Navegando por Palavras-chave "Calcitonin Gene-Related Peptide"

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    Effects of subcutaneous carbon dioxide on calcitonin gene related peptide and substance P secretion in rat skin
    (Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2014-04-01) Raymundo, Erica Calcagno [UNIFESP]; Hochman, Bernardo [UNIFESP]; Nishioka, Michele Akemi [UNIFESP]; Freitas, Jose Octavio Gonçalves de [UNIFESP]; Maximino, Jessica Ruivo; Chadi, Gerson; Ferreira, Lydia Masako [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)
    PURPOSE:To investigate the subcutaneous injection of carbon dioxide (CO2) on neuropeptides Calcitonin Gene-Related Peptide (CGRP) and Substance P (SP) secretion in rat skin. METHODS:Fifty-six Wistar-EPM rats were distributed in two groups: one for CGRP analysis, the other for SP analysis. Each group was subdivided into four subgroups: control (Cont), control with needle (ContNd), CO2 injection (CO2Inj) and atmospheric air injection (AirInj) - with seven animals each. Sample analyses of partial skin were conducted by Western Blotting (WB). RESULTS:In SP group, there was a decrease in the amount of neuropeptides in subgroups CO2Inj and AirInj. Similarly, in CGRP group, there was a decrease in the amount of pro-CGRP neuropeptides (15 kDa) in subgroups CO2Inj and AirInj; Nevertheless, there was no decrease in the amount of CGRP (5 kDa) in any subgroups. CONCLUSION:Subcutaneous injection of CO2 and atmospheric air decreased the amount of Substance P and pro-Calcitonin Gene-Related Peptide (15 kDa) neuropeptides in rat skin.