Navegando por Palavras-chave "Drug eruptions"

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    Bleomycin-induced flagellate dermatitis
    (Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular, 2014-07-01) Mota, Guilherme Devidé; Penna, Adriana Marques Damasco; Soares, Regina Cláudia; Baiocchi, Otavio Carvalho Guimarães [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    A 29-year-old woman with stage IVB Hodgkin's lymphoma was treated with doxorubicin, bleomycin, vinblastine, and dacarbazine. Two weeks after the first cycle was completed, she developed pruritic, linear erythematous lesions in a flagellate-like pattern on the trunk, neck and arms. After oral prednisone therapy and cessation of bleomycin, the lesions started to recede.
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    DRESS: clinicopathological features of 10 cases from an University Hospital in São Paulo
    (Sociedade Brasileira de Dermatologia, 2012-10-01) Botelho, Luciane Francisca Fernandes [UNIFESP]; Higashi, Viviane Shinsato [UNIFESP]; Padilha, Maria Helena Valle de Queiroz [UNIFESP]; Enokihara, Mílvia Maria Simões e Silva [UNIFESP]; Porro, Adriana Maria [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    BACKGROUND: Drug reaction with eosinophilia and systemic symptoms is a severe form of drug-induced reaction with multiorgan involvement. OBJECTIVES: The aim of this study is to evaluate the epidemiological, clinical and pathological features and prognosis of this drug reaction among patients seen at a dermatology service. METHOD: Retrospective review of medical records of ten patients diagnosed with drug reaction with eosinophilia and systemic symptoms at the Federal University of São Paulo, from august 2008 to may 2011. RESULTS: Phenytoin was the leading cause of drug reaction with eosinophilia and systemic symptoms in our cases, followed by allopurinol. Abnormal liver function tests were observed in 7 patients and renal function impairment in 2 patients. In all cases, patients were hospitalized and the culprit drug was withdrawn. The main treatment was systemic corticosteroid. Drug reaction with eosinophilia and systemic symptoms resulted in death in 2 cases. The causes of death were septic shock and hepatic failure. CONCLUSION: Our mortality rate of 20%, supports that drug reaction with eosinophilia and systemic symptoms is a severe form of drug-induced reaction and must be recognized by all dermatologists.
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    Vancomycin-associated linear IgA disease mimicking toxic epidermal necrolysis
    (Soc Brasileira Dermatologia, 2016) Pereira, Amanda Regio [UNIFESP]; Siqueira Pinheiro, Jhonatan Rafael [UNIFESP]; Enokihara, Mílvia Maria Simões e Silva [UNIFESP]; Moura, Luis Henrique Barbizan de [UNIFESP]; Pasin, Victor Pavan [UNIFESP]; Porro, Adriana Maria [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Linear IgA dermatosis is a rare subepidermal autoimmune blistering disease characterized by linear deposition of IgA along the basement membrane zone. In the last three decades, many different drugs have been associated with the druginduced form of the disease, especially vancomycin. We report a case of vancomycin-induced linear IgA disease mimicking toxic epidermal necrolysis. The aim of this work is to emphasize the need to include this differential diagnosis in cases of epidermal detachment and to review the literature on the subject and this specific clinical presentation.