Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/8365
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dc.contributor.authorAlves, Rodrigo Andrade
dc.contributor.authorMiszputen, Sender Jankiel
dc.contributor.authorFigueiredo, Maria Stella [UNIFESP]
dc.date.accessioned2015-06-14T13:47:05Z
dc.date.available2015-06-14T13:47:05Z
dc.date.issued2014-04-14
dc.identifierhttp://dx.doi.org/10.1590/1516-3180.2014.1323568
dc.identifier.citationSão Paulo Medical Journal. Associação Paulista de Medicina - APM, v. 132, n. 3, p. 140-146, 2014.
dc.identifier.issn1516-3180
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/8365
dc.description.abstractCONTEXT AND OBJECTIVES:Anemia is the most frequent extraintestinal complication of inflammatory bowel disease. This study aimed to: 1) determine the prevalence of anemia among patients with inflammatory bowel disease; 2) investigate whether routine laboratory markers are useful for diagnosing anemia; and 3) evaluate whether any association exists between anemia and clinical/laboratory variables.DESIGN AND SETTING:Cross-sectional at a federal university.METHODS:44 outpatients with Crohn's disease and 55 with ulcerative colitis were evaluated. Clinical variables (disease activity index, location of disease and pharmacological treatment) and laboratory variables (blood count, iron laboratory, vitamin B12 and folic acid) were investigated.RESULTS:Anemia and/or iron laboratory disorders were present in 75% of the patients with Crohn's disease and in 78.2% with ulcerative colitis. Anemia was observed in 20.5% of the patients with Crohn's disease and in 23.6% with ulcerative colitis. Iron-deficiency anemia was highly prevalent in patients with Crohn's disease (69.6%) and ulcerative colitis (76.7%). Anemia of chronic disease in combination with iron deficiency anemia was present in 3% of the patients with Crohn's disease and in 7% of the patients with ulcerative colitis. There was no association between anemia and disease location. In ulcerative colitis, anemia was associated with the disease activity index.CONCLUSIONS:Most patients present iron laboratory disorders, with or without anemia, mainly due to iron deficiency. The differential diagnosis between the two most prevalent types of anemia was made based on clinical data and routine laboratory tests. In ulcerative colitis, anemia was associated with the disease activity index.en
dc.description.abstractCONTEXTO E OBJETIVOS:Anemia é a mais frequente complicação extraintestinal na doença inflamatória intestinal. Este estudo objetivou: 1) determinar a prevalência de anemia em portadores de doença inflamatória intestinal; 2) investigar se os marcadores laboratoriais de uso rotineiro são úteis para o diagnóstico da anemia; 3) avaliar se existe associação entre anemia e variáveis clínico-laboratoriais.TIPO DE ESTUDO E LOCAL:Estudo transversal em uma universidade federal.MÉTODOS:Foram avaliados 44 pacientes ambulatoriais com doença de Crohn e 55 com retocolite ulcerativa. Foram investigados aspectos clínicos (índice de atividade da doença, localização da doença e tratamento farmacológico) e laboratoriais (hemograma, ferrocinética, vitamina B12 e ácido fólico).RESULTADOS:Anemia e/ou anormalidades na ferrocinética estavam presentes em 75% dos pacientes com doença de Crohn e em 78,2% dos pacientes com retocolite. Anemia foi observada em 20,5% do grupo com doença de Crohn e em 23,6% do grupo com retocolite. Anemia por deficiência de ferro predominou entre os pacientes com doença de Crohn (69,6%) e com retocolite (76,7%). Anemia de doença crônica associada à anemia ferropriva estava presente em 3% dos pacientes com doença de Crohn e em 7% daqueles com retocolite. Na retocolite, a anemia estava associada com o índice de atividade da doença.CONCLUSÕES:A maioria dos pacientes apresentava alterações na ferrocinética com ou sem anemia, principalmente decorrente da ferropenia. O diagnóstico diferencial entre os dois tipos mais prevalentes de anemia foi baseado nos dados clínicos e nos testes laboratoriais de rotina. Anemia estava associada com o índice de atividade na retocolite.pt
dc.format.extent140-146
dc.language.isoeng
dc.publisherAssociação Paulista de Medicina - APM
dc.relation.ispartofSão Paulo Medical Journal
dc.rightsAcesso aberto
dc.subjectAnemiaen
dc.subjectInflammatory bowel diseasesen
dc.subjectPrevalenceen
dc.subjectAssociationen
dc.subjectDiagnosis, differentialen
dc.subjectAnemiapt
dc.subjectDoenças inflamatórias intestinaispt
dc.subjectPrevalênciapt
dc.subjectAssociaçãopt
dc.subjectDiagnóstico diferencialpt
dc.titleAnemia in inflammatory bowel disease: prevalence, differential diagnosis and association with clinical and laboratory variablesen
dc.title.alternativeAnemia na doença inflamatória intestinal: prevalência, diagnóstico diferencial e associação com variáveis clínicas e laboratoriaispt
dc.typeArtigo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Department of Medicine
dc.description.affiliationUnifespUNIFESP, Department of Medicine
dc.identifier.fileS1516-31802014000300140.pdf
dc.identifier.scieloS1516-31802014000300140
dc.identifier.doi10.1590/1516-3180.2014.1323568
dc.description.sourceSciELO
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