Navegando por Palavras-chave "Mucositis"

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    Mucosite em pacientes portadores de câncer de cabeça e pescoço submetidos à radioquimioterapia
    (Universidade de São Paulo, Escola de Enfermagem, 2011-12-01) Santos, Renata Cristina Schmidt [UNIFESP]; Dias, Rodrigo Souza [UNIFESP]; Giordani, Adelmo José [UNIFESP]; Segreto, Roberto Araujo [UNIFESP]; Segreto, Helena Regina Comodo [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    The objective of present study was to classify oral mucositis according to the Common Toxicity Criterion (CTC) international parameters in head and neck tumor patients simultaneously treated with radio and chemotherapy, and characterize a patient profile in our area, observing the individuals' habits, tumor characteristics, treatment protocol and acute reaction intensity. Fifty patients undergoing simultaneous 66 to 70 Gy megavoltage radiotherapy and cisplatin/carboplatin chemotherapy were evaluated in this study. Weekly evaluations of the degree of mucositis were perfoemed according to CTC, a four-degree ordinal scale; 36% of all patients and 100% of those with diabetes discontinued treatment due to mucositis, showing that this pathology contributes to the severity of mucositis.
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    Risk factors for enterococcal bacteremia in allogeneic hematopoietic stem cell transplant recipients
    (Wiley-Blackwell, 2010-12-01) Mikulska, Malgorzata; Del Bono, V.; Prinapori, R.; Boni, L.; Raiola, A. M.; Gualandi, F.; Van Lint, Maria Teresa; Dominietto, A.; Lamparelli, T.; Cappellano, Paola [UNIFESP]; Bacigalupo, Andrea; Viscoli, Claudio; San Martino Univ Hosp; Ist Toscano AOU Tumori Careggi; Universidade Federal de São Paulo (UNIFESP)
    P>Bacteremia is a well known cause of morbidity and mortality in hematopoietic stem cell transplant (HSCT) recipients and enterococci are among the most frequently isolated pathogens. the aim of this study was to identify risk factors for enterococcal bacteremia during the first 30 days after allogeneic HSCT. A retrospective case-control study was performed; for each case, 3 controls were randomly selected among 306 patients transplanted during the study period (January 1, 2004 to December 31, 2007). Odds ratios (OR) with 95% confidence intervals (CI) were calculated for variables influencing the risk for bacteremia. Overall, 33 patients developed enterococcal bacteremia, within a median of 9 days after HSCT (range, 2-24). the cumulative incidence was 10.8%. Multivariate analysis identified the following variables as risk factors for enterococcal bacteremia: donor and transplant type (greater risk for mismatched related or cord blood) (OR=8.98, 95% CI, 1.65-48.99 and OR=7.52, 95% CI, 1.56-36.31, respectively, P=0.047); severe (grades 3-4) mucositis (OR=9.04, 95% CI, 1.97-41.52, P=0.018); pharyngeal enterococcal colonization (OR=4.48, 95% CI, 1.11-18.03, P=0.035); and previous empirical therapy with cephalosporins (OR=4.16, 95% CI, 0.93-18.66 for 1-7 days of therapy, and OR=7.31, 95% CI, 1.78-30.12 for 8-23 days, P=0.018). Higher Karnofsky score (>= 50) and previous empirical therapy with glycopeptides were associated with a decreased risk (OR=0.25, 95% CI, 0.06-0.97, P=0.045 and OR=0.11, 95% CI, 0.02-0.59, P=0.010, respectively). the crude mortality at 7 and 30 days was 12% (4/33) and 24% (8/33), respectively. Enterococcal bacteremia is frequent after allogeneic HSCT. the factors associated with this infection are type of transplant, pharyngeal colonization, severe mucositis, and use of cephalosporins. Good general conditions and the use of vancomycin were associated with lower risk of enterococcal bacteremia.
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    Tratamento da mucosite em pacientes submetidos a transplante de medula óssea: uma revisão sistemática
    (Escola Paulista de Enfermagem, Universidade Federal de São Paulo (UNIFESP), 2011-01-01) Ferreira, Patrícia; Gamba, Mônica Antar [UNIFESP]; Saconato, Humberto; Gutiérrez, Maria Gaby Rivero de [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade Federal do Rio Grande do Norte
    OBJECTIVE: To identify therapeutic measures to reduce the severity of oral mucositis in adult patients undergoing bone marrow transplantation (BMT). METHODS: A systematic review using the following databases: LILACS, MEDLINE, CINAHL, EMBASE, CENTRAL (Cochrane Central) and DARE (Database of abstracts of reviews of effects), for the period between 1972 to July 2010, using the key words mucositis, stomatitis and bone marrow transplantation. RESULTS: We identified 3,839 abstracts, 22 of which were included in the systematic review; these articles identified 14 topical and systemic interventions, among which eight showed statistical significance for the reduction of this complication. The topical therapies were: cryotherapy, chlorhexidine, glutamine, laser and Traumeel ®. The systemic therapies were: amifostine, Granulokine ®, and palifermin. CONCLUSION: The heterogeneity of the results of these interventions and the lack of better elucidation for healthcare practice indicate the need for more accurate research to identify the effectiveness of topical therapies for repair of mucosal cells.