLT laser was applied before each training session with 808 nm and 4 J of energy to the indicated groups throughout training. the rats were euthanized, and muscle tissue and serum were collected for muscle cross-sectional area and IL-6 and TNF-alpha protein analysis. in VO2 showed statistical difference between young- and aged-control groups (used as baseline) (p < 0.05). the same difference can be observed in the young control group compared with all intervention groups (exercise, LLLT and LLLT + exercise). in comparison with the aged-control group, a difference was observed only for comparison with the exercise group (p < 0.05), and exercise associated with LLLT group (p < 0.001). Levels of IL-6 and TNF-alpha for the aged-exercise and the aged-LLLT/exercise groups were significantly decreased compared to the aged-control group (p < 0.05). Analysis of the transverse section of the gastrocnemius muscle showed a significant difference between the aged-exercise and aged-LLLT/exercise groups (p < 0.001). These results suggest that laser therapy in conjunction with aerobic training may provide a therapeutic approach for reducing the inflammatory markers (IL-6 and TNF-alpha), however, LLLT without exercise was not able to improve physical performance of aged rats.
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    Aptidão cardiorrespiratória e estado nutricional de escolares: evolução em 30 anos
    (Sociedade Brasileira de Pediatria, 2013-08-01) Ferrari, Gerson Luis de Moraes [UNIFESP]; Bracco, Mario Maia [UNIFESP]; Matsudo, Victor Keihan Rodrigues; Fisberg, Mauro [UNIFESP]; Centro de Estudos do Laboratório de Aptidão Física de São Caetano do Sul; Universidade Federal de São Paulo (UNIFESP); Sociedade Beneficente Israelita Brasileira Albert Einstein Hospital Israelita Albert Einstein
    OBJECTIVE: To compare the changes in cardiorespiratory fitness in evaluations performed every ten years since 1978/1980, according to the nutritional status and gender of students in the city of Ilhabela, Brazil. METHODS: The study is part of the Mixed Longitudinal Project on Growth, Development and Physical Fitness of Ilhabela. The study included 1,291 students of both genders, aged 10 to 11 years old. The study periods were: 1978/1980, 1988/1990, 1998/2000, and 2008/2010. The variables analyzed were: body weight, height, and cardiorespiratory fitness (VO2max -L.min-1 and mL.kg-1.min-1) performed using a submaximal progressive protocol on a cycle ergometer. Individuals were classified as normal weight and overweight according to curves proposed by the World Health Organization of body mass index for age and gender. Analysis of variance (ANOVA) with three factors followed by the Bonferroni method were used to compare the periods. RESULTS: The number of normal weight individuals (61%) was higher than that of overweight. There was a significant decrease in cardiorespiratory fitness in both genders. Among the schoolchildren with normal weight, there was a decrease of 22% in males and 26% in females. In overweight schoolchildren, males showed a decrease of 12.7% and females, of 18%. CONCLUSION: During a 30-year analysis with reviews every ten years from 1978/1980, there was a significant decrease in cardiorespiratory fitness in schoolchildren of both genders, which cannot be explained by the nutritional status. The decline in cardiorespiratory fitness was greater in individuals with normal weight than in overweight individuals.
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    Avaliação do nível de dor e aptidão cardiorrespiratória antes e depois de um programa de exercício aeróbio associado aos efeitos da fotobiomodulação em mulheres com osteoartrite de joelho.
    (Universidade Federal de São Paulo (UNIFESP), 2019-11-25) Wen, Yu Pin [UNIFESP]; Vassão, Patricia Gabrielli [UNIFESP]; Renno, Ana Claudia Muniz [UNIFESP]; http://lattes.cnpq.br/4106611304688552; http://lattes.cnpq.br/8746855238862798; http://lattes.cnpq.br/5498435787402512; Universidade Federal de São Paulo (UNIFESP)
    Introdução: o aparecimento de doenças crônicos degenerativas está intimamente ligado ao processo de envelhecimento. Dentre estas doenças, podemos destacar a osteoartrite (OA). A OA é uma doença caracterizada pela perda gradual da cartilagem articular e do osso subcondral, além do comprometimento na cápsula articular, sinóvia e músculos periarticulares de uma articulação sinovial. Diante isso, estudos mostram que pacientes com OA apresentam capacidades aeróbias prejudicada. As recomendações para os tratamentos consistem primeiramente em tratamentos não farmacológicos como os exercícios aeróbios. Além disso, recursos como fotobiomodulação (FBM) apresenta resultados promissores na sintomatologia de pacientes com OA de joelho. Objetivo: avaliar o antes e o depois do tratamento com exercício aeróbio associado a FBM (placebo ou ativa) no nível de dor e na aptidão cardiorrespiratória em mulheres com OA de joelho grau II e III em comparações intra e intergrupos. Materiais e métodos: foram avaliadas 19 mulheres entre 50 a 70 anos de idade que apresentam OA de joelho grau II e III, radomizadas em 2 grupos: 1) Grupo Exercício FBM Placebo (GEFP, n = 10) tratamento exercício aeróbio associado à FBM placebo; 2) Grupo Exercício FBM Ativa (GEFA, n = 9) tratamento exercício aeróbio associado à FBM ativa. As intervenções foram realizadas 2 vezes por semana com duração de 40 minutos por um período de 8 semanas. A FBM do tipo cluster foi aplicada no joelho com OA (parâmetros: modo contínuo, 808nm, 100mW, 4J/ponto totalizando 56J). Para avaliação inicial e reavalição foram aplicados o questionário Knee Injury and Osteoarthritis Outcome Score (KOOS), escala visual analógica (EVA) de dor e teste de exercício cardiopulmonar (TECP). Análise estatística: foi empregado o modelo de análise de variância com medidas repetidas (ANOVA) para comparar grupos e efeito do tratamento e método de comparações múltiplas de Bonferroni foi utilizado para ajustes intergrupais de comparações múltiplas. Resultados: após 8 semanas de treinamento, houve uma melhora nas variáveis nível de dor (p < 0,001), limiar anaeróbio (p = 0,006) e categorias presentes no questionário KOOS (p < 0,001 para sintoma, atividades desportivas e lazer e qualidade de vida; p = 0,020 para dor; e p = 0,003 para atividades da vida diária). No caso do VO2 máximo, foi estatisticamente significativa somente para o GEFP (p = 0,030). Conclusão: um programa de exercício aeróbio foi capaz de melhorar nível de dor, limiar anaeróbio e funcionalidade em mulheres com OA de joelho. Porém, não foi observada uma potencialização desses efeitos benéficos com a aplicação da FBM após o exercício.
