Este é o sistema de informação de acesso à produção intelectual da Universidade Federal de São Paulo(UNIFESP). Um projeto da Coordenadoria da Rede de Bibliotecas da Unifesp.(CRBU), em parceria com a Superintendência de Tecnologia da Informação(STI).

  • Vocabulário expressivo em crianças com TEA: análise em dois momentos 

    Camargo, Aline Andrade (Universidade Federal de São Paulo, 2021)
    O vocabulário expressivo da criança corresponde ao léxico que pode ser utilizado por ela e, a partir do momento que a criança começa a falar, já é possível medir a extensão, ritmo de desenvolvimento e características de ...
  • Mitochondrial Sirtuin TcSir2rp3 Affects TcSODA Activity and Oxidative Stress Response in Trypanosoma cruzi 

    Moura, Leila dos Santos; Nunes, Vin ́ıcius Santana; Gomes, Antoniel A. S.; Sousa, Ana Caroline de Castro Nascimento; Fontes, Marcos R. M.; Schenkman, Sergio; Moretti, Nilmar Silvio (Frontiers, 2021)
    rypanosoma cruzi faces a variety of environmental scenarios during its life cycle, which include changes in the redox environment that requires a !ne regulation of a complex antioxidant arsenal of enzymes. Reversible ...
  • Trypanosoma cruzi 

    Moretti, Nilmar Silvio [UNIFESP]; Mortara, Renato Arruda [UNIFESP]; Schenkman, Sergio [UNIFESP] (Cell Press, 2021)
    Trypanosoma cruzi is the etiological agent of American trypanosomiasis, or Chagas disease, and is transmitted mainly by blood-sucking reduviid insects in endemic countries. Metacyclic trypomastigotes released in the feces ...
  • Protein acetylation in the critical biological processes in protozoan parasites 

    Maran, Suellen Rodrigues [UNIFESP]; Fleck, Krista; Monteiro-Teles, Natália Melquie; Isebe, Tony; Walrad, Pegine; Jeffers, Victoria; Cestari, Igor; Vasconcelos, Elton J.R.; Moretti, Nilmar [UNIFESP] (Cell Press, 2021)
    Protein lysine acetylation has emerged as a major regulatory post-translational modi!cation in different organisms, present not only on histone proteins affecting chromatin structure and gene expression but also on nonhistone ...
  • Epitranscriptome machinery in Trypanosomatids: new players on the table? 

    Maran, Suellen Rodrigues [UNIFESP]; Pitta, João Luiz de Lemos Padilha; Vasconcelos, Crhisllane Rafaele dos Santos; McDermott, Suzanne M.; Rezende, Antonio Mauro; Moretti, Nilmar Silvio (Wiley, 2021)
    Trypanosoma and Leishmania parasites cause devastating tropical diseases resulting in serious global health consequences. These organisms have complex life cycles with mammalian hosts and insect vectors. The parasites must, ...
  • Use of LeishGEdit CRISPR-Cas9 technology for genetic manipulation of protozoan parasite Leishmania 

    Maran, Suellen Rodrigues [UNIFESP]; Bonifácio, Bruno Souza [UNIFESP]; Zanchetta, Myrna [UNIFESP]; Garcia, Miguel Antonio do Nascimento [UNIFESP]; Catta-Preta, Carolina M. C.; Moretti, Nilmar Silvio [UNIFESP] (JoVE, 2021)
    The cell biology of a parasitic protozoan as well as the impact of the infection in host cells can be addressed using genome modification techniques. The development of robust methods eases the burden to obtain gene mutants ...
  • Effect of lysine acetylation on the regulation of Trypanosoma brucei glycosomal aldolase activity 

    Leite, Ariely Barbosa [UNIFESP]; Gomes, Antoniel Augusto Severo; Sousa, Ana Caroline de Castro Nascimento [UNIFESP]; Fontes, Marcos Roberto de Mattos; Schenkman, Sergio [UNIFESP]; Moretti, Nilmar Silvio [UNIFESP] (Portland Press, 2020)
    Post-translational modifications provide suitable mechanisms for cellular adaptation to environmental changes. Lysine acetylation is one of these modifications and occurs with the addition of an acetyl group to Nε-amino ...
  • Raising the Bar(-seq) in Leishmania genetic screens 

