Navegando por Palavras-chave "Cardiovascular system"
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- ItemAcesso aberto (Open Access)O efeito da poluição atmosférica na variabilidade da frequência cardíaca em indivíduos com excesso de peso(Universidade Federal de São Paulo (UNIFESP), 2019-01-31) Base, Luis Henrique [UNIFESP]; Ferreira, Celso [UNIFESP]; Ferreira Filho, Celso; http://lattes.cnpq.br/6851397444757156; http://lattes.cnpq.br/5104524767299502; Universidade Federal de São Paulo (UNIFESP)Introduction. Among the several factors related to the development of cardiovascular diseases, air pollution and obesity contribute significantly to this increase. Objective. To analyze the effect of air pollution on the autonomic modulation of heart rate in overweight individuals. Method. We analyzed adult individuals, aged between 18 and 49 years, with BMI >25 kg/m2. The municipality of Cubatão (SP) was selected as an experimental area, due to a study carried out by the Companhia de Tecnologia de Saneamento Ambiental in 2001 and 2013, which proved toxic sources in the territory. It is a control area located in the municipality of Peruíbe (SP). Intergroup analyzes were performed with the linear indexes of the time and frequency domain, in addition to the geometric indexes. Result. There was a reduction in the general heart rate variability in the overweight individuals exposed to air pollution through SDNN, SD2, RRTri and TINN indexes (p = 0.012, p = 0.013, p-0.009, p = 0.010, respectively). In addition, the indexes responsible for parasympathetic control such as rMSSD, pNN50 and SD1 showed a tendency to fall in their values, as well as, the LF index, which represents the action of the sympathetic, although not significant. Conclusion. The study showed that overweight individuals exposed to air pollution had lower overall HRV when compared to the control group. In addition, parasympathetic and sympathetic modulation were shown to have a downward trend, although not significant.
- ItemAcesso aberto (Open Access)Effect of Global Postural Reeducation on cardiovascular system of healthy subjects(Pontifícia Universidade Católica do Paraná, 2014-09-01) Abreu, Elizângela Márcia de Carvalho; Cunha, Tatiana Sousa [UNIFESP]; Paula Júnior, Alderico Rodrigues de; Oliveira, Marco Antonio de; Universidade Paulista; Universidade Federal de São Paulo (UNIFESP); Universidade do Vale do ParaíbaObjectiveTo evaluate the effect of Global Postural Reeducation (GPR) on cardiovascular system by heart rate variability (HRV), blood pressure (BP) and heart rate (HR). Materials and methodSeventeen healthy men (22.47 ± 3.02 years) were submitted to the postures frog on the floor, frog on the air, sitting, standing against the wall and inclined standing, two postures per session. The systolic and diastolic blood pressure (SBP and DBP) and HR were recorded. The intervals between heartbeats were collected during the whole session (Polar S810i). The frequency domain was analyzed (Wavelet Transform), the low frequency (LF) and high frequency (HF) were obtained. The data were analyzed by ANOVA and Tukey (p < 0.05). ResultIncreased LF/HF ratio was observed in the frog on the floor (1 ± 0.1 vs. 2 ± 0.3 p < 0.05) and on the air postures (1 ± 0.1 vs. 2 ± 0.2 p < 0.01). There was an increase in SBP in the postures frog on the floor (123 ± 2 vs. 136 ± 4 p < 0.05), frog on the air (122 ± 2 vs. 133 ± 3 p < 0.05), standing against the wall (123 ± 2 vs. 136 ± 4 p < 0.05), inclined standing (124 ± 3 vs. 146 ± 5 p < 0.05). There was increase of DBP in the postures frog on the floor (69 ± 2 vs. 81 ± 2 p < 0.01), frog on the air (72 ± 2 vs. 83 ± 3 p < 0.05), sitting (85 ± 2 vs. 102 ± 3 p < 0.01). There was increase in HR in the postures frog on the air (67 ± 2 vs. 77 ± 3 p < 0.05) and inclined standing (88 ± 3.5 vs. 101 ± 3 p < 0.05). ConclusionThe increase in LF/HF ratio and also the BP and HR indicates high sympathetic activity, possibly related to the work isometric developed during GPR method. [P]
- ItemSomente MetadadadosMelatonin, mitochondria and hypertension(Springer Basel Ag, 2017) Baltatu, Ovidiu C.; Amaral, Fernanda G. [UNIFESP]; Campos, Luciana A.; Cipolla-Neto, JoseMelatonin, due to its multiple means and mechanisms of action, plays a fundamental role in the regulation of the organismal physiology by fine tunning several functions. The cardiovascular system is an important site of action as melatonin regulates blood pressure both by central and peripheral interventions, in addition to its relation with the renin-angiotensin system. Besides, the systemic management of several processes, melatonin acts on mitochondria regulation to maintain a healthy cardiovascular system. Hypertension affects target organs in different ways and cellular energy metabolism is frequently involved due to mitochondrial alterations that include a rise in reactive oxygen species production and an ATP synthesis decrease. The discussion that follows shows the role played by melatonin in the regulation of mitochondrial physiology in several levels of the cardiovascular system, including brain, heart, kidney, blood vessels and, particularly, regulating the renin-angiotensin system. This discussion shows the putative importance of using melatonin as a therapeutic tool involving its antioxidant potential and its action on mitochondrial physiology in the cardiovascular system.