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    Cardiorespiratory fitness and nutritional status of schoolchildren: 30-year evolution
    (Soc Brasil Pediatria, 2013-07-01) Ferrari, Gerson Luis de Moraes [UNIFESP]; Bracco, Mario Maia; Rodrigues Matsudo, Victor K.; Fisberg, Mauro [UNIFESP]; Ctr Estudos Lab Aptidao Fis Sao Caetano Sul CELAF; Universidade Federal de São Paulo (UNIFESP); Hosp Israelita Albert Einstein; CELAFISCS
    Objective: To compare the changes in cardiorespiratory fitness in evaluations performed every ten years since 1978/1980, according to the nutritional status and gender of students in the city of Ilhabela, Brazil.Methods: the study is part of the Mixed Longitudinal Project on Growth, Development and Physical Fitness of Ilhabela. the study included 1,291 students of both genders, aged 10 to 11 years old. the study periods were: 1978/1980, 1988/1990, 1998/2000, and 2008/2010. the variables analyzed were: body weight, height, and cardiorespiratory fitness (VO2max - L.min-1 and mL.kg-1.min-1) performed using a submaximal progressive protocol on a cycle ergometer. Individuals were classified as normal weight and overweight according to curves proposed by the World Health Organization of body mass index for age and gender. Analysis of variance (ANOVA) with three factors followed by the Bonferroni method were used to compare the periods.Results: the number of normal weight individuals (61%) was higher than that of overweight. There was a significant decrease in cardiorespiratory fitness in both genders. Among the schoolchildren with normal weight, there was a decrease of 22% in males and 26% in females. in overweight schoolchildren, males showed a decrease of 12.7% and females, of 18%.Conclusion: During a 30-year analysis with reviews every ten years from 1978/1980, there was a significant decrease in cardiorespiratory fitness in schoolchildren of both genders, which cannot be explained by the nutritional status. the decline in cardiorespiratory fitness was greater in individuals with normal weight than in overweight individuals. (C) 2013 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.
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    Efeito de diferentes sessões agudas de exercícios físicos na pressão arterial clínica e ambulatorial de idosos hipertensos
    (Universidade Federal de São Paulo (UNIFESP), 2010-12-15) Scudeler, Luiz Henrique Piccin [UNIFESP]; Medeiros, Alessandra [UNIFESP]; http://lattes.cnpq.br/0071198026371230; http://lattes.cnpq.br/6284345847316078; Universidade Federal de São Paulo (UNIFESP)
    Introdução: Associado a maus hábitos comportamentais, como alimentação inadequada, estilo de vida sedentário e dependência química, o envelhecimento populacional traz como consequência o aumento da prevalência de doenças crônicas, entre elas a hipertensão arterial. Objetivo: Tendo em vista os benefícios trazidos pela prática regular de exercícios físicos, este estudo teve como objetivo analisar os possíveis efeitos de diferentes sessões agudas de exercício físico sobre a pressão arterial clínica e ambulatorial. Métodos: Quatro mulheres idosas hipertensas foram submetidas a quatro sessões agudas distintas de exercícios físicos: sessão controle, na qual era composta por 50 minutos de repouso sentado; sessão de exercício aeróbio a 70% da frequência cardíaca máxima, com duração de 50 minutos em esteira rolante; sessão de exercício resistido, com carga de 50% de 1 repetição máxima; sessão de exercício concorrente, que era composta por 25 minutos na esteira rolante, a uma intensidade de 70% da frequência cardíaca máxima e 20 minutos de sessão resistida, a uma intensidade de 50% de 1 repetição máxima. Foram aferidas pressão arterial sistólica, diastólica, média e frequência cardíaca em um momento préexercício e após 20 minutos do seu término. Em seguida, foram instalados os monitores de pressão arterial ambulatorial nos indivíduos a fim de se obter as médias ambulatoriais, nos períodos de vigília e sono, das mesmas variáveis descritas. Resultados: Os achados deste estudo sugerem que as três sessões de exercícios físicos promoveram o efeito hipotensor pósexercício. Observamos o efeito hipotensor nos valores clínicos e ambulatoriais da pressão arterial, após sessões de exercício aeróbio e resistido. Já após a sessão de exercícios concorrente, observamos apenas o fenômeno hipotensor nas médias ambulatoriais da pressão arterial. Conclusão: Após este estudo, sugerimos que a prática de exercícios aeróbios, resistidos e concorrentes é uma importante estratégia para reduzir valores de pressão arterial em idosas hipertensas. Assim sendo, o exercício físico é um coadjuvante para o tratamento, prevenção da hipertensão arterial.
