Navegando por Palavras-chave "Cicatrização de Ferida"

Agora exibindo 1 - 1 de 1
  • Imagem de Miniatura
    Item
    Embargo
    Casca da Musa Sapientum Verde na cicatrização de ferida operatória em ratos
    (Universidade Federal de São Paulo (UNIFESP), 2010-08-25) Atzingen, Dênia Amélia Novato Castelli Von [UNIFESP]; Gragnani, Alfredo [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Introduction: The use of unripe banana peel in wound care has been previously described, especially for oral administration. The indication for topical use requires further investigation. Objective: To evaluate the action of unripe banana (Musa sapientum) peel in the healing of surgical wounds in rats. Methods: The study was conducted with 120 rats, which were divided into two groups: the control group (gel without the active ingredient) and experimental group (4% unripe M. sapientum peel gel). The animals were anesthetized with ketamine and xylazine, a 4 x 4 cm surgical wound was created on the back of each animal, and the wound was covered with a primary dressing. The wounds were treated daily with 0.9% saline solution and the gel formulations were applied to their respective groups. The animals were euthanized on postoperative days 7, 14 and 21, and the tissue from the wound site with a margin of normal tissue was removed for histological analysis. Results: There were no significant differences between groups in mean wound contraction (p = 0.982). There were significant differences in the percentage of wound contraction between times of measurement within groups (p = 0.023). No significant differences were found between histological variables between groups. Only in the control group, there was a progressive increase with time in the number of collagen fibers (p = 0.035) and vascular proliferation (p = 0.033). In the experimental group, there were only significant differences in the number of polymorphonucleated cells between times of measurement (p = 0.026). Conclusion: The gel of unripe banana (M. sapientum) peel in the concentration of 4% did not improve the healing of surgical wounds in rats.