Navegando por Palavras-chave "Lung diseases"
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- ItemAcesso aberto (Open Access)Doenças granulomatosas ocupacionais(Sociedade Brasileira de Pneumologia e Tisiologia, 2006-05-01) Bagatin, Ericson; Pereira, Carlos Alberto De Costa [UNIFESP]; Afiune, Jorge Barros; Universidade Estadual de Campinas (UNICAMP); Universidade Federal de São Paulo (UNIFESP); Instituto Clemente FerreiraA variety of diseases are encompassed in the didactic denomination of granulomatous diseases of probable occupational etiology. As well as presenting similar clinical aspects, such diseases are characterized by certain common traits: formation of granulomas; systemic and respiratory manifestations; environmental or occupational exposure to organic or inorganic agents; and T lymphocyte involvement in the pathogenesis. Included in this category are hypersensitivity pneumonitis, mycobacteriosis (all forms) and sarcoidosis, as well as beryllium disease and other lung diseases caused by exposure to heavy metals. In order to highlight the risk of developing one of these diseases as a result of environmental or occupational exposure to etiologic agents, we address aspects related to epidemiology, pathogenesis and evaluation of exposure of these diseases, as well as those related to diagnostic criteria, prevention and control. We have given special emphasis to groups of individuals considered to be at high risk for developing these diseases, as well as to the need for health care professionals to remain aware of the potential occupational etiology of such diseases, a decisive factor in devising effective measures of prevention and epidemiological surveillance.
- ItemAcesso aberto (Open Access)Efeito da teofilina associada ao beta2-agonista inalatório de curta ou longa duração, em pacientes com doença pulmonar obstrutiva crônica estável: revisão sistemática(Sociedade Brasileira de Pneumologia e Tisiologia, 2007-04-01) Zacarias, Eliane Cristina [UNIFESP]; Castro, Aldemar Araujo [UNIFESP]; Cendon Filha, Sônia Perez [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)OBJECTIVES: To determine whether, in stable patients with chronic obstructive pulmonary disease, administration of theophylline in combination with short-acting or long-acting inhaled beta2-agonists is more efficacious than is a placebo or each of these drugs used in isolation. METHODS: A systematic review and meta-analysis were carried out. All randomized and double-blind clinical trials found in the literature were selected. RESULTS: A total of eight studies were included. In comparing the effect of theophylline combined with beta2-agonists to that of a placebo, we found a statistically significant improvement in mean FEV1 (0.27 L; 95%CI: 0.11 to 0.43) and mean dyspnea (-0.78; 95%CI: -1.26 to -0.29). None of the meta-analyses performed detected any difference between the results obtained using theophylline combined with beta2-agonists and those obtained using beta2-agonists alone. When the administration of theophylline combined with beta2-agonists was compared to that of theophylline alone, there was a statistically significant improvement in mean dyspnea (-0.19; 95%CI: -0.34 to 0.04). CONCLUSION: In patients with stable chronic obstructive pulmonary disease, theophylline combined with beta2 agonists is more efficacious than is a placebo in terms of improving FEV1 and dyspnea. In addition, theophylline combined with beta2 agonists is more efficacious than is theophylline in improving dyspnea. Furthermore, administration of theophylline combined with beta2 agonists is no more efficacious, for any of the variables studied, than is the use of beta2-agonists in isolation.
- ItemSomente MetadadadosImpact of chronic obstructive pulmonary disease on exercise ventilatory efficiency in heart failure(Elsevier B.V., 2015-06-15) Apostolo, Anna; Laveneziana, PierAntonio; Palange, Paolo; Agalbato, Cecilia; Molle, Roberta; Popovic, Dejana; Bussotti, Maurizio; Internullo, Mattia; Sciomer, Susanna; Bonini, Matteo; Alencar, Maria Clara [UNIFESP]; Godinas, Laurent; Arbex, Flavio [UNIFESP]; Garcia, Gilles; Alberto Neder, J. [UNIFESP]; Agostoni, Piergiuseppe; IRCCS; Hopital Univ Bicetre; Univ Paris 06; INSERM; Grp Hosp Pitie Salpetriere Charles Foix; Univ Roma La Sapienza; Univ Belgrade; Fdn Salvatore Maugeri; La Sapienza; Universidade Federal de São Paulo (UNIFESP); Univ Paris 11; Queens Univ; Univ MilanBackground: Heart failure (HF) and chronic obstructive pulmonary disease (COPD) coexistence increases morbidity and mortality. the intercept of ventilation ((V) over dotEint) on the (V) over dotE vs. carbon dioxide production ((V) over dot CO2) relationship during exercise has been found to vary in proportion with dead space (VD) in HF. Considering that increased VD is the key pathophysiological abnormality in COPD but a secondary finding in HF we hypothesized that a high (V) over dotEint would be useful in suggesting COPD as HF co-morbidity. Our aim was to assess whether an elevated (V) over dotEint suggests the presence of COPD in HF.Methods: in a multicenter retrospective study, the (V) over dotE-(V) over dotCO(2) relationship was analyzed both as slope and intercept in HF (n = 108), HF-COPD (n = 106) and COPD (n = 95). Patients with pulmonary arterial hypertension (PAH) (n= 85) and healthy subjects (HF) (n= 56) served as positive and negative controls relative to (V) over dotE-(V) over dotCO(2) abnormalities, respectively.Results: Slope and (V) over dotEint varied in opposite directions in all groups (p < 0.05) being (V) over dotE-(V) over dotCO(2) slope highest and lowest in PAH and healthy subjects, respectively. No slope differences were observed among HF, HF-COPD and COPD (32 +/- 7, 31 +/- 7, and 31 +/- 6, respectively). (V)over dotEint was higher in HF-COPD and COPD compared to HF, PAH and controls (4.8 +/- 2.4 L/min, 5.9 +/- 3.0 L/min, 3.0 +/- 2.6 L/min, 2.3 +/- 3.3 L/min and 3.9 +/- 2.5 L/min, respectively; p < 0.01). A (V) over dotEint >= 4.07 L/min identified patients with high probability of having COPD or HF-COPD (sensitivity of 71.6% and specificity of 72.0%).Conclusion: These data provide novel evidence that a high (V) over dotEint (>= 4.07 L/min) should be valued to suggest coexistent COPD in HF patients. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