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    Efeito do exercício aeróbico à distância em relação ao presencial sobre os parâmetros cardiorrespiratórios e capacidade funcional de pacientes com doença renal crônica e excesso de peso
    (Universidade Federal de São Paulo (UNIFESP), 2016-02-29) Aoike, Danilo Takashi [UNIFESP]; Cuppari, Lilian [UNIFESP]; http://lattes.cnpq.br/3552074553183694; http://lattes.cnpq.br/2761150276098022; Universidade Federal de São Paulo (UNIFESP)
    Introduction: In patients with chronic kidney disease (CKD) the presence of overweight or obesity is associated with several metabolic complications, including worsening renal function. In addition, the association between CKD and excess body fat can lead to aggravation of cardiorespiratory capacity, physical function and quality of life of the patients. Studies show that aerobic training improves several aspects of physical capacity of these patients. Although the incorporation of physical exercise on a CKD standard treatment is a challenge and this is recommended by current guidelines for all stages of disease. Besides, the lack of studies showing real benefits of practical and affordable programs further complicates the implementation of training programs for these patients. Objective: The aim of this study was compare the performance of aerobic exercise performed remotely (home-based) with the conducted in person (center-base) on cardiorespiratory and functional capacity of overweight patients with non- dialysis dependent CKD (stage 3 or 4). Methods: This was a prospective, randomized, interventional, controlled trial of a 24 weeks. Forty sedentary patients were studied (27 men), aged 55.5±8.3 years (mean±SD); BMI of 31.2±4.4 kg/m2 and estimated glomerular filtration rate of 26.9±11.7 mL/min/1.73m2. The patients were randomly assigned to the control group or the exercise group. Those who were assigned to the exercise group could choose to perform the home-based exercise or center-based exercise. The control group was instructed not to perform exercise during the follow-up. The patients from the center-based exercise group performed the aerobic training on a treadmill three times per week during 12 weeks on 9 alternate days at the Psychobiology and Exercise Study Centre under supervision of an exercise physiologist. The patients from the home-based exercise group performed aerobic training at locations nearby their home, backyard, park or street three times per week on alternate days during 12 weeks according to the instructions given by exercise physiologist. The exercised groups were subjected to the same continuous aerobic exercise protocol consisted of three weekly sessions on alternate days, at the intensity of anaerobic threshold lasting 30 minutes. The duration was increased by 10 minutes every four weeks until it reached 50 minutes. Patients underwent assessment of cardiorespiratory fitness, functional capacity tests, the questionnaire of quality of life (SF-36), questionnaire of quality of sleep (Pittsburgh sleep quality index) and routine laboratory tests before, after 12 weeks and after 24 weeks of follow-up. Results: A significant increase (p<0.05) of VO2 peak, speed at anaerobic threshold, VO2 at respiratory compensation point and maximum ventilation was observed after 12 weeks of training in the home-based group, reaching values similar to those obtained in the center-based group . As for the functional testing was observed improvement in 6-minute walk test, time up and go test, step test, sit and stand test and arm curl test was found after 12 weeks of training in the home-based group, achieving values not different from those in the center-based group. In both exercised groups the values achieved in the tests were maintained until the end of 24 weeks. No changes in those parameters were observed in the control group. The benefits observed in cardiorespiratory parameters and functional capacity resulting from the exercise reflected in improved quality of life and sleep. In addition, only in the exercised groups there 10 was a decrease in blood pressure, with no change in antihypertensive medication, sodium intake and body weight. No adverse effects were observed. Conclusion: Home-based aerobic training promoted similar benefits to those found in the center-based group in cardiorespiratory fitness, functional capacity, quality of life and sleep besides reducing blood pressure of overweight patients with CKD. The results of this study indicate that home-based exercise is effective and can be used safely.
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    Efeito do exercício aeróbico sobre marcadores séricos do metabolismo mineral e ósseo de pacientes com doença renal crônica e excesso de peso na fase não dialítica
    (Universidade Federal de São Paulo (UNIFESP), 2016-11-30) Gomes, Tarcisio Santana [UNIFESP]; Cuppari, Lilian [UNIFESP]; http://lattes.cnpq.br/3552074553183694; http://lattes.cnpq.br/6346206363371233; Universidade Federal de São Paulo (UNIFESP)
    Introduction: Chronic kidney disease (CKD) is currently considered a public health problem. Obesity, condition commonly observed in this population, has been identified as an independent risk factor for the development and progression of CKD. Studies show the prevalence of obesity is increasing in parallel with the growing incidence of CKD. Hormonal and metabolic changes due CKD, including hyperphosphatemia, hypocalcemia, increased secretion of parathyroid hormone (PTH) and fibroblast growth factor (FGF-23) and reduced renal synthesis of calcitriol (1,25 (OH)2D) are the main factors responsible for the development of mineral and bone disorder of CKD (CKD-MBD), which is a broad clinical syndrome that includes bone mineral calcification and cardiovascular disorders. The association of CKD and obesity may promote changes in bone, contributing for worsening the quality of life of these patients. Studies show that physical exercise improves several aspects of physical and functional capacity of patients with CKD. However, the impact of exercise on bone metabolism in these patients has been poorly investigated. Recently, serum markers of bone metabolism have been identified and used to detect the dynamics of bone metabolism in response to exercise. Objective: To investigate the effect of aerobic exercise training on bone metabolism markers in overweight patients with non-dialysis-dependent CKD (NDD-CKD). Methods: This is a prospective, longitudinal study with post hoc analysis. The study was randomized and controlled aimed to compare the effect of home-based aerobic exercise (walking) and performed in a specialized center on cardiorespiratory and functional parameters of patients with CKD and overweight. We studied 39 sedentary patients (69% male) who were on stage 3 or 4 of CKD, aged 55.5±8.3 years (mean ± SD), BMI 31.2±4,4 kg / m2 and estimated glomerular filtration rate (eGFR) of 26.9±11.7 mL / min / 1.73m2 who were randomly assigned to the aerobic exercise group (n = 24) or the control group (n = 15). Patients were tested for cardiorespiratory fitness, functional capacity and routine laboratory tests before and after 24 weeks of follow-up. Training program was conducted in accordance with the VO2peak patients. Traditional markers of bone and mineral metabolism such as PTH, calcium, phosphorus and total alkaline phosphatase, were analyzed. Carboxylated osteocalcin (GLA), undercarboxylated osteocalcin (GLU), sclerostin, tartrate-resistant acid phosphatase isoform 5b (TRAP 5b) from serum stored at -80 °C. were determined by enzyme-linked immunosorbent assay (ELISA) according to the specifications of the suppliers. Results: At baseline there were no differences between the groups regarding demographic, clinical, physical and functional capacity, body composition and bone metabolism markers. At baseline, GLA and GLU were inversely correlated with eGFR. Both osteocalcin fragments were positively correlated with total alkaline phosphatase. An inverse correlation was found between GLA and sclerostin with body fat. In contrast, GLU was negatively correlated with markers of muscle mass. TRAP-5b and sclerostin were inversely correlated with 6-min walk test and time up and go test, respectively. The VO2peak, marker of cardiorespiratory capacity is not related to any of the bone metabolism markers analyzed. In both groups, eGFR, body weight and body composition parameters did not change during the study. After 24 weeks all physical capacity parameters increased in the exercise group (p < 0.001). Except for total alkaline phosphatase that increased after 24 weeks in the exercise group (p < 0.05), no other changes were observed in both groups in relation to the bone metabolism markers investigated. Conclusion: Our study showed that the proposed aerobic training did not promote relevant changes in the bone metabolism markers studied despite the improvement in physical capacity of patients.
