Navegando por Palavras-chave "chronic GVHD"

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    Refractory chronic GVHD emerging after splenectomy in a marrow transplant recipient with accelerated phase CML
    (Nature Publishing Group, 2003-08-01) Rodrigues, C. A.; Fermino, Fabiana Aidar [UNIFESP]; Vasconcelos, Yuri [UNIFESP]; Oliveira, JSR de; Universidade Federal de São Paulo (UNIFESP)
    We report a 39-year-old female patient who underwent HLA-identical sibling allogeneic BMT for CML in accelerated phase. Severe pancytopenia refractory to G-CSF associated with progressive splenomegaly and RBC/ platelet transfusion dependency were present from day + 60 after BMT. MRD assessed by FISH and RT-PCR multiplex for BCR-ABL rearrangement was negative, and complete chimerism was documented by VNTR on days + 100, + 180, + 360 and 2 years after BMT. Splenectomy was performed on day + 225 and pancytopenia resolved but chronic extensive graft-versus-host disease developed, with hepatic cholestasis, diffuse scleroderma and sicca-like syndrome. She was sequentially and progressively treated with different immunosuppressive therapy combinations with no clear benefit. On day + 940, she presented with infection over the previously present ulcers on both limbs, which culminated in septic shock and death on day + 1041. We conclude that, although splenectomy may reverse poor graft function after allogeneic BMT, hyposplenism may trigger or worsen chronic extensive GVHD leading to increased morbidity and mortality.