    Ferreira, Tiago R.; Couñago, Rafael M.; Moretti, Nilmar Silvio [UNIFESP] (Cell Press, 2021)
    Our understanding of regulatory factors in Leishmania differentia- tion has long been restricted by the available genetic tools, but the availability of CRISPR/Cas9 has changed the landscape forever. Recently, Baker and ...
  • Chromatin proteomics reveals variable histone modifications during the life cycle of Trypanosoma cruzi 

    de Jesus, Teresa Cristina Leandro; Nunes, Vinícius Santana [UNIFESP]; Lopes, Mariana de Camargo; Martil, Daiana Evelin; Iwai, Leo Kei; Moretti, Nilmar Silvio [UNIFESP]; Machado, Fabrício Castro [UNIFESP]; Lima-Stein, Mariana L. de [UNIFESP]; Thiemann, Otavio Henrique; Elias, Maria Carolina; Janzen, Christian; Schenkman, Sergio [UNIFESP]; Cunha, Julia Pinheiro Chagas da (ACS Publications, 2016)
    Histones are well-conserved proteins that form the basic structure of chromatin in eukaryotes and undergo several post-translational modifications, which are important for the control of transcription, replication, DNA ...
  • Impressão 3D de scaffolds de vidro S53P4/alginato de sódio reticulados com cloreto de cálcio: processamento, atividade antimicrobiana e bioatividade in vitro 

    Oliveira, Rodrigo Luiz Moraes Saldanha [UNIFESP] (Universidade Federal de São Paulo, 2021-10-26)
    A reconstrução de defeitos ósseos críticos é um desafio recorrente na medicina e odontologia, principalmente se tratando de defeitos provenientes de infecções. Por isso, pesquisas na engenharia tecidual procuram desenvolver ...
  • Chemogenetic characterization of inositol phosphate metabolic pathway reveals druggable enzymes for targeting kinetoplastid parasites 

    Cestari, Igor; Haas, Paige; Moretti, Nilmar Silvio [UNIFESP]; Schenkman, Sergio [UNIFESP]; Stuart, Ken (Cell Press, 2016)
    Kinetoplastids cause Chagas disease, human Afri- can trypanosomiasis, and leishmaniases. Current treatments for these diseases are toxic and ineffi- cient, and our limited knowledge of drug targets and inhibitors has ...
  • Preclinical gold complexes as oral drug candidates to treat leishmaniasis are potent Trypanothione reductase inhibitors 

    Tunes, Luiza G.; Morato, Roberta E.; Garcia, Adriana; Schmitz, Vinicius; Steindel, Mario; Correa-Junior, Jose A.D.; Santos, Helio F. Dos; Frezard, Frederic; Almeida, Mauro V. de; Silva, Heveline; Moretti, Nilmar S. [UNIFESP]; de Barros, Andre L. B.; Monte-Neto, Rubens L. do (ACS Publications, 2020)
    The drugs currently used to treat leishmaniases have limitations concerning cost, e!cacy, and safety, making the search for new therapeutic approaches urgent. We found that the gold(I)-derived complexes were active against ...
  • Characterization of Trypanosoma cruzi Sirtuins as possible drug targets for Chagas disease 

    Moretti, Nilmar Silvio [UNIFESP]; Augusto, Leonardo da Silva [UNIFESP]; Clemente, Tatiana Mordente [UNIFESP]; Antunes, Raysa Paes Pinto [UNIFESP]; Yoshida, Nobuko [UNIFESP]; Torrecilhas, Ana Claudia; Cano, Maria Isabel Nogueira; Schenkman, Sergio [UNIFESP] (ASM, 2015)
    Acetylation of lysine is a major posttranslational modification of proteins and is catalyzed by lysine acetyltransferases, while lysine deacetylases remove acetyl groups. Among the deacetylases, the sirtuins are NAD(+)-dependent ...
  • Massagem shantala: uma intervenção de enfermagem para favorecer a parentalidade 