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    Efeito do exercício agudo realizado em altitude simulada sobre parâmetros imunológicos e bioquímicos
    (Universidade Federal de São Paulo, 2012-03-14) Machado, Paola Próspero [UNIFESP]; Santos, Ronaldo Vagner Thomatieli dos [UNIFESP]; http://lattes.cnpq.br/9928572887023286; http://lattes.cnpq.br/1145122222906874; Universidade Federal de São Paulo (UNIFESP)
    Elevadas altitudes sempre foram desafios para a humanidade. A hipóxia é a explicação para essas dificuldades já que representa um estresse adicional ao organismo além daquele causado pelo exercício físico agudo. A realização de exercício físico agudo induz diversas respostas fisiológicas e bioquímicas com elevado poder imunossupressor. Objetivo: verificar os efeitos do exercício em hipóxia sobre parâmetros inflamatórios e metabólicos. Metodologia: os voluntários foram submetidos a duas sessões de exercício agudo, sendo uma em normóxia e outra em hipóxia simulando altitude de 4200 metros. Antes, imediatamente após as sessões de exercício e depois de 60 minutos de recuperação foram coletados 10 ml de sangue para as dosagens plasmáticas. Resultados: ambas as sessões de exercícios, em normóxia e hipóxia, promoveram diminuição da saturação de oxigênio e o aumento de marcadores de lesão celular de forma mais acentuada ocorreu em hipóxia. Enquanto em normóxia o exercício promoveu alterações aumentando a reposta inflamatória pósexercício, em hipóxia as alterações induziram maior efeito antiinflamatório. Conclusão: o exercício em hipóxia, simulando altitude de 4200 metros, representa estresse maior do que o mesmo exercício em normóxia; a maior exigência em virtude da hipóxia não foi suficiente para impor modificações adicionais nos marcadores de dano celular; o exercício moderado na hipóxia atenua os efeitos inflamatórios que a hipóxia apresenta.
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    Efeitos da fotobiomodulação com dosagem progressiva associada a um protocolo de exercício aeróbio no nível de dor e qualidade de vida de mulheres com fibromialgia: controlado, randomizado e cego
    (Universidade Federal de São Paulo, 2022-01-25) Credidio, Beatriz Mendes [UNIFESP]; Renno, Ana Claudia Muniz [UNIFESP]; Vassão, Patricia Gabrielli [UNIFESP]; Balão, Ana Beatriz [UNIFESP]; http://lattes.cnpq.br/8746855238862798; http://lattes.cnpq.br/2381613310217783; http://lattes.cnpq.br/4106611304688552; http://lattes.cnpq.br/8765685906733380; Universidade Federal de São Paulo (UNIFESP)
    A fibromialgia (FM) é caracterizada pela dor muscular generalizada crônica, que acomete principalmente mulheres. Vários estudos já demonstraram que exercícios aeróbicos se mostram efetivos para a melhora da dor e da qualidade de vida desta população; outros estudos que a fotobiomodulação (FBM) também é efetiva neste sentido. No entanto, não há consenso na literatura a respeito dos melhores parâmetros da FBM do tipo cluster para tratar pacientes com FM, bem como, o uso em dosagem progressiva ao longo do tratamento. Assim, o objetivo deste estudo foi verificar o efeito da associação de um protocolo de exercício aeróbio e a FBM, com dosagem progressiva, no nível de dor e na qualidade de vida relacionado a saúde de mulheres com FM. As mulheres foram randomizadas e divididas em dois grupos: GEFA: grupo exercício e FBM ativa (n=4), ou GEFP: grupo exercício e FBM placebo (n=8). Antes da primeira sessão e após a última sessão de tratamento foi avaliado como desfecho primário o nível de dor através da Escala Visual Analógica (EVA), e como desfechos secundários o Questionário do Impacto de Fibromialgia Revisado (FIQR-Br, do inglês Fibromyalgia Impact Questionnaire), qualidade de vida pelo Medical Outcomes Study 36-item Short Form Health Survey (SF-36), e qualidade do sono pelo Pittsburgh Sleep Quality Index (PSQI) e Epworth Sleepiness Scale (ESS). As intervenções tiveram duração de 12 semanas, 2 vezes por semana com a realização do exercício aeróbio em bicicleta estacionária com progressão de carga associado a aplicação da FBM do tipo cluster (808nm, 100mW, de 20 a 40J por aplicação) ativo ou placebo. Os resultados demonstraram que o tratamento proposto foi capaz de melhorar significativamente o nível de dor para o domínio EVA da menor dor sentida na semana anterior, GEPA (p= 0,007) e GEFP (p= 0,002), a qualidade de vida, GEPA (p<0,0001) e GEFP (p= 0,005), o impacto da doença, GEPA (p=0,01) e GEFP (p= 0,003), e a qualidade do sono, GEFA (p= 0,001) e GEFP (p= 0,0001), em ambos os grupos. Ainda, o GEFP melhorou significativamente o nível de dor em movimento pela EVA (p=0,004), da qualidade de vida nos domínios limitação por aspectos emocionais (p= 0,0002) e dor (p= 0,019), e a qualidade do sono (p= 0,043) pelo PSQI. E o GEFA apresentou melhora significativa nos domínios função física (p= 0,033) e vitalidade (p=0,004). E por fim, a qualidade de vida para o domínio limitação por aspectos emocionais foi significativamente maior para o GEFP (p<0,0001), sendo que o GEFP apresentou valor superior ao GEFA. Assim, podemos concluir que os dados parciais deste estudo demonstram que um programa de treino aeróbico em bicicleta ergométrica foi capaz de demonstrar benefícios na dor, qualidade de vida e sono em mulheres com FM, mas a associação da FBM com o exercício não produziu o efeito extra na maioria das variáveis analisadas. Com isso, torna-se de suma importância a continuidade do estudo para conclusões mais definitivas.
