Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/8521
Title: Imbalanced expression of functional surface molecules in regulatory and effector T cells in systemic lupus erythematosus
Authors: Mesquita Júnior, Danilo [UNIFESP]
Cruvinel, Wilson de Melo [UNIFESP]
Araujo, J.a.p.
Carvalho, Karina Inacio [UNIFESP]
Kallas, Esper Georges [UNIFESP]
Andrade, Luiz Eduardo Coelho [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade Católica de Goiás Departamento de Biomedicina
Universidade de São Paulo (USP)
Keywords: Systemic lupus erythematosus
T lymphocytes
Regulatory T cells
Effector T cells
Issue Date: 1-Aug-2014
Publisher: Associação Brasileira de Divulgação Científica
Citation: Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 47, n. 8, p. 662-669, 2014.
Abstract: Regulatory T (TREG) cells play an important role in maintaining immune tolerance and avoiding autoimmunity. We analyzed the expression of membrane molecules in TREG and effector T cells in systemic lupus erythematosus (SLE). TREG and effector T cells were analyzed for the expression of CTLA-4, PD1, CD28, CD95, GITR, HLA-DR, OX40, CD40L, and CD45RO in 26 patients with active disease, 31 with inactive disease, and 26 healthy controls. TREG cells were defined as CD25+/highCD127Ø/lowFoxP3+, and effector T cells were defined as CD25+CD127+FoxP3Ø. The ratio of TREG to effector T cells expressing GITR, PD1, HLA-DR, OX40, CD40L, and CD45RO was determined in the three groups. The frequency of TREG cells was similar in patients with SLE and controls. However, SLE patients had a decreased frequency of CTLA-4+TREG and CD28+TREG cells and an increased frequency of CD40L+TREG cells. There was a decrease in the TREG/effector-T ratio for GITR+, HLA-DR+, OX40+, and CD45RO+ cells, and an increased ratio of TREG/effector-T CD40L+ cells in patients with SLE. In addition, CD40L+TREG cell frequency correlated with the SLE disease activity index (P=0.0163). In conclusion, our findings showed several abnormalities in the expression of functionally critical surface molecules in TREG and effector T cells in SLE that may be relevant to the pathogenesis of this disease.
URI: http://repositorio.unifesp.br/handle/11600/8521
ISSN: 0100-879X
Other Identifiers: http://dx.doi.org/10.1590/1414-431X20143483
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