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dc.contributor.authorMoraes-Pinto, Maria Isabel de [UNIFESP]
dc.contributor.authorOno, Erika [UNIFESP]
dc.contributor.authorSantos-Valente, Elisangela Calheiro dos [UNIFESP]
dc.contributor.authorAlmeida, Liziane C
dc.contributor.authorAndrade, Paula Rosemberg de
dc.contributor.authorDinelli, Maria Isabel Saraiva [UNIFESP]
dc.contributor.authorDos Santos, Amelia Miyashiro [UNIFESP]
dc.contributor.authorSalomão, Reinaldo [UNIFESP]
dc.identifier.citationMemórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 109, n. 8, p. 989-998, 2014.
dc.description.abstractEthnic origin, genetics, gender and environmental factors have been shown to influence some immunologic indices, so that development of reference values for populations of different backgrounds may be necessary. We have determined the distribution of lymphocyte subsets in healthy Brazilian individuals from birth to adulthood. Lymphocyte subsets were determined using four-colour cytometry in a cross-sectional study of 463 human immunodeficiency virus-unexposed children and adults from birth through 49 years of age. Lymphocyte subsets varied according to age, as previously observed in other studies. However, total CD4+ T cell numbers were lower than what was described in the Pediatric AIDS Clinical Trials Group P1009 (PACTG P1009), which assessed an American population of predominantly African and Hispanic backgrounds until the 12-18 year age range, when values were comparable. Naïve percentages and absolute values of CD8+ T cells, as assessed by CD45RA expression, were also lower than the PACTG P1009 data for all analysed age ranges. CD38 expression on both CD4+ and CD8+ T cells was lower than the PACTG P1009 values, with a widening gap between the two studies at older age ranges. Different patterns of cell differentiation seem to occur in different settings and may have characteristic expression within each population.en
dc.publisherInstituto Oswaldo Cruz, Ministério da Saúde
dc.relation.ispartofMemórias do Instituto Oswaldo Cruz
dc.rightsAcesso aberto
dc.subjectlymphocyte subsetsen
dc.subjectflow cytometryen
dc.subjectclinical profileen
dc.titleLymphocyte subsets in human immunodeficiency virus-unexposed Brazilian individuals from birth to adulthooden
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionCentro Assistencial Cruz de Malta
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Medicina
dc.description.affiliationCentro Assistencial Cruz de Malta
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Pediatria
dc.description.affiliationUnifespUNIFESP, Depto. de Medicina
dc.description.affiliationUnifespUNIFESP, Depto. de Pediatria
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