Navegando por Palavras-chave "Cholestasis"

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    Late-onset systemic lupus erythematosus-associated liver disease
    (Springer, 2012-09-01) Schiavon, Leonardo L. [UNIFESP]; Carvalho-Filho, Roberto J. [UNIFESP]; Narciso-Schiavon, Janaina Luz [UNIFESP]; Lanzoni, Valeria P. [UNIFESP]; Ferraz, Maria Lucia G. [UNIFESP]; Silva, Antonio Eduardo B. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease, which predominantly affects women under 50 years old. Although liver disease is not included in the diagnostic criteria, abnormal liver tests are common among patients with SLE and, in a significant proportion of those patients, no other underlying condition can be identified. We described a case of liver involvement in late-onset SLE presenting with a predominantly cholestatic pattern. Other conditions associated with abnormal liver tests were excluded, and the patient showed a prompt response to steroid therapy. the spectrum of the liver involvement in SLE is discussed, with emphasis on the differential diagnosis with autoimmune hepatitis.
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    Relação entre níveis séricos dos marcadores laboratoriais de colestase e intensidade do prurido
    (Universidade Federal de São Paulo (UNIFESP), 2021) Nietsche, Thais Reginatto [UNIFESP]; Ferraz, Maria Lucia Cardoso Gomes [UNIFESP]; Universidade Federal de São Paulo
    Introduction: pruritus is a frequent and agonizing symptom that accompanies several liver diseases, particularly the cholestatic ones. It can be mild and tolerable, but it can also dramatically reduce the quality of life. It is still a challenge to determine the intensity of this symptom in an objective manner, however it is extremely relevant in research purposes or clinical practice. Low-cost cholestasis markers already used in the medical routine to assess the liver and bile ducts - such as alkaline phosphatase, gamma-glutamyltransferase and bilirubins - could be associated with the severity of cholestatic pruritus. Objective: to analyze whether there is a correlation between laboratory levels of cholestasis and the clinical intensity of pruritus. Methods: sixty patients with chronic cholestasis from the gastroenterology clinic were consecutively allocated. To the participants were applied: the Dermatology Quality of Life Index (DLQI), the 5D Pruritus Scale (5-DPS) and the Visual Analogue Scale (VAS). The results of laboratory tests were analyzed, particularly the cholestasis parameters, according to the scores obtained in the referred scales. Results: among patients with cholestasis 2/3 had pruritus. The presence or intensity of the pruritus, assessed with the VAS and 5-DPS instruments, as well as the quality of life estimated by the DLQI questionnaire, were not related to laboratory markers of cholestasis. Conclusion: There was no association between serum levels of laboratory markers of cholestasis and the intensity of pruritus. There was also no relationship between the values of these tests and the impact on patients' quality of life.