- ItemAcesso aberto (Open Access)Increased chemical acetylation of peptides and proteins in rats after daily ingestion of diacetyl analyzed by Nano-LC-MS/MS(Peerj Inc, 2018) Jedlicka, Leticia Dias Lima [UNIFESP]; Guterres, Sheila Barreto [UNIFESP]; Balbino, Aleksandro Martins [UNIFESP]; Bruno Neto, Giuseppe [UNIFESP]; Landgraf, Richardt Gama [UNIFESP]; Fernandes, Liliam [UNIFESP]; Carrilho, Emanuel; Bechara, Etelvino José Henriques [UNIFESP]; Assunção, Nilson Antonio [UNIFESP]Background. Acetylation alters several protein properties including molecular weight, stability, enzymatic activity, protein protein interactions, and other biological functions. Our previous findings demonstrating that diacetyl/peroxynitrite can acetylate L-lysine, L-histidine, and albumin in vitro led us to investigate whether diacetyl-treated rats suffer protein acetylation as well. Methods. Wistar rats were administered diacetyl daily for four weeks, after which they were sacrificed, and their lung proteins were extracted to be analysed by Nano-LC-MS/MS (Q-TOF). A C18 reversed-phase colurnn and gradient elution with formic acid/acetonitrile solutions from 2 to 50% over 150 min were used to separate the proteins. Protein detection was performed using a microTOE-Q II (QTOF) equipped with captive source and an electrospray-ionization source. The data frommass spectrometry were processed using a Compass 1.7 and analyzed using Protein Scape, software that uses Mascot algorithms to perform protein searches. Results. A set of 3,162 acetylated peptides derived from 351 acetylated proteins in the diacetyl-treated group was identified. Among them, 23 targeted proteins were significantly more acetylated in the diacetyl-treated group than in the PBS control. Protein acetylation of the group treated with 540 mg/kg/day of diacetyl was corroborated by Western blotting analysis. Conclusions. These data support our hypothesis that diacetyl exposure in animals may lead to the generation of acetyl radicals, compounds that attach to proteins, affecting their functions and triggering adverse health problems.
- ItemAcesso aberto (Open Access)Novas terapias ergogênicas no tratamento da doença pulmonar obstrutiva crônica(Sociedade Brasileira de Pneumologia e Tisiologia, 2006-02-01) Villaça, Debora Strose [UNIFESP]; Lerario, Maria Cristina [UNIFESP]; Dal Corso, Simone [UNIFESP]; Neder, Jose Alberto [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Chronic obstructive pulmonary disease is currently considered a systemic disease, presenting structural and metabolic alterations that can lead to skeletal muscle dysfunction. This negatively affects the performance of respiratory and peripheral muscles, functional capacity, health-related quality of life and even survival. The decision to prescribe ergogenic aids for patients with chronic obstructive pulmonary disease is based on the fact that these drugs can avert or minimize catabolism and stimulate protein synthesis, thereby reducing the loss of muscle mass and increasing exercise tolerance. This review summarizes the available data regarding the use of anabolic steroids, creatine, L-carnitine, branched-chain amino acids and growth hormones in patients with chronic obstructive pulmonary disease. The advantage of using these ergogenic aids appears to lie in increasing lean muscle mass and inducing bioenergetic modifications. Within this context, most of the data collected deals with anabolic steroids. However, to date, the clinical benefits in terms of increased exercise tolerance and muscle strength, as well as in terms of the effect on morbidity and mortality, have not been consistently demonstrated. Dietary supplementation with substances of ergogenic potential might prove to be a valid adjuvant therapy for treating patients with advanced chronic obstructive pulmonary disease, especially those presenting loss of muscle mass or peripheral muscle weakness.
- ItemAcesso aberto (Open Access)Ossificação pulmonar dendriforme(Sociedade Brasileira de Pneumologia e Tisiologia, 2006-06-01) Duarte, Andrezza Araújo De Oliveira; Nakatani, Jorge [UNIFESP]; Rigueiro, Moacyr Pezati [UNIFESP]; Saad, Tânia; Hospital Santa Marcelina; Universidade Federal de São Paulo (UNIFESP)Diffuse pulmonary ossification is a rare condition of unknown pathogenesis in which mature bone is found in the pulmonary parenchyma. It is almost invariably discovered as an incidental finding at autopsy. Most commonly, it affects middle-aged men and is asymptomatic. We present the case of a 75-year-old man in which the chest X-ray showed diffuse interstitial infiltrate. Diagnosis was based on histopathological examination by open-lung biopsy, which revealed interstitial fibrosis with pulmonary ossification.