Navegando por Palavras-chave "Pregabalin"

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    Avaliação do efeito da pregabalina pré-operatória para analgesia e concentrações plasmáticas de interleucina 6, 8 e 10 após nefrectomia por lombotomia. Estudo clínico randomizado duplo-encoberto.
    (Universidade Federal de São Paulo (UNIFESP), 2018-10-25) Santiago, Ana Ellen de Queiroz [UNIFESP]; Sakata, Rioko Kimiko [UNIFESP]; Leal, Plinio da Cunha [UNIFESP]; http://lattes.cnpq.br/2150178332757393; http://lattes.cnpq.br/9796401471904195; http://lattes.cnpq.br/8078969063032908; São Paulo; Universidade Federal de São Paulo (UNIFESP)
    Background and Objectives: Pregabalin is an anticonvulsant, modulator of alpha2delta subunit of calcium channels, promoting inhibition of excitatory neurotransmitters release. It is possible that the pre-operatory administration of pregabalin promotes analgesic effect and act on release of cytokines. The objective of the study was to evaluate the analgesic effect of pregabalin after nephrectomy. Methods: A randomized double-blind study was performed in 40 patients submitted to nephrectomy for kidney transplantation. Group-1 patients received 300mg of pregabalin before the surgery and group-2 received placebo. Epidural anesthesia was performed with 15 mL of 0.5% ropivacaine followed by general anesthesia with fentanyl (3 μg.kg-1), propofol, atracurium, 50% oxygen, without nitrous oxide, and sevoflurane. There were evaluated: pain intensity after 6 and 24 hours; pain threshold with algometer periincisional and in the tennar eminence of the hand; dosage of IL 6, 8 and 10 before surgery and 6 and 24 h after a surgical incision; number of patients needing complementation; time for complementation; supplemental analgesic dose (tramadol); and adverse effects. Results: Pain intensity was lower after 24h with pregabalin, in G1; there was no difference of pain threshold with algometer in the tennar region; There were no differences between groups about IL-6, IL-8 and IL-10, after 6 and 24h; There were no differences in number of patients needing complementation, and dose of analgesic. There was no difference in the incidence of adverse effects (nausea, vomiting, headache, dizziness, agitation and pruritus). Conclusions: The administration of a single dose of 300mg of pregabalin before lombotomy decreased the intensity of pain after 24h; did not reduce supplemental analgesic dose; did not change the concentration of IL6, IL8 and IL10; did not change the incidence of adverse effects.
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    Estudo randomizado, comparativo, duplo encoberto do efeito analgésico da pregabalina pré e pós-operatória para correção ligamentar artroscópica de joelho
    (Universidade Federal de São Paulo (UNIFESP), 2019-12-18) Tobias, Alexandro Ferraz [UNIFESP]; Sakata, Rioko Kimiko [UNIFESP]; Leal, Plinio da Cunha [UNIFESP]; http://lattes.cnpq.br/2150178332757393; http://lattes.cnpq.br/9796401471904195; http://lattes.cnpq.br/2023042604389377; Universidade Federal de São Paulo (UNIFESP)
    Background and Objectives: The effect of pregabalin for postoperative analgesia is controversial. There is a need to evaluate whether pregabalin promotes better pain control after anterior cruciate ligament surgery, enabling better and earlier return to activities and greater comfort for performing physical therapy. The aim of this study was to evaluate the pre and postoperative analgesic effect of pregabalin in patients undergoing arthroscopic anterior cruciate ligament correction of knee and adverse effects. Methods: The study was prospective, randomized, placebo-controlled, and double-blinded conducted with 60 patients, of both genders, with 18 years age or older, physical status ASA I or II, who underwent knee anterior cruciate ligament (ACL) correction, by arthroscopy. The participants were divided into two groups: group 1 (pregabalin) received 14 capsules with 75mg and group 2 received 14 placebo capsules and were instructed to take 1 capsule daily, starting 7 days before surgery until 7 days after. Spinal anesthesia was with 0.5% hyperbaric bupivacaine (15 mg). If analgesic supplementation was required for pain control, patients with pain intensity of 1 to 3 received iv. dipyrone 1g; with no pain control after 30min, iv. ketoprofen 100mg was administered; and if no effect after 30min, iv. tramadol 100mg; and in cases of non-pain control, iv. morphine 5mg was administered, followed by 5mg doses, until pain control. There were evaluated: pain intensity at T0 (surgery completion), after 12h, 24h, 1week, 2week, 1month and 2months, by numerical scale from zero to 10; and postoperative complementary analgesic consumption. Data were submitted to statistical analysis. Results: There was no statistically significant difference in pain intensity between the groups. Morphine consumption was lower in the pregabalin group, 12 and 24h after surgery; ketoprofen and tramadol consumption was lower after 24h in pregabalin group. The adverse effects observed were nausea, vomiting and dizziness; the last was more frequent in the pregabalin group. Conclusions: The reduced need for analgesic supplementation in pregabalin group shows that this drug promotes analgesic effect. However, the patients in pregabalin group presented more dizziness, which should be taken into consideration when it is using the drug.
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    Restless Legs Syndrome and Pain Disorders: What's in common?
    (Springer, 2014-11-01) Goulart, Leonardo Ierardi; Delgado Rodrigues, Raimundo Nonato; Peres, Mario Fernando Prieto [UNIFESP]; Hosp Israelita Albert Einstein; Universidade de Brasília (UnB); Universidade Federal de São Paulo (UNIFESP)
    Between 10 % and 30 % of the population report chronic pain. More than half of these also have sleep complaints. From considering these data, it can be inferred there is a significant overlapping between these conditions. Restless Legs Syndrome/Willis-Ekbom Disease (RLS/WED) is characterized by complaints of an urge to move frequently associated with dysesthesias. From that perspective, these sensations can also have painful characteristics. By the same token, the presence of comorbid diseases as predicted by a higher prevalence RLS/WED, have many of them with pain as an important complaint. Pain is a multidimensional response involving several levels of expression ranging from somatosensory to emotional. the potential shared mechanisms between RLS/WED and pain may involve sleep deprivation/fragmentation effect, inducing an increase in markers of inflammation and reduction in pain thresholds. These are modulated by several different settings of neurotransmitters with a huge participation of monoaminergic dysfunctional circuits. A thorough comprehension of these mechanisms is of utmost importance for the correct approach and treatment choices.