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    Efeitos terapêuticos do quiabo e/ou treinamento físico nas alterações renais observadas em animais com síndrome metabólica
    (Universidade Federal de São Paulo (UNIFESP), 2018) José, Carolina Gonçalves dos Reis [UNIFESP]; Medeiros, Alessandra [UNIFESP]; Moura, Elizabeth de Orleans Carvalho de [UNIFESP]; http://lattes.cnpq.br/7179837567280020; http://lattes.cnpq.br/0071198026371230; http://lattes.cnpq.br/6645776696028954; Universidade Federal de São Paulo (UNIFESP)
    Para prevenção e tratamento da síndrome metabólica (SM) podem ser utilizadas terapias não farmacológicas como o treinamento físico (TF) e intervenções nutricionais como a suplementação com quiabo (Q). OBJETIVO: Analisar os possíveis efeitos terapêuticos do quiabo associado ou não ao treinamento físico no tecido renal. MATERIAIS E MÉTODOS: 38 ratos Zuckers foram separados em 5 grupos: 10 ratos controle (CTL), 7 ratos que não passaram por nenhuma intervenção (SM), 7 ratos que receberam quiabo (Q), 7 ratos que realizaram treinamento físico aeróbico (TF) e 7 ratos que receberam quiabo e realizaram treinamento físico (TF+Q). O quiabo foi administrado por gavagem (200 mg/Kg do animal) e o TF foi realizado em esteira rolante, 1h por dia, ambos durante 6 semanas. Foi analisado o consumo hídrico e a diurese desses animais. Na urina foram mensurados os níveis úricos de bilirrubina, urobilinogênio, cetona, ácido ascórbico, glicose, proteína, sangue, pH, nitrito, leucócito e densidade através de fitas reagentes Uriquest Plus da marca Labtest, após a eutanásia foram pesados os rins desses animais e foi feito uma análise de estresse oxidativo. RESULTADOS: Dentre as análises realizadas, foram encontradas diferenças estatísticas no consumo hídrico, nas concentrações de proteína e de leucócitos, além do status antioxidante total. O grupo SM apresentou menor consumo hídrico quando comparado ao grupo CTL, e dentre as terapias utilizadas, apenas o grupo Q apresentou normalização dessa variável. Em relação à proteína, o grupo SM apresentou uma concentração mais elevada na urina quando comparado ao grupo CTL e apenas o grupo TF+Q apresentou redução parcial dessa concentração na urina. Com relação aos leucócitos, o grupo SM também apresentou valor mais alto quando comparado ao grupo CTL, e todas as intervenções (Q, TF e TF+Q) proporcionaram redução dessa concentração na urina. Já o status antioxidativo total foi semelhante entre os grupos CTL e SM, no entanto, foi menor nos grupos TF e TF+Q. CONCLUSÃO: Os resultados encontrados no presente estudo demonstram que a associação de TF e Q proporcionou maiores benefícios para os rins dos animais com SM
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    Efetividade do exercício físico na insuficiência renal crônica
    (Pontifícia Universidade Católica do Paraná, 2012-03-01) Nascimento, Leilane Cristielle de Alencar; Coutinho, Érika Bona; Silva, Kelson Nonato Gomes da [UNIFESP]; Universidade Estadual do Piauí; Centro Universitário de Maringá; Universidade Federal de São Paulo (UNIFESP)
    INTRODUCTION: Physical activity in nephropathy patients submitted to hemodialysis becomes important since these patients presents marked reduction in the functionality and conditioning that impairs life quality. However, the benefits, the most appropriate type of exercise and parameters such as intensity, frequency and duration are not well defined in this population. OBJECTIVES: To review the literature about the effects of physical exercise in chronic renal patients submitted to hemodialysis. MATERIALS AND METHODS: MEDLINE, LILACS, PEDro, PubMed and SciELO bases were searched, being selected articles (clinical randomized controlled trials, series of case and case study) in languages, English and Portuguese, published between 2000 and 2010. RESULTS: 105 articles were found, 82 from PubMed database, 16 from PEDro and 7 from SciELO base. No articles were found in MEDLINE and LILACS bases. From these ones, only seven fulfilled the inclusion criteria. From these seven articles, an active manual search was held in the list of references of these publications, being possible to verify in them the presence of only three references. CONCLUSION: By the reviewed articles it was possible to conclude that either aerobic and/or physical exercise have incremental effects on functional capacity, muscle function and life quality of nephropathy patients submitted to hemodialysis. Therefore, physical training should be considered as an important therapeutic modality, being central the insertion of the physiotherapist in dialysis centers as part of a multidisciplinary team.
