Navegando por Palavras-chave "osteoartrite placebo ozônio intra-articular/uso terapêutico ensaio clínico randomizado duplo-cego"

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    Comparação entre ozônio intra-articular e placebo no tratamento da artrite do joelho
    (Universidade Federal de São Paulo (UNIFESP), 2015-08-31) Jesus, Carlos Cesar Lopes de [UNIFESP]; Trevisani, Virginia Fernandes Moca Trevisani [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    In spite of the high prevalence of osteoarthritis, there are no currently approved treatments capable of slowing its clinical progression or delaying the need for total knee replacement 1, 2. Ozone (O3) is a triatomic variety of oxygen, applied to the human organism with therapeutic aims, mainly in chronic diseases like osteoarthritis 3.However, there are only few studies about the use of intra articular ozone in the treatment of knee osteoarthritis and they are just case reports 3, 4, 5, 6, 7, 8. Objectives: To determine if the treatment of knee osteoarthritis with intra articular ozone is more effective than the treatment of knee osteoarthritis with placebo in relation to pain reduction and improvement of function and quality of life. Methods: 98 patients, aged between 60 and 85 years, with knee osteoarthritis according to the American College of Rheumatology, attending the Paulista School of Medicine ? Sao Paulo Federal University (EPM-UNIFESP) Geriatrics and Gerontology Disciplines Clinic, Santo Amaro Medicine College - Rheumatology Discipline Clinic and at Pró-Vida. Participants were randomized to receive ozone (n= 61) or placebo (n= 35), in the most painful and worst functional knee, once a week, during eight weeks. They were done two control interviews during the treatment, with a four-week interval between them, besides the last interview, eight weeks after the last joint puncture. The instruments used to evaluate the results were: 1) Visual Analogue Scale (VAS); 2) Lequesne Algofunctional Index (LEQ); 3) Timed Up and Go Test (TUG); 4) SF-36; 5) WOMAC (?Western Ontario and McMaster Universities Osteoarthritis Index?) and 6) Geriatric pain Measure (GPM). Results: After 8 weeks of treatment, ozone was more effective than placebo, in relation to pain relief, joint function and life quality improvement: VAS (MD = 3,16; p < 0.001); LEQ (MD = 4,39; p < 0,001); TUG = no statistical difference; SF-36 (PH = -37,72; p < 0,001; GSH = -2,40; p < 0,001; FC = -27,70; p < 0,001; SA = -13,29; p < 0,001); WOMAC (PD = 0,47; p = 0,111) e GPM (MD = 23,10; p < 0,001). Adverse events occurred in 3 patients (2 in placebo group and 1 in ozone group) and included just puncture accidents. Conclusions: The study confirms the efficacy of ozone concerning pain relief and improvement of functional and quality of life in patients with knee osteoarthritis.