Navegando por Palavras-chave "Toxinas Urêmicas"

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    Efeito do uso de prebiótico (Frutooligossacarídeo) sobre toxinas urêmicas em pacientes com doença renal crônica
    (Universidade Federal de São Paulo, 2018-08-23) Ramos, Christiane Ishikawa [UNIFESP]; Valle, Lilian Cuppari [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Introduction: The Modulation Of Uremic Gut Environment To Control Microbial-Derived Uremic Toxins Has Been Widely Investigated In Chronic Kidney Disease (Ckd). Among The Toxins, P-Cresyl Sulfate (Pcs), Indoxyl Sulfate (Is), And Indole-3-Acetic Acid (Iaa) Have Been Associated With Cardiovascular Risk, Progression Of The Disease, And Mortality In Patients With Ckd. Prebiotics Have Emerged As An Alternative Approach To Modulate The Gut Environment To Attenuate The Production Of Toxins. Aims: 1) To Evaluate The Effect Of A Prebiotic (Fructooligosaccharide, Fos) On Uremic Toxins (Pcs, Is And Iaa) Of Non-Diabetic Non-Dialysis-Dependent Ckd (Ndd-Ckd) Patients. 2) To Evaluate The Effect Of Such Intervention On Serum Markers Of Intestinal Permeability (Zonulin), Gut-Trophic Factors [(Epidermal Growth Factor (Egf) And Glucagon-Like Peptide-2 (Glp-2)], Inflammation [C-Reactive Protein And Interleukin-6 (Il-6)], Insulin Resistance, Lipid Profile, Renal Function And Gastrointestinal Symptoms. 3) To Evaluate The Associatio