Please use this identifier to cite or link to this item: http://repositorio.unifesp.br/handle/11600/8337
Title: Do differences exist between chronic hepatitis C genotypes 2 and 3?
Authors: Melo, Isaura Cunha de [UNIFESP]
Ferraz, Maria Lucia Cardoso Gomes [UNIFESP]
Perez, Renata de Mello [UNIFESP]
Emori, Christini Takemi [UNIFESP]
Uehara, Silvia Naomi de Oliveira [UNIFESP]
Carvalho-Filho, Roberto José de [UNIFESP]
Silva, Antonio Eduardo Benedito [UNIFESP]
Souza e Silva, Ivonete Sandra de [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Rio de Janeiro Departamento de Medicina Interna
Keywords: Hepatitis C
HCV-2
HCV-3
Fibrosis
Issue Date: 1-Apr-2014
Publisher: Sociedade Brasileira de Medicina Tropical - SBMT
Citation: Revista da Sociedade Brasileira de Medicina Tropical. Sociedade Brasileira de Medicina Tropical - SBMT, v. 47, n. 2, p. 143-148, 2014.
Abstract: Introduction Six genotypes of the hepatitis C virus (HCV) have been identified thus far, and their distribution is well defined. Genotype 1, which is the most prevalent worldwide, is always compared to genotypes 2 and 3, particularly in terms of treatment response. However, little is known about the differences between genotypes 2 and 3 because these genotypes are analyzed together in most studies. Therefore, the aim of this study was to evaluate differences in the clinical, epidemiological, laboratory, and histological parameters between HCV-2 and HCV-3. Methods Patients with chronic hepatitis C infected with genotypes 2 and 3 were studied retrospectively and compared according to clinical, laboratory, and histological aspects. Hepatitis C virus-ribonucleic acid (HCV-RNA) was analyzed quantitatively by TaqMan® real-time PCR, and the HCV genotype was determined by sequencing the 5′-untranslated region. Results A total of 306 patients with chronic HCV-2 (n=50) and HCV-3 (n = 256) were studied. Subtype 2b (n=17/50) and subtype 3a (n=244/256) were the most prevalent among patients infected with HCV-2 and HCV-3, respectively. The mean age was 47 ± 10 years, and there was a predominance of men in the group studied (61%). Comparative analysis between HCV-2 and HCV-3 showed a younger age (p=0.002), less prevalence of arterial hypertension (p=0.03), higher serum albumin levels (p=0.01), more advanced stage of liver fibrosis (p=0.03), and higher frequency of steatosis in patients with HCV-3 (p=0.001). After multivariate regression analysis, all the variables, except serum albumin, remained as variables associated with HCV-3 in the final model. Conclusions Clinical and histological differences exist between HCV-2 and HVC-3, which suggests the need for separate analyses of these genotypes.
URI: http://repositorio.unifesp.br/handle/11600/8337
ISSN: 0037-8682
Other Identifiers: http://dx.doi.org/10.1590/0037-8682-0269-2013
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