Navegando por Palavras-chave "ALPHA(2)-MACROGLOBULIN"

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    PARTICIPATION of the ADRENAL-GLAND in the ANTIINFLAMMATORY EFFECT of POLYUNSATURATED DIETS
    (Rapid Science Publishers, 1995-09-01) Silveira, Vera Lucia Flor [UNIFESP]; Limaos, E. A.; Nunes, D. W.; Universidade Federal de São Paulo (UNIFESP)
    THE effect of an n-3 (fish) and n-6 (soybean) fatty acid-rich diet on carrageenin paw oedema in rats, and the participation of adrenal gland, corticosterone and alpha(2)-macroglobulin (alpha(2)-M) in this process were studied. A significant inhibition of carrageenin oedema was observed not only in rats fed a diet rich in fish oil but also in the soybean group. alpha(2)-M was not detectable before carrageenin injection, suggesting that this putative anti-inflammatory factor does not participate in the observed anti-inflammatory effect. Corticosterone levels were higher in fat-fed than in control rats, before carrageenin stimulus and adrenalectomy abolished the anti-inflammatory response in fat-fed animals, showing the important role of the adrenocortical hormones in this process.
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    PLASMA, KALLIKREIN CLEARANCE BY THE LIVER - A REVIEW
    (Assoc Bras Divulg Cientifica, 1994-08-01) Borges, Durval Rosa [UNIFESP]; Kouyoumdjian, Maria [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    1. The liver is the main organ clearing both plasma and tissue kallikreins from the circulation. Hepatocytes are responsible for the internalization of rat plasma kallikrein (RPK) and the clearance of plasma kallikrein by the liver is Ca2+-independent. The binding site of RPK to the liver cell is located on its heavy chain which is not exposed on prokallikrein. An S-type lectin accounts for the receptor-mediated endocytosis of RPK.2. These properties of the liver are affected by pathological situations, particularly the acute-phase response to inflammation, in which the kallikrein-kinin system plays a major role. The hepatic clearance of the alpha(2)-macroglobulin-plasma kallikrein complex is less efficient than the clearance of the free enzyme.