- ItemSomente MetadadadosMethadone Increases and Prolongs Detomidine-Induced Arterial Hypertension in Horses, but These Effects Are Not Mediated by Increased Plasma Concentrations of Arginine Vasopressin or Serum Concentrations of Catecholamines(Elsevier Science Inc, 2016) Pignaton, Wangles; Luna, Stelio Pacca Loureiro; Teixeira Neto, Francisco Jose; de Oliveira, Flavia Augusta; de Castro Neto, Eduardo Ferreira [UNIFESP]; Naffah-Mazzacoratti, Maria da Graca [UNIFESP]; Gozalo-Marcilla, MiguelCatecholamines and arginine vasopressin (AVP) release can affect arterial blood pressure (ABP) and hemodynamic stability in standing, sedated horses. Six mature horses were included in this prospective, randomized, crossover, blinded, experimental study. All the horses were sedated with detomidine (DET) alone (0.01 mg/kg, IV) or combined with methadone (MET) (0.01 mg/kg DET and 0.2 mg/kg MET, IV). Cardiopulmonary data and blood samples were collected 30 minutes before (prebaseline and baseline) and for 120 minutes postinjection. The combination DET/MET produced a significant increase (31%) in mean ABP (MAP) 5 minutes after drug administration which lasted for 120 minutes. Detomidine alone induced only a short-term increase in MAP (15%) at 5 minutes compared with baseline. There were significant differences between groups at 5, 15, and from 60 to 120 minutes. Plasma AVP concentrations were higher in horses receiving the treatment DET from 60 to 120 minutes than those in the combination group, for the same period. There were no significant differences in norepinephrine and epinephrine serum concentrations respect to baseline and between treatments. Detomidine induces a short-term MAP increase, and this effect was prolonged and potentiated by MET association. There is no evidence of AVP, norepinephrine, and epinephrine involvement in this effect. (C) 2016 Elsevier Inc. All rights reserved.
- ItemSomente MetadadadosMethadone Increases and Prolongs Detomidine-Induced Arterial Hypertension in Horses, but These Effects Are Not Mediated by Increased Plasma Concentrations of Arginine Vasopressin or Serum Concentrations of Catecholamines(Elsevier Science Inc, 2016) Pignaton, Wangles; Luna, Stelio Pacca Loureiro; Teixeira Neto, Francisco Jose; de Oliveira, Flavia Augusta; de Castro Neto, Eduardo Ferreira [UNIFESP]; Naffah-Mazzacoratti, Maria da Graca [UNIFESP]; Gozalo-Marcilla, MiguelCatecholamines and arginine vasopressin (AVP) release can affect arterial blood pressure (ABP) and hemodynamic stability in standing, sedated horses. Six mature horses were included in this prospective, randomized, crossover, blinded, experimental study. All the horses were sedated with detomidine (DET) alone (0.01 mg/kg, IV) or combined with methadone (MET) (0.01 mg/kg DET and 0.2 mg/kg MET, IV). Cardiopulmonary data and blood samples were collected 30 minutes before (prebaseline and baseline) and for 120 minutes postinjection. The combination DET/MET produced a significant increase (31%) in mean ABP (MAP) 5 minutes after drug administration which lasted for 120 minutes. Detomidine alone induced only a short-term increase in MAP (15%) at 5 minutes compared with baseline. There were significant differences between groups at 5, 15, and from 60 to 120 minutes. Plasma AVP concentrations were higher in horses receiving the treatment DET from 60 to 120 minutes than those in the combination group, for the same period. There were no significant differences in norepinephrine and epinephrine serum concentrations respect to baseline and between treatments. Detomidine induces a short-term MAP increase, and this effect was prolonged and potentiated by MET association. There is no evidence of AVP, norepinephrine, and epinephrine involvement in this effect. (C) 2016 Elsevier Inc. All rights reserved.