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    Effect of exercise on glutamine synthesis and transport in skeletal muscle from rats
    (Wiley-Blackwell, 2009-08-01) Santos, Ronaldo Vagner Thomatieli dos [UNIFESP]; Caperuto, Erico C.; Mello, Marco Tulio de [UNIFESP]; Batista, Miguel L.; Rosa, Luis F. B. P. C.; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)
    P>Reductions in plasma glutamine are observed after prolonged exercise. Three hypotheses can explain such a decrease: (i) high demand by the liver and kidney; (ii) impaired release from muscles; and (iii) decreased synthesis in skeletal muscle. the present study investigated the effects of exercise on glutamine synthesis and transport in rat skeletal muscle.Rats were divided into three groups: (i) sedentary (SED; n = 12); (ii) rats killed 1 h after the last exercise bout (EX-1; n = 15); and (iii) rats killed 24 h after the last exercise bout (EX-24; n = 15). Rats in the trained groups swam 1 h/day, 5 days/week for 6 weeks with a load equivalent to 5.5% of their bodyweight.Plasma glutamine and insulin were lower and corticosterone was higher in EX-1 compared with SED rats (P < 0.05 and P < 0.01, respectively). Twenty-four hours after exercise (EX-24), plasma glutamine was restored to levels seen in SED rats, whereas insulin levels were higher (P < 0.001) and costicosterone levels were lower (P < 0.01) than in EX-1. in the soleus, ammonia levels were lower in EX-1 than in SED rats (P < 0.001). After 24 h, glutamine, glutamate and ammonia levels were lower in EX-24 than in SED and EX-1 rats (P < 0.001). Soleus glutamine synthetase (GS) activity was increased in EX-1 and was decreased in EX-24 compared with SED rats (both P < 0.001).The decrease in plasma glutamine concentration in EX-1 is not mediated by GS or glutamine transport in skeletal muscle. However, 24 h after exercise, lower GS may contribute to the decrease in glutamine concentration in muscle.
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    The effect of low-level laser therapy on oxidative stress and functional fitness in aged rats subjected to swimming: an aerobic exercise
    (Springer London Ltd, 2016) Guaraldo, Simone A.; Serra, Andrey Jorge; Amadio, Eliane Martins; Antonio, Ednei Luis [UNIFESP]; Silva, Flavio [UNIFESP]; Portes, Leslie Andrews [UNIFESP]; Ferreira Tucci, Paulo Jose [UNIFESP]; Pinto Leal-Junior, Ernesto Cesar; Camillo de Carvalho, Paulo de Tarso
    The aim of the present study was to determine whether low-level laser therapy (LLLT) in conjunction with aerobic training interferes with oxidative stress, thereby influencing the performance of old rats participating in swimming. Thirty Wistar rats (Norvegicus albinus) (24 aged and six young) were tested. The older animals were randomly divided into aged-control, aged-exercise, aged-LLLT, aged-LLLT/exercise, and young-control. Aerobic capacity (VO2max0.75) was analyzed before and after the training period. The exercise groups were trained for 6 weeks, and the LLLT was applied at 808 nm and 4 J energy. The rats were euthanized, and muscle tissue was collected to analyze the index of lipid peroxidation thiobarbituric acid reactive substances (TBARS), glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) activities. VO(2)(0.75)max values in the aged-LLLT/exercise group were significantly higher from those in the baseline older group (p < 0.01) and the LLLT and exercise group (p < 0.05). The results indicate that the activities of CAT, SOD, and GPx were higher and statistically significant (p < 0.05) in the LLLT/exercise group than those in the LLLT and exercise groups. Young animals presented lesser and statistically significant activities of antioxidant enzymes compared to the aged group. The LLLT/exercise group and the LLLT and exercise group could also mitigate the concentration of TBARS (p > 0.05). Laser therapy in conjunction with aerobic training may reduce oxidative stress, as well as increase VO(2)(0.75)max, indicating that an aerobic exercise such as swimming increases speed and improves performance in aged animals treated with LLLT.
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    Effectiveness of physical activity in reducing pain in patients with fibromyalgia: a blinded randomized clinical trial
    (Springer, 2012-08-01) Kayo, Andrea Harumi [UNIFESP]; Peccin, Maria Stella [UNIFESP]; Sanches, Carla Munhoz [UNIFESP]; Moca Trevisani, Virginia Fernandes [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Santo Amaro Univ UNISA
    The purpose of this study was to evaluate and compare the effectiveness of muscle-strengthening exercises (MS) and a walking program (WA) in reducing pain in patients with fibromyalgia. Ninety women, 30-55 years of age, diagnosed with fibromyalgia according to the American College of Rheumatology 1990 criteria, were randomized into 3 groups: WA Group, MS Group, and control group. Pain (visual analog scale) was evaluated as the primary outcome. Physical functioning (Fibromyalgia Impact Questionnaire, FIQ), health-related quality of life (Short-Form 36 Health Survey, SF-36), and use of medication were evaluated as secondary outcomes. Assessments were performed at baseline, 8, 16, and 28 weeks. Intention-to-treat and efficacy analyses were conducted. Sixty-eight patients completed the treatment protocol. All 3 groups showed improvement after the 16-week treatment compared to baseline. At the 28-week follow-up, pain reduction was similar for the WA and MS groups (P = 0.39), but different from the control group (P = 0.01). At the end of the treatment, 80% of subjects in the control group took pain medication, but only 46.7% in the WA and 41.4% in the MS groups. Mean FIQ total scores were lower for the WA and MS groups (P = 0.96) compared with the control group (P < 0.01). Patients in the WA and MS groups reported higher scores (better health status) than controls in almost all SF-36 subscales. MS was as effective as WA in reducing pain regarding all study variables; however, symptoms management during the follow-up period was more efficient in the WA group.
