Navegando por Palavras-chave "Muscle repair"

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    Comparative study of the effects of low-intensity pulsed ultra-sound and low level laser therapy on injured muscle repair
    (Spie-int Soc Optical Engineering, 2011-01-01) Renno, Ana Claudia Muniz [UNIFESP]; Toma, Renata Luri [UNIFESP]; Feitosa, Suellen Maurin [UNIFESP]; Fernandes, Kelly Rossetti [UNIFESP]; Oliveira, Poliani de [UNIFESP]; Parizotto, Nivaldo Antonio [UNIFESP]; Ribeiro, Daniel Araki [UNIFESP]; Hamblin, Michael R.; Waynant, R. W.; Anders, J.; Universidade Federal de São Paulo (UNIFESP)
    Muscle tissue is one of the most frequently affected by injury, whether during sports activities, or work activities. in this context, biochemical and biophysical resources have been studied to minimize the time of muscle regeneration. Among these, low intensity pulsed ultrasound (US) and low level laser therapy (LLLT) may be highlighted. Despite a series of evidences about the positive effects of these resources in the process of tissue regeneration, the cellular and morphological changes triggered by LLLT and U. S. are still largely unknown. Thus, the aim of this study was to investigate the effects of US and LLLT on muscle repair after cryolesion by means of histopathological analysis and immunohistochemistry for COX-2. A total of thirty five male Wistar rats were randomly distributed into 4 groups: intact control group; injured control group: muscle injured animals without any treatment; laser treated group: muscle injured animals treated with 830 nm laser and ultra-sound treated group: muscle injured animals treated with US. the treatments started 24 hours post-surgery and were performed during 6 sessions. the animals exposed to lasertherapy pointed out minor degenerative changes of muscle tissue. in the same way, exposure to ultrasound was able to reduce tissue injuries induced by cryolesion, but less intense than laser therapy. Strong COX-2 positive cells were found in rats submitted to cryolesion only, whereas COX-2 immunoexpression was lower in laser treated or ultrasound treated groups. in summary, this study reveals that both lasertherapy and ultrasound have positive effects on muscle repair in rats.
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    Low-level laser therapy (LLLT) (660 nm) alters gene expression during muscle healing in rats
    (Elsevier B.V., 2013-03-05) Rodrigues, Natalia Camargo; Brunelli, Roberta; Selistre de Araujo, Heloisa Sobreiro; Parizotto, Nivaldo Antonio; Renno, Ana Claudia Muniz [UNIFESP]; Universidade Federal de São Carlos (UFSCar); Universidade Estadual de Campinas (UNICAMP); Universidade Federal de São Paulo (UNIFESP)
    Introduction: the effects of LLLT were studied during muscle regeneration through gene expression.Methods: It was evaluated 10 and 50 J/cm(2) doses during 7, 14 and 21 days post cryoinjury, through histopathological analysis and mRNA MyoD, Myogenin, Vegf and Cox-2 expression.Results: Irradiated groups presented less inflammatory process than control group after 14 and 21 days. Cox-2 levels were downregulated in all irradiated groups after 7, 14 and 21 days. On day 7, both treated groups had a downregulation of Vegf levels, and an upregulation after 14 and 21 days, mainly with 50 J/cm(2). the MyoD levels were upregulated with high dose in all periods and with low dose after 21 days. Myogenin expression was downregulated in both treated groups after 7 days, and was upregulated with 10 J/cm(2) after 21 days.Conclusion: These responses suggest that LLLT can improve the skeletal muscle regeneration through the gene expression stimulation. (C) 2013 Elsevier B.V. All rights reserved.