- ItemAcesso aberto (Open Access)Relação estrutura vs. atividade de peptídeos análogos BPP-10c sobre os parâmetros cardiovasculares de ratos espontaneamente hipertensos(Universidade Federal de São Paulo (UNIFESP), 2010-12-02) Paschoal, Juliana Fontes Beltran [UNIFESP]; Camargo, Antonio Carlos Martins de [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Estudos realizados em nosso laboratório têm mostrado que as ações do BPP-10c (
- ItemAcesso aberto (Open Access)Respostas cardiopulmonares durante o esforço em crianças e adolescentes nascidas prematuras(Sociedade de Pediatria de São Paulo, 2011-09-01) Davidson, Josy [UNIFESP]; João, Priscila Cristina [UNIFESP]; Rodrigues, Regiane de Oliveira; Scavacini, Ana Sílvia [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Hospital de CarapicuibaOBJECTIVE: To describe cardiopulmonary outcomes during physical stress in prematurely born children and adolescents. DATA SOURCES: Studies were obtained from PubMed, SciELO and Lilacs in Portuguese and in English from the last 20 years. The following key-words were searched: arterial pressure, physical capacity, cardiovascular, premature, children, adolescent and pulmonary function. DATA SYNTHESIS: Prematurely born children and adolescents have airway obstruction, worse lung function and exercise capacity, more frequency of hypertension and/or higher systolic arterial pressure than those born at term. Furthermore, studies suggest that these infants have cardiovascular resistance alterations since their first days of life that could endanger the development of this system until adulthood, increasing cardiovascular risks. CONCLUSIONS: Physical stress in prematurely born individuals may lead to different cardiopulmonary outcomes compared to those born full-term. These alterations could be attributed to peculiarities of the cardiopulmonary system development.
- ItemSomente MetadadadosSex differences in blood pressure responses to mental stress are abolished after a single bout of exercise: underlying hemodynamic mechanisms(Springer, 2014-05-01) Vianna, Lauro C.; Silva, Bruno M. [UNIFESP]; Nobrega, Antonio Claudio L.; Universidade Federal Fluminense (UFF); Universidade Federal de São Paulo (UNIFESP)We aimed to investigate whether the pressor responses to mental stress (MS) are exaggerated in men due to heightened cardiac responses, before and after a bout of exercise. Fifteen men and 19 women underwent a protocol consisting of blood pressure (BP), cardiac output (CO) and forearm vascular assessments at baseline and during MS, and these measurements were performed before and 60 min after a bout of exercise. Before exercise, BP response was significantly augmented in men (Delta 16 +/- A 2 mmHg) compared to women (Delta 11 +/- A 1 mmHg). This BP response was accompanied by greater increases in CO in men and similar vascular responses between sexes. After exercise, BP and CO responses to MS were attenuated in men and, consequently, no sex differences were observed. Vascular responses were not affected by exercise. the mechanism underlying the lack of sex differences in BP response to MS after exercise was found to be a marked attenuation in CO in men only.
- ItemSomente MetadadadosSlow breathing influences cardiac autonomic responses to postural maneuver Slow breathing and HRV(Elsevier Sci Ltd, 2016) Vidigal, Giovanna Ana de Paula; Tavares, Bruna S.; Garner, David M.; Porto, Andrey A. [UNIFESP]; Abreu, Luiz Carlos de; Ferreira, Celso [UNIFESP]; Valenti, Vitor E.Chronic slow breathing has been reported to improve Heart Rate Variability (HRV) in patients with cardiovascular disorders. However, it is not clear regarding its acute effects on HRV responses on autonomic analysis. We evaluated the acute effects of slow breathing on cardiac autonomic responses to postural change manoeuvre (PCM). The study was conducted on 21 healthy male students aged between 18 and 35 years old. In the control protocol, the volunteer remained at rest seated for 15 min under spontaneous breathing and quickly stood up within 3 s and remained standing for 15 min. In the slow breathing protocol, the volunteer remained at rest seated for 10 min under spontaneous breath, then performed slow breathing for 5 min and rapidly stood up within 3 s and remained standing for 15 min. Slow breathing intensified cardiac autonomic responses to postural maneuver. (C) 2016 Elsevier Ltd. All rights reserved.