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    Home-based versus center-based aerobic exercise on cardiopulmonary performance, physical function, quality of life and quality of sleep of overweight patients with chronic kidney disease
    (Springer, 2018) Aoike, Danilo Takashi [UNIFESP]; Baria, Flavia [UNIFESP]; Kamimura, Maria Ayako [UNIFESP]; Ammirati, Adriano [UNIFESP]; Cuppari, Lilian [UNIFESP]
    The association between chronic kidney disease (CKD) and obesity can decrease the patients' cardiopulmonary capacity, physical functioning and quality of life. The search for effective and practical alternative methods of exercise to engage patients in training programs is of great importance. Therefore, we aimed to compare the effects of home-based versus center-based aerobic exercise on the cardiopulmonary and functional capacities, quality of life and quality of sleep of overweight non-dialysis-dependent patients with CKD (NDD-CKD). Forty sedentary overweight patients CKD stages 3 and 4 were randomly assigned to an exercise group [home-based group (n = 12) or center-based exercise group (n = 13)] or to a control group (n = 15) that did not perform any exercise. Cardiopulmonary exercise test, functional capacity tests, quality of life, quality of sleep and clinical parameters were assessed at baseline, 12 and 24 weeks. The VO2peak and all cardiopulmonary parameters evaluated were similarly improved (p < 0.05) after 12 and 24 weeks in both exercise groups. The functional capacity tests improved during the follow-up in the home-based group (p < 0.05) and reached values similar to those obtained in the center-based group. The benefits achieved in both exercise groups were also reflected in improvement of quality of life and sleep (p < 0.05). No differences were observed between the exercise groups, and no changes in any of the parameters investigated were found in the control group. Home-based aerobic training was as effective as center-based training in improving the physical and functional capabilities, quality of life and sleep in overweight NDD-CKD patients.
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    A influência de diferentes sessões agudas de exercícios físicos nos aspectos psicobiológicos de idosos hipertensos
    (Universidade Federal de São Paulo (UNIFESP), 2011-12-06) Oliveira, Renan Luis de [UNIFESP]; Medeiros, Alessandra [UNIFESP]; http://lattes.cnpq.br/0071198026371230; http://lattes.cnpq.br/0071198026371230; Universidade Federal de São Paulo (UNIFESP)
    Introdução: O presente estudo teve como objetivo verificar a influência de diferentes sessões de exercício físico agudo resistido (musculação), aeróbio e concorrente (aeróbio mais musculação) nos aspectos psicológicos em idosos hipertensos. Para tanto, foram selecionados 4 idosos (67,6 ± 7,15 anos), todos do sexo feminino.Materiais e métodos: Os voluntários foram submetidos a uma avaliação inicial, na qual foram aplicados questionários que avaliam ansiedade (IDATE-Estado), humor (BRUMS) pré sessão e imediatamente após o término da sessão aguda de exercício e posteriormente foram avaliadas quais mudanças ocorreram. Resultados: Os resultados apesar de não apresentarem significância estatística mostraram que uma única sessão de exercício físico pode impactar sobre os aspectos psicobiológicos de maneira positiva ou negativa, cabendo maiores investigações sobre as sessões propostas. Conclusão: A análise dos dados observados com a aplicação dos questionários sugere que apenas uma sessão aguda de exercício físico, pode auxiliar na redução dos escores de ansiedade e humor negativo (raiva e depressão).
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    Influência do treinamento físico combinado nas vias de sinalização da mTOR e da PGC-1α renal em ratos com diabetes experimental
    (Universidade Federal de São Paulo (UNIFESP), 2016-06-30) Jorge, Luciana [UNIFESP]; Schor, Nestor [UNIFESP]; http://lattes.cnpq.br/8276708741672261; http://lattes.cnpq.br/0873489026647730; Universidade Federal de São Paulo (UNIFESP)
    Diabetes Mellitus (DM) is a multifactorial disease resulting from either failure in the secretion of insulin, and in the commitment of its action, leading to hyperglycemia and producing changes in the metabolism of carbohydrates, fats and proteins. These changes induce complications, among which stands out the diabetic nephropathy (DN). In these cases, the activation of molecular pathways plays an important role in the pathophysiological process. Studies indicated that regular physical exercise is an effective tool to decrease the progression of DN being indicated as a non-­? pharmacological treatment. The aim of this study was to evaluate the benefits of aerobic and resistance exercise in the pathophysiology of ND with subsequent possibility of prescription of this type of training for both healthy subjects and diabetic, aimed to minimize the deterioration of renal function. In this study, Wistar rats were submitted to three different exercise training (ET) protocols, which were prescribed with intensity of 40 to 60%, based on the results of stress tests specific to each modality. Streptozotocin (STZ) was used to diabetes induction (50 mg / kg IV). Animals were separated into eight groups: four controls (non-­?trained, trained resisted, trained aerobic and combined trained) and four diabetics (non-­?trained, trained resisted, trained aerobic and combined trained), with 6 to 8 rats / group. Were analyzed blood glucose, response to the maximum test effort, weight and kidney function, renal histology and proteins expression in dynamic mitochondrial pathway (AMPK/Mfn2/DRP-­?1) and renal hyperthrophy pathway (AKT/mTOR) (assessed by Western blot). Ours results showed that all ET modality can modulate the in dynamic mitochondrial pathway (p<0,05) and renal hyperthrophy pathway (p<0,05) when compared with the diabetics non trained, in addition the progression of diabetic nephropathy,atenued the proteinuria and renal dysfunction (p<0,05). This results showed that the associated the aerobic and resistance can be control/prevent the diabetic nephropathy, may be a non pharmacological treatments in a significant way.
