Navegando por Palavras-chave "progressive supranuclear palsy"

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    Clinical features of dystonia in atypical parkinsonism
    (Academia Brasileira de Neurologia - ABNEURO, 2008-12-01) Godeiro-Junior, Clecio [UNIFESP]; Felício, André Carvalho [UNIFESP]; Barsottini, Orlando Graziani Povoas [UNIFESP]; Aguiar, Patricia M. de Carvalho [UNIFESP]; Silva, Sonia M.a. [UNIFESP]; Borges, Vanderci [UNIFESP]; Ferraz, Henrique B. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    BACKGROUND: The association between Dystonia and Parkinson's disease (PD) has been well described especially for foot and hand dystonia. There is however few data on dystonic postures in patients with atypical parkinsonism. OBJECTIVE: To evaluate the frequency and pattern of dystonia in a group of patients with atypical parkinsonism (multiple system atrophy - MSA, progressive supranuclear palsy - PSP, and corticobasal degeneration - CBD) and to investigate whether dystonia could be the first presenting symptom at disease onset in those patients. METHOD: A total of 38 medical charts were reviewed (n=23/MSA group; n=7/CBD group; n=8/PSP group) and data values were described as means/standard deviations. The variables evaluated were sex, age at onset, disease duration, first symptom, clinical features of dystonia and other neurological signs, response to levodopatherapy, Hoehn&Yahr scale >3 after three years of disease, and magnetic resonance imaging findings. RESULTS: The overall frequency of dystonia in our sample was 50% with 30.4% (n=7) in the MSA group, 62.5% (n=5) in the PSP group, and 100% (n=8) in the CBD group. In none of these patients, dystonia was the first complaint. Several types of dystonia were found: camptocormia, retrocollis, anterocollis, blepharoespasm, oromandibular, and foot/hand dystonia. CONCLUSION: In our series, dystonia was a common feature in atypical parkinsonism (overall frequency of 50%) and it was part of the natural history although not the first symptom at disease onset. Neuroimaging abnormalities are not necessarily related to focal dystonia, and levodopa therapy did not influence the pattern of dystonia in our group of patients.
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    Differentiation of Parkinson's disease and progressive supranuclear palsy with magnetic resonance imaging: the first Brazilian experience
    (Elsevier B.V., 2007-01-01) Barsottini, Orlando G. P.; Ferraz, Henrique B.; Maia, Antonio C. M.; Silva, Carlos J.; Rocha, Antonio J.; Universidade Federal de São Paulo (UNIFESP); Fleury Inst
    Background: the objective of this study is to differentiate PSP from Parkinson's disease through magnetic resonance imaging. Methods: We included 14 consecutive patients with PD (9) or PSP (5). These measures included the third ventricle, midbrain diameter, quadrigeminal plate, brainstem volumetry, and interpeduncular angle. Results: Patients with PSP presented enlargement of third ventricle (100% vs. 33%), lower midbrain diameter (mean 13.2 +/- 1.7 mm vs. 16.5 +/- 1.7 mm) and thinning of the quadrigeminal plate (mean 2.7 +/- 0.3 mm vs. 3.6 +/- 0.3 mm) in comparison with PD. Conclusions: Characteristic findings on MRI may help to differentiate PD from PSP. (C) 2006 Elsevier B.V. All rights reserved.
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    Progressive supranuclear palsy: new concepts
    (Academia Brasileira de Neurologia - ABNEURO, 2010-12-01) Barsottini, Orlando Graziani Povoas [UNIFESP]; Felício, André Carvalho [UNIFESP]; Aquino, Camila Catherine Henriques de [UNIFESP]; Pedroso, José Luiz [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Progressive supranuclear palsy (PSP) is a distinctive form of neurodegenerative disease which affects the brainstem and basal ganglia. Patients present supranuclear ophthalmoplegia, postural instability and mild dementia. PSP is defined neuropathologically by the accumulation of neurofibrillary tangles in the subthalamic nucleus, pallidum, red nucleus, substantia nigra, striatum, pontine tegmentum, oculomotor nucleus, medulla and dentate nucleus. Over the last decade many lines of investigations have helped refine PSP in many aspects and it is the purpose of this review to help neurologists identify PSP, to better understand its pathophysiology and to provide a more focused, symptom-based treatment approach.