    Cunha, Deborah de Almeida [UNIFESP] (Universidade Federal de São Paulo, 2021)
    Com este estudo discorremos sobre as contribuições da ação educativa realizada com a Massagem Shantala, uma intervenção de enfermagem por meio da monitoria no Grupo Terapêutico de Massagem e Estimulação com Bebês (GTMEB). ...
  • Panacea within a Pandora's box: the antiparasitic effects of phospholipases A2 (PLA2s) from snake venoms 

    Teixeira, Samuel Cota; Silva, Marcelo Santos da; Gomes, Antoniel Augusto Severo; Moretti, Nilmar Silvio [UNIFESP]; Lopes, Daiana Silva; Ferro, Eloisa Amália Vieira; Rodrigues, Veridiana de Melo (Cell Press, 2021)
    Parasitic diseases affect millions of individuals worldwide, mainly in low-income regions. There is no cure for most of these diseases, and the treatment relies on drugs that have side effects and lead to drug resistance, ...
  • Esperança e força: simbologia do tsuru para os pais com filhos em unidade de terapia intensiva neonatal 

    Silva, Alana Karin Alves [Unifesp] (Universidade Federal de São Paulo, 2021)
    Introdução: a internação do filho em Cuidados Intensivos Neonatais, pode gerar nos pais sentimentos diversos, como medo, culpa, ansiedade, estresse, sensação de incompetência e a vivência de luto antecipado. Diante desse ...
  • Caracterização da pressão de lábios e língua em pacientes com apneia obstrutiva do sono 

    Ferreira, Amanda Santiago [UNIFESP] (Universidade Federal de São Paulo, 2021)
    Introdução: A Apneia Obstrutiva do Sono (AOS) é um distúrbio comum caracterizada pelo colapso repetitivo das vias aéreas da faringe durante o sono, sendo a principal estrutura colapsante a língua . Objetivo: Correlacionar ...
  • Lysine acetylation as drug target in fungi: an underexplored potential in Aspergillus spp. 

    Wassano, Natália Sayuri; Leite, Ariely Barbosa [UNIFESP]; Reichert-Lima, Franqueline; Schreiber, Angelica Zaninelli; Moretti, Nilmar S. [UNIFESP]; Damasio, André (SBM, 2020)
    In recent years, the intensification of the use of immunosuppressive therapies has increased the incidence of invasive infections caused by opportunistic fungi. Considering that, the spread of azole resistance and amphotericin ...
  • Identification of inhibitors to Trypanosoma cruzi Sirtuins based on compounds developed to human enzymes 

    Bastos, Tanira Matutino; Soares, Milena Botelho Pereira; Franco, Caio Haddad; Alcântara, Laura; Antonini, Lorenzo; Sabatino, Manuela; Mautone, Nicola; Freitas-Junior, Lucio Holanda; Moraes, Carolina Borsoi; Ragno, Rino; Rotili, Dante; Schenkman, Sergio [UNIFESP]; Mai, Antonello; Moretti, Nilmar Silvio [UNIFESP] (MDPI, 2020)
    Chagas disease is an illness caused by the protozoan parasite Trypanosoma cruzi, a↵ecting more than 7 million people in the world. Benznidazole and nifurtimox are the only drugs available for treatment and in addition to ...
  • Chemical constituents of Anacardium occidentale as inhibitors of Trypanosoma cruzi Sirtuins 

    Bastos, Tanira Matutino; Russo, Helena Mannochio; Moretti, Nilmar Silvio [UNIFESP]; Schenkman, Sergio [UNIFESP]; Marcourt, Laurence; Gupta, Mahabir Prashad; Wolfender, Jean-Luc; Queiroz, Emerson Ferreira; Soares, Milena Botelho Pereira (MDPI, 2019)
    Benznidazole and nifurtimox, the only drugs available for the treatment of Chagas disease, have limited efficacy and have been associated with severe adverse side effects. Thus, there is an urgent need to find new biotargets ...

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