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    Moderate exercise increases the metabolism and immune function of lymphocytes in rats
    (Springer, 2013-05-01) Navarro, Francisco; Nova Bacurau, Aline Villa; Pereira, Guilherme Borges; Araujo, Ronaldo Carvalho [UNIFESP]; Almeida, Sandro Soares [UNIFESP]; Moraes, Milton Rocha [UNIFESP]; Uchida, Marco Carlos; Pereira Costa Rosa, Luis Fernando Bicudo; Navalta, James; Prestes, Jonato; Pereira Bacurau, Reury Frank; Univ Fed Maranhao; Universidade de São Paulo (USP); Universidade Federal de São Carlos (UFSCar); Universidade Federal de São Paulo (UNIFESP); Universidade Estadual de Campinas (UNICAMP); Univ Nevada; Univ Catolica Brasilia
    Exercise modulates both glucose and glutamine metabolism which influences lymphocyte function. We investigated the influence of chronic moderate exercise on glucose and glutamine metabolism in lymphocytes, the associated influence on proliferation, and cytokine and immunoglobulin production. Male Wistar rats (8 weeks old) were placed in an exercise training group (N = 15, 1 h day(-1) at 60 % VO2max, 5 days week(-1)) for 8 weeks of exercise, or a sedentary control group. Twenty-four hours following the final training session, lymphocytes were separated, and the incorporation of [U-14C]-glucose, [U-14C]-glutamine, and [2-14C]-thymidine from the supernatant was measured. the activity of glucose-6-phosphate dehydrogenase, hexokinase, and glutaminase was measured. Lymphocytes were stimulated with ConA and LPS and incubated with the Mycobacterium bovis bacille Calmette-Guerin (BCG) vaccine and plasma IgG and IgE were measured. Glutamine metabolism increased in both T and B lymphocytes in the trained group. in the trained group, proliferative capacity increased T lymphocytes under ConA stimulation, and increased B lymphocytes with LPS. There was a significant increase in IL-2 production and decrease in IL-4 in the trained group compared with sedentary controls. IL-2R and TNFR increased in trained rats while IL-4R decreased and were more pronounced in T lymphocytes compared with B lymphocytes. in both lymphocyte subsets, exercise training significantly increased the expression of CD54+ and CD30+ cell markers. Exercise training increased plasma IgG compared with the sedentary group. in conclusion, moderate exercise training improves immune function and metabolism in T and B lymphocytes, reflecting an increased ability to respond to immune challenges.
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    Physical exercise, neuroplasticity, spatial learning and memory
    (Springer Basel Ag, 2016) Cassilhas, Ricardo Cardoso [UNIFESP]; Tufik, Sergio [UNIFESP]; Mello, Marco Tulio de
    There has long been discussion regarding the positive effects of physical exercise on brain activity. However, physical exercise has only recently begun to receive the attention of the scientific community, with major interest in its effects on the cognitive functions, spatial learning and memory, as a non-drug method of maintaining brain health and treating neurodegenerative and/or psychiatric conditions. In humans, several studies have shown the beneficial effects of aerobic and resistance exercises in adult and geriatric populations. More recently, studies employing animal models have attempted to elucidate the mechanisms underlying neuroplasticity related to physical exercise-induced spatial learning and memory improvement, even under neurodegenerative conditions. In an attempt to clarify these issues, the present review aims to discuss the role of physical exercise in the improvement of spatial learning and memory and the cellular and molecular mechanisms involved in neuroplasticity.
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    Strength and power training did not modify cardiovascular responses to aerobic exercise in elderly subjects
    (Associação Brasileira de Divulgação Científica, 2011-09-01) Kanegusuku, Hélcio; Queiroz, Andréia Carneiro Carrenho; Chehuen, Marcel da Rocha; Costa, Luiz Augusto Riani; Wallerstein, Lilian França; Mello, Marco Tulio de [UNIFESP]; Ugrinowitsch, Carlos; Forjaz, Cláudia Lúcia de Moraes; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
    Resistance training increases muscle strength in older adults, decreasing the effort necessary for executing physical tasks, and reducing cardiovascular load during exercise. This hypothesis has been confirmed during strength-based activities, but not during aerobic-based activities. This study determined whether different resistance training regimens, strength training (ST, constant movement velocity) or power training (PT, concentric phase performed as fast as possible) can blunt the increase in cardiovascular load during an aerobic stimulus. Older adults (63.9 ± 0.7 years) were randomly allocated to: control (N = 11), ST (N = 13, twice a week, 70-90% 1-RM) and PT (N = 15, twice a week, 30-50% 1-RM) groups. Before and after 16 weeks, oxygen uptake (VO2), systolic blood pressure (SBP), heart rate (HR), and rate pressure product (RPP) were measured during a maximal treadmill test. Resting SBP and RPP were similarly reduced in all groups (combined data = -5.7 ± 1.2 and -5.0 ± 1.7%, respectively, P < 0.05). Maximal SBP, HR and RPP did not change. The increase in measured VO2, HR and RPP for the increment in estimated VO2 (absolute load) decreased similarly in all groups (combined data = -9.1 ± 2.6, -14.1 ± 3.9, -14.2 ± 3.0%, respectively, P < 0.05), while the increments in the cardiovascular variables for the increase in measured VO2 did not change. In elderly subjects, ST and PT did not blunt submaximal or maximal HR, SBP and RPP increases during the maximal exercise test, showing that they did not reduce cardiovascular stress during